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The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials

Paloyelis, Y., Krahé, C., Maltezos, S., Williams, S. C., Howard, M. A., & Fotopoulou, A. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12347 · Cited by 61 · see citing works

The psychophysiology of music-based interventions and the experience of pain

Arnold, C. A., Bagg, M. K., & Harvey, A. R. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1361857 · Cited by 64 · see citing works

An overview of the oxytocin-oxytocin receptor signaling network

Chatterjee, O., Patil, K., Sahu, A., Gopalakrishnan, L., Mol, P., Advani, J., Mukherjee, S., Christopher, R., & Prasad, T. S. K. (2016) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-016-0353-7 · Cited by 55 · see citing works

Oxytocin in the anterior cingulate cortex is involved in helping behaviour

Yamagishi, A., Lee, J., & Sato, N. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112790 · Cited by 50 · see citing works

Pain, Parental Involvement, and Oxytocin in the Neonatal Intensive Care Unit

Filippa, M., Poisbeau, P., Mairesse, J., Monaci, M. G., Baud, O., Hüppi, P. S., Grandjean, D., & Kuhn, P. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00715 · Cited by 56 · see citing works

Potential treatment targets for migraine: emerging options and future prospects

Chiang, C., Porreca, F., Robertson, C. E., & Dodick, D. W. (2024) · The Lancet Neurology · doi:10.1016/s1474-4422(24)00003-6 · Cited by 37 · see citing works

Oxytocin as a regulatory neuropeptide in the trigeminovascular system: Localization, expression and function of oxytocin and oxytocin receptors

Warfvinge, K., Krause, D. N., Maddahi, A., Grell, A.-S., Edvinsson, J. C. A., Haanes, K. A., & Edvinsson, L. I. (2020) · Cephalalgia · doi:10.1177/0333102420929027 · Cited by 36 · see citing works

The role of peripheral vasopressin 1A and oxytocin receptors on the subcutaneous vasopressin antinociceptive effects

Manzano‐García, A., González‐Hernández, A., Tello-García, I. A., Martı́nez-Lorenzana, G., & Condés‐Lara, M. (2017) · European Journal of Pain · doi:10.1002/ejp.1134 · Cited by 32 · see citing works

Oxytocin, GABA, and TRPV1, the Analgesic Triad?

González‐Hernández, A., & Charlet, A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00398 · Cited by 32 · see citing works

Oxytocin inhibits the rat medullary dorsal horn Sp5c/C1 nociceptive transmission through OT but not V 1A receptors

García-Boll, E., Martı́nez-Lorenzana, G., Condés‐Lara, M., & González‐Hernández, A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.031 · Cited by 30 · see citing works

ATP-Sensitive Potassium Channels in Migraine: Translational Findings and Therapeutic Potential

Clement, A., Guo, S., Jansen‐Olesen, I., & Christensen, S. L. (2022) · Cells · doi:10.3390/cells11152406 · Cited by 29 · see citing works

Vasopressin and oxytocin in sensory neurones: expression, exocytotic release and regulation by lactation

Dayanithi, G., Forostyak, O., Forostyak, S., Kayano, T., Ueta, Y., & Verkhratsky, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-31361-1 · Cited by 26 · see citing works

The Comprehensive Neural Mechanism of Oxytocin in Analgesia

Yang, L., Chen, K., Yin, X., Liu, D., & Zhu, L. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210826142107 · Cited by 26 · see citing works

Oxytocin structure and function in New World monkeys: from pharmacology to behavior

Mustoe, A. C., Taylor, J. H., & French, J. A. (2018) · Integrative Zoology · doi:10.1111/1749-4877.12318 · Cited by 25 · see citing works

Oxytocin: pain relief in skin

Grinevich, V., & Charlet, A. (2017) · Pain · doi:10.1097/j.pain.0000000000001006 · Cited by 24 · see citing works

The antinociception of oxytocin on colonic hypersensitivity in rats was mediated by inhibition of mast cell degranulation via Ca2+-NOS pathway

Gong, L., Li, J., Tang, Y., Han, T., Wei, C., Yu, X., Li, J., Wang, R., Ma, X., Liu, K., et al. (2016) · Scientific Reports · doi:10.1038/srep31452 · Cited by 24 · see citing works

A new hypothesis linking oxytocin to menstrual migraine

Bharadwaj, V. N., Porreca, F., Cowan, R. P., Kori, S. H., Silberstein, S. D., & Yeomans, D. C. (2021) · Headache The Journal of Head and Face Pain · doi:10.1111/head.14152 · Cited by 23 · see citing works

The role of oxytocin, vasopressin, and their receptors at nociceptors in peripheral pain modulation

