Potential Mechanisms Underlying Centralized Pain and Emerging Therapeutic Interventions
Open accessAbstract
Centralized pain syndromes are associated with changes within the central nervous system that amplify peripheral input and/or generate the perception of pain in the absence of a noxious stimulus. Examples of idiopathic functional disorders that are often categorized as centralized pain syndromes include fibromyalgia, chronic pelvic pain syndromes, migraine, and temporomandibular disorder. Patients often suffer from widespread pain, associated with more than one specific syndrome, and report fatigue, mood and sleep disturbances, and poor quality of life. The high degree of symptom comorbidity and a lack of definitive underlying etiology make these syndromes notoriously difficult to treat. The main purpose of this review article is to discuss potential mechanisms of centrally-driven pain amplification and how they may contribute to increased comorbidity, poorer pain outcomes, and decreased quality of life in patients diagnosed with centralized pain syndromes, as well as discuss emerging non-pharmacological therapies that improve symptomology associated with these syndromes. Abnormal regulation and output of the hypothalamic-pituitary-adrenal (HPA) axis is commonly associated with centralized pain disorders. The HPA axis is the primary stress response system and its activation results in downstream production of cortisol and a dampening of the immune response. Patients with centralized pain syndromes often present with hyper- or hypocortisolism and evidence of altered downstream signaling from the HPA axis including increased Mast cell (MC) infiltration and activation, which can lead to sensitization of nearby nociceptive afferents. Increased peripheral input via nociceptor activation can lead to "hyperalgesic priming" and/or "wind-up" and eventually to central sensitization through long term potentiation in the central nervous system. Other evidence of central modifications has been observed through brain imaging studies of functional connectivity and magnetic resonance spectroscopy and are shown to contribute to the widespreadness of pain and poor mood in patients with fibromyalgia and chronic urological pain. Non-pharmacological therapeutics, including exercise and cognitive behavioral therapy (CBT), have shown great promise in treating symptoms of centralized pain.
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Local infiltration and migration of mast cells, leading to sensitization of nearby nociceptive afferents, are considered vital contributors to nociplastic pain pathogenesis.
“Local infiltration and migration of mast cells, leading to sensitization of nearby nociceptive afferents, are considered vital contributors to NPP pathogenesis (69).”
From Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization (2026) · cites this paper as [69]
The HPA Axis sections report increased mast-cell infiltration in several centralized pain syndromes and describe mast-cell activation as a possible cause of sensitization in nearby sensory nerve endings (page not available). They discuss migration of mast-cell precursors generally, but do not establish local migration as a vital contributor to nociplastic pain pathogenesis; the proposed causal mechanism is more tentative. (LLM, conf=0.84)
Experimental — accuracy not yet measuredNociplastic pain is widely reported to be correlated with mast cell activation.
“NPP is widely reported to be correlated with mast cell activation.”
From Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization (2026) · cites this paper as [69]
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Cites
(1985) · Europe PMC (PubMed Central) · Cited by 9,143 · see citing works
(1968) · American Association of Industrial Nurses Journal · doi:10.1177/216507996801601208 · Cited by 8,811 · see citing works
Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., Das, S. R., de Ferranti, S., Després, J.-P., Fullerton, H. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000350 · Cited by 6,596 · see citing works
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155 · see citing works
Central sensitization: implications for the diagnosis and treatment of pain
Woolf, C. J. (2011) · Pain · doi:10.1016/j.pain.2010.09.030 · Cited by 4,771 · see citing works
Neural regulation of endocrine and autonomic stress responses
Ulrich-Lai, Y. M., & Herman, J. P. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2647 · Cited by 3,318 · see citing works
Classification of chronic pain
Merskey, H. (1994) · Medical Entomology and Zoology · Cited by 2,952 · see citing works
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904 · see citing works
The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis
Chrousos, G. P. (1992) · JAMA · doi:10.1001/jama.1992.03480090092034 · Cited by 2,689 · see citing works
Molecular mechanisms of nociception
Julius, D., & Basbaum, A. I. (2001) · Nature · doi:10.1038/35093019 · Cited by 2,685 · cited 1× · see citing works
“…enhances pain-related afferent input to the central nervous system; however, they also generate and maintain peripheral neurogenic inflammation by releasing neuropeptides, including SP and CGRP, which perpetuates inflammatory mediator release in the proximate milieu (Julius and Basbaum, 2001).”
