Cited by 193Cytokine Signaling Pathways and InteractionsHead and Neck Cancer StudiesProtein Tyrosine Phosphatases

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The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations

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Geiger, Jessica L., Grandis, Jennifer R., Bauman, Julie E.·2016·Oral Oncology

DOI 10.1016/j.oraloncology.2015.11.022PMC PMC5590227

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Abstract

Proteins of the signal transducer and activator of transcription (STAT) family mediate cellular responses to cytokines and growth factors. Aberrant regulation of the STAT3 oncogene contributes to tumor formation and progression in many cancers, including head and neck squamous cell carcinoma (HNSCC), where hyperactivation of STAT3 is implicated in both treatment resistance and immune escape. There are no oncogenic gain-of-function mutations in HNSCC. Rather, aberrant STAT3 signaling is primarily driven by upstream growth factor receptors, such as Janus kinase (JAK) and epidermal growth factor receptor (EGFR). Moreover, genomic silencing of select protein tyrosine phosphatase receptors (PTPRs), tumor suppressors that dephosphorylate STAT3, may lead to prolonged phosphorylation and activation of STAT3. This review will summarize current knowledge of the STAT3 pathway and its contribution to HNSCC growth, survival, and resistance to standard therapies, and discuss STAT3-targeting agents in various phases of clinical development.

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Authors: Geiger, J. L., Grandis, J. R., & Bauman, J. E.
Affiliations: University of Pittsburgh (US)
University of California, San Francisco (US)
Corresponding author: Bauman, Julie E.
ORCID: Geiger, Jessica L.
Grandis, Jennifer R.
Bauman, Julie E.
Venue: Oral Oncology
Publisher: Elsevier BV
Published: 2016-05
Volume: 56
Pages: 84-92
ISSN: 1368-8375 (ISSN-L)
DOI: 10.1016/j.oraloncology.2015.11.022
PMC: PMC5590227
OpenAlex: W2207542692
Cited by: 193
References: 159
Citations by year: 2026: 11 · 2025: 20 · 2024: 25 · 2023: 13 · 2022: 24 · 2021: 21 · 2020: 25 · 2019: 18 · 2018: 16 · 2017: 15 · 2016: 4
FWCI: 1.25
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Oral Oncology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Cancer Institute (R01CA077308)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: STAT3 signaling, head and neck squamous cell carcinoma, therapeutic target, JAK, epidermal growth factor receptor, treatment resistance, immune evasion, clinical development
MeSH terms: Carcinoma, Squamous Cell, Head and Neck Neoplasms, Humans, Dimerization, STAT3 Transcription Factor

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The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations

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