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Cited by 486

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Prevalence of Age-Related Macular Degeneration in Europe

Open access
Colijn, Johanna M., Buitendijk, Gabriëlle H.S., Prokofyeva, Elena, Alves, Dalila, Cachulo, Maria L., Khawaja, Anthony P., Cougnard-Gregoire, Audrey, Merle, Bénédicte M.J., Korb, Christina, Erke, Maja G., Bron, Alain, Anastasopoulos, Eleftherios, Meester-Smoor, Magda A., Segato, Tatiana, Piermarocchi, Stefano, de Jong, Paulus T.V.M., Vingerling, Johannes R., Topouzis, Fotis, Creuzot-Garcher, Catherine, Bertelsen, Geir, Pfeiffer, Norbert, Fletcher, Astrid E., Foster, Paul J., Silva, Rufino, Korobelnik, Jean-François, Delcourt, Cécile, Klaver, Caroline C.W., Ajana, Soufiane, Arango-Gonzalez, Blanca, Arndt, Verena, Bhatia, Vaibhav, Bhattacharya, Shomi S., Biarnés, Marc, Borrell, Anna, Bühren, Sebastian, Calado, Sofia M., Colijn, Johanna M., Cougnard-Grégoire, Audrey, Dammeier, Sascha, de Jong, Eiko K., De la Cerda, Berta, Delcourt, Cécile, den Hollander, Anneke I., Diaz-Corrales, Francisco J., Diether, Sigrid, Emri, Eszter, Endermann, Tanja, Ferraro, Lucia L., Garcia, Míriam, Heesterbeek, Thomas J., Honisch, Sabina, Hoyng, Carel B., Kersten, Eveline, Kilger, Ellen, Klaver, Caroline C.W., Langen, Hanno, Lengyel, Imre, Luthert, Phil, Maugeais, Cyrille, Meester-Smoor, Magda, Merle, Bénédicte M.J., Monés, Jordi, Nogoceke, Everson, Peto, Tunde, Pool, Frances M., Rodríguez, Eduardo, Ueffing, Marius, Ulrich Bartz-Schmidt, Karl U., van Leeuwen, Elisabeth M., Verzijden, Timo, Zumbansen, Markus, Acar, Niyazi, Anastosopoulos, Eleftherios, Azuara-Blanco, Augusto, Bergen, Arthur, Bertelsen, Geir, Binquet, Christine, Bird, Alan, Brétillon, Lionel, Bron, Alain, Buitendijk, Gabrielle, Cachulo, Maria Luz, Chakravarthy, Usha, Chan, Michelle, Chang, Petrus, Colijn, Johanna, Cougnard-Grégoire, Audrey, Creuzot-Garcher, Catherine, Cumberland, Philippa, Cunha-Vaz, José, Daien, Vincent, Deak, Gabor, Delcourt, Cécile, Delyfer, Marie-Noëlle, den Hollander, Anneke, Dietzel, Martha, Erke, Maja Gran, Fauser, Sascha, Finger, Robert, Fletcher, Astrid, Foster, Paul, Founti, Panayiota, Göbel, Arno, Gorgels, Theo, Grauslund, Jakob, Grus, Franz, Hammond, Christopher, Helmer, Catherine, Hense, Hans-Werner, Hermann, Manuel, Hoehn, René, Hogg, Ruth, Holz, Frank, Hoyng, Carel, Jansonius, Nomdo, Janssen, Sarah, Khawaja, Anthony, Klaver, Caroline, Korobelnik, Jean-François, Lamparter, Julia, Le Goff, Mélanie, Leal, Sergio, Lechanteur, Yara, Lehtimäki, Terho, Lotery, Andrew, Leung, Irene, Mauschitz, Matthias, Merle, Bénédicte, Meyer zu Westrup, Verena, Midena, Edoardo, Miotto, Stefania, Mirshahi, Alireza, Mohan-Saïd, Sadek, Mueller, Michael, Muldrew, Alyson, Nunes, Sandrina, Oexle, Konrad, Peto, Tunde, Piermarocchi, Stefano, Prokofyeva, Elena, Rahi, Jugnoo, Raitakari, Olli, Ribeiro, Luisa, Rougier, Marie-Bénédicte, Sahel, José, Salonikiou, Aggeliki, Sanchez, Clarisa, Schmitz-Valckenberg, Steffen, Schweitzer, Cédric, Segato, Tatiana, Shehata, Jasmin, Silva, Rufino, Silvestri, Giuliana, Simader, Christian, Souied, Eric, Springelkamp, Henriet, Tapp, Robyn, Topouzis, Fotis, Verhoeven, Virginie, Von Hanno, Therese, Vujosevic, Stela, Williams, Katie, Wolfram, Christian, Yip, Jennifer, Zerbib, Jennyfer, Zwiener, Isabella·2017·Ophthalmology
DOI 10.1016/j.ophtha.2017.05.035
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Abstract