BackgroundTwo receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580 · see citing works
The Economic Costs of Pain in the United States
Gaskin, D. J., & Richard, P. (2012) · The Journal of Pain · doi:10.1016/j.jpain.2012.03.009 · Cited by 2,359 · see citing works
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586 · see citing works
Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.055 · Cited by 1,475 · see citing works
Chronic back pain is associated with decreased prefrontal and thalamic gray matter density
Apkarian, A. V., Sosa, Y., Sonty, S., Levy, R. M., Harden, R. N., Parrish, T. B., & Gitelman, D. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2541-04.2004 · Cited by 1,434 · see citing works
Hoffman, S. G., & Smits, J. A. J. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0415 · Cited by 1,420 · see citing works
Limbic system mechanisms of stress regulation: Hypothalamo-pituitary-adrenocortical axis
Herman, J. P., Ostrander, M. M., Mueller, N. K., & Figueiredo, H. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.08.006 · Cited by 1,322 · see citing works
CRF and CRF receptors: role in stress responsivity and other behaviors
Bale, T. L., & Vale, W. W. (2004) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121410 · Cited by 1,270 · see citing works
Chuang, H.-H., Prescott, E. D., Kong, H., Shields, S. D., Jordt, S. E., Basbaum, A. I., Chao, M. V., & Julius, D. J. (2001) · Nature · doi:10.1038/35082088 · Cited by 1,257 · see citing works
Fries, E., Hesse, J., Hellhammer, J., & Hellhammer, D. H. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.04.006 · Cited by 1,204 · see citing works
Black, J. E., Isaacs, K. R., Anderson, B. J., Alcantara, A. A., & Greenough, W. T. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5568 · Cited by 1,161 · see citing works
Protease-Activated Receptors: Contribution to Physiology and Disease
Ossovskaya, V., & Bunnett, N. W. (2004) · Physiological Reviews · doi:10.1152/physrev.00028.2003 · Cited by 1,079 · see citing works
Corticostriatal functional connectivity predicts transition to chronic back pain
Baliki, M. N., Petre, B., Torbey, S., Herrmann, K. M., Huang, L., Schnitzer, T. J., Fields, H. L., & Apkarian, A. V. (2012) · Nature Neuroscience · doi:10.1038/nn.3153 · Cited by 1,050 · see citing works
Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
Steinhoff, M. S., Vergnolle, N., Young, S. H., Tognetto, M., Amadesi, S., Ennes, H. S., Trevisani, M., Hollenberg, M. D., Wallace, J. L., Caughey, G. H., et al. (2000) · Nature Medicine · doi:10.1038/72247 · Cited by 936 · see citing works
Estimates of Pain Prevalence and Severity in Adults: United States, 2012
Nahin, R. L. (2015) · The Journal of Pain · doi:10.1016/j.jpain.2015.05.002 · Cited by 918 · see citing works
The Triggers or Precipitants of the Acute Migraine Attack
Kelman, L. (2007) · Cephalalgia · doi:10.1111/j.1468-2982.2007.01303.x · Cited by 871 · see citing works
Di, S., Malcher‐Lopes, R., Halmos, K. C., & Tasker, J. G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-04850.2003 · Cited by 801 · see citing works
Heim, C., Newport, D. J., Bonsall, R., Miller, A. H., & Nemeroff, C. B. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.4.575 · Cited by 746 · see citing works
Silverman, M. N., & Sternberg, E. M. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06633.x · Cited by 740 · see citing works
Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1
Birder, L. A., Nakamura, Y., Kiss, S., Nealen, M. L., Barrick, S., Kanai, A., Wang, E., Ruiz, G. W., de Groat, W. C., Apodaca, G. L., et al. (2002) · Nature Neuroscience · doi:10.1038/nn902 · Cited by 703 · see citing works
AUA Guideline for the Diagnosis and Treatment of Interstitial Cystitis/Bladder Pain Syndrome
Hanno, P. M., Burks, D., Clemens, J. Q., Dmochowski, R. R., Erickson, D. R., FitzGerald, M. P., Forrest, J. B., Gordon, B., GRAY, M. L., Mayer, R. D., et al. (2011) · The Journal of Urology · doi:10.1016/j.juro.2011.03.064 · Cited by 689 · see citing works
Elevated cerebrospinal fluid levels of substance p in patients with the fibromyalgia syndrome
Russell, I. J., Orr, M. D., Littman, B., Vipraio, G. A., Alboukrek, D., Michalek, J. E., Lopez, Y., & Mackillip, F. (1994) · Arthritis & Rheumatism · doi:10.1002/art.1780371106 · Cited by 679 · see citing works
Steward, O., & Levy, W. (1982) · The Journal of Neuroscience · doi:10.1523/jneurosci.02-03-00284.1982 · Cited by 676 · see citing works
Neurobiology of fibromyalgia and chronic widespread pain
Sluka, K. A., & Clauw, D. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.006 · Cited by 671 · see citing works
Mast cells synthesize, store, and release nerve growth factor.
