BDNF promotes the growth of human neurons through crosstalk with the Wnt/β-catenin signaling pathway via GSK-3β
Abstract
Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal growth; however, the downstream regulatory mechanisms remain unclear. In this study, we investigated whether BDNF exerts its neurotrophic effects through the Wnt/β-catenin signaling pathway in human embryonic spinal cord neurons in vitro. We found that neuronal growth (soma size and average neurite length) was increased by transfection with a BDNF overexpression plasmid. Western blotting and real-time quantitative PCR showed that expression of the BDNF pathway components TrkB, PI3K, Akt and PLC-γ was increased by BDNF overexpression. Furthermore, the Wnt signaling factors Wnt, Frizzled and Dsh and the downstream target β-catenin were upregulated, whereas GSK-3β was downregulated. In contrast, when BDNF signaling was downregulated with BDNF siRNA, the growth of neurons was decreased. Furthermore, BDNF signaling factors, Wnt pathway components and β-catenin were all downregulated, whereas GSK-3β was upregulated. This suggests that BDNF affects the growth of neurons in vitro through crosstalk with Wnt signaling, and that GSK-3β may be a critical factor linking these two pathways. To evaluate this possibility, we treated neurons with 6-bromoindirubin-3'-oxime (BIO), a small molecule GSK-3β inhibitor. BIO reduced the effects of BDNF upregulation/downregulation on soma size and average neurite length, and suppressed the impact of BDNF modulation on the Wnt signaling pathway. Taken together, our findings suggest that BDNF promotes the growth of neurons in vitro through crosstalk with the Wnt/β-catenin signaling pathway, and that this interaction may be mediated by GSK-3β.
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Exercise may activate extracellular signals known to inhibit GSK-3, including BDNF.
“Exercise may activate some extracellular signals that are known to inhibit GSK-3, including BDNF [180,206].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [206]
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- Authors
- Yang, J.-W., Ru, J., Ma, W., Gao, Y., Liang, Z., Liu, J., Guo, J.-H., & Li, L.-Y.
- Affiliations
- Kunming Medical University (CN)
- First People's Hospital of Yunnan Province (CN)
- Venue
- Neuropeptides
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 54
- Pages
- 35-46
- ISSN
- 0143-4179 (ISSN-L)
- OpenAlex
- W1146627176
- Cited by
- 70
- References
- 75
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 12 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 5 · 2017: 8 · 2016: 4
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropeptides (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of China (30960156, 31260253)
- Priority Union Foundation of Yunnan Provincial Science and Technology Department
- Kunming Medical University (2012FB002)
- Special Major Foundation of Yunnan Province Education Department (No. ZD2013002)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- brain-derived neurotrophic factor, Wnt/β-catenin signaling, GSK3β, neuronal growth, signaling crosstalk, TrkB, PI3K/Akt signaling, phospholipase C-gamma, Frizzled receptors, DSH, neurite length, soma size
- MeSH terms
- Glycogen Synthase Kinase 3 beta, Cell Survival, Cells, Cultured, Fetus, Humans, Indoles, Neurons, Oximes, RNA, Messenger, Spinal Cord, Brain-Derived Neurotrophic Factor, Glycogen Synthase Kinase 3, Wnt Signaling Pathway
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