Cited by 18Smoking Behavior and CessationNeurotransmitter Receptor Influence on BehaviorNicotinic Acetylcholine Receptors Study

Adolescent exposure to nicotine alters the aversive effects of cocaine in adult rats

Hutchison, Mary Anne, Riley, Anthony L.·2008·Neurotoxicology and Teratology

Abstract

Nicotine is one of the most commonly used drugs in adolescence and has been shown to alter the rewarding effects of cocaine when administered in adulthood. Although the abuse potential of a drug has been suggested to be a balance between its rewarding and aversive effects, the long-term effects of nicotine on the aversive properties of other drugs had not been studied. To that end, in the present study rats exposed to nicotine (0.4 mg/kg) during adolescence (postnatal days 35-44) were tested for the acquisition and extinction of a cocaine-induced conditioned taste aversion (10, 18 or 32 mg/kg) in adulthood. Conditioning consisted of four saccharin-drug pairings followed by six extinction trials. Although cocaine-induced aversions at all doses, no effect of nicotine preexposure was seen during acquisition. During extinction, the nicotine-preexposed groups conditioned with 10 and 18 mg/kg cocaine displayed a decreased rate of extinction compared to their respective controls. These results suggest that while adolescent nicotine exposure does not appear to directly alter the aversive properties of cocaine it may affect other processes related to the response to drugs given in adulthood.

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Crossref · 10.1016/j.ntt.2008.04.004

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  • Nicotine follows an inverted U-shaped dose-response curve, and smokers titrate intake to get rewarding effects while avoiding aversive effects of high doses.

    “Nicotine follows an inverted U-shaped dose-response curve [18, 60], and smokers titrate their nicotine intake to experience the rewarding while avoiding the aversive effects produced by high nicotine doses [61–64].”

    From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [61]

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Authors
Hutchison, M. A., & Riley, A. L.
Affiliations
American University (US)
Corresponding author
Hutchison, Mary Anne
Venue
Neurotoxicology and Teratology
Publisher
Elsevier BV
Published
2008-09
Volume
30
Issue
5
Pages
404-411
ISSN
0892-0362 (ISSN-L)
OpenAlex
W2038200540
Cited by
18
References
99
Citations by year
2021: 2 · 2020: 2 · 2017: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
FWCI
1.58
Type
journal article
Language
en
Open access
closed
Locations
  • Neurotoxicology and Teratology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
adolescent nicotine exposure, cocaine, conditioned taste aversion, extinction, abuse liability, developmental drug exposure
MeSH terms
Age Factors, Animals, Avoidance Learning, Brain, Brain Chemistry, Cocaine, Dose-Response Relationship, Drug, Drug Synergism, Extinction, Psychological, Male, Nicotine, Taste, Rats, Sprague-Dawley, Nicotinic Agonists, Dopamine Uptake Inhibitors, Cocaine-Related Disorders, Rats

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