Léon, A., Buriani, A., Toso, R. D., Fabris, M., Romanello, S., Aloe, L., & Levi‐Montalcini, R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3739 · Cited by 669 · see citing works
Migraine Headache Triggered Specifically by Sunlight: Report of 16 Cases
Tekataş, A., & Mungen, B. (2013) · European Neurology · doi:10.1159/000354165 · Cited by 665 · see citing works
Carro, E., Trejo, J. L., Busiguina, S., & Torres-Aleman, I. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05678.2001 · Cited by 601 · see citing works
Responses of Single Dorsal Cord Cells to Peripheral Cutaneous Unmyelinated Fibres
Mendell, L. M., & Wall, P. D. (1965) · Nature · doi:10.1038/206097a0 · Cited by 586 · see citing works
Conditioned Pain Modulation in Populations With Chronic Pain: A Systematic Review and Meta-Analysis
Lewis, G. N., Rice, D. A., & McNair, P. J. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.07.005 · Cited by 564 · see citing works
Neurophysiologic evidence for a central sensitization in patients with fibromyalgia
Desmeules, J. A., Cedraschi, C., Rapiti, E., Baumgartner, E., Finckh, A., Cohen, P., Dayer, P., & VISCHER, T. L. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10893 · Cited by 561 · see citing works
Cortical excitation and chronic pain
Zhuo, M. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.01.003 · Cited by 534 · see citing works
Akbar, A., Yiangou, Y., Facer, P., Walters, J. R. F., Anand, P., & Ghosh, S. (2008) · Gut · doi:10.1136/gut.2007.138982 · Cited by 526 · see citing works
H+-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels
Waldmann, R., & Lazdunski, M. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80070-6 · Cited by 504 · see citing works
The effect of exercise on depression, anxiety and other mood states: A review
Byrne, A., & Byrne, D. G. (1993) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(93)90050-p · Cited by 497 · see citing works
Critical role of nociceptor plasticity in chronic pain
Reichling, D. B., & Levine, J. D. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.07.007 · Cited by 495 · see citing works
Vellani, V., Mapplebeck, S., Moriondo, A., Davis, J. B., & McNaughton, P. A. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00813.x · Cited by 488 · see citing works
Heterogeneity of Mast Cells and Phenotypic Change Between Subpopulations
Kitamura, Y. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.000423 · Cited by 475 · see citing works
Voluntary wheel running: a review and novel interpretation
Sherwin, C. M. (1998) · Animal Behaviour · doi:10.1006/anbe.1998.0836 · Cited by 459 · see citing works
Bhave, G. B., Hu, H., Glauner, K. S., Zhu, W., Wang, H., Brasier, D. J., Oxford, G. S., & Gereau, R. W. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2032100100 · Cited by 459 · see citing works
Synaptic Amplifier of Inflammatory Pain in the Spinal Dorsal Horn
Ikeda, H., Stark, J., Fischer, H., Wagner, M. W., Drdla-Schutting, R., Jäger, T., & Sandkühler, J. (2006) · Science · doi:10.1126/science.1127233 · Cited by 451 · see citing works
Mast cells are closely apposed to nerves in the human gastrointestinal mucosa
Stead, R. H., Dixon, M. F., Bramwell, N. H., Riddell, R. H., & Bienenstock, J. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90627-6 · Cited by 445 · see citing works
Scholz, J., Broom, D. C., Youn, D. H., Mills, C. D., Kohno, T., Suter, M. R., Moore, K. A., Décosterd, I., Coggeshall, R. E., & Woolf, C. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1526-05.2005 · Cited by 437 · see citing works
Physical Activity Improves Symptoms in Irritable Bowel Syndrome: A Randomized Controlled Trial
Johannesson, E., Simrén, M., Strid, H., Bajor, A., & Sadik, R. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.480 · Cited by 431 · see citing works
