The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes
Abstract
For thousands of years, cinnamon has been used as a traditional treatment in China. However, there are no studies to date that investigate whether cinnamon supplements are able to aid in the treatment of type 2 diabetes in Chinese subjects. We hypothesized cinnamon should be effective in improving blood glucose control in Chinese patients with type 2 diabetes. To address this hypothesis, we performed a randomized, double-blinded clinical study to analyze the effect of cinnamon extract on glycosylated hemoglobin A(1c) and fasting blood glucose levels in Chinese patients with type 2 diabetes. A total of 66 patients with type 2 diabetes were recruited and randomly divided into 3 groups: placebo and low-dose and high-dose supplementation with cinnamon extract at 120 and 360 mg/d, respectively. Patients in all 3 groups took gliclazide during the entire 3 months of the study. Both hemoglobin A(1c) and fasting blood glucose levels were significantly reduced in patients in the low- and high-dose groups, whereas they were not changed in the placebo group. The blood triglyceride levels were also significantly reduced in the low-dose group. The blood levels of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and liver transaminase remained unchanged in the 3 groups. In conclusion, our study indicates that cinnamon supplementation is able to significantly improve blood glucose control in Chinese patients with type 2 diabetes.
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“Most of the studies have reported a generally favorable effect of cinnamon on postprandial/fasting hyperglycemia and diurnal glucose fluctuations [368,369,370,371,372,373,374,375].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [372]
Citations
Cites
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Cinnamon improves glucose and lipids of people with type 2 diabetes
Khan, A., Safdar, M., Ali Khan, M. M., Khattak, K. N., & Anderson, R. A. (2003) · Diabetes Care · doi:10.2337/diacare.26.12.3215 · Cited by 981
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Effects of a cinnamon extract on plasma glucose, HbA1c, and serum lipids in diabetes mellitus type 2
Mang, B., Wolters, M., Schmitt, B., Kelb, K., Lichtinghagen, R., Stichtenoth, D. O., & Hahn, A. (2006) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2006.01629.x · Cited by 354
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Effect of cinnamon on glucose and lipid levels in non insulin-dependent type 2 diabetes
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Kim, Y., Keogh, J. B., & Clifton, P. M. (2016) · Nutrients · doi:10.3390/nu8010017 · Cited by 583
Cinnamaldehyde in diabetes: A review of pharmacology, pharmacokinetics and safety
Zhu, R., Liu, H., Liu, C., Wang, L., Ma, R., Chen, B., Li, L., Niu, J., Fu, M., Zhang, D., et al. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.05.019 · Cited by 310
Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis
Allen, R. W., Schwartzman, E., Baker, W. L., Coleman, C. I., & Phung, O. J. (2013) · The Annals of Family Medicine · doi:10.1370/afm.1517 · Cited by 269
How Effective Are Antioxidant Supplements in Obesity and Diabetes?
Abdali, D., Samson, S. E., & Grover, A. K. (2015) · Medical Principles and Practice · doi:10.1159/000375305 · Cited by 214
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Metadata
- Authors
- Lu, T., Sheng, H., Wu, J., Cheng, Y., Zhu, J., & Chen, Y.
- Affiliations
- Jiangsu University (CN)
- Shanghai Xuhui Central Hospital (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Chen, Yan
- Venue
- Nutrition Research
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 32
- Issue
- 6
- Pages
- 408-412
- ISSN
- 0271-5317 (ISSN-L)
- OpenAlex
- W2033747510
- Cited by
- 178
- References
- 13
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 14 · 2023: 17 · 2022: 20 · 2021: 22 · 2020: 15 · 2019: 14 · 2018: 14 · 2017: 11 · 2016: 11 · 2015: 10 · 2014: 11 · 2013: 5 · 2012: 1
- FWCI
- 6.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- cinnamon extract, type 2 diabetes, fasting blood glucose, HbA1c, glycemic control, dietary supplementation, gliclazide, triglycerides, Chinese patients
- MeSH terms
- Aged, Blood Glucose, China, Cinnamomum zeylanicum, Diabetes Mellitus, Type 2, Double-Blind Method, Fasting, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Cholesterol, HDL, Cholesterol, LDL, Middle Aged, Plant Extracts, Dietary Supplements, Asian People
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