Tomato juice supplementation in young women reduces inflammatory adipokine levels independently of body fat reduction
Abstract
Objectives Lycopene is a carotene and phytochemical known to protect against metabolic diseases. It is found in red fruits and vegetables, predominantly tomatoes. This study aimed to show the supplementation effect of tomato juice on indices associated with metabolic health and adipokine profiles in generally healthy people. Methods A total of 30 young females (20- to 30-years-old) with a body mass index (BMI) ≥ 20 were recruited, of whom 25 completed the entire study. The subjects continued with their normal diet and exercise schedule, but were given 280 mL of tomato juice (containing 32.5 mg of lycopene) daily for 2 mo. Metabolic indices, including anthropometric data and serum levels of glucose, lipids, adipokines, lycopene, and antioxidants, were compared pre- and postintervention. Results Tomato juice supplementation significantly reduced body weight, body fat, waist circumference, BMI, and serum levels of cholesterol, monocyte chemoattractant protein-1 (MCP-1), and thiobarbituric reactive substances, while significantly increasing serum levels of adiponectin, triglyceride, and lycopene. When subjects were stratified by body fat change, i.e., reduction or non-reduction (including increase or no change), the tomato juice-induced reduction in waist circumference, serum cholesterol, and MCP-1 levels and increase in adiponectin and lycopene levels were seen in both subgroups. The changes in waist circumference, cholesterol, MCP-1, and adiponectin levels remained significant…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Tomato consumption has been associated with reduced body weight.
“Tomato consumption has been associated with reduced body weight [46].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [46]
Cites
Inflammatory Mechanisms in Obesity
Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754 · see citing works
Draper, H. H., Squires, E. J., Mahmoodi, H., Wu, J., Agarwal, S., & Hadley, M. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90035-s · Cited by 916 · see citing works
Adiponectin as an anti-inflammatory factor
Ouchi, N., & Walsh, K. X. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.01.026 · Cited by 883 · see citing works
Harman-Boehm, I., Blüher, M., Redel, H., Sion-Vardy, N., Ovadia, S., Avinoach, E., Shai, I., Klöting, N., Stumvoll, M., Bashan, N., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1811 · Cited by 574 · see citing works
Kim, C.-S., Park, H.-S., Kawada, T., Kim, J.-H., Lim, D., Hubbard, N. E., Kwon, B.-S., Erickson, K. L., & Yu, R. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803259 · Cited by 511 · see citing works
Insulin resistance and atherosclerosis
Semenkovich, C. F. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29024 · Cited by 481 · see citing works
Tomato lycopene and low density lipoprotein oxidation: A human dietary intervention study
Agarwal, S., & Rao, A. V. (1998) · Lipids · doi:10.1007/s11745-998-0295-6 · Cited by 430 · see citing works
Pan, W., Flegal, K. M., Chang, H., Yeh, W., Yeh, C., & Lee, W. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.1.31 · Cited by 368 · see citing works
Dietary Lycopene, Tomato-Based Food Products and Cardiovascular Disease in Women
Sesso, H. D., Liu, S., Gaziano, J. M., & Buring, J. E. (2003) · Journal of Nutrition · doi:10.1093/jn/133.7.2336 · Cited by 294 · see citing works
Role of adipokines in cardiovascular disease
Mattu, H. S., & Randeva, H. S. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0232 · Cited by 292 · see citing works
Relationship of Serum Adiponectin and Leptin Concentrations with Body Fat Distribution in Humans
Staiger, H., Tschritter, O., Machann, J., Thamer, C., Fritsche, A., Maerker, E., Schick, F., Häring, H., & Stümvoll, M. (2003) · Obesity Research · doi:10.1038/oby.2003.48 · Cited by 250 · see citing works
Rao, A. V., Ray, M. R., & RAO, L. G. S. (2006) · Advances in food and nutrition research · doi:10.1016/s1043-4526(06)51002-2 · Cited by 225 · see citing works
Jacob, K., Periago, M. J., Böhm, V., & Ros, G. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507791894 · Cited by 193 · see citing works
Hadley, C. W., Clinton, S. K., & Schwartz, S. J. (2003) · Journal of Nutrition · doi:10.1093/jn/133.3.727 · Cited by 176 · see citing works
Oswal, A., & Yeo, G. S. H. (2009) · Obesity · doi:10.1038/oby.2009.228 · Cited by 164 · see citing works
Effect of Lycopene and Tomato Products on Cholesterol Metabolism
Palozza, P., Catalano, A., Simone, R. E., Mele, M. C., & Cittadini, A. R. M. (2012) · Annals of Nutrition and Metabolism · doi:10.1159/000342077 · Cited by 159 · see citing works
Tomato juice decreases LDL cholesterol levels and increases LDL resistance to oxidation