Clinical Importance of Pain and Stress in Preterm Neonates
Anand, K. J. S. (1997) · Neonatology · doi:10.1159/000013953 · Cited by 430 · see citing works
Reynolds, W. M., & Coats, K. I. (1986) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.54.5.653 · Cited by 425 · see citing works
TRPA1: A Gatekeeper for Inflammation
Bautista, D. M., Pellegrino, M., & Tsunozaki, M. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183811 · Cited by 411 · see citing works
Level of chronic life stress predicts clinical outcome in irritable bowel syndrome
Bennett, E. J., Tennant, C. C., Piesse, C., Badcock, C.-A., & Kellow, J. E. (1998) · Gut · doi:10.1136/gut.43.2.256 · Cited by 405 · see citing works
Galli, S. J., & Tsai, M. (2010) · European Journal of Immunology · doi:10.1002/eji.201040559 · Cited by 403 · see citing works
Janal, M. N., Colt, E. W. D., Clark, C. W., & Glusman, M. (1984) · Pain · doi:10.1016/0304-3959(84)90061-7 · Cited by 400 · see citing works
Motor unit physiology: Some unresolved issues
Enoka, R. M., & Fuglevand, A. J. (2001) · Muscle & Nerve · doi:10.1002/1097-4598(200101)24:1 · Cited by 386 · see citing works
Vincent, A., Lahr, B. D., Wolfe, F., Clauw, D. J., Whipple, M. O., Oh, T. H., Barton, D. L., & Sauver, J. L. S. (2012) · Arthritis Care & Research · doi:10.1002/acr.21896 · Cited by 385 · see citing works
Hillhouse, E. W., & Grammatopoulos, D. K. (2006) · Endocrine Reviews · doi:10.1210/er.2005-0034 · Cited by 353 · see citing works
Windup leads to characteristics of central sensitization
Li, J., Simone, D. A., & Larson, A. A. (1999) · Pain · doi:10.1016/s0304-3959(98)00154-7 · Cited by 343 · see citing works
Forced and voluntary exercise differentially affect brain and behavior
Leasure, J. L., & Jones, M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.041 · Cited by 335 · see citing works
Exercise therapy for fibromyalgia
Busch, A. J., Webber, S. C., Brachaniec, M., Bidonde, J., Bello-Haas, V. D., Danyliw, A. D., Overend, T. J., Richards, R. S., Sawant, A., & Schachter, C. L. (2011) · Current Pain and Headache Reports · doi:10.1007/s11916-011-0214-2 · Cited by 333 · see citing works
Increased pain sensitivity in fibromyalgia: effects of stimulus type and mode of presentation
Petzke, F. W., Clauw, D. J., Ambrose, K., Khine, A. H., & Gracely, R. H. (2003) · Pain · doi:10.1016/s0304-3959(03)00204-5 · Cited by 332 · see citing works
Running induces widespread structural alterations in the hippocampus and entorhinal cortex
Stranahan, A. M., Khalil, D., & Gould, E. (2007) · Hippocampus · doi:10.1002/hipo.20348 · Cited by 327 · see citing works
Characterization of Protease-activated Receptor-2 Immunoreactivity in Normal Human Tissues
D’Andrea, M. R., Derian, C. K., Leturcq, D. J., Baker, S. M., Brunmark, A. B., Ling, P., Darrow, A. L., Santulli, R. J., Brass, L. F., & Andrade‐Gordon, P. (1998) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549804600204 · Cited by 320 · see citing works
Heim, C., Ehlert, U., Hanker, J. P., & Hellhammer, D. H. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199805000-00017 · Cited by 309 · see citing works
Cognitive-behavioral therapy increases prefrontal cortex gray matter in patients with chronic pain
Seminowicz, D. A., Shpaner, M., Keaser, M. L., Krauthamer, G. M., Mantegna, J., Dumas, J. A., Newhouse, P. A., Filippi, C. G., Keefe, F. J., & Naylor, M. R. (2013) · The Journal of Pain · doi:10.1016/j.jpain.2013.07.020 · Cited by 305 · cited 2× · see citing works
“One study found that 11 weeks of CBT in a mixed group of chronic pain patients resulted in significant gray matter differences in sensory, motor, and affective brain areas as measured using voxelbased morphometry (Seminowicz et al., 2013).”
