The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Oxytocin plasma concentrations after single intranasal oxytocin administration–a study in healthy men
Abstract
The neuropeptide oxytocin has become a subject of great interest in studies investigating human social cognition. Single intranasal administration of the hormone has been reported to have positive behavioral effects, such as increasing trust or facilitating social approach, 45-80 min after administration. However, little is still known about the long-term pharmacokinetics of oxytocin nasal spray application in humans. This study addressed the question how long oxytocin plasma levels remain elevated following nasal spray administration. Another goal was to examine the influence of oxytocin administration on endogenous steroid hormones since such alterations might modulate social behavior via an indirect way. Eight healthy Caucasian men were challenged with a single intranasal application of 26 international units of oxytocin. Changes in oxytocin blood plasma levels, as well as steroid hormone levels of progesterone, testosterone and estradiol were assessed at 5 consecutive time points over a period of 3.5 h (-5, +30, +90, +150, +210 min relative to oxytocin administration). Results gave evidence for a substantial rise of oxytocin plasma levels 30 min after intranasal administration, observed in 7 of 8 participants. Group mean oxytocin plasma level was found to have returned to baseline already 90 min post administration, though in some individuals the plasma levels was still elevated relative to sampling at post 150 min. Steroid hormone analyses yielded a slight augmentation of endogenous testosterone levels 210 min after oxytocin administration. Our data confirms previous findings that oxytocin administered as a nasal spray enters the blood circulation, elevating oxytocin plasma levels for a limited time. Our findings suggest that this time window differs between individuals, but that, for the used dose, it does not extend beyond 150 min post administration. The data further provides preliminary evidence that intranasal oxytocin has an enhancing effect on testosterone in healthy men.
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In the citing paper
“Although there is good evidence that intranasal OXT increases the concentration of endogenous OXT found in blood plasma and saliva (Daughters et al., 2015;Gossen et al., 2012;Weisman et al., 2012)”
From Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear (2017) · cites this paper as Gossen et al., 2012
In the citing paper
“This significant difference lasted until the end of testing, approximately 108 minutes after administration, and peaked at 30 minutes.”
From Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study (2015) · cites this paper as [18]
In the citing paper
“except to corroborate other evidence that the impact of IN-OT lasts for at least 90 minutes in both plasma and saliva [18].”
From Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study (2015) · cites this paper as [18]
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Social effects of oxytocin in humans: context and person matter
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Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans
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Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520
“Indeed, intranasal OT administration also leads to increases in OT in plasma and saliva in humans (Gossen et al., 2012; van Ijzendoorn et al., 2012) and rhesus macaques (Modi et al., 2014).”
BackgroundIncreased brain and plasma oxytocin after nasal and peripheral administration in rats and mice
Neumann, I. D., Maloumby, R., Beiderbeck, D. I., Lukas, M., & Landgraf, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.003 · Cited by 511
Striepens, N., Kendrick, K. M., Hanking, V., Landgraf, R., Wüllner, U., Maier, W., & Hurlemann, R. (2013) · Scientific Reports · doi:10.1038/srep03440 · Cited by 452
Baribeau, D. A., & Anagnostou, E. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00335 · Cited by 241
Groppe, S. E., Gossen, A., Rademacher, L., Hahn, A., Westphal, L., Gründer, G., & Spreckelmeyer, K. N. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.023 · Cited by 218
Self-citation
Metadata
- Authors
- Gossen, A., Hahn, A., Westphal, L., Prinz, S., Schultz, R. T., Gründer, G., & Spreckelmeyer, K. N.
- Affiliations
- Jülich Aachen Research Alliance (DE)
- RWTH Aachen University (DE)
- University of Pennsylvania (US)
- Corresponding author
- Spreckelmeyer, K.N.
- Venue
- Neuropeptides
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 46
- Issue
- 5
- Pages
- 211-215
- ISSN
- 0143-4179 (ISSN-L)
- OpenAlex
- W2136974459
- Cited by
- 189
- References
- 21
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 7 · 2023: 9 · 2022: 14 · 2021: 16 · 2020: 18 · 2019: 11 · 2018: 22 · 2017: 13 · 2016: 16 · 2015: 17 · 2014: 12 · 2013: 15 · 2012: 1
- FWCI
- 21.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropeptides (publishedVersion)
- PubMed (publishedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, intranasal administration, plasma oxytocin, pharmacokinetics, testosterone, steroid hormones, progesterone, estradiol, social behavior, healthy men
- MeSH terms
- Administration, Intranasal, Adult, Estradiol, Humans, Male, Oxytocin, Progesterone, Testosterone
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