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Cited by 178Natural Antidiabetic Agents StudiesDiabetes Treatment and ManagementMedicinal Plant Research

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes

Lu, Ting, Sheng, Hongguang, Wu, Johnna, Cheng, Yuan, Zhu, Jianming, Chen, Yan·2012·Nutrition Research
DOI 10.1016/j.nutres.2012.05.003
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Abstract

For thousands of years, cinnamon has been used as a traditional treatment in China. However, there are no studies to date that investigate whether cinnamon supplements are able to aid in the treatment of type 2 diabetes in Chinese subjects. We hypothesized cinnamon should be effective in improving blood glucose control in Chinese patients with type 2 diabetes. To address this hypothesis, we performed a randomized, double-blinded clinical study to analyze the effect of cinnamon extract on glycosylated hemoglobin A(1c) and fasting blood glucose levels in Chinese patients with type 2 diabetes. A total of 66 patients with type 2 diabetes were recruited and randomly divided into 3 groups: placebo and low-dose and high-dose supplementation with cinnamon extract at 120 and 360 mg/d, respectively. Patients in all 3 groups took gliclazide during the entire 3 months of the study. Both hemoglobin A(1c) and fasting blood glucose levels were significantly reduced in patients in the low- and high-dose groups, whereas they were not changed in the placebo group. The blood triglyceride levels were also significantly reduced in the low-dose group. The blood levels of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and liver transaminase remained unchanged in the 3 groups. In conclusion, our study indicates that cinnamon supplementation is able to significantly improve blood glucose control in Chinese patients with type 2 diabetes.

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Crossref · 10.1016/j.nutres.2012.05.003

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Metadata

Authors
Lu, T., Sheng, H., Wu, J., Cheng, Y., Zhu, J., & Chen, Y.
Affiliations
  • Jiangsu University (CN)
  • Shanghai Xuhui Central Hospital (CN)
  • Chinese Academy of Sciences (CN)
Corresponding author
Chen, Yan
ORCID
Venue
Nutrition Research
Publisher
Elsevier BV
Published
2012-06
Volume
32
Issue
6
Pages
408-412
ISSN
0271-5317 (ISSN-L)
DOI
10.1016/j.nutres.2012.05.003
OpenAlex
W2033747510
Cited by
178
References
13
Citations by year
2026: 3 · 2025: 9 · 2024: 14 · 2023: 17 · 2022: 20 · 2021: 22 · 2020: 15 · 2019: 14 · 2018: 14 · 2017: 11 · 2016: 11 · 2015: 10 · 2014: 11 · 2013: 5 · 2012: 1
FWCI
6.93
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Nutrition Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China
  • Chinese Academy of Sciences
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
cinnamon extract, type 2 diabetes, fasting blood glucose, HbA1c, glycemic control, dietary supplementation, gliclazide, triglycerides, Chinese patients
MeSH terms
Aged, Blood Glucose, China, Cinnamomum zeylanicum, Diabetes Mellitus, Type 2, Double-Blind Method, Fasting, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Cholesterol, HDL, Cholesterol, LDL, Middle Aged, Plant Extracts, Dietary Supplements, Asian People

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