Zheng, H., Lim, J. Y., Kim, Y., Jung, S. T., & Hwang, S. W. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100942 · Cited by 23 · see citing works

Activation of oxytocin receptor in the trigeminal ganglion attenuates orofacial ectopic pain attributed to inferior alveolar nerve injury

Huang, C., Liu, F., Zhang, Y., Lin, J., Fu, M., Li, Y., Zhou, C., Li, C., & Shen, J. (2020) · Journal of Neurophysiology · doi:10.1152/jn.00646.2020 · Cited by 23 · see citing works

Oxytocin modulates neural processing of mitral/tufted cells in the olfactory bulb

Sun, C., Yin, Z., Li, B., Du, H., Tang, K., Liu, P., Pun, S. H., Lei, T. C., & Li, A. (2021) · Acta Physiologica · doi:10.1111/apha.13626 · Cited by 23 · see citing works

Deletion of Kir6.2/SUR1 potassium channels rescues diminishing of DA neurons via decreasing iron accumulation in PD

Zhang, Q., CHENG-WU, L., Zhang, T., Ge, Y., Han, X., Sun, S., Ding, J., Lu, M., & Hu, G. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.08.006 · Cited by 20 · see citing works

Inhibition of nociceptive dural input to the trigeminocervical complex through oxytocinergic transmission

García-Boll, E., Martı́nez-Lorenzana, G., Condés‐Lara, M., & González‐Hernández, A. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113079 · Cited by 20 · see citing works

Peripheral oxytocin restores light touch and nociceptor sensory afferents towards normal after nerve injury

Boada, M. D., Gutierrez, S., & Eisenach, J. C. (2019) · Pain · doi:10.1097/j.pain.0000000000001495 · Cited by 19 · see citing works

The neuroprotective effect of oxytocin on vincristine-induced neurotoxicity in mice

Zhu, J., Li, Y., Liang, J., Li, J., Huang, K., Li, J., & Liu, C. (2021) · Toxicology Letters · doi:10.1016/j.toxlet.2021.01.008 · Cited by 18 · see citing works

Epigenomic landscape of the human dorsal root ganglion: sex differences and transcriptional regulation of nociceptive genes

Franco‐Enzástiga, Ú., Inturi, N. N., Natarajan, K., Mwirigi, J. M., Mazhar, K., Schlachetzki, J. C. M., Schumacher, M. A., & Price, T. J. (2025) · Pain · doi:10.1097/j.pain.0000000000003508 · Cited by 17 · see citing works

A Proposed Molecular Mechanism for Physical Analgesia in Chronic Pain

Saito, N., Shima, R., Yamada, Y., Nagaoka, M., Ito, E., & Yoshioka, T. (2018) · Neural Plasticity · doi:10.1155/2018/1260285 · Cited by 17 · see citing works

Insulin-Like Growth Factor 1 Increases GABAergic Neurotransmission to GnRH Neurons via Suppressing the Retrograde Tonic Endocannabinoid Signaling Pathway in Mice

Bálint, F., Csillag, V., Vastagh, C., Liposits, Z., & Farkas, I. (2020) · Neuroendocrinology · doi:10.1159/000514043 · Cited by 17 · see citing works

Plasticity and Function of Spinal Oxytocin and Vasopressin Signaling during Recovery from Surgery with Nerve Injury

Severino, A. L., Chen, R., Hayashida, K., Aschenbrenner, C. A., Sun, H., Peters, C. M., Gutierrez, S., Pan, B., & Eisenach, J. C. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002290 · Cited by 17 · see citing works

Oxytocin-Dependent Regulation of TRPs Expression in Trigeminal Ganglion Neurons Attenuates Orofacial Neuropathic Pain following Infraorbital Nerve Injury in Rats

Ando, M., Hayashi, Y., Hitomi, S., Shibuta, I., Furukawa, A., Oto, T., Inada, T., Matsui, T., Fukaya, C., Noma, N., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239173 · Cited by 17 · see citing works

Role of central oxytocin and dopamine systems in nociception and their possible interactions: suggested hypotheses

Gamal‐Eltrabily, M., & Manzano-García, A. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0068 · Cited by 14 · see citing works

Involvement of oxytocin receptor deficiency in psychiatric disorders and behavioral abnormalities

Wei, J., Zheng, H., Li, G., Chen, Z., Fang, G., & Yan, J. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1164796 · Cited by 13 · see citing works

Post-Inhibitory Rebound Firing of Dorsal Root Ganglia Neurons

Zhu, T., Wei, S., & Wang, Y. (2022) · Journal of Pain Research · doi:10.2147/jpr.s370335 · Cited by 11 · see citing works

