Cited by 334Advanced Neuroimaging Techniques and ApplicationsAdvanced MRI Techniques and ApplicationsMultiple Sclerosis Research Studies

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Magnetic Resonance Imaging of Myelin

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Laule, Cornelia, Vavasour, Irene M., Kolind, Shannon H., Li, David K.B., Traboulsee, Tony L., Moore, G.R. Wayne, MacKay, Alex L.·2007·Neurotherapeutics

DOI 10.1016/j.nurt.2007.05.004PMC PMC7479725

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Abstract

The ability to measure myelin in vivo has great consequences for furthering our knowledge of normal development, as well as for understanding a wide range of neurological disorders. The following review summarizes the current state of myelin imaging using MR. We consider five MR techniques that have been used to study myelin: 1) conventional MR, 2) MR spectroscopy, 3) diffusion, 4) magnetization transfer, and 5) T2 relaxation. Fundamental studies involving peripheral nerve and MR/histology comparisons have aided in the interpretation and validation of MR data. We highlight a number of important findings related to myelin development, damage, and repair, and we conclude with a critical summary of the current techniques available and their potential to image myelin in vivo.

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Authors: Laule, C., Vavasour, I. M., Kolind, S. H., Li, D. K. B., Traboulsee, T. L., Moore, G. R. W., & MacKay, A. L.
Affiliations: University of British Columbia (CA)
University of British Columbia Hospital (CA)
Corresponding author: Laule, Cornelia
ORCID: Laule, Cornelia
Vavasour, Irene M.
Kolind, Shannon H.
Li, David K.B.
MacKay, Alex L.
Venue: Neurotherapeutics
Publisher: Elsevier BV
Published: 2007-07
Volume: 4
Issue: 3
Pages: 460-484
ISSN: 1878-7479 (ISSN-L)
DOI: 10.1016/j.nurt.2007.05.004
PMC: PMC7479725
OpenAlex: W2080423736
Cited by: 334
References: 291
Citations by year: 2026: 9 · 2025: 17 · 2024: 20 · 2023: 19 · 2022: 17 · 2021: 28 · 2020: 32 · 2019: 28 · 2018: 23 · 2017: 27 · 2016: 16 · 2015: 17 · 2014: 18 · 2013: 15 · 2012: 8
FWCI: 1.15
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5886 d)
Locations: Neurotherapeutics (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Multiple Sclerosis Society of Canada
Multiple Sclerosis Society
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: myelin imaging, myelin, myelination, myelin damage, remyelination, MR spectroscopy, diffusion MRI, magnetization transfer, T2 relaxation, peripheral nerves
MeSH terms: Animals, Humans, Magnetic Resonance Imaging, Myelin Sheath

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