The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Mechanisms underlying development of spatially distributed chronic pain (fibromyalgia)
Abstract
Chronic fibromyalgia (FM) pain is prevalent (estimated as high as 13%), predominantly affects women, and is associated with a variety of focal pain conditions. Ongoing FM pain is referred to deep tissues and is described as widespread but usually is maximally located within a restricted region such as the shoulders. Palpation of deep tissues reveals an enhanced nociceptive sensitivity that is not restricted to regions of clinical pain. Similarly, psychophysical testing reveals allodynia and hyperalgesia for cutaneous stimulation at locations beyond regions of clinical pain referral. The combination of widely distributed clinical pain and generalized hypersensitivity is highly disabling, but no satisfactory treatment is regularly prescribed. A thorough understanding of mechanisms will likely be required to develop and document adequate therapies. The generalized hypersensitivity associated with FM has focused considerable interest on central (CNS) mechanisms for the disorder. These include central sensitization, central disinhibition and a dysfunctional hypothalamic-pituitary-adrenal (HPA) axis. However, the central effects associated with FM can be produced by a peripheral source of pain. Chronic nociceptive input induces central sensitization, magnifying pain, and it activates the HPA and the sympathetic nervous system. Chronic sympathetic activation indirectly sensitizes peripheral nociceptors and sets up a vicious cycle. Thus, it appears that central mechanisms of FM pain are dependent on abnormal peripheral input(s) for development and maintenance of this condition. A substantial literature defines peripheral-CNS-peripheral interactions that are integral to FM pain. These reciprocal actions and related phenomena of relevance to FM pain are reviewed here, leading to suggestions for testing of therapeutic approaches.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270
Sympathetic-Nerve Activity during Sleep in Normal Subjects
Somers, V. K., Dyken, M. E., Mark, A. L., & Abboud, F. M. (1993) · New England Journal of Medicine · doi:10.1056/nejm199302043280502 · Cited by 1,574
Whitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116 · cited 2×
“, 1995), irritable bowel syndrome (Whitehead et al., 2002) and interstitial cystitis (Clauw et al.”
BackgroundBiofeedback/relaxation training and exercise interventions for fibromyalgia: A prospective trial
Buckelew, S. P., Conway, R., Parker, J., Deuser, W. E., Read, J., Witty, T. E., Hewett, J. E., Minor, M., Johnson, J. C., Van Male, L., et al. (1998) · Arthritis & Rheumatism · doi:10.1002/art.1790110307 · Cited by 258
The relationship between fibromyalgia and interstitial cystitis
Clauw, D. J., Schmidt, M., Radulovic, D., Singer, A., Katz, P., & Bresette, J. (1997) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(96)00051-9 · Cited by 230
VEALE, D., KAVANAGH, G., FIELDING, J. F., & FITZGERALD, O. (1991) · Rheumatology · doi:10.1093/rheumatology/30.3.220 · Cited by 199
Laursen, B. S., Bajaj, P., Olesen, A. S., Delmar, C., & Arendt‐Nielsen, L. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2004.07.003 · Cited by 191 · cited 2×
“…1995; Okifuji and Turk, 2002), interstitial cystitis (Alagiri et al., 1997; Clauw et al., 1997), facial pain (Sipila et al., 2005), pelvic pain (Bajaj et al., 2002), trapezius myalgia (Leffler et al., 2002a), endometriosis (Laursen et al., 2005) and burning mouth syndrome (Svensson et al., 1993).”
BackgroundDavis, M. C., Zautra, A. J., & Reich, J. W. (2001) · Annals of Behavioral Medicine · doi:10.1207/s15324796abm2303_9 · Cited by 189
Ge, H.-Y., Madeleine, P., & Arendt-Nielsen, L. (2004) · Pain · doi:10.1016/j.pain.2004.03.005 · Cited by 146 · cited 1×
“For example, females report more pain than males after intramuscular injection of hypertonic saline or glutamate (Ge et al., 2004, 2005).”
BackgroundGur, A., Cevik, R., Nas, K., Colpan, L., & Sarac, S. (2004) · Arthritis Res Ther · doi:10.1186/ar1163 · Cited by 88
Potts, J. T. (2002) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2002.03613.x · Cited by 60
Long-term exposure to β2-receptor agonist specifically desensitizes β-receptor—mediated venodilation
Stein, M., Deegan, R., & Wood, A. J. J. (1993) · Clinical Pharmacology and Therapeutics · doi:10.1038/clpt.1993.130 · Cited by 29 · cited 1×
“According to the flip side of this principle, excessive sympathetic activation down-regulates b-adrenergic receptors (Stein et al., 1993; Elfellah et al., 1998).”
Background
Cited by
Chapman, C. R., & Vierck, C. J. (2017) · The Journal of Pain · doi:10.1016/j.jpain.2016.11.004 · Cited by 423
Self-citationThe role of sleep in pain and fibromyalgia
Choy, E. H. S. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.56 · Cited by 333
Potential Mechanisms Underlying Centralized Pain and Emerging Therapeutic Interventions
Eller-Smith, O. C., Nicol, A. L., & Christianson, J. A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00035 · Cited by 227
Cöster, L., Kendall, S., Gerdle, B., Henriksson, C., Henriksson, K. G., & Bengtsson, A. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2007.10.001 · Cited by 119
La Touche, R., París-Alemany, A., Mannheimer, J. S., Angulo-Díaz-Parreño, S., Bishop, M. D., Lopéz-Valverde-Centeno, A., von Piekartz, H., & Fernández-Carnero, J. (2013) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e318250f3cd · Cited by 112
Metadata
- Authors
- Vierck, C. J.
- Venue
- Pain
- Published
- 2006-10
- Volume
- 124
- Issue
- 3
- Pages
- 242-263
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2058582924
- Cited by
- 297
- References
- 12
- FWCI
- 14.95
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
