Cited by 107Migraine and Headache StudiesNeuropeptides and Animal PhysiologyPain Mechanisms and Treatments

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The interaction between the oxytocin and pain modulation in headache patients

Wang, Yong-Liang, Yuan, Yan, Yang, Jun, Wang, Chang-Hong, Pan, Yan-Juan, Lu, Lu, Wu, Yu-Quan, Wang, Da-Xin, Lv, Lu-Xian, Li, Ren-Ren, Xue, Lei, Wang, Xin-Hua, Bi, Jian-Wei, Liu, Xin-Feng, Qian, Yan-Ning, Deng, Zhi-Kuan, Zhang, Zhi-Jian, Zhai, Xin-Huan, Zhou, Xin-Jian, Wang, Guo-Liang, Zhai, Jian-Xin, Liu, Wen-Yan·2013·Neuropeptides

DOI 10.1016/j.npep.2012.12.003

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Abstract

Oxytocin (OXT), a nonapeptide hormone of posterior pituitary, reaches the central nervous system from systemic blood circulation with a difficulty because of the blood-brain barrier (BBB). The interest has been expressed in the use of the nasal route for delivery of OXT to the brain directly, exploiting the olfactory pathway. Our previous study has demonstrated that OXT in the central nervous system rather than the blood circulation plays an important role in rat pain modulation. The communication tried to investigate the interaction between the OXT and pain modulation in Chinese patients with headache to understand the OXT effect on human pain modulation. The results showed that (1) intranasal OXT could relieve the human headache in a dose-dependent manner; (2) OXT concentration in both plasma and cerebrospinal fluid (CSF) increased significantly in headache patients in relation with the pain level; and (3) there was a positive relationship between plasma and CSF OXT concentration in headache patients. The data suggested that intranasal OXT, which was delivered to the central nervous system through olfactory region, could treat human headache and OXT might be a potential drug of headache relief by intranasal administration.

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Authors: Wang, Y.-L., Yuan, Y., Yang, J., Wang, C.-H., Pan, Y.-J., Lu, L., Wu, Y.-Q., Wang, D.-X., Lv, L.-X., Li, R.-R., Xue, L., Wang, X.-H., Bi, J.-W., Liu, X.-F., Qian, Y.-N., Deng, Z.-K., Zhang, Z.-J., Zhai, X.-H., Zhou, X.-J., Wang, G.-L., Zhai, J.-X., & Liu, W.-Y.
Affiliations: First Affiliated Hospital of Xinxiang Medical University (CN)
Henan Medical University (CN)
117th Hospital of People's Liberation Army (CN)
Guangdong 999 Brain Hospital (CN)
Nanfang Hospital (CN)
Tongji University (CN)
Army Medical University (CN)
Chinese People's Liberation Army (CN)
General Hospital of Guangzhou Military Command (CN)
Wuxi Fourth People's Hospital (CN)
Corresponding author: Yang, Jun
ORCID: Yuan, Yan
Yang, Jun
Deng, Zhi-Kuan
Wang, Guo-Liang
Venue: Neuropeptides
Publisher: Elsevier BV
Published: 2013-04
Volume: 47
Issue: 2
Pages: 93-97
ISSN: 0143-4179 (ISSN-L)
DOI: 10.1016/j.npep.2012.12.003
OpenAlex: W2027956310
Cited by: 107
References: 22
Citations by year: 2026: 6 · 2025: 2 · 2024: 12 · 2023: 7 · 2022: 7 · 2021: 9 · 2020: 8 · 2019: 11 · 2018: 7 · 2017: 13 · 2016: 4 · 2015: 6 · 2014: 12 · 2013: 2
FWCI: 5.67
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropeptides (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Keywords: oxytocin, headache, pain modulation, intranasal administration, olfactory pathway, cerebrospinal fluid, blood-brain barrier, headache treatment
MeSH terms: Administration, Intranasal, Adult, Dose-Response Relationship, Drug, Female, Headache, Humans, Male, Middle Aged, Oxytocin, Pain, Pain Measurement, Asian People, Young Adult

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The interaction between the oxytocin and pain modulation in headache patients

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