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Cited by 83Adipokines, Inflammation, and Metabolic DiseasesDiet, Metabolism, and DiseaseAdipose Tissue and Metabolism

Modulation of cytokines, resistin, and distribution of adipose tissue in C57BL/6 mice by different high-fat diets

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Catta-Preta, Mariana, Martins, Marcela Anjos, Cunha Brunini, Tatiana Marlowe, Mendes-Ribeiro, Antonio Claudio, Mandarim-de-Lacerda, Carlos Alberto, Aguila, Marcia Barbosa·2012·Nutrition
DOI 10.1016/j.nut.2011.05.011
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Abstract

OBJECTIVE To investigate whether changing the lipid source induces metabolic changes and/or modulates the adipose tissue distribution in mice fed with a high-fat (HF) diet. METHODS C57BL/6 mice were subjected to a 10-wk control diet (10% fat) or an HF diet (60% fat) containing lard (HF-L), olive oil (HF-O), sunflower oil, or canola oil. Food intake and body weight were measured. At euthanasia, blood was collected and adipose tissue was dissected. Serum hormones and cytokines were determined. RESULTS The plasma insulin levels were higher in the HF-L and HF-O groups than in the other three groups (P < 0.0001). The levels of resistin were highest in the HF-L and HF-O groups (P < 0.0001). Leptin expression was also highest in these two groups (P < 0.0001). Of the four groups, interleukin-6 was expressed at the highest level in the HF-L group (P < 0.0005), whereas adiponectin was expressed at the lowest level (P < 0.0001). The accumulation of subcutaneous and visceral adipose tissues was higher in the HF-L group compared with the other groups. This group was hypertrophic because of excess subcutaneous fat and epididymal fat in the adipocytes. However, the ratio of subcutaneous to visceral fat was significantly lower in the HF-L and HF-O groups compared with the other groups. CONCLUSION In mice fed fat-rich diets, the level of adipokines, the distribution of adipose tissue, and the metabolism of carbohydrates are more significantly influenced by the lipid content rather than the absolute amount of lipid.

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  • Animals fed diets high in SFAs compared with MUFA or PUFA sources showed greater body weight gain, body fat accumulation, aSCAT, VAT, and liver fat.

    “Animals fed diets high in SFAs (beef tallow, lard) compared with MUFA (olive oil, canola oil) or PUFA sources [safflower oil, soybean oil (SBO), sunflower oil] showed greater body weight gain, body fat accumulation, aSCAT, VAT, and liver fat (14-17).”

    From Eucaloric diets enriched in palm olein, cocoa butter, and soybean oil did not differentially affect liver fat concentration in healthy participants: a 16-week randomized controlled trial. (2021) · cites this paper as [15]

    The Body mass and Adipose tissue sections report that lard-fed mice gained more weight and had greater subcutaneous and visceral fat masses than the olive-, sunflower-, and canola-oil groups. The paper does not report a liver-fat comparison or identify the measured subcutaneous fat specifically as abdominal. Its beef-tallow comparison comes from a cited rat study, and it does not compare a soybean-oil diet with the other diets. (LLM, conf=0.87)

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  • Evidence from nutrition intervention studies in animal models has been inconsistent.

    “On the contrary, evidence from nutrition intervention studies in animal models has been inconsistent.”

    From Eucaloric diets enriched in palm olein, cocoa butter, and soybean oil did not differentially affect liver fat concentration in healthy participants: a 16-week randomized controlled trial. (2021) · cites this paper as [15]

    The Discussion says few animal studies compare different high-fat diet components and that the role of monounsaturated fats is unclear. It does not say that findings across animal nutrition intervention studies have been inconsistent; the animal comparisons it describes point in the same direction. Searched our copy for inconsistent or conflicting intervention results. (LLM, conf=0.73)

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  1. [32]32. Gallou-Kabani C, Vige A, Gross MS, Rabes JP, Boileau C, Larue-Achagiotis C, et al. C57BL/6J and A/J mice fed a high-fat diet delineate components of metabolic syndrome. Obesity (Silver Spring) 2007;15:1996-2005.

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Authors
Catta-Preta, M., Martins, M. A., Cunha Brunini, T. M., Mendes-Ribeiro, A. C., Mandarim-de-Lacerda, C. A., & Aguila, M. B.
Affiliations
Universidade do Estado do Rio de Janeiro (BR)
Venue
Nutrition
Publisher
Elsevier BV
Published
2012-02
Volume
28
Issue
2
Pages
212-219
ISSN
0899-9007 (ISSN-L)
DOI
10.1016/j.nut.2011.05.011
OpenAlex
W2070063697
Semantic Scholar
a8bbe0b3b7315e600a3288ed0ed2032109eebc08
Cited by
83
References
54
Citations by year
2026: 3 · 2025: 4 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 10 · 2014: 7 · 2013: 9 · 2012: 5
FWCI
5.04
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
high-fat diet, body fat distribution, resistin, adipokines, leptin, interleukin-6, adiponectin, insulin, lard, olive oil, sunflower oil, canola oil, subcutaneous adipose tissue, visceral fat, adipocyte hypertrophy, lipid sources, C57BL/6 mice
MeSH terms
Adipose Tissue, Animals, Dietary Fats, Insulin, Male, Mice, Inbred C57BL, Plant Oils, Interleukin-6, Adipocytes, Leptin, Subcutaneous Fat, Intra-Abdominal Fat, Body Fat Distribution, Mice, Adiponectin, Resistin, Adipokines, Diet, High-Fat

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