Nicotine enhances both foreground and background contextual fear conditioning
Open accessAbstract
The present study examined if nicotine enhances contextual fear conditioning when the training context is either a background stimulus or a foreground stimulus. In the background conditioning experiment, mice were trained using two auditory conditioned stimulus (CS; 30 s, 85 dB white noise)-footshock unconditioned stimulus (US; 2 s, 0.57 mA) pairings and tested 24 h later. In the foreground conditioning experiment, mice were trained with two presentations of a footshock US (2 s, 0.57 mA) and tested 24 h later. Mice received 0.09 mg/kg nicotine before training and testing. For both the foreground and background conditioning experiments, nicotine enhanced contextual conditioning. No enhancement of the auditory CS-US association was seen. These results demonstrate that nicotine enhances contextual fear conditioning regardless of whether the context is a background stimulus or a foreground stimulus during conditioning.
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Exposure to cigarette smoke at the time of stressful experience potentiates fear conditioning and makes long-term post-traumatic stress and autonomic imbalance more likely.
“Exposure to CS at the time of stressful experience potentiates fear conditioning (Davis et al., 2006; Cohen et al., 2007; Kutlu and Gould, 2015), and makes long-term post-traumatic stress and autonomic imbalance more likely (van der Velden et al., 2008).”
From Effectiveness of a Novel Qigong Meditative Movement Practice for Impaired Health in Flight Attendants Exposed to Second-Hand Cigarette Smoke (2017) · cites this paper as Davis et al., 2006
Cigarette smoke exposure during stress has been shown to strengthen learned fear responses.
“CS exposure during stress has been shown to strengthen learned fear responses (Davis et al., 2006; Elias et al., 2010; Kutlu and Gould, 2015).”
From Effectiveness of a Novel Qigong Meditative Movement Practice for Impaired Health in Flight Attendants Exposed to Second-Hand Cigarette Smoke (2017) · cites this paper as Davis et al., 2006
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Self-citation
- Authors
- Davis, J. A., Porter, J., & Gould, T. J.
- Affiliations
- Temple University (US)
- Corresponding author
- Gould, Thomas J.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 394
- Issue
- 3
- Pages
- 202-205
- ISSN
- 0304-3940 (ISSN-L)
- PMC
- PMC2697563
- OpenAlex
- W1994014150
- Cited by
- 65
- References
- 28
- Citations by year
- 2022: 2 · 2020: 1 · 2019: 1 · 2018: 7 · 2017: 1 · 2016: 9 · 2015: 9 · 2014: 7 · 2013: 3 · 2012: 5
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (DA017949, T32DA07237)
- Temple University
- Pennsylvania Department of Health
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotine, contextual fear conditioning, auditory conditioned stimulus, footshock, memory enhancement, mice
- MeSH terms
- Acoustic Stimulation, Animals, Conditioning, Operant, Electroshock, Fear, Male, Mice, Inbred C57BL, Nicotine, Nicotinic Agonists, Mice
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