PURPOSE: Age-related macular degeneration (AMD) is a frequent, complex disorder in elderly of European ancestry. Risk profiles and treatment options have changed considerably over the years, which may have affected disease prevalence and outcome. We determined the prevalence of early and late AMD in Europe from 1990 to 2013 using the European Eye Epidemiology (E3) consortium, and made projections for the future. DESIGN: Meta-analysis of prevalence data. PARTICIPANTS: A total of 42 080 individuals 40 years of age and older participating in 14 population-based cohorts from 10 countries in Europe. METHODS: AMD was diagnosed based on fundus photographs using the Rotterdam Classification. Prevalence of early and late AMD was calculated using random-effects meta-analysis stratified for age, birth cohort, gender, geographic region, and time period of the study. Best-corrected visual acuity (BCVA) was compared between late AMD subtypes; geographic atrophy (GA) and choroidal neovascularization (CNV). MAIN OUTCOME MEASURES: Prevalence of early and late AMD, BCVA, and number of AMD cases. RESULTS: Prevalence of early AMD increased from 3.5% (95% confidence interval [CI] 2.1%-5.0%) in those aged 55-59 years to 17.6% (95% CI 13.6%-21.5%) in those aged ≥85 years; for late AMD these figures were 0.1% (95% CI 0.04%-0.3%) and 9.8% (95% CI 6.3%-13.3%), respectively. We observed a decreasing prevalence of late AMD after 2006, which became most prominent after age 70. Prevalences were similar for gender across all age groups except for late AMD in the oldest age category, and a trend was found showing a higher prevalence of CNV in Northern Europe. After 2006, fewer eyes and fewer ≥80-year-old subjects with CNV were visually impaired (P = 0.016). Projections of AMD showed an almost doubling of affected persons despite a decreasing prevalence. By 2040, the number of individuals in Europe with early AMD will range between 14.9 and 21.5 million, and for late AMD between 3.9 and 4.8 million. CONCLUSION: We observed a decreasing prevalence of AMD and an improvement in visual acuity in CNV occuring over the past 2 decades in Europe. Healthier lifestyles and implementation of anti-vascular endothelial growth factor treatment are the most likely explanations. Nevertheless, the numbers of affected subjects will increase considerably in the next 2 decades. AMD continues to remain a significant public health problem among Europeans.

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Authors
Colijn, J. M., Buitendijk, G. H. S., Prokofyeva, E., Alves, D., Cachulo, M. L., Khawaja, A. P., Cougnard-Gregoire, A., Merle, B. M. J., Korb, C., Erke, M. G., Bron, A., Anastasopoulos, E., Meester-Smoor, M. A., Segato, T., Piermarocchi, S., de Jong, P. T. V. M., Vingerling, J. R., Topouzis, F., Creuzot-Garcher, C., Bertelsen, G., Pfeiffer, N., Fletcher, A. E., Foster, P. J., Silva, R., Korobelnik, J.-F., Delcourt, C., Klaver, C. C. W., Ajana, S., Arango-Gonzalez, B., Arndt, V., Bhatia, V., Bhattacharya, S. S., Biarnés, M., Borrell, A., Bühren, S., Calado, S. M., Colijn, J. M., Cougnard-Grégoire, A., Dammeier, S., de Jong, E. K., De la Cerda, B., Delcourt, C., den Hollander, A. I., Diaz-Corrales, F. J., Diether, S., Emri, E., Endermann, T., Ferraro, L. L., Garcia, M., Heesterbeek, T. J., Honisch, S., Hoyng, C. B., Kersten, E., Kilger, E., Klaver, C. C. W., Langen, H., Lengyel, I., Luthert, P., Maugeais, C., Meester-Smoor, M., Merle, B. M. J., Monés, J., Nogoceke, E., Peto, T., Pool, F. M., Rodríguez, E., Ueffing, M., Ulrich Bartz-Schmidt, K. U., van Leeuwen, E. M., Verzijden, T., Zumbansen, M., Acar, N., Anastosopoulos, E., Azuara-Blanco, A., Bergen, A., Bertelsen, G., Binquet, C., Bird, A., Brétillon, L., Bron, A., Buitendijk, G., Cachulo, M. L., Chakravarthy, U., Chan, M., Chang, P., Colijn, J., Cougnard-Grégoire, A., Creuzot-Garcher, C., Cumberland, P., Cunha-Vaz, J., Daien, V., Deak, G., Delcourt, C., Delyfer, M.-N., den Hollander, A., Dietzel, M., Erke, M. G., Fauser, S., Finger, R., Fletcher, A., Foster, P., Founti, P., Göbel, A., Gorgels, T., Grauslund, J., Grus, F., Hammond, C., Helmer, C., Hense, H.-W., Hermann, M., Hoehn, R., Hogg, R., Holz, F., Hoyng, C., Jansonius, N., Janssen, S., Khawaja, A., Klaver, C., Korobelnik, J.-F., Lamparter, J., Le Goff, M., Leal, S., Lechanteur, Y., Lehtimäki, T., Lotery, A., Leung, I., Mauschitz, M., Merle, B., Meyer zu Westrup, V., Midena, E., Miotto, S., Mirshahi, A., Mohan-Saïd, S., Mueller, M., Muldrew, A., Nunes, S., Oexle, K., Peto, T., Piermarocchi, S., Prokofyeva, E., Rahi, J., Raitakari, O., Ribeiro, L., Rougier, M.-B., Sahel, J., Salonikiou, A., Sanchez, C., Schmitz-Valckenberg, S., Schweitzer, C., Segato, T., Shehata, J., Silva, R., Silvestri, G., Simader, C., Souied, E., Springelkamp, H., Tapp, R., Topouzis, F., Verhoeven, V., Von Hanno, T., Vujosevic, S., Williams, K., Wolfram, C., Yip, J., Zerbib, J., & Zwiener, I.
Venue
Ophthalmology
Publisher
Elsevier BV
Published
2017-12
Volume
124
Issue
12
Pages
1753-1763
ISSN
0161-6420 (ISSN-L)
DOI
10.1016/j.ophtha.2017.05.035
OpenAlex
W2734721636
Cited by
486
References
50
FWCI
35.50
Type
journal article
Language
en
Open access
hybrid

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Colijn, J. M., Buitendijk, G. H. S., Prokofyeva, E., Alves, D., Cachulo, M. L., Khawaja, A. P., Cougnard-Gregoire, A., Merle, B. M. J., Korb, C., Erke, M. G., Bron, A., Anastasopoulos, E., Meester-Smoor, M. A., Segato, T., Piermarocchi, S., de Jong, P. T. V. M., Vingerling, J. R., Topouzis, F., Creuzot-Garcher, C., . . . Zwiener, I. (2017). Prevalence of Age-Related Macular Degeneration in Europe. Ophthalmology. https://doi.org/10.1016/j.ophtha.2017.05.035

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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