Secretin Regulates Excitatory GABAergic Neurotransmission to GnRH Neurons via Retrograde NO Signaling Pathway in Mice

Csillag, V., Vastagh, C., Liposits, Z., & Farkas, I. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00371 · Cited by 11 · see citing works

Cellular Mechanisms for Antinociception Produced by Oxytocin and Orexins in the Rat Spinal Lamina II—Comparison with Those of Other Endogenous Pain Modulators

Kumamoto, E. (2019) · Pharmaceuticals · doi:10.3390/ph12030136 · Cited by 11 · see citing works

Profile of dorsal root ganglion neurons: study of oxytocin expression

Noguri, T., Hatakeyama, D., Kitahashi, T., Oka, K., & Ito, E. (2022) · Molecular Brain · doi:10.1186/s13041-022-00927-6 · Cited by 10 · see citing works

Activation of spinal MrgC-Gi-NR2B-nNOS signaling pathway by Mas oncogene-related gene C receptor agonist bovine adrenal medulla 8-22 attenuates bone cancer pain in mice.

Sun, Y., Zhang, J., Lei, Y., Lu, C., Hou, B., Ma, Z., & Gu, X. (2016) · PubMed Central · Cited by 10 · see citing works

Molecular aspects of delta opioid receptors

Gendron, L., Nagi, K., Zeghal, M., Giguère, P. M., & Piñeyro, G. (2019) · Vitamins and hormones · doi:10.1016/bs.vh.2019.06.001 · Cited by 9 · see citing works

Exaggerated potassium current reduction by oxytocin in visceral sensory neurons following chronic intermittent hypoxia

Dantzler, H. A., & Kline, D. D. (2020) · Autonomic Neuroscience · doi:10.1016/j.autneu.2020.102735 · Cited by 9 · see citing works

Adhesive pyramidal thorn patches provide pain relief to athletes

Saito, N., Shima, R., Yen, C., Yang, R., Ito, E., & Yoshioka, T. (2019) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.12044 · Cited by 9 · see citing works

ALPK1 Expressed in IB4-Positive Neurons of Mice Trigeminal Ganglions Promotes MIA-Induced TMJ pain

Zhu, T., Li, H., Chen, Y., Jia, X., Ma, X., Liu, X., Feng, Y., & Ke, J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03462-0 · Cited by 8 · see citing works

Hypothalamic and sex-related hormones in migraine

Warfvinge, K., Edvinsson, J. C. A., Maddahi, A., & Edvinsson, L. I. (2026) · The Journal of Headache and Pain · doi:10.1186/s10194-026-02289-z · Cited by 7 · see citing works

Presynaptic glutamatergic transmission and feedback system of oxytocinergic neurons in the hypothalamus of a rat model of adjuvant arthritis

Fujitani, T., Matsuura, T., Kawasaki, M., Suzuki, H., Nishimura, H., Baba, K., Yamanaka, Y., Ohnishi, H., Ueta, Y., & Sakai, A. (2020) · Molecular Pain · doi:10.1177/1744806920943334 · Cited by 8 · see citing works

Intradermal Injection of Oxytocin Aggravates Chloroquine-Induced Itch Responses via Activating the Vasopressin-1a Receptor/Nitric Oxide Pathway in Mice

Li, R., Sun, H., Zheng, H., Zong, Z., Li, S., Meng, T., Li, J., Liu, Y., Wang, C., & Li, J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01380 · Cited by 6 · see citing works

In Vivo Dissection of Two Intracellular Pathways Involved in the Spinal Oxytocin-Induced Antinociception in the Rat

Monteros-Zúñiga, A. E. D. L., Martı́nez-Lorenzana, G., Condés‐Lara, M., & González‐Hernández, A. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00471 · Cited by 6 · see citing works

Infiltrated Macrophages Aggravate TMJOA Chronic Pain via Piezo2 in IB4 + ‐ TG Neurons

Jia, X., Liu, X., Zhu, T., Ma, X., Chen, R., Li, H., Feng, Y., Zheng, L. W., Liu, Y., & Ke, J. (2025) · Oral Diseases · doi:10.1111/odi.15304 · Cited by 5 · see citing works

Nitric oxide synthase contributes to the maintenance of LTP in the oxytocin– mRFP1 neuron of the rat hypothalamus

Matsuura, T., Kawasaki, M., Suzuki, H., Fujitani, T., Baba, K., Nishimura, H., Ikeda, N., Yamanaka, Y., Tsukamoto, M., Yoshimi, Y., et al. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13340 · Cited by 5 · see citing works

Effects of systemic oxytocin administration on ultraviolet B-induced nociceptive hypersensitivity and tactile hyposensitivity in mice

Boada, M. D., Gutierrez, S., & Eisenach, J. C. (2024) · Molecular Pain · doi:10.1177/17448069241226553 · Cited by 4 · see citing works

Inflammatory Orofacial Pain Activates Peptidergic Neurons and Upregulates the Oxytocin Receptor Expression in Trigeminal Ganglion

Kemenesi-Gedei, P. B., Csabafi, K., & Kis, G. (2023) · Biomedicines · doi:10.3390/biomedicines11092419 · Cited by 4 · see citing works

The antipsychotic aripiprazole induces peripheral antinociceptive effects through PI3Kγ/NO/cGMP/KATP pathway activation

Ferreira, R. C. M., Almeida, D. L., Duarte, I. D. G., de Aguiar, D. C., Moreira, F. A., & Romero, T. R. L. (2022) · European Journal of Pain · doi:10.1002/ejp.1910 · Cited by 4 · see citing works

The effects of extended nitric oxide release on responses of the human non-pregnant myometrium to endothelin-1 or vasopressin

Modzelewska, B., Jóźwik, M., Jóźwik, M., Tylicka, M., & Kleszczewski, T. (2019) · Pharmacological Reports · doi:10.1016/j.pharep.2019.05.003 · Cited by 3 · see citing works

Influence of gap junctions upon Ca2+ propagation from stimulated keratinocytes to DRG neurons

Seto, C., Toyoda, K., Inada, K., Oka, K., & Ito, E. (2022) · Biophysics and Physicobiology · doi:10.2142/biophysico.bppb-v19.0041 · Cited by 3 · see citing works

Exploring the Painless Nature and Potential Mechanisms of Asymptomatic Irreversible Pulpitis: A Narrative Review

Abad, D. P. C., Jara-Vergara, V. C., & Álvarez-Vásquez, J. L. (2024) · The Open Dentistry Journal · doi:10.2174/0118742106281444240219050149 · Cited by 2 · see citing works

Oxytocin Attenuates Sympathetic Innervation with Inhibition of Cardiac Mast Cell Degranulation in Rats after Myocardial Infarction

Yin, J., Ye, W., Han, W., Ge, W., Yu, Q., Jing, Y., Yan, W., Liu, Q., Gong, L., Yan, S., et al. (2024) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.124.002064 · Cited by 2 · see citing works

The role of the endocannabinoid 2-arachidonoylglycerol in the in vivo spinal oxytocin-induced antinociception in male rats

Salinas-Abarca, A. B., Martı́nez-Lorenzana, G., Condés‐Lara, M., & González‐Hernández, A. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114383 · Cited by 2 · see citing works

Hormones and the Regulation of Neuronal Voltage-Sensing Ion Channels

Lyons, D. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813814-4.00011-0 · Cited by 1 · see citing works

Peripheral Branch Injury Induces Oxytocin Receptor Expression at the Central Axon Terminals of Primary Sensory Neurons

Heni, H. E., Kemenesi-Gedei, P. B., Pálvölgyi, L., Szeredi, I. D., & Kis, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010007 · Cited by 1 · see citing works

Infiltrated macrophages aggravate TMJOA chronic pain via Piezo2 in IB4 + - TG neuronsPreprint

Jia, X., Liu, X., Zhu, T., Ma, X., Chen, R., Li, H., Feng, Y., Zheng, L. W., Liu, Y., & Jin, K. (2024) · Research Square · doi:10.21203/rs.3.rs-3829042/v1 · Cited by 1 · see citing works

Presynaptic feedback system of oxytocinergic neurons in the hypothalamus of a rat model of adjuvant arthritisPreprint

Fujitani, T., Matsuura, T., Kawasaki, M., Suzuki, H., Nishimura, H., Baba, K., Yamanaka, Y., Ohnishi, H., Ueta, Y., & Sakai, A. (2019) · doi:10.21203/rs.2.18454/v1

Oxytocin attenuates sympathetic innervation with inhibition of cardiac mast cell degranulation in rats post myocardial infarctionPreprint

Hu, H., Yin, J., Ge, W., Yu, Q., Jing, Y., Yan, W., Liu, Q., Gong, L., Yan, S., Wang, S., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3565452/v1

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Oxytocin Inhibits the Membrane Depolarization-Induced Increase in Intracellular Calcium in Capsaicin Sensitive Sensory Neurons: A Peripheral Mechanism of Analgesic Action

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Oxytocin down‐regulates mesenteric afferent sensitivity via the enteric OTR / nNOS / NO /KATP pathway in rat

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