Cited by 453Antioxidant Activity and Oxidative StressEicosanoids and Hypertension PharmacologyInflammatory mediators and NSAID effects

Isoprostanes: Potential Markers of Oxidant Stress in Atherothrombotic Disease

Open access
Patrono, Carlo, FitzGerald, Garret A.·1997·Arteriosclerosis, Thrombosis, and Vascular Biology

Abstract

Abstract Isoprostanes are emerging as a new class of biologically active products of arachidonic acid metabolism of potential relevance to human vascular disease. Their formation in vivo seems to reflect primarily, if not exclusively, a nonenzymatic process of lipid peroxidation. Enhanced urinary excretion of 8-iso-PGF 2α has been described in association with cardiac reperfusion injury and with cardiovascular risk factors, including cigarette smoking, diabetes mellitus, and hypercholesterolemia. Besides providing a likely noninvasive index of lipid peroxidation in these settings, measurements of specific F 2 isoprostanes in urine may provide a sensitive biochemical end point for dose-finding studies of natural and synthetic inhibitors of lipid peroxidation. Although the biological effects of 8-iso-PGF 2α in vitro suggest that it and other isoeicosanoids may modulate the functional consequences of lipid peroxidation, evidence that this is likely in vivo remains inadequate at this time.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1161/01.atv.17.11.2309

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 9

  1. O'Connor DE, Mihelic ED, Coleman MC. Stereochemical course of the auto-oxidative cyclization of lipid hydroperoxides to prosta- glandin-like bicyclo endoperoxides. J Am Chem Soc. 1984;106: 3577-3584.
  2. Kinsella BT, O'Mahony DJ, FitzGerald GA. The human thromboxane A2 receptor a isoform (TPa) functionally couples to the G-proteins G q and G n in vivo and is activated by the iso- prostane 8-epi prostaglandin F 2 ". J Pharmacol Exp Ther. In press.
  3. Kunapuli P, Lawson JA, Rokach JA, FitzGerald GA. Functional characterization of the ocular PGF 2a receptor: activation by the isoprostane 12-epi-PGF 2a . J Biol Chem. 1997;272:27147-27154.
  4. Reilly MP, Delanty N, O'Callaghan P, Crean P, Roy L, FitzGerald GA. Increased generation of the F 2 isoprostanes, IPF 2o -l and 8-iso-PGF 2 " in acute coronary angioplasty: evidence for oxidant stress during coronary reperfusion in humans. Circulation. In press.
  5. Ciabattoni G, Patrono C, Van Kooten F, Koudstaal PJ. Disso- ciation of platelet activation and lipid peroxidation in acute ische- mic stroke. J Invest Med. 1995;43:292A. Abstract.
  6. Catella-Lawson F, Kapoor S, Pratico D, Braunstein SN, Caraballo V, FitzGerald GA. Oxidative stress and diabetes mellitus. J Invest Med. 1996;44:223A. Abstract.
  7. Ciabattoni G, Consoli A, Vitacolonna E, Mezzetti A, Santarone S, Pennese E, Falco A, Davi G, Patrono C. In vivo formation of 8-epi-prostaglandin F 2o in diabetes mellitus: effects of tight meta- bolic control and vitamin E supplementation. Thromb Haemost. In press. Abstract.
  8. Davi G, Alessandrini P, Mezzetti A, Minotti G, Bucciarelli T, Constantini F, Cipallone F, Bittolo Bon G, Ciabattoni G, Patrono C. In vivo formation of 8-epi-PGF 2o is increased in hypercholester- olemia. Arterioscler Thromb Vase Biol. In press.
  9. Palinski W, Witztum JL. Oxidative stress and diabetes mellitus. In: Schwartz CJ, Born GVR, eds. New Horizons in Diabetes Mellitus and Cardiovascular Disease. Rapid Science Publishers; 1996:81-93.

Cited by

Sorted by citations

Authors
Patrono, C., & FitzGerald, G. A.
Affiliations
University of Pennsylvania (US)
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Published
1997-11
Volume
17
Issue
11
Pages
2309-2315
ISSN
  • 1079-5642 (ISSN-L)
  • 1524-4636
OpenAlex
W2087724955
Cited by
453
References
61
Citations by year
2026: 1 · 2025: 3 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 9 · 2015: 11 · 2014: 8 · 2013: 10 · 2012: 15
FWCI
20.14
Type
journal article
Language
en
Open access
Locations
  • Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Bayer
  • Wellcome Trust
  • European Commission
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (P50HL054500, 1P50HL54500)
  • National Center for Research Resources (MO1-RR-00040, M01RR000040)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
Keywords
isoprostanes, lipid peroxidation, oxidative stress, arachidonic acid metabolism, atherothrombosis, urinary biomarkers, cardiovascular risk factors, smoking, diabetes mellitus, hypercholesterolemia, ischemia-reperfusion injury, lipid peroxidation inhibitors, dose-finding
MeSH terms
Antioxidants, Arteriosclerosis, Cardiovascular Diseases, Diabetes Mellitus, Free Radicals, Humans, Hyperlipidemias, Immunoassay, Indicator Dilution Techniques, Gas Chromatography-Mass Spectrometry, Platelet Aggregation, Prostaglandins F, Risk Factors, Thrombosis, Vasoconstrictor Agents, Lipid Peroxidation, Dinoprost, Biomarkers, Oxidative Stress, F2-Isoprostanes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review