The DOI matches its Crossref record; 284 of the 291 references it cites were found in a registry or an index.
Magnetic Resonance Imaging of Myelin
Open accessAbstract
The ability to measure myelin in vivo has great consequences for furthering our knowledge of normal development, as well as for understanding a wide range of neurological disorders. The following review summarizes the current state of myelin imaging using MR. We consider five MR techniques that have been used to study myelin: 1) conventional MR, 2) MR spectroscopy, 3) diffusion, 4) magnetization transfer, and 5) T2 relaxation. Fundamental studies involving peripheral nerve and MR/histology comparisons have aided in the interpretation and validation of MR data. We highlight a number of important findings related to myelin development, damage, and repair, and we conclude with a critical summary of the current techniques available and their potential to image myelin in vivo.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“a relatively abundant MAG level might indicate a relatively intact myelin-axon interface in the CD1 mice, albeit a damaged outer myelin sheath.”
From Strain differences in cuprizone induced demyelination (2017) · cites this paper as [37]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Solving least squares problems
Björk, Ǎ., Lawson, C., & Hanson, R. (1976) · Classics in applied mathematics · doi:10.2307/2286501 · Cited by 7,171
Solving Least Squares Problems
Lawson, C. L., & Hanson, R. J. (1995) · doi:10.1137/1.9781611971217 · Cited by 7,103
The basis of anisotropic water diffusion in the nervous system—A technical review.
Beaulieu, C. (2002) · NMR in Biomedicine · doi:10.1002/nbm.782 · Cited by 4,628
Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029
Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water
Song, S.-K., Sun, S.-W., Ramsbottom, M. J., Chang, C., Russell, J., & Cross, A. H. (2002) · NeuroImage · doi:10.1006/nimg.2002.1267 · Cited by 2,582
Regional Development of the Brain in Early Life
(1968) · Archives of Disease in Childhood · doi:10.1136/adc.43.229.388 · Cited by 2,107
Song, S.-K., Sun, S.-W., Ju, W.-K., Lin, S.-J., Cross, A. H., & Neufeld, A. H. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.07.005 · Cited by 1,738
A Method for the Combined Staining of Cells and Fibers in the Nervous System
Klüver, H., & Barrera, E. (1953) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-195312040-00008 · Cited by 1,724
Demyelination increases radial diffusivity in corpus callosum of mouse brain
Song, S.-K., Yoshino, J., Le, T. Q., Lin, S.-J., Sun, S.-W., Cross, A. H., & Armstrong, R. C. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.01.028 · Cited by 1,658
Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo
Wolff, S. D., & Balaban, R. S. (1989) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910100113 · Cited by 1,482
Research works printed but not linked: 5
- Yung, 2004, Measurements of myelin water in rat spinal cord in vivo, Int Soc Magn Reson Med, 1537
- Minty, 2002, Measurement of myelin water in human and bovine spinal cord, Int Soc Magn Reson Med Sci, 940
- Laule, 2003, Cervical cord abnormalities in primary progressive multiple sclerosis: atrophy and myelin water changes, Mult Scler, 9, S63
- Helms, 2000, Regression analysis of metabolite concentrations estimated from localized proton MR spectra of active and chronic multiple sclerosis lesions, Magn Reson Med, 43, 102, 10.1002/(SICI)1522-2594(200001)43:1<102::AID-MRM12>3.0.CO;2-I · DOI
- Leuzzi, 2007, The pathogenesis of the white matter abnormalities in phenylketonuria, J Inherit Metab Dis, 23, 23
Cited by
Sorted by citations
Plasticity in gray and white: neuroimaging changes in brain structure during learning
Zatorre, R. J., Fields, R. D., & Johansen-Berg, H. (2012) · Nature Neuroscience · doi:10.1038/nn.3045 · Cited by 1,685
Myelin and iron concentration in the human brain: a quantitative study of MRI contrast
Stüber, C., Morawski, M., Schäfer, A., Labadie, C., Wähnert, M., Leuze, C., Streicher, M., Barapatre, N., Reimann, K., Geyer, S., et al. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.02.026 · Cited by 635
Rae, C. D. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1199-5 · Cited by 524
Growth of white matter in the adolescent brain: Myelin or axon?
Paus, T. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.06.002 · Cited by 424
Growth of white matter in the adolescent brain: role of testosterone and androgen receptor
Perrin, J. S., Hervé, P.-Y., Leonard, G., Perron, M., Pike, G. B., Pitiot, A., Richer, L., Veillette, S., Pausova, Z., & Paus, T. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1212-08.2008 · Cited by 331
Metadata
- Authors
- Laule, C., Vavasour, I. M., Kolind, S. H., Li, D. K. B., Traboulsee, T. L., Moore, G. R. W., & MacKay, A. L.
- Affiliations
- University of British Columbia (CA)
- University of British Columbia Hospital (CA)
- Corresponding author
- Laule, Cornelia
- Venue
- Neurotherapeutics
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 4
- Issue
- 3
- Pages
- 460-484
- ISSN
- 1878-7479 (ISSN-L)
- PMC
- PMC7479725
- OpenAlex
- W2080423736
- Cited by
- 334
- References
- 291
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 20 · 2023: 19 · 2022: 17 · 2021: 28 · 2020: 32 · 2019: 28 · 2018: 23 · 2017: 27 · 2016: 16 · 2015: 17 · 2014: 18 · 2013: 15 · 2012: 8
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neurotherapeutics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Multiple Sclerosis Society of Canada
- Multiple Sclerosis Society
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- myelin imaging, myelin, myelination, myelin damage, remyelination, MR spectroscopy, diffusion MRI, magnetization transfer, T2 relaxation, peripheral nerves
- MeSH terms
- Animals, Humans, Magnetic Resonance Imaging, Myelin Sheath
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review