BackgroundMast cells as targets of corticotropin-releasing factor and related peptides
Theoharides, T. C., Donelan, J., Papadopoulou, N., Cao, J., Kempuraj, D., & Conti, P. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.09.007 · Cited by 301 · see citing works
Schmidt‐Wilcke, T., Luerding, R., Weigand, T., Jürgens, T. P., Schuierer, G. R., Leinisch, E., & Bogdahn, U. (2007) · Pain · doi:10.1016/j.pain.2007.05.010 · Cited by 301 · see citing works
Reynolds, W. M., & Coats, K. I. (1986) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.54.5.653 · Cited by 300 · see citing works
Regional Gray Matter Density Changes in Brains of Patients With Irritable Bowel Syndrome
Seminowicz, D. A., Labus, J. S., Bueller, J. A., Tillisch, K., Naliboff, B. D., Bushnell, M. C., & Mayer, E. A. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.049 · Cited by 298 · see citing works
Mechanisms underlying development of spatially distributed chronic pain (fibromyalgia)
Vierck, C. J. (2006) · Pain · doi:10.1016/j.pain.2006.06.001 · Cited by 294 · see citing works
Stress‐induced visceral hypersensitivity to rectal distension in rats: role of CRF and mast cells
Gué, M., Rio-Lacheze, C. D., Eutamène, H., Théodorou, V., Fioramonti, J., & Bueno, L. P. (1997) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.1997.d01-63.x · Cited by 282 · see citing works
Ke, Z., Yip, S. P., Li, L., Zheng, X., & Tong, R. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016643 · Cited by 281 · see citing works
The c-kit receptor, stem cell factor, and mast cells. What each is teaching us about the others.
Galli, S. J., Tsai, M. M., & Wershil, B. K. (1993) · PubMed · Cited by 278 · see citing works
Arnold, L. D., Bachmann, G. A., Rosen, R. C., Kelly, S., & Rhoads, G. G. (2006) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000199951.26822.27 · Cited by 277 · see citing works
Mast cell involvement in interstitial cystitis: a review of human and experimental evidence
Theoharides, T. C., Kempuraj, D., & Sant, G. R. (2001) · Urology · doi:10.1016/s0090-4295(01)01129-3 · Cited by 277 · see citing works
Mannerkorpi, K., Nyberg, B., Ahlmén, M., & Ekdahl, C. S. (2000) · PubMed · Cited by 277 · see citing works
Mechanisms of rapid glucocorticoid feedback inhibition of the hypothalamic–pituitary–adrenal axis
Tasker, J. G., & Herman, J. P. (2011) · Stress · doi:10.3109/10253890.2011.586446 · Cited by 277 · see citing works
Mast cells: The immune gate to the brain
Theoharides, T. C. (1990) · Life Sciences · doi:10.1016/0024-3205(90)90129-f · Cited by 274 · see citing works
Psychological therapies (Internet-delivered) for the management of chronic pain in adults
Eccleston, C., Fisher, E., Craig, L., Duggan, G. B., Rosser, B. A., & Keogh, E. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010152.pub2 · Cited by 271 · cited 2× · see citing works
“…Hofmann and Smits (2008) Chronic pelvic pain Pelvic pain, widespread pain, dyschezia, dyspareunia, quality of life, disability, depression, anxiety Eccleston et al. (2014) and Meissner et al. (2016) Migraine Headache frequency, headache duration, headache intensity, anxiety, depression,…”
BackgroundBurke, N. N., Finn, D. P., McGuire, B. E., & Roche, M. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23802 · Cited by 268 · see citing works
The Ion Channel TRPA1 Is Required for Normal Mechanosensation and Is Modulated by Algesic Stimuli
