Cited by 588Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchCholinesterase and Neurodegenerative Diseases

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Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

Barage, Sagar H., Sonawane, Kailas D.·2015·Neuropeptides

DOI 10.1016/j.npep.2015.06.008

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Abstract

Alzheimer's disease is an irreversible, progressive neurodegenerative disorder. Various therapeutic approaches are being used to improve the cholinergic neurotransmission, but their role in AD pathogenesis is still unknown. Although, an increase in tau protein concentration in CSF has been described in AD, but several issues remains unclear. Extensive and accurate analysis of CSF could be helpful to define presence of tau proteins in physiological conditions, or released during the progression of neurodegenerative disease. The amyloid cascade hypothesis postulates that the neurodegeneration in AD caused by abnormal accumulation of amyloid beta (Aβ) plaques in various areas of the brain. The amyloid hypothesis has continued to gain support over the last two decades, particularly from genetic studies. Therefore, current research progress in several areas of therapies shall provide an effective treatment to cure this devastating disease. This review critically evaluates general biochemical and physiological functions of Aβ directed therapeutics and their relevance.

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BindingDB Entry 50013955: Huprine Y - Tryptophan heterodimers with potential implication to Alzheimer's disease treatment.
BindingDB (2022) · UC San Diego · doi:10.7270/q2wd44bg
BindingDB Entry 50007526: Synthesis and evaluation of novel GSK-3β inhibitors as multifunctional agents against Alzheimer's disease.
BindingDB (2021) · UC San Diego · doi:10.7270/q26976wc
BindingDB Entry 50007468: Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
BindingDB (2021) · UC San Diego · doi:10.7270/q2v69nvx

Authors: Barage, S. H., & Sonawane, K. D.
Affiliations: Shivaji University (IN)
Corresponding author: Sonawane, Kailas D.
ORCID: Barage, Sagar H.
Sonawane, Kailas D.
Venue: Neuropeptides
Publisher: Elsevier BV
Published: 2015-08
Volume: 52
Pages: 1-18
ISSN: 0143-4179 (ISSN-L)
DOI: 10.1016/j.npep.2015.06.008
OpenAlex: W2099751992
Cited by: 579
References: 371
Citations by year: 2026: 22 · 2025: 57 · 2024: 75 · 2023: 69 · 2022: 58 · 2021: 67 · 2020: 59 · 2019: 58 · 2018: 51 · 2017: 33 · 2016: 24 · 2015: 5
FWCI: 4.66
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropeptides (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Keywords: Alzheimer's disease, amyloid hypothesis, amyloid-beta, amyloid plaques, tau protein, cerebrospinal fluid biomarkers, cholinergic neurotransmission, neurodegeneration, Alzheimer's disease therapeutics, genetic risk factors
MeSH terms: Acetylcholine, Alzheimer Disease, Animals, Brain, Humans, Signal Transduction, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Neurofibrillary Tangles, tau Proteins

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Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

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