Cited by 334Advanced Neuroimaging Techniques and ApplicationsAdvanced MRI Techniques and ApplicationsMultiple Sclerosis Research Studies

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Magnetic Resonance Imaging of Myelin

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Laule, Cornelia, Vavasour, Irene M., Kolind, Shannon H., Li, David K.B., Traboulsee, Tony L., Moore, G.R. Wayne, MacKay, Alex L.·2007·Neurotherapeutics

DOI 10.1016/j.nurt.2007.05.004PMC PMC7479725

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Abstract

The ability to measure myelin in vivo has great consequences for furthering our knowledge of normal development, as well as for understanding a wide range of neurological disorders. The following review summarizes the current state of myelin imaging using MR. We consider five MR techniques that have been used to study myelin: 1) conventional MR, 2) MR spectroscopy, 3) diffusion, 4) magnetization transfer, and 5) T2 relaxation. Fundamental studies involving peripheral nerve and MR/histology comparisons have aided in the interpretation and validation of MR data. We highlight a number of important findings related to myelin development, damage, and repair, and we conclude with a critical summary of the current techniques available and their potential to image myelin in vivo.

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Solving least squares problems
Björk, Ǎ., Lawson, C., & Hanson, R. (1976) · Classics in applied mathematics · doi:10.2307/2286501 · Cited by 7,171
Solving Least Squares Problems
Lawson, C. L., & Hanson, R. J. (1995) · doi:10.1137/1.9781611971217 · Cited by 7,103
The basis of anisotropic water diffusion in the nervous system—A technical review.
Beaulieu, C. (2002) · NMR in Biomedicine · doi:10.1002/nbm.782 · Cited by 4,628
Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029
Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water
Song, S.-K., Sun, S.-W., Ramsbottom, M. J., Chang, C., Russell, J., & Cross, A. H. (2002) · NeuroImage · doi:10.1006/nimg.2002.1267 · Cited by 2,582
Regional Development of the Brain in Early Life
(1968) · Archives of Disease in Childhood · doi:10.1136/adc.43.229.388 · Cited by 2,107
Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia
Song, S.-K., Sun, S.-W., Ju, W.-K., Lin, S.-J., Cross, A. H., & Neufeld, A. H. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.07.005 · Cited by 1,738
A Method for the Combined Staining of Cells and Fibers in the Nervous System
Klüver, H., & Barrera, E. (1953) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-195312040-00008 · Cited by 1,724
Demyelination increases radial diffusivity in corpus callosum of mouse brain
Song, S.-K., Yoshino, J., Le, T. Q., Lin, S.-J., Sun, S.-W., Cross, A. H., & Armstrong, R. C. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.01.028 · Cited by 1,658
Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo
Wolff, S. D., & Balaban, R. S. (1989) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910100113 · Cited by 1,482
From charcot to lou gehrig: deciphering selective motor neuron death in als
Cleveland, D. W., & Rothstein, J. D. (2001) · Nature reviews. Neuroscience · doi:10.1038/35097565 · Cited by 1,389
Basic Neurochemistry: Molecular, Cellular, and Medical Aspects
Siegel, G. J., & Agranoff, B. W. (1989) · Cited by 1,359
Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia
Hakak, Y., Walker, J. R., Li, C., Wong, W. H., Davis, K. L., Buxbaum, J. D., Haroutunian, V., & Fienberg, A. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081071198 · Cited by 1,192
Basic Neurochemistry: Molecular, Cellular, and Medical Aspects
DAVISON, A. N. (1989) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.52.8.1021-a · Cited by 949
Magnetization transfer in MRI: a review
Henkelman, R. M., Stanisz, G. J., & Graham, S. J. (2001) · NMR in Biomedicine · doi:10.1002/nbm.683 · Cited by 922
In vivo visualization of myelin water in brain by magnetic resonance
MacKay, A. L., Whittall, K. P., Adler, J., Li, D. K. B., Paty, D. W., & Graeb, D. A. (1994) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910310614 · Cited by 916
Self-citation
Sequence of Central Nervous System Myelination in Human Infancy. II. Patterns of Myelination in Autopsied Infants
Kinney, H. C., Ann brody, B., Kloman, A. S., & Gilles, F. H. (1988) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-198805000-00003 · Cited by 888
Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS
Filbin, M. T. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1195 · Cited by 873
In vivo measurement of T 2 distributions and water contents in normal human brain
Whittall, K. P., MacKay, A. L., Graeb, D. A., Nugent, R. A., Li, D. K. B., & Paty, D. W. (1997) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910370107 · Cited by 796
Self-citation
Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain
Schmierer, K., Scaravilli, F., Altmann, D. R., Barker, G. J., & Miller, D. H. (2004) · Annals of Neurology · doi:10.1002/ana.20202 · Cited by 777
Normal maturation of the neonatal and infant brain: MR imaging at 1.5 T.
Barkovich, A. J., Kjos, B. O., Jackson, D. E., & Norman, D. M. (1988) · Radiology · doi:10.1148/radiology.166.1.3336675 · Cited by 741
Microstructural Development of Human Newborn Cerebral White Matter Assessed in Vivo by Diffusion Tensor Magnetic Resonance Imaging
Hüppi, P. S., Maier, S. E., Peled, S., Zientara, G. P., Barnes, P. D., Jolesz, F. A., & Volpe, J. J. (1998) · Pediatric Research · doi:10.1203/00006450-199810000-00019 · Cited by 722
Experimental allergic encephalomyelitis and multiple sclerosis: lesion characterization with magnetization transfer imaging.
Dousset, V., Grossman, R. I., Ramer, K., Schnall, M. D., YOUNG, L. H. Y., González‐Scarano, F., Lavi, E., & Cohen, J. A. (1992) · Radiology · doi:10.1148/radiology.182.2.1732968 · Cited by 689
Development of the human brain: In vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy
Kreis, R., Ernst, T., & Ross, B. D. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910300405 · Cited by 680
Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis
van Walderveen, M. A. A., Kamphorst, W., Scheltens, P., van Waesberghe, J. H. T. M., Ravid, R., Valk, J., Polman, C. H., & Barkhof, F. (1998) · Neurology · doi:10.1212/wnl.50.5.1282 · Cited by 656
Diffusion tensor imaging and aging
Sullivan, E. V., & Pfefferbaum, A. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.06.002 · Cited by 649
Quantitative interpretation of NMR relaxation data
Whittall, K. P., & MacKay, A. L. (1989) · Journal of Magnetic Resonance (1969) · doi:10.1016/0022-2364(89)90011-5 · Cited by 633
Self-citation
In vivo imaging of axonal degeneration and regeneration in the injured spinal cord
Kerschensteiner, M., Schwab, M. E., Lichtman, J. W., & Misgeld, T. (2005) · Nature Medicine · doi:10.1038/nm1229 · Cited by 582
On standardizing the MR image intensity scale
Ny�l, L. G., & Udupa, J. K. (1999) · Magnetic Resonance in Medicine · doi:10.1002/(sici)1522-2594(199912)42:6 · Cited by 575
White matter damage in Alzheimer’s disease assessed in vivo using diffusion tensor magnetic resonance imaging
Bozzali, M. (2002) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.6.742 · Cited by 568
Inflammatory central nervous system demyelination: Correlation of magnetic resonance imaging findings with lesion pathology
Brück, W., Bitsch, A., Kolenda, H., Brück, Y., Stiefel, M., & Lassmann, H. (1997) · Annals of Neurology · doi:10.1002/ana.410420515 · Cited by 520
Electron microscopy of oligodendroglia in severe mental illness
Uranova, N., Orlovskaya, D., Vikhreva, O., Zimina, I., Kolomeets, N., Vostrikov, V., & Rachmanova, V. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00528-7 · Cited by 495
White matter changes in mild cognitive impairment and AD: a diffusion tensor imaging study
Medina, D., deToledo-Morrell, L., Urresta, F., Gabrieli, J. D. E., Moseley, M., Fleischman, D., Bennett, D. A., Leurgans, S., Turner, D. A., & Stebbins, G. T. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.026 · Cited by 492
Myelin water imaging in multiple sclerosis: quantitative correlations with histopathology
Laule, C., Leung, E., Li, D. K., Traboulsee, A. L., Paty, D. W., MacKay, A. L., & Moore, G. R. (2006) · Multiple Sclerosis Journal · doi:10.1177/1352458506070928 · Cited by 489
Self-citation
Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences
Bjartmar, C., & Trapp, B. D. (2001) · Current Opinion in Neurology · doi:10.1097/00019052-200106000-00003 · Cited by 479
Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum
Sun, S., Liang, H., Trinkaus, K., Cross, A. H., Armstrong, R. C., & Song, S. (2006) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20774 · Cited by 461
Concepts of myelin and myelination in neuroradiology.
Barkovich, A. J. (2000) · PubMed Central · Cited by 460
Myelination and organization of the frontal white matter in children
Klingberg, T., Vaidya, C. J., Gabrieli, J. D. E., Moseley, M. E., & Hedehus, M. (1999) · Neuroreport · doi:10.1097/00001756-199909090-00022 · Cited by 460
Compromised White Matter Tract Integrity in Schizophrenia Inferred From Diffusion Tensor Imaging
Lim, K. O., Hedehus, M., Moseley, M. E., de Crespigny, A. J., Sullivan, E. V., & Pfefferbaum, A. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.4.367 · Cited by 447
Abnormalities of myelination in schizophrenia detected in vivo with MRI, and post-mortem with analysis of oligodendrocyte proteins
Flynn, S. W., Lang, D. J., MacKay, A. L., Goghari, V. M., Vavasour, I. M., Whittall, K. P., Smith, G. N., Arango, V., Mann, J. J., Dwork, A. J., et al. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001337 · Cited by 439
Self-citation
DTI and MTR abnormalities in schizophrenia: Analysis of white matter integrity
Kubicki, M. R., Park, H., Westin, C., Nestor, P. G., Mulkern, R. V., Maier, S. E., Niznikiewicz, M. A., Connor, E. E., Levitt, J. J., Frumin, M., et al. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.03.026 · Cited by 433
White Matter Structural Integrity in Healthy Aging Adults and Patients With Alzheimer Disease
Bartzokis, G., Cummings, J. L., Sultzer, D. L., Henderson, V. W., Nuechterlein, K. H., & Mintz, J. (2003) · Archives of Neurology · doi:10.1001/archneur.60.3.393 · Cited by 431
Water diffusion compartmentation and anisotropy at high b values in the human brain
Clark, C. A., & Bihan, D. L. (2000) · Magnetic Resonance in Medicine · doi:10.1002/1522-2594(200012)44:6 · Cited by 431
Self-citation
Regional axonal loss in the corpus callosum correlates with cerebral white matter lesion volume and distribution in multiple sclerosis
Evangelou, N. (2000) · Brain · doi:10.1093/brain/123.9.1845 · Cited by 416
Practical T2 quantitation for clinical applications
Poon, C. S., & Henkelman, R. M. (1992) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1880020512 · Cited by 396
Diffusion tensor imaging of post mortem multiple sclerosis brain
Schmierer, K., Wheeler-Kingshott, C. A. M., Boulby, P. A., Scaravilli, F., Altmann, D. R., Barker, G. J., Tofts, P. S., & Miller, D. H. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.010 · Cited by 395
Magnetization transfer changes in the normal appering white matter precede the appearance of enhancing lesions in patients with multiple sclerosis
Filippi, M., Rocca, M. A., Martino, G., Horsfield, M. A., & Comi, G. (1998) · Annals of Neurology · doi:10.1002/ana.410430616 · Cited by 395
Water content and myelin water fraction in multiple sclerosis
Laule, C., Vavasour, I. M., Moore, G. R. W., Oger, J. J.-F., Li, D. K. B., Paty, D. W., & MacKay, A. L. (2004) · Journal of Neurology · doi:10.1007/s00415-004-0306-6 · Cited by 369
Self-citation
A Magnetization Transfer Imaging Study of Normal-Appearing White Matter in Multiple Sclerosis
Filippi, M., Campi, A., Dousset, V., Baratti, C., Martinelli, V., Canal, N., Scotti, G., & Comi, G. (1995) · Neurology · doi:10.1212/wnl.45.3.478 · Cited by 366
Cajal's Degeneration and Regeneration of the Nervous System
y Cajal, S. R., & May, R. M. (1991) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195065169.001.0001 · Cited by 365
Heterogeneous age-related breakdown of white matter structural integrity: Implications for cortical “disconnection” in aging and Alzheimer's disease.
Bartzokis, G., Sultzer, D., Lu, P. H., Nuechterlein, K. H., Mintz, J., & Cummings, J. L. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.09.005 · Cited by 363
Remyelinated Lesions in Multiple Sclerosis
Barkhof, F., Brück, W., Groot, C. J. A. D., Bergers, E., Hulshof, S. C. J., Geurts, J. J. G., Polman, C. H., & van der Valk, P. (2003) · Archives of Neurology · doi:10.1001/archneur.60.8.1073 · Cited by 331
Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia
Edgar, J. M., McLaughlin, M., Yool, D., Zhang, S.-C., Fowler, J. H., Montague, P., Barrie, J. A., McCulloch, M. C., Duncan, I. D., Garbern, J., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312012 · Cited by 328
Multiple Sclerosis
Keegan, B. M., & Noseworthy, J. H. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.103909 · Cited by 317
Neuropathological abnormalities of the corpus callosum in schizophrenia: a diffusion tensor imaging study
Foong, J. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.68.2.242 · Cited by 316
Serial proton magnetic resonance spectroscopic imaging, contrast‐enhanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis
Narayana, P. A., Doyle, T. J., Lai, D., & Wolinsky, J. S. (1998) · Annals of Neurology · doi:10.1002/ana.410430112 · Cited by 316
Myelin Biology and Disorders
Lazzarini, R. A., Griffin, J. W., Lassman, H., Nave, K., Miller, R. H., & Trapp, B. D. (2004) · Elsevier eBooks · doi:10.1016/b978-0-12-439510-7.x5051-7 · Cited by 313
Iron in Chronic Brain Disorders: Imaging and Neurotherapeutic Implications
Stankiewicz, J. M., Panter, S. S., Neema, M., Arora, A., Batt, C. E., & Bakshi, R. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.05.006 · Cited by 304
Quantitation of proton NMR spectra of the human brain using tissue water as an internal concentration reference
Barker, P. B., Soher, B. J., Blackband, S. J., Chatham, J. C., Mathews, V. P., & Bryan, R. N. (1993) · NMR in Biomedicine · doi:10.1002/nbm.1940060114 · Cited by 299
High field MRI correlates of myelin content and axonal density in multiple sclerosis
Mottershead, J. P., Schmierer, K., Clemence, M., Thornton, J. S., Scaravilli, F., Barker, G. J., Tofts, P. S., Newcombe, J., Cuzner, M. L., Ordidge, R. J., et al. (2003) · Journal of Neurology · doi:10.1007/s00415-003-0192-3 · Cited by 296
Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging
Harsan, L. A., Poulet, P., Guignard, B., Steibel, J., Parizel, N., de Sousa, P. L., Boehm, N., Grucker, D., & Ghandour, M. S. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20742 · Cited by 295
Age‐Related Changes in Prefrontal White Matter Measured by Diffusion Tensor Imaging
SALAT, D. H., TUCH, D. S., HEVELONE, N. D., FISCHL, B., CORKIN, S., ROSAS, H. D., & DALE, A. M. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1340.009 · Cited by 292
Magnetisation transfer ratio and mean diffusivity of normal appearing white and grey matter from patients with multiple sclerosis
Cercignani, M. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.70.3.311 · Cited by 287
Relaxivity and magnetization transfer of white matter lipids at MR imaging: importance of cerebrosides and pH.
Kucharczyk, W., Macdonald, P. M., Stanisz, G. J., & Henkelman, R. M. (1994) · Radiology · doi:10.1148/radiology.192.2.8029426 · Cited by 273
Color-coded diffusion-tensor-imaging of posterior cingulate fiber tracts in mild cognitive impairment
Fellgiebel, A., Müller, M. J., Wille, P. R., Dellani, P. R., Scheurich, A., Schmidt, L., & Stoeter, P. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.11.006 · Cited by 266
1 H MR spectroscopy in common dementias
Kantarci, K., Petersen, R. C., Boeve, B. F., Knopman, D. S., Tang‐Wai, D. F., O’Brien, P. C., Weigand, S. D., Edland, S. D., Smith, G. E., Ivnik, R. J., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000141849.21256.ac · Cited by 263
Immunocytochemical observations on the distribution of myelin‐associated glycoprotein and myelin basic protein in multiple sclerosis lesions
Itoyama, Y., Sterhberger, N. H., Webster, H. D., Quarles, R. H., Cohen, S. R., & Richardson, E. P. (1980) · Annals of Neurology · doi:10.1002/ana.410070212 · Cited by 241
Defining and Categorizing Leukoencephalopathies of Unknown Origin: MR Imaging Approach
van der Knaap, M. S., Breiter, S. N., Naidu, S., Hart, A. A. M., & Valk, J. (1999) · Radiology · doi:10.1148/radiology.213.1.r99se01121 · Cited by 240
Detecting axon damage in spinal cord from a mouse model of multiple sclerosis
Kim, J. H., Budde, M. D., Liang, H.-F., Klein, R. S., Russell, J. H., Cross, A. H., & Song, S.-K. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.09.009 · Cited by 235
Relative indices of water diffusion anisotropy are equivalent in live and formalin-fixed mouse brains
Sun, S., Neil, J. J., & Song, S. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10605 · Cited by 231
White matter development during late adolescence in healthy males: A cross-sectional diffusion tensor imaging study
Ashtari, M., Cervellione, K. L., Hasan, K. M., Wu, J., McIlree, C., Kester, H. M., Ardekani, B. A., Roofeh, D., Szeszko, P. R., & Kumra, S. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.10.047 · Cited by 227
Abnormal brain white matter in schizophrenia: a diffusion tensor imaging study
Agartz, I., Andersson, J., & Skare, S. T. (2001) · Neuroreport · doi:10.1097/00001756-200107200-00041 · Cited by 225
Differential sensitivity of in vivo and ex vivo diffusion tensor imaging to evolving optic nerve injury in mice with retinal ischemia
Sun, S., Liang, H., Le, T. Q., Armstrong, R. C., Cross, A. H., & Song, S. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.04.212 · Cited by 222
Diffusion tensor imaging in early Alzheimer's disease.
Naggara, O., Oppenheim, C., Rieu, D., Raoux, N., Rodrigo, S., Barba, G. D., & Meder, J. (2006) · Psychiatry Research · doi:10.1016/j.pscychresns.2006.01.005 · Cited by 218
A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions
Bitsch, A., Kuhlmann, T., Stadelmann, C., Lassmann, H., Lucchinetti, C. F., & Brück, W. (2001) · Annals of Neurology · doi:10.1002/ana.1053 · Cited by 216
Neuropathology of white matter changes in Alzheimer’s disease and vascular dementia
Englund, E. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051183 · Cited by 213
Age-related degeneration of corpus callosum measured with diffusion tensor imaging
Ota, M., Obata, T., Akine, Y., Ito, H., Ikehira, H., Asada, T., & Suhara, T. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.02.008 · Cited by 209
Wallerian degeneration after cerebral infarction: evaluation with sequential MR imaging.
Kuhn, M. J., Mikulis, D. J., Ayoub, D. M., Kosofsky, B. E., Davis, K. R., & Taveras, J. M. (1989) · Radiology · doi:10.1148/radiology.172.1.2740501 · Cited by 204
Remyelination in multiple sclerosis
Brück, W., Kuhlmann, T., & Stadelmann, C. (2003) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(02)00191-0 · Cited by 203
A serial study of new MS lesions and the white matter from which they arise
Goodkin, D. E., Rooney, W. D., Sloan, R., Bacchetti, P., Gee, L., Vermathen, M., Waubant, E. L., Abundo, M. A., Majumdar, S., Nelson, S. J., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1689 · Cited by 201
Gradual loss of myelin and formation of an astrocytic scar during Wallerian degeneration in the human spinal cord
Buss, A. (2003) · Brain · doi:10.1093/brain/awh001 · Cited by 188
Pathologic damage in MS assessed by diffusion-weighted and magnetization transfer MRI
Cercignani, M., Iannucci, G., Rocca, M. A., Comı, G., Horsfield, M. A., & Filippi, M. (2000) · Neurology · doi:10.1212/wnl.54.5.1139 · Cited by 185
Use of magnetic resonance imaging for in vivo measurements of water content in human brain: method and normal values
Fatouros, P. P., & Marmarou, A. (1999) · Journal of neurosurgery · doi:10.3171/jns.1999.90.1.0109 · Cited by 185
Increased water self-diffusion in chronic plaques and in apparently normal white matter in patients with multiple sclerosis
Christiansen, P., Gideon, P., Thomsen, C., Stubgaard, M., Henriksen, O. M., & Larsson, H. B. W. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1993.tb04100.x · Cited by 185
A pathology–MRI study of the short-T2 component in formalin-fixed multiple sclerosis brain
Moore, G. R. W., Leung, E., MacKay, A. L., Vavasour, I. M., Whittall, K. P., Cover, K. S., Li, D. K. B., Hashimoto, S. A., Oger, J., Sprinkle, T. J., et al. (2000) · Neurology · doi:10.1212/wnl.55.10.1506 · Cited by 185
Self-citation
Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging
Schuff, N. W., Ezekiel, F., Gamst, A. C., Amend, D. L., Capizzano, A. A., Maudsley, A. A., & Weiner, M. W. (2001) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1119 · Cited by 183
In vivo magnetic resonance diffusion measurement in the brain of patients with multiple sclerosis
Larsson, H. B. W., Thomsen, C., Frederiksen, J., Stubgaard, M., & Henriksen, O. (1992) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(92)90367-9 · Cited by 181
Criteria for analysis of multicomponent tissue T2 relaxation data
Graham, S. J., Stanchev, P. L., & Bronskill, M. J. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910350315 · Cited by 179
Quantification of tissue damage in AD using diffusion tensor and magnetization transfer MRI
Bozzali, M., Franceschi, M., Falini, A., Pontesilli, S., Cercignani, M., Magnani, G., Scotti, G., Comi, G., & Filippi, M. (2001) · Neurology · doi:10.1212/wnl.57.6.1135 · Cited by 179
Remyelination of CNS axons by Schwann cells transplanted from the sciatic nerve
Blakemore, W. F. (1977) · Nature · doi:10.1038/266068a0 · Cited by 178
Changes in brain water diffusion during childhood
Morriss, M. C., Zimmerman, R. A., Bilaniuk, L. T., Hunter, J. V., & Haselgrove, J. C. (1999) · Neuroradiology · doi:10.1007/s002340050869 · Cited by 174
Is multicomponent T2 a good measure of myelin content in peripheral nerve?
Webb, S., Munro, C. A., Midha, R., & Stanisz, G. J. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10411 · Cited by 172
Lack of correlation between cortical demyelination and white matter pathologic changes in multiple sclerosis.
Bö, L., Geurts, J., van der Valk, P., Polman, C., & Barkhof, F. (2007) · Archives of Neurology · doi:10.1001/archneur.64.1.76 · Cited by 172
MRI characterization of diffusion coefficients in a rat spinal cord injury model
Ford, J. C., Hackney, D. B., Alsop, D. C., Jara, H. J., Joseph, P. M., Hand, C. M., & Black, P. (1994) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910310504 · Cited by 170
Inside-Out versus Outside-In models for virus induced demyelination: axonal damage triggering demyelination
Tsunoda, I., & Fujinami, R. S. (2002) · Springer Seminars in Immunopathology · doi:10.1007/s00281-002-0105-z · Cited by 164
Lysolecithin-induced demyelination in primates: preliminary in vivo study with MR and magnetization transfer.
Dousset, V., Brochet, B., Vital, A., Gross, C. E., Benazzouz, A., Boullerne, A. I., Bidabé, A. M., Gin, A.-M., & Caillé, J. (1995) · PubMed Central · Cited by 162
Diffusion Tensor Imaging of Frontal White Matter Microstructure in Early Alzheimer’s Disease: A Preliminary Study
Choi, S. J., Lim, K. O., Monteiro, I. M., & Reisberg, ‌. (2005) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988704271763 · Cited by 156
Neuropathology of Phenylketonuria
Malamud, N. (1966) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-196604000-00006 · Cited by 155
Magnetization transfer effects in MR-detected multiple sclerosis lesions: comparison with gadolinium-enhanced spin-echo images and nonenhanced T1-weighted images.
Hiehle, J. F., Grossman, R. I., Ramer, K., González‐Scarano, F., & Cohen, J. A. (1995) · PubMed Central · Cited by 154
In vivo evaluation of remyelination in rat brain by magnetization transfer imaging
Deloire-Grassin, M., Brochet, B., Quesson, B., Delalande, C., Dousset, V., Canioni, P., & Petry, K. G. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00331-2 · Cited by 150
Choline is increased in pre-lesional normal appearing white matter in multiple sclerosis
Tartaglia, M. C., Narayanan, S., Stefano, N. D., Arnaoutelis, R., Antel, S. B., Francis, S. J., dos Santos, A. C., Lapierre, Y., & Arnold, D. L. (2002) · Journal of Neurology · doi:10.1007/s00415-002-0846-6 · Cited by 149
Measurement of in vivo multi-component T2 relaxation times for brain tissue using multi-slice T2 prep at 1.5 and 3 T
Oh, J., Han, E. T., Pelletier, D., & Nelson, S. J. (2005) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2005.10.016 · Cited by 148
The Spinal Cord in Multiple Sclerosis: Relationship of High-Spatial-Resolution Quantitative MR Imaging Findings to Histopathologic Results
Bot, J., Blezer, E. L. A., Kamphorst, W., Nijeholt, G. J. L. À., Adèr, H. J., Castelijns, J. A., Nicolay, K., Bergers, E., Ravid, R., Polman, C. H., et al. (2004) · Radiology · doi:10.1148/radiol.2332031572 · Cited by 147
Axonal damage in the spinal cord of MS patients occurs largely independent of T2 MRI lesions
Bergers, E., Bot, J., Groot, C. J. A. D., Polman, C. H., Nijeholt, G. J. L. À., Castelijns, J. A., van der Valk, P., & Barkhof, F. (2002) · Neurology · doi:10.1212/01.wnl.0000036566.00866.26 · Cited by 146
A Proton Magnetic Resonance Spectroscopy Study of Age-related Changes in Frontal Lobe Metabolite Concentrations
Brooks, J. C. W., Roberts, N., Kemp, G. J., Gosney, M., Lye, M., & Whitehouse, G. H. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.7.598 · Cited by 146
Proton magnetic resonance spectroscopy in multiple sclerosis
Wolinsky, J. S., Narayana, P. A., & Fenstermacher, M. J. (1990) · Neurology · doi:10.1212/wnl.40.11.1764 · Cited by 145
MR spectroscopic evidence for glial increase but not for neuro‐axonal damage in MS normal‐appearing white matter
Vrenken, H., Barkhof, F., Uitdehaag, B. M. J., Castelijns, J. A., Polman, C. H., & Pouwels, P. J. W. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20366 · Cited by 144
A Wallerian degeneration pattern in patients at risk for MS
Simon, J. H., Kinkel, R. P., Jacobs, L., Bub, L., & Simonian, N. A. (2000) · Neurology · doi:10.1212/wnl.54.5.1155 · Cited by 142
Morphologic and histoanatomic observations of the brain in untreated human phenylketonuria
Bauman, M. L., & Kemper, T. (1982) · Acta Neuropathologica · doi:10.1007/bf00692698 · Cited by 141
Magnetic resonance techniques in the assessment of myelin and myelination
Barkovich, A. J. (2005) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-005-5952-z · Cited by 140
Magnetization transfer imaging in normal aging, mild cognitive impairment, and Alzheimer's disease
van der Flier, W. M., van den Heuvel, D. M. J., Weverling‐Rijnsburger, A. W. E., Bollen, E. L. E. M., Westendorp, R. G. J., van Buchem, M. A., & Middelkoop, H. A. M. (2002) · Annals of Neurology · doi:10.1002/ana.10244 · Cited by 139
MR properties of excised neural tissue following experimentally induced inflammation
Stanisz, G. J., Webb, S., Munro, C. A., Pun, T., & Midha, R. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20008 · Cited by 138
BOLD-f MRI response to single-pulse transcranial magnetic stimulation (TMS)
Bohning, D. E., Shastri, A., Wassermann, E. M., Ziemann, U., Lorberbaum, J. P., Nahas, Z. H., Lomarev, M. P., & George, M. S. (2000) · Journal of Magnetic Resonance Imaging · doi:10.1002/1522-2586(200006)11:6 · Cited by 138
MR properties of excised neural tissue following experimentally induced demyelination
Odrobina, E., Lam, T. Y. J., Pun, T., Midha, R., & Stanisz, G. (2005) · NMR in Biomedicine · doi:10.1002/nbm.951 · Cited by 138
Comparison of the pathology of cerebral white matter with post‐mortem magnetic resonance imaging (MRI) in the elderly brain
Fernando, M. S., O'Brien, J. T., Perry, R. H., English, P. T., Forster, G., McMeekin, W., Slade, J. Y., Golkhar, A., Matthews, F. E., Barber, R., et al. (2004) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2004.00550.x · Cited by 137
Age-related Changes in Conventional, Magnetization Transfer, and Diffusion-Tensor MR Imaging Findings: Study with Whole-Brain Tissue Histogram Analysis1
Rovaris, M., Iannucci, G., Cercignani, M., Sormani, M. P., Stefano, N. D., Gerevini, S., Comi, G., & Filippi, M. (2003) · Radiology · doi:10.1148/radiol.2273020721 · Cited by 137
A Comprehensive Review of Proton Magnetic Resonance Spectroscopy Studies in Dementia and Parkinson’s Disease
Firbank, M., Harrison, R. M., & O'Brien, J. T. (2002) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000064927 · Cited by 133
CHEMISTRY OF WALLERIAN DEGENERATION
Johnson, A. C. (1950) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1950.02310250111010 · Cited by 130
In vivo determination of T1 and T2 in the brain of patients with severe but stable multiple sclerosis
Larsson, H. B. W., Frederiksen, J. L., Kjær, L., Henriksen, O. M., & Olesen, J. (1988) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910070106 · Cited by 129
Fine-structural changes of myelin sheaths after axonal degeneration in the spinal cord of rats.
Lampert, P. W., & Cressman, M. R. (1966) · PubMed · Cited by 128
Spin‐spin relaxation in experimental allergic Encephalomyelitis. Analysis of CPMG data using a non‐linear least squares method and linear inverse theory
Stewart, W. A., MacKay, A. L., Whittall, K. P., Moore, G. R. W., & Paty, D. W. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910290608 · Cited by 128
Self-citation
Superparamagnetic Iron Oxide-Labeled Schwann Cells and Olfactory Ensheathing Cells Can Be TracedIn Vivoby Magnetic Resonance Imaging and Retain Functional Properties after Transplantation into the CNS
Dunning, M., Lakatos, A., Loizou, L., Kettunen, M. I., ffrench‐Constant, C., Brindle, K. M., & Franklin, R. J. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3126-04.2004 · Cited by 126
Diffusion tensor imaging in multiple sclerosis: assessment of regional differences in the axial plane within normal-appearing cervical spinal cord.
(2006) · PubMed Central · Cited by 126
Diffusional anisotropy of T2 components in bovine optic nerve
Stanisz, G. J., & Henkelman, R. M. (1998) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910400310 · Cited by 121
Detection of age-dependent brain injury in a mouse model of brain amyloidosis associated with Alzheimer's disease using magnetic resonance diffusion tensor imaging
Sun, S.-W., Song, S.-K., Harms, M. P., Lin, S.-J., Holtzman, D. M., Merchant, K. M., & Kotyk, J. J. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2004.09.006 · Cited by 121
Nuclear magnetic resonance relaxation in experimental brain edema: Effects of water concentration, protein concentration, and temperature
Kamman, R. L., Go, K. G., Brouwer, W., & Berendsen, H. J. C. (1988) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910060304 · Cited by 117
Visualization of nonstructural changes in early white matter development on diffusion-weighted MR images: evidence supporting premyelination anisotropy.
Prayer, D., Barkovich, A. J., Kirschner, D. A., Prayer, L., Roberts, T. P. L., Kucharczyk, J. R., & Moseley, M. E. (2001) · PubMed Central · Cited by 117
Diffusion-weighted MR imaging in leukodystrophies
Patay, Z. J. (2005) · European Radiology · doi:10.1007/s00330-005-2846-2 · Cited by 114
Dysregulated brain development in adult men with schizophrenia: a magnetic resonance imaging study
Bartzokis, G., Nuechterlein, K. H., Lu, P., Gitlin, M. J., Rogers, S., & Mintz, J. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01835-8 · Cited by 114
Multi-component apparent diffusion coefficients in human brain: Relationship to spin-lattice relaxation
Mulkern, R. V., Zengingönül, H. P., Robertson, R. L., Bogner, P., Zou, K. H., Guðbjartsson, H., Guttmann, C. R. G., Holtzman, D. H., Kyriakos, W. E., Jolesz, F. A., et al. (2000) · Magnetic Resonance in Medicine · doi:10.1002/1522-2594(200008)44:2 · Cited by 111
A comparison between magnetization transfer ratios and myelin water percentages in normals and multiple sclerosis patients
Vavasour, I. M., Whittall, K. P., MacKay, A. L., Li, D. K. B., Vorobeychik, G., & Paty, D. W. (1998) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910400518 · Cited by 111
Self-citation
Gray and White Matter Brain Abnormalities in First-Episode Schizophrenia Inferred From Magnetization Transfer Imaging
Bagary, M. S., Symms, M. R., Barker, G. J., Mutsatsa, S., Joyce, E. M., & Ron, M. A. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.779 · Cited by 110
Magnetization transfer and diffusion tensor MR imaging of acute disseminated encephalomyelitis.
Inglese, M., Salvi, F., Iannucci, G., Mancardi, G., Mascalchi, M., & Filippi, M. (2002) · PubMed Central · Cited by 110
MRI of the brain with ultra-short echo-time pulse sequences
Waldman, A. D., Rees, J. H., Brock, C., Robson, M. D., Gatehouse, P. D., & Bydder, G. M. (2003) · Neuroradiology · doi:10.1007/s00234-003-1076-z · Cited by 109
MR diffusion tensor imaging and fiber tracking in inflammatory diseases of the spinal cord.
Renoux, J., Facon, D., Fillard, P., Huynh‐Charlier, I., Lasjaunias, P. L., & Ducreux, D. (2006) · PubMed Central · Cited by 109
Diffusion-weighted and magnetization transfer imaging of the corpus callosum in Alzheimer’s disease
Hanyu, H., Asano, T., Sakurai, H., Imon, Y., Iwamoto, T., Takasaki, M., Shindo, H., & Abe, K. (1999) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(99)00135-5 · Cited by 108
Magnetization transfer MR of the normal adult brain.
Mehta, R. C., Pike, G. B., & Enzmann, D. R. (1996) · PubMed · Cited by 108
Early structural changes in acute MS lesions assessed by serial magnetization transfer studies
Dousset, V., Gayou, A., Brochet, B., & Caillé, J. (1998) · Neurology · doi:10.1212/wnl.51.4.1150 · Cited by 108
Serial magnetization transfer imaging to characterize the early evolution of new MS lesions
Silver, N., Lai, M., Symms, M. R., Barker, G. J., McDonald, W. I., & Miller, D. H. (1998) · Neurology · doi:10.1212/wnl.51.3.758 · Cited by 107
Diffraction Studies of Molecular Organization and Membrane Interactions in Myelin
Kirschner, D. A., Ganser, A. L., & Caspar, D. L. D. (1984) · Springer eBooks · doi:10.1007/978-1-4757-1830-0_2 · Cited by 106
Changes in Microtubule Stability and Density in Myelin-Deficient Shiverer Mouse CNS Axons
Kirkpatrick, L., Witt, A. S., Payne, H. R., Shine, H. D., & Brady, S. T. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02288.2001 · Cited by 105
In vivo investigation of white matter pathology in schizophrenia with magnetisation transfer imaging
Foong, J. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.68.1.70 · Cited by 104
Magnetization Transfer Ratio in Mild Cognitive Impairment and Dementia of Alzheimer's Type
Kabani, N. J., Sled, J. G., & Chertkow, H. M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0992 · Cited by 103
Magnetisation transfer ratio of normal brain white matter: a normative database spanning four decades of life.
Silver, N., Barker, G. J., MacManus, D. G., Tofts, P. S., & Miller, D. H. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.62.3.223 · Cited by 103
Long-term changes of magnetization transfer-derived measures from patients with relapsing-remitting and secondary progressive multiple sclerosis.
Rocca, M. A., Mastronardo, G., Rodegher, M., Comi, G., & Filippi, M. (1999) · PubMed Central · Cited by 102
Age-dependent changes in magnetization transfer contrast of white matter in the pediatric brain.
Engelbrecht, V., Rassek, M., Preiss, S., Wald, C., & Mödder, U. (1998) · PubMed Central · Cited by 102
Multicontrast MRI of remyelination in the central nervous system
Merkler, D., Boretius, S., Stadelmann, C., Ernsting, T., Michaelis, T., Frahm, J., & Brück, W. (2005) · NMR in Biomedicine · doi:10.1002/nbm.972 · Cited by 102
Regional variations in normal brain shown by quantitative magnetization transfer imaging
Sled, J. G., Levesque, I. R., dos Santos, A. C., Francis, S. J., Narayanan, S., Brass, S. D., Arnold, D. L., & Pike, G. B. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10701 · Cited by 101
Further evidence for altered myelin biosynthesis and glutamatergic dysfunction in schizophrenia
Tkachev, D., Mimmack, M. L., Huffaker, S. J., Ryan, M., & Bahn, S. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145706007334 · Cited by 101
Localized 1H NMR spectroscopy in Canavan's Disease: A report of two cases
Austin, S. J., Connelly, A., Gadian, D. G., Benton, J. S., & Brett, E. M. (1991) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910190235 · Cited by 101
Quantification of cervical cord pathology in primary progressive MS using diffusion tensor MRI
Agosta, F., Benedetti, B., Rocca, M. A., Valsasina, P., Rovaris, M., Comi, G., & Filippi, M. (2005) · Neurology · doi:10.1212/01.wnl.0000151852.15294.cb · Cited by 98
Lactate, N‐acetylaspartate, choline and creatine concentrations, and spin‐spin relaxation in thalamic and occipito‐parietal regions of developing human brain
Cady, E. B., Penrice, J., Amess, P., Lorek, A., Wylezinska, M., Aldridge, R. F., Franconi, F., Wyatt, J. S., & Reynolds, E. O. R. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910360610 · Cited by 97
The pathogenesis of the white matter abnormalities in phenylketonuria. A multimodal 3.0 tesla MRI and magnetic resonance spectroscopy (1H MRS) study
Leuzzi, V., Tosetti, M., Montanaro, D., Carducci, C., Artiola, C., Carducci, C., Antonozzi, I., Burroni, M., Carnevale, F. A., Chiarotti, F., et al. (2007) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-006-0399-4 · Cited by 97
Multiexponential T2 relaxation in degenerating peripheral nerve
Does, M. D., & Snyder, R. E. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910350212 · Cited by 95
Normal Brain Maturation Characterized With Age-Related T2 Relaxation Times: An Attempt to Develop a Quantitative Imaging Measure for Clinical Use
Ding, X. Q., Kucinski, T., Wittkugel, O., Goebell, E., Grzyska, U., Görg, M., Kohlschütter, A., & Zeumer, H. (2004) · Investigative Radiology · doi:10.1097/00004424-200412000-00005 · Cited by 95
Quantitative measurements with localized 1H MR spectroscopy in children with Canavan's disease
Wittsack, H., Kugel, H., Roth, B. J., & Heindel, W. L. (1996) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1880060609 · Cited by 94
Characterization of the NMR behavior of white matter in bovine brain
Bjarnason, T. A., Vavasour, I. M., Chia, C. L. L., & MacKay, A. L. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20680 · Cited by 94
Self-citation
Normal-appearing white matter in multiple sclerosis has heterogeneous, diffusely prolonged T2
Whittall, K. P., MacKay, A. L., Li, D. K. B., Vavasour, I. M., Jones, C. K., & Paty, D. W. (2002) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10076 · Cited by 92
Self-citation
Integrated data acquisition and processing to determine metabolite contents, relaxation times, and macromolecule baseline in single examinations of individual subjects
Kreis, R., Slotboom, J., Hofmann, L., & Boesch, C. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20673 · Cited by 91
Water compartments in the myelinated nerve. III. Pulsed NMR result
Vasilescu, V., Katona, É., Simplăceanu, V., & Demco, D. E. (1978) · Cellular and Molecular Life Sciences · doi:10.1007/bf01932339 · Cited by 90
Proton Relaxation Studies of Water Compartmentalization in a Model Neurological System
Menon, R. S., Rusinko, M. S., & Allen, P. S. (1992) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910280208 · Cited by 89
The myelinated axon is dependent on the myelinating cell for support and maintenance: Molecules involved
Edgar, J. M., & Garbern, J. Y. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20063 · Cited by 89
Diffusion tensor tractography-based group mapping of the pyramidal tract in relapsing-remitting multiple sclerosis patients.
Lin, F., Yu, C., Jiang, T., Li, K., & Chan, P. (2007) · PubMed Central · Cited by 88
Myelin in Multiple Sclerosis
Suzuki, K. (1973) · Archives of Neurology · doi:10.1001/archneur.1973.00490230029002 · Cited by 87
Quantitative MR imaging R2 relaxometry in elderly participants reporting memory loss.
House, M. J., Pierre, T. G. S., Foster, J. K., Martins, R. N., & Clarnette, R. (2006) · PubMed Central · Cited by 86
Multi-component T1 relaxation and magnetisation transfer in peripheral nerve
Does, M. D., Beaulieu, C., Allen, P. S., & Snyder, R. E. (1998) · Magnetic Resonance Imaging · doi:10.1016/s0730-725x(98)00139-8 · Cited by 83
Detection of myelin breakdown products by proton magnetic resonance spectroscopy
Davie, C. A., Barker, G. J., Tofts, P. S., Hawkins, C. P., Brennan, A., Miller, D. H., & McDonald, W. I. (1993) · The Lancet · doi:10.1016/0140-6736(93)90390-3 · Cited by 83
Diffusion Tensor Imaging in Multiple Sclerosis: Assessment of Regional Differences in the Axial Plane within Normal-Appearing Cervical Spinal Cord
Bowen, B. C. (2007) · Yearbook of Neurology and Neurosurgery · doi:10.1016/s0513-5117(08)70121-2 · Cited by 82
Proton MRS profile of cerebral metabolic abnormalities in Krabbe disease
Brockmann, K., Dechent, P., Wilken, B., Rusch, O., Frahm, J., & Hanefeld, F. A. (2003) · Neurology · doi:10.1212/01.wnl.0000049469.29011.e9 · Cited by 82
NEUROPATHOLOGIC OBSERVATIONS IN PHENYLKETONURIA
Poser, C. M., & van Bogaert, L. (1959) · Brain · doi:10.1093/brain/82.1.1-a · Cited by 82
Quantifying Age-Related Myelin Breakdown with MRI: Novel Therapeutic Targets for Preventing Cognitive Decline and Alzheimer's Disease
Bartzokis, G., Lu, P. H., & Mintz, J. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6s604 · Cited by 81
A 1H magnetic resonance spectroscopy study of aging in parietal white matter: implications for trials in multiple sclerosis
Leary, S. M., Brex, P., MacManus, D. G., Parker, G. J. M., Barker, G. J., Miller, D. H., & Thompson, A. J. (2000) · Magnetic Resonance Imaging · doi:10.1016/s0730-725x(00)00131-4 · Cited by 81
Global estimation of myelination in the developing brain on the basis of magnetization transfer imaging: a preliminary study.
van Buchem, M. A., Steens, S. C. A., Vrooman, H. A., Zwinderman, A. H., McGowan, J. C., Rassek, M., & Engelbrecht, V. (2001) · PubMed Central · Cited by 79
Optimized spiral imaging for measurement of myocardial T2 relaxation
Foltz, W. D., Al-Kwifi, O. S., Sussman, M. S., Stainsby, J. A., & Wright, G. A. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10467 · Cited by 79
Frontal lobe N-acetylaspartate correlates with psychopathology in schizophrenia: a proton magnetic resonance spectroscopy study
Sigmundsson, T., Maier, M., Toone, B., Williams, S., Simmons, A., Greenwood, K., & Ron, M. A. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00533-9 · Cited by 78
Magnetic resonance spectroscopy of multiple sclerosis: in-vivo detection of myelin breakdown products
Koopmans, R. A., Li, D. K. B., Zhu, G., Allen, P. S., Penn, A., & Paty, D. W. (1993) · The Lancet · doi:10.1016/0140-6736(93)90391-s · Cited by 78
Self-citation
Directional diffusion in relapsing‐remitting multiple sclerosis: A possible in vivo signature of Wallerian degeneration
Henry, R. G., Oh, J., Nelson, S. J., & Pelletier, D. (2003) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.10379 · Cited by 77
MR spectroscopy of cervical spinal cord in patients with multiple sclerosis
Kendi, A. T. K., Tan, F. U., Kendi, M., Huvaj, S., & Tellioğlu, S. (2004) · Neuroradiology · doi:10.1007/s00234-004-1231-1 · Cited by 77
MR characteristics and neuropathology in adult-onset autosomal dominant leukodystrophy with autonomic symptoms.
Melberg, A., Hallberg, L., Kalimo, H., & Raininko, R. (2006) · PubMed Central · Cited by 76
Lipid alterations in apparently normal white matter in multiple sclerosis
Alling, C., Vanier, M.-T. ́., & Svennerholm, L. T. (1971) · Brain Research · doi:10.1016/0006-8993(71)90478-1 · Cited by 76
Assessment of the pathological grade of astrocytic gliomas using an MRI score
Asari, S., Makabe, T., Katayama, S., Itoh, T., Tsuchida, S., & Ohmoto, T. (1994) · Neuroradiology · doi:10.1007/bf00593267 · Cited by 75
Formalin fixed brains are useful for magnetic resonance imaging (MRI) study
Nagara, H., Inoue, T., Koga, T., Kitaguchi, T., Tateishi, J., & Goto, I. (1987) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(87)90184-5 · Cited by 75
MR imaging and proton MR spectroscopy in adult Krabbe disease.
Farina, L., Bizzi, A., Finocchiaro, G., Pareyson, D., Sghirlanzoni, A., Bertagnolio, B., Savoiardo, M., Naidu, S., Singhal, B. S., & Wenger, D. A. (2000) · PubMed Central · Cited by 75
Abnormalities in the Macroscopically Normal White Matter in Cases of Mild or Spinal Multiple Sclerosis (MS)
Allen, I. V., Glover, G., & Anderson, R. (1981) · Acta neuropathologica. Supplementum · doi:10.1007/978-3-642-81553-9_53 · Cited by 74
Pathological correlates of magnetization transfer imaging abnormalities in animal models and humans with multiple sclerosis.
Brochet, B., & Dousset, V. (1999) · PubMed · Cited by 74
Investigation of corpus callosum in schizophrenia with diffusion imaging
Brambilla, P., Cerini, R., Gasparini, A., Versace, A., Andreone, N., Vittorini, E., Barbui, C., Pelizza, L., Nosè, M., & Barlocco, L. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.04.012 · Cited by 74
Glial levels determine severity of white matter disease in Alzheimer's disease: a neuropathological study of glial changes
Sjöbeck, M., & Englund, E. M. (2003) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2003.00456.x · Cited by 73
Neuropathology: Methods and Diagnosis
Bailey, O. T. (1971) · JAMA · doi:10.1001/jama.1971.03180220086031 · Cited by 71
Magnetic resonance imaging, magnetisation transfer imaging, and diffusion weighted imaging correlates of optic nerve, brain, and cervical cord damage in Leber's hereditary optic neuropathy
Inglese, M. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.70.4.444 · Cited by 71
Normal-appearing White Matter in Patients with Phenylketonuria: Water Content, Myelin Water Fraction, and Metabolite Concentrations
Sirrs, S. M., Laule, C., Mädler, B., Brief, E., Tahir, S., Bishop, C., & MacKay, A. L. (2007) · Radiology · doi:10.1148/radiol.2421051758 · Cited by 71
Self-citation
Quantitative magnetization transfer imaging of pre-lesional white-matter changes in multiple sclerosis
Fazekas, F., Ropele, S., Enzinger, C., Seifert‐Held, T., & Strasser‐Fuchs, S. (2002) · Multiple Sclerosis Journal · doi:10.1191/1352458502ms860oa · Cited by 70
A comparison of magnetization transfer ratio, magnetization transfer rate, and the native relaxation time of water protons related to relapsing-remitting multiple sclerosis.
Ropele, S., Strasser‐Fuchs, S., Augustin, M., Stollberger, R., Enzinger, C., Hartung, H., & Fazekas, F. (2000) · PubMed Central · Cited by 70
Diffusion-weighted MR Imaging in Patients with Phenylketonuria: Relationship between Serum Phenylalanine Levels and ADC Values in Cerebral White Matter
Kono, K., Okano, Y., Nakayama, K., Hase, Y., Minamikawa, S., Ozawa, N., Yokote, H., & Inoue, Y. (2005) · Radiology · doi:10.1148/radiol.2362040611 · Cited by 69
Quantitative MRI‐pathology correlations of brain white matter lesions developing in a non‐human primate model of multiple sclerosis
Blezer, E. L. A., Bauer, J., Brok, H., Nicolay, K., & Hart, B. A. ‘. (2006) · NMR in Biomedicine · doi:10.1002/nbm.1085 · Cited by 69
Correlation of apparent myelin measures obtained in multiple sclerosis patients and controls from magnetization transfer and multicompartmental T2 analysis
Tozer, D. J., Davies, G. R., Altmann, D. R., Miller, D., & Tofts, P. S. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20479 · Cited by 68
Implications of lipid biology for the pathogenesis of schizophrenia
Berger, G. E., Wood, S. J., Pantelis, C., Velakoulis, D., Wellard, R. M., & McGorry, P. D. (2002) · Australian & New Zealand Journal of Psychiatry · doi:10.1046/j.1440-1614.2001.01021.x · Cited by 67
Structure of the Myelinated Axon
Trapp, B. D., & Kidd, G. J. (2004) · Elsevier eBooks · doi:10.1016/b978-012439510-7/50054-1 · Cited by 65
LIPID COMPOSITION OF HUMAN CEREBRAL WHITE MATTER AND MYELIN IN PHENYLKETONURIA1
Shah, S., Peterson, N. A., & McKean, C. M. (1972) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1972.tb01291.x · Cited by 65
Method for quantitative imaging of the macromolecular 1H fraction in tissues
Ropele, S., Seifert‐Held, T., Enzinger, C., & Fazekas, F. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10427 · Cited by 65
Quantitative proton magnetic resonance spectroscopy of the human cervical spinal cord at 3 tesla
Marliani, A. F., Clementi, V., Albini‐Riccioli, L., Agati, R., & Leonardi, M. (2006) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21113 · Cited by 64

Flagged first, then by citations

7 of the 291 references couldn’t be matched to a known paper.

Research works printed but not linked: 5

Yung, 2004, Measurements of myelin water in rat spinal cord in vivo, Int Soc Magn Reson Med, 1537
Minty, 2002, Measurement of myelin water in human and bovine spinal cord, Int Soc Magn Reson Med Sci, 940
Laule, 2003, Cervical cord abnormalities in primary progressive multiple sclerosis: atrophy and myelin water changes, Mult Scler, 9, S63
Helms, 2000, Regression analysis of metabolite concentrations estimated from localized proton MR spectra of active and chronic multiple sclerosis lesions, Magn Reson Med, 43, 102, 10.1002/(SICI)1522-2594(200001)43:1<102::AID-MRM12>3.0.CO;2-I · DOI
Leuzzi, 2007, The pathogenesis of the white matter abnormalities in phenylketonuria, J Inherit Metab Dis, 23, 23

Sorted by citations

Plasticity in gray and white: neuroimaging changes in brain structure during learning
Zatorre, R. J., Fields, R. D., & Johansen-Berg, H. (2012) · Nature Neuroscience · doi:10.1038/nn.3045 · Cited by 1,685
Myelin and iron concentration in the human brain: a quantitative study of MRI contrast
Stüber, C., Morawski, M., Schäfer, A., Labadie, C., Wähnert, M., Leuze, C., Streicher, M., Barapatre, N., Reimann, K., Geyer, S., et al. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.02.026 · Cited by 635
A Guide to the Metabolic Pathways and Function of Metabolites Observed in Human Brain 1H Magnetic Resonance Spectra
Rae, C. D. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1199-5 · Cited by 524
Growth of white matter in the adolescent brain: Myelin or axon?
Paus, T. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.06.002 · Cited by 424
Growth of white matter in the adolescent brain: role of testosterone and androgen receptor
Perrin, J. S., Hervé, P.-Y., Leonard, G., Perron, M., Pike, G. B., Pitiot, A., Richer, L., Veillette, S., Pausova, Z., & Paus, T. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1212-08.2008 · Cited by 331

See all 334

Authors: Laule, C., Vavasour, I. M., Kolind, S. H., Li, D. K. B., Traboulsee, T. L., Moore, G. R. W., & MacKay, A. L.
Affiliations: University of British Columbia (CA)
University of British Columbia Hospital (CA)
Corresponding author: Laule, Cornelia
ORCID: Laule, Cornelia
Vavasour, Irene M.
Kolind, Shannon H.
Li, David K.B.
MacKay, Alex L.
Venue: Neurotherapeutics
Publisher: Elsevier BV
Published: 2007-07
Volume: 4
Issue: 3
Pages: 460-484
ISSN: 1878-7479 (ISSN-L)
DOI: 10.1016/j.nurt.2007.05.004
PMC: PMC7479725
OpenAlex: W2080423736
Cited by: 334
References: 291
Citations by year: 2026: 9 · 2025: 17 · 2024: 20 · 2023: 19 · 2022: 17 · 2021: 28 · 2020: 32 · 2019: 28 · 2018: 23 · 2017: 27 · 2016: 16 · 2015: 17 · 2014: 18 · 2013: 15 · 2012: 8
FWCI: 1.15
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5886 d)
Locations: Neurotherapeutics (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Multiple Sclerosis Society of Canada
Multiple Sclerosis Society
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: myelin imaging, myelin, myelination, myelin damage, remyelination, MR spectroscopy, diffusion MRI, magnetization transfer, T2 relaxation, peripheral nerves
MeSH terms: Animals, Humans, Magnetic Resonance Imaging, Myelin Sheath

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