Brierley, S. M., Hughes, P. A., Page, A. J., Kwan, K. Y., Martin, C. M., O’Donnell, T. A., Cooper, N. J., Harrington, A. M., Adam, B., Liebregts, T., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.07.048 · Cited by 266 · see citing works
Adlard, P. A., & Cotman, C. W. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.12.039 · Cited by 265 · see citing works
The role of mast cells in migraine pathophysiology
Theoharides, T. C., Donelan, J., Kandere‐Grzybowska, K., & Konstantinidou, A. D. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.11.006 · Cited by 264 · see citing works
Fibromyalgia and related conditions
Clauw, D. J. (2015) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2015.03.014 · Cited by 259 · see citing works
Dysregulation of the hypothalamic‐pituitary‐adrenal (HPA) axis in irritable bowel syndrome
Chang, L., Sundaresh, S., Elliott, J. E., Anton, P. A., Baldi, P., Licudine, A., Mayer, M., Vuong, T., Hirano, M., Naliboff, B. D., et al. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01171.x · Cited by 250 · see citing works
Childhood parental loss and adult hypothalamic-pituitary-adrenal function
Tyrka, A. R., Wier, L., Price, L. H., Ross, N., Anderson, G. M., Wilkinson, C. W., & Carpenter, L. L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.01.011 · Cited by 250 · see citing works
Understanding fibromyalgia: lessons from the broader pain research community.
Williams, D. A., & Clauw, D. J. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.06.001 · Cited by 250 · see citing works
Increased number of substance P positive nerve fibres in interstitial cystitis
Pang, X., Marchand, J. E., Sant, G. R., Kream, R. M., Theoharides, T. C., & J. (1995) · British Journal of Urology · doi:10.1111/j.1464-410x.1995.tb07384.x · Cited by 248 · see citing works
Gunnar, M. R., & Quevedo, K. M. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)67010-1 · Cited by 246 · see citing works
Migraine Symptoms: Results of a Survey of Self‐Reported Migraineurs
Silberstein, S. D. (1995) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.1995.hed3507387.x · Cited by 240 · see citing works
Psychosocial treatments for adolescent depression
Lewinsohn, P. M. (1999) · Clinical Psychology Review · doi:10.1016/s0272-7358(98)00055-5 · Cited by 237 · see citing works
The relationship between fibromyalgia and interstitial cystitis
Clauw, D. J., Schmidt, M., Radulovic, D., Singer, A., Katz, P., & Bresette, J. (1997) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(96)00051-9 · Cited by 230 · see citing works
Tak, L. M., Cleare, A. J., Ormel, J., Manoharan, A., Kok, I. C., Wessely, S., & Rosmalen, J. G. M. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.02.002 · Cited by 230 · see citing works
Melemedjian, O. K., Asiedu, M. N., Tillu, D. V., Peebles, K. A., Yan, J., Ertz, N., Dussor, G. O., & Price, T. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3947-10.2010 · Cited by 225 · see citing works
de Lange, F. P., Koers, A., Kalkman, J. S., Bleijenberg, G., Peter Hagoort, A., van der Meer, J. W. M., & Toni, I. (2008) · Brain · doi:10.1093/brain/awn140 · Cited by 223 · see citing works
Theoharides, T. C., Spanos, C., Pang, X., Alferes, L., Ligris, K., Letourneau, R., Rozniecki, J. J., Webster, E., & Chrousos, G. P. (1995) · Endocrinology · doi:10.1210/endo.136.12.7588332 · Cited by 214 · see citing works
Rózniecki, J., Dimitriadou, V., Lambracht-Hall, M., Pang, X., & Theoharides, T. C. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01855-7 · Cited by 213 · see citing works
Beneficial effects of exercise and its molecular mechanisms on depression in rats.
Zheng, H., Liu, Y., Li, W., Yang, B., Chen, D., Wang, X., Jiang, Z., Wang, H., Wang, Z., Cornelisson, G., et al. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.10.007 · Cited by 212 · see citing works
The TRPA1 Channel in Inflammatory and Neuropathic Pain and Migraine
Nassini, R., Materazzi, S., Benemei, S., & Geppetti, P. (2014) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2014_18 · Cited by 210 · see citing works
CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-α
Overman, E. L., Rivier, J. E., & Moeser, A. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039935 · Cited by 207 · see citing works
Videlock, E. J., Adeyemo, M. A., Licudine, A., Hirano, M., Ohning, G., Mayer, M., Mayer, E. A., & Chang, L. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.058 · Cited by 198 · see citing works
Giovengo, S. L., Russell, I. J., & Larson, A. A. (1999) · PubMed · Cited by 195 · see citing works
Herman, J. P., Dolgas, C. M., & Carlson, S. L. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00055-4 · Cited by 193 · see citing works
Increased gray matter density in young women with chronic vulvar pain
Schweinhardt, P., Kuchinad, A., Pukall, C. F., & Bushnell, M. C. (2008) · Pain · doi:10.1016/j.pain.2008.09.014 · Cited by 192 · see citing works
Migraine pain, meningeal inflammation, and mast cells
Levy, D. (2009) · Current Pain and Headache Reports · doi:10.1007/s11916-009-0040-y · Cited by 191 · see citing works
Daenen, L., Varkey, E., Kellmann, M., & Nijs, J. (2014) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000099 · Cited by 190 · see citing works
Evidence for Overlap Between Urological and Nonurological Unexplained Clinical Conditions
Rodríguez, M. Á. B., Afari, N., & Buchwald, D. (2012) · The Journal of Urology · doi:10.1016/j.juro.2012.11.019 · Cited by 185 · see citing works
Synergistic Role of TRPV1 and TRPA1 in Pancreatic Pain and Inflammation
Schwartz, E. S., Christianson, J. A., Chen, X., La, J., Davis, B. M., Albers, K. M., & Gebhart, G. F. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.12.033 · Cited by 178 · see citing works
Self-citationProlonged Gabapentin Analgesia in an Experimental Mouse Model of Fibromyalgia
Nishiyori, M., & Ueda, H. (2008) · Molecular Pain · doi:10.1186/1744-8069-4-52 · Cited by 176 · see citing works
Pain Mechanisms and Centralized Pain in Temporomandibular Disorders
Harper, D., Schrepf, A., & Clauw, D. J. (2016) · Journal of Dental Research · doi:10.1177/0022034516657070 · Cited by 174 · see citing works
Boyle, M. P., Kolber, B. J., Vogt, S. K., Wozniak, D. F., & Muglia, L. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2173-05.2006 · Cited by 172 · see citing works
Self-reported Physical Activity Predicts Pain Inhibitory and Facilitatory Function
Naugle, K. M., & Riley, J. L. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3182a69cf1 · Cited by 170 · see citing works
(2002) · PubMed · Cited by 167 · see citing works
Svensson, M., Rosvall, P., Boza‐Serrano, A., Andersson, E., Lexell, J. E., & Deierborg, T. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.09.002 · Cited by 164 · see citing works
Nickel, J. C., Tripp, D. A., Pontari, M. A., Moldwin, R., Mayer, R., Carr, L. K., Doggweiler, R., Yang, C. C., Mishra, N. N., & Nordling, J. (2009) · The Journal of Urology · doi:10.1016/j.juro.2009.08.133 · Cited by 163 · see citing works
Electron microscopical evidence for a direct contact between nerve fibres and mast cells
Wiesner-Menzel, L., Schulz, B., Vakilzadeh, F., & Bm, C. (1981) · Acta Dermato Venereologica · doi:10.2340/0001555561465469 · Cited by 158 · see citing works
Kutch, J. J., Ichesco, E., Hampson, J. P., Labus, J. S., Farmer, M. A., Martucci, K. T., Ness, T. J., DEUTSCH, G., Apkarian, A. V., Mackey, S., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000001001 · Cited by 156 · see citing works
The MAPP research network: a novel study of urologic chronic pelvic pain syndromes
The MAPP Research Network Study Group, Clemens, J. Q., Mullins, C., Kusek, J. W., Kirkali, Z., Mayer, E. A., Rodríguez, L. V., Klumpp, D. J., Schaeffer, A. J., Kreder, K. J., et al. (2014) · BMC Urology · doi:10.1186/1471-2490-14-57 · Cited by 155 · cited 2× · see citing works
“…particularly from the Multidisciplinary Approach to Pelvic Pain (MAPP) network, have greatly increased our knowledge of phenotypic and central changes that occur in patients with centralized pain syndromes (Clemens et al., 2014; Kutch et al., 2017a,b; Lai et al., 2017; Harper et al., 2018).”
BackgroundA new animal model for assessing mechanisms and management of muscle hyperalgesia
Kehl, L. J., Trempe, T. M., & Hargreaves, K. (2000) · Pain · doi:10.1016/s0304-3959(99)00282-1 · Cited by 150 · see citing works
Nerve growth factor and chronic prostatitis/chronic pelvic pain syndrome
MILLER, L. J., FISCHER, K. A., GORALNICK, S. J., Litt, M. D., Burleson, J. A., Albertsen, P. C., & Kreutzer, D. L. (2002) · Urology · doi:10.1016/s0090-4295(01)01597-7 · Cited by 147 · see citing works
Bardin, L., Malfetes, N., Newman‐Tancredi, A., & Depoortère, R. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.07.005 · Cited by 146 · see citing works
CRF receptor type 1 and 2 expression and anatomical distribution in the rat colon
Chatzaki, Ε., Crowe, P. D., Wang, L., Million, M., Taché, Y., & Grigoriadis, D. E. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02490.x · Cited by 146 · see citing works
Commonalities Between Pain and Memory Mechanisms and Their Meaning for Understanding Chronic Pain
Price, T. J., & Inyang, K. E. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2014.11.010 · Cited by 143 · see citing works
Levy‐Gigi, E., Szabó, C. A., Kelemen, O., & Kéri, S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.017 · Cited by 143 · see citing works
Mannerkorpi, K., Nordeman, L., Cider, Å., & Jonsson, G. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3159 · Cited by 142 · see citing works
Maniam, J., & Morris, M. J. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.05.012 · Cited by 140 · see citing works
Staud, R. M., Price, D. D., Robinson, M. E., Mauderli, A. P., & Vierck, C. J. (2004) · Pain · doi:10.1016/j.pain.2004.05.009 · Cited by 139 · see citing works
Allodynia in Migraine: Association With Comorbid Pain Conditions
Tietjen, G. E., Brandes, J. L., Peterlin, B. L., Eloff, A., Dafer, R. M., Stein, M. R., Drexler, E. D., Martin, V. T., Hutchinson, S. L., Aurora, S. K., et al. (2009) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2009.01521.x · Cited by 137 · see citing works
New magnetic resonance imaging methods for cerebrovascular disease: Emerging clinical applications
Neumann‐Haefelin, T., Moseley, M. E., & Albers, G. W. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200005)47:5 · Cited by 137 · see citing works
Xu, G., Winston, J. H., Shenoy, M. M., Yin, H., Pendyala, S., & Pasricha, P. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.06.015 · Cited by 136 · see citing works
Kaplan, C. M., Nascimento, T. D., Foerster, B. R., Clauw, D. J., Zubieta, J., Harris, R. E., & DaSilva, A. F. M. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-016-0934-0 · Cited by 135 · see citing works
Riegel, B., Bruenahl, C. A., Ahyai, S., Bingel, U., Fisch, M. M., & Löwe, B. (2014) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2014.09.012 · Cited by 134 · see citing works
Uddman, R., Luts, A., & Sundler, F. (1985) · Cell and Tissue Research · doi:10.1007/bf00214575 · Cited by 130 · see citing works
Liu, H., Shie, J., Chen, S., Wang, Y., & Kuo, H. (2012) · Urology · doi:10.1016/j.urology.2012.01.047 · Cited by 129 · see citing works
Jiang, Y., Peng, C., Liu, H., & Kuo, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076779 · Cited by 128 · see citing works
Levels of nerve growth factor in cerebrospinal fluid of chronic daily headache patients
Sarchielli, P., Alberti, A., Floridi, A., & