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Cited by 1,062Retinal Diseases and TreatmentsRetinal Imaging and AnalysisOcular Diseases and Behçet’s Syndrome

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Prevalence of Age-related Maculopathy in Australia

Mitchell, Paul, Smith, Wayne, Attebo, Karin, Wang, Jie Jin·1995·Ophthalmology
DOI 10.1016/s0161-6420(95)30846-9
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Abstract

Purpose To examine the prevalence of age-related maculopathy (drusen and retinal pigmentary abnormalities) and end-stage age-related macular degeneration lesions (neovascular maculopathy or geographic atrophy) in a defined older Australian urban population.Subjects All noninstitutionalized residents 49 years of age or older who were identified in a door-to-door census of two postcode areas west of Sydney, Australia.Methods All participants received a detailed eye examination, including stereoscopic photographs of each macula. Two trained graders used the Wisconsin Age-related Maculopathy Grading System to assess the presence and severity of typical lesions.Results A marked age-related increase in all typical lesions of age-related maculopathy and macular degeneration was observed. End-stage age-related macular degeneration was present in 1.9% of the population, rising from 0% among people younger than 55 years of age to 18.5% among those 85 years of age or older. Soft drusen were found in 13.3% of people, with distinct drusen more frequent than indistinct soft drusen. Retinal pigmentary abnormalities were found in 12.6% of people. For end-stage lesions and soft drusen, females had higher age-specific prevalence rates than males, whereas retinal pigmentary abnormalities were more frequent in males, although most of these differences were not significant. Prevalence rates for all lesions were lower (statistically significant for retinal pigmentary abnormalities and soft drusen) than for the United States Beaver Dam Eye Study which examined a similar population.Conclusions These data provide detailed prevalence rates for most components of ARM in an Australian population and reinforce the Beaver Dam Eye Study findings for the relative age-specific frequency of age-related macular degeneration components.

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  • Age is the strongest risk factor for age-related macular degeneration; all population-based studies confirm that the prevalence of age-related macular degeneration increases with age in white individuals.

    “Age is the strongest risk factor for age-related macular degeneration; all population-based studies confirm that the prevalence of age-related macular degeneration increases with age in white individuals.3,22–27”

    From Age-related macular degeneration (2008) · cites this paper as [22]

  • The 5-year incidence of soft drusen in the Reykjavik Eye Study was similar to that of the Beaver Dam Eye Study and the Blue Mountains Eye Study.

    “The 5-y incidence of soft drusen in the Reykjavik Eye Study, a population-based epidemiological study of individuals aged 50 y and older [28,29], was found to be similar to that of the Beaver Dam Eye Study in the US [30], and the Blue Mountains Eye Study in Australia [31].”

    From CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD (2005) · cites this paper as [31]

  • Neovascular AMD outnumbers GA by approximately three to one in the Beaver Dam Eye Study and the Blue Mountains Eye Study.

    “Neovascular AMD outnumbers GA by approximately three to one in both the Beaver Dam Eye Study and the Blue Mountains Eye Study.”

    From CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD (2005) · cites this paper as [31]

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Metadata

Authors
Mitchell, P., Smith, W., Attebo, K., & Wang, J. J.
Affiliations
The University of Sydney (AU)
Corresponding author
Mitchell, Paul
ORCID
Venue
Ophthalmology
Publisher
Elsevier BV
Published
1995-10
Volume
102
Issue
10
Pages
1450-1460
ISSN
0161-6420 (ISSN-L)
DOI
10.1016/s0161-6420(95)30846-9
OpenAlex
W1882214116
Cited by
1,062
References
24
Citations by year
2026: 10 · 2025: 8 · 2024: 16 · 2023: 23 · 2022: 21 · 2021: 20 · 2020: 28 · 2019: 16 · 2018: 30 · 2017: 35 · 2016: 29 · 2015: 48 · 2014: 52 · 2013: 60 · 2012: 42
FWCI
26.73
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Ophthalmology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords
age-related maculopathy, age-related macular degeneration, drusen, geographic atrophy, neovascular age-related macular degeneration, prevalence, older adults, sex differences, age-specific prevalence, Australian population
MeSH terms
Aged, Aged, 80 and over, Australia, Female, Humans, Macular Degeneration, Male, Middle Aged, Reproducibility of Results, Observer Variation, Prevalence, Age Distribution

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