Silaste, M.-L., Alfthan, G., Aro, A., Kesäniemi, Y. A., & Hörkkö, S. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507787445 · Cited by 151 · see citing works
Lycopene inhibits proinflammatory cytokine and chemokine expression in adipose tissue
Gouranton, E., Thabuis, C., Riollet, C., Malezet‐Desmoulins, C., Yazidi, C. E., Amiot, M. J., Borel, P., & Landrier, J. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.04.016 · Cited by 143 · see citing works
Lehrke, M., & Lazar, M. A. (2004) · Nature Medicine · doi:10.1038/nm0204-126 · Cited by 138 · see citing works
Sluijs, I., Beulens, J. W. J., Grobbee, D. E., & van der Schouw, Y. T. (2009) · Journal of Nutrition · doi:10.3945/jn.108.101451 · Cited by 136 · see citing works
Tomato juice consumption reduces systemic inflammation in overweight and obese females
Ghavipour, M., Saedisomeolia, A., Djalali, M., Sotoudeh, G., Eshraghyan, M. R., Moghadam, A. M., & Wood, L. G. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512004278 · Cited by 134 · see citing works
Ahn, J., Lee, H., Jung, C. H., & Ha, T. Y. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200182 · Cited by 129 · see citing works
Sirtuins regulate key aspects of lipid metabolism
Lomb, D. J., Laurent, G., & Haigis, M. C. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.11.021 · Cited by 123 · see citing works
Luvizotto, R. D. A. M., do Nascimento, A. F., Imaizumi, E., Pierine, D. T., Conde, S. J., Corrêa, C. R., Yeum, K., & Ferreira, A. L. A. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513001256 · Cited by 104 · see citing works
Lin, C.-C., & Yin, M. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507793881 · Cited by 87 · see citing works
Reliability of leptin, but not adiponectin, as a biomarker for diet-induced weight loss in humans
Klempel, M. C., & Varady, K. A. (2011) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00373.x · Cited by 86 · see citing works
Armoza, A., Haim, Y., Basiri, A., et al. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e32835c1d01 · Cited by 85 · see citing works
Chung, J., Koo, K., Lian, F., Hu, K. Q., Ernst, H., & Wang, X. (2012) · Journal of Nutrition · doi:10.3945/jn.111.150052 · Cited by 80 · see citing works
Bernal, C., Martín‐Pozuelo, G., Lozano, A. B., Sevilla, A., García‐Alonso, J., Cánovas, M., & Periago, M. J. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.05.003 · Cited by 53 · see citing works
NAVARRO-GONZÁLEZ, I., Pérez‐Sánchez, H., Martín‐Pozuelo, G., García‐Alonso, J., & Periago, M. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083968 · Cited by 47 · see citing works
Sicilia, T., Bub, A., Rechkemmer, G., et al. (2005) · Journal of Nutrition · doi:10.1093/jn/135.11.2616 · Cited by 23 · see citing works
Llanos, A. A. M., Peng, J., Pennell, M. L., Krok, J. L., Vitolins, M. Z., DeGraffinreid, C. R., & Paskett, E. D. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3222 · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders
Imran, M., Ghorat, F., Ul-Haq, I., Ur-Rehman, H., Aslam, F., Heydari, M., Shariati, M. A., Okuskhanova, E., Yessimbekov, Z., Thiruvengadam, M., et al. (2020) · Antioxidants · doi:10.3390/antiox9080706 · Cited by 426 · see citing works
Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing
Gantenbein, K. V., & Kanaka-Gantenbein, C. (2021) · Nutrients · doi:10.3390/nu13061951 · Cited by 288 · see citing works
van Steenwijk, H. P., Bast, A., & de Boer, A. (2020) · Molecules · doi:10.3390/molecules25194378 · Cited by 41 · see citing works
- Authors
- Li, Y.-F., Chang, Y.-Y., Huang, H.-C., Wu, Y.-C., Yang, M.-D., & Chao, P.-M.
- Affiliations
- China Medical University (TW)
- China Medical University Hospital (TW)
- Corresponding author
- Yang, Mei-Due
- Chao, Pei-Min
- Venue
- Nutrition
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 31
- Issue
- 5
- Pages
- 691-696
- ISSN
- 0899-9007 (ISSN-L)
- OpenAlex
- W2064860204
- Cited by
- 81
- References
- 32
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 3 · 2023: 6 · 2022: 7 · 2021: 9 · 2020: 9 · 2019: 10 · 2018: 9 · 2017: 10 · 2016: 6
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence (DOH102-TD-B-111-004)
- National Science Council, Taiwan (NSC 102-2815-C-039-122-B)
- Taiwan Kagome Co. Ltd
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- tomato juice, lycopene, adipokines, adiponectin, MCP-1, inflammation, waist circumference, serum cholesterol, fat mass, young women, dietary supplementation, metabolic health, antioxidants
- MeSH terms
- Fruit and Vegetable Juices, Lycopene, Adipose Tissue, Adult, Anthropometry, Antioxidants, Blood Glucose, Body Weight, Carotenoids, Cholesterol, Female, Humans, Inflammation, Lipids, Body Mass Index, Thiobarbituric Acid Reactive Substances, Solanum lycopersicum, Chemokine CCL2, Dietary Supplements, Adiponectin, Adipokines, Waist Circumference, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
