Adolescent exposure to nicotine alters the aversive effects of cocaine in adult rats
Abstract
Nicotine is one of the most commonly used drugs in adolescence and has been shown to alter the rewarding effects of cocaine when administered in adulthood. Although the abuse potential of a drug has been suggested to be a balance between its rewarding and aversive effects, the long-term effects of nicotine on the aversive properties of other drugs had not been studied. To that end, in the present study rats exposed to nicotine (0.4 mg/kg) during adolescence (postnatal days 35-44) were tested for the acquisition and extinction of a cocaine-induced conditioned taste aversion (10, 18 or 32 mg/kg) in adulthood. Conditioning consisted of four saccharin-drug pairings followed by six extinction trials. Although cocaine-induced aversions at all doses, no effect of nicotine preexposure was seen during acquisition. During extinction, the nicotine-preexposed groups conditioned with 10 and 18 mg/kg cocaine displayed a decreased rate of extinction compared to their respective controls. These results suggest that while adolescent nicotine exposure does not appear to directly alter the aversive properties of cocaine it may affect other processes related to the response to drugs given in adulthood.
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Nicotine follows an inverted U-shaped dose-response curve, and smokers titrate intake to get rewarding effects while avoiding aversive effects of high doses.
“Nicotine follows an inverted U-shaped dose-response curve [18, 60], and smokers titrate their nicotine intake to experience the rewarding while avoiding the aversive effects produced by high nicotine doses [61–64].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [61]
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“N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript Dani et al. 2009, Hutchison & Riley 2008, Kassel et al. 2007, Simpson & Riley 2005, Wise et al. 1976).”
BackgroundMechanistic insights into nicotine withdrawal
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- Authors
- Hutchison, M. A., & Riley, A. L.
- Affiliations
- American University (US)
- Corresponding author
- Hutchison, Mary Anne
- ORCID
- Riley, Anthony L.
- Venue
- Neurotoxicology and Teratology
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 30
- Issue
- 5
- Pages
- 404-411
- ISSN
- 0892-0362 (ISSN-L)
- OpenAlex
- W2038200540
- Cited by
- 18
- References
- 99
- Citations by year
- 2021: 2 · 2020: 2 · 2017: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurotoxicology and Teratology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- adolescent nicotine exposure, cocaine, conditioned taste aversion, extinction, abuse liability, developmental drug exposure
- MeSH terms
- Age Factors, Animals, Avoidance Learning, Brain, Brain Chemistry, Cocaine, Dose-Response Relationship, Drug, Drug Synergism, Extinction, Psychological, Male, Nicotine, Taste, Rats, Sprague-Dawley, Nicotinic Agonists, Dopamine Uptake Inhibitors, Cocaine-Related Disorders, Rats
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