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Magnetic Resonance Imaging of Myelin
Open accessAbstract
The ability to measure myelin in vivo has great consequences for furthering our knowledge of normal development, as well as for understanding a wide range of neurological disorders. The following review summarizes the current state of myelin imaging using MR. We consider five MR techniques that have been used to study myelin: 1) conventional MR, 2) MR spectroscopy, 3) diffusion, 4) magnetization transfer, and 5) T2 relaxation. Fundamental studies involving peripheral nerve and MR/histology comparisons have aided in the interpretation and validation of MR data. We highlight a number of important findings related to myelin development, damage, and repair, and we conclude with a critical summary of the current techniques available and their potential to image myelin in vivo.
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“a relatively abundant MAG level might indicate a relatively intact myelin-axon interface in the CD1 mice, albeit a damaged outer myelin sheath.”
From Strain differences in cuprizone induced demyelination (2017) · cites this paper as [37]
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Magnetic Resonance Imaging of Brain Development in Fetal Alcohol Spectrum Disorders
Treit, S. (2015) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3bk1716f
Chatterjee, S., Commowick, O., Afacan, O., Combès, B., Warfield, S. K., & Barillot, C. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/365379
Measuring tissue variations in the human brain using quantitative MRI
Sood, S. (2019) · The University of Queensland · doi:10.14264/uql.2019.168
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Xiang, B. (2019) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/394k-bg62
A Multivariate Approach for Denoising of T2 Relaxation Decay Curves in Myelin Water Fraction Imaging
Baumeister, T. R., Wang, Z. J., & McKeown, M. J. (2019) · IEEE Global Conference on Signal and Information Processing · doi:10.1109/globalsip45357.2019.8969130
Metadata
- Authors
- Laule, C., Vavasour, I. M., Kolind, S. H., Li, D. K. B., Traboulsee, T. L., Moore, G. R. W., & MacKay, A. L.
- Affiliations
- University of British Columbia (CA)
- University of British Columbia Hospital (CA)
- Corresponding author
- Laule, Cornelia
- Venue
- Neurotherapeutics
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 4
- Issue
- 3
- Pages
- 460-484
- ISSN
- 1878-7479 (ISSN-L)
- PMC
- PMC7479725
- OpenAlex
- W2080423736
- Cited by
- 334
- References
- 291
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 20 · 2023: 19 · 2022: 17 · 2021: 28 · 2020: 32 · 2019: 28 · 2018: 23 · 2017: 27 · 2016: 16 · 2015: 17 · 2014: 18 · 2013: 15 · 2012: 8
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neurotherapeutics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Multiple Sclerosis Society of Canada
- Multiple Sclerosis Society
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- myelin imaging, myelin, myelination, myelin damage, remyelination, MR spectroscopy, diffusion MRI, magnetization transfer, T2 relaxation, peripheral nerves
- MeSH terms
- Animals, Humans, Magnetic Resonance Imaging, Myelin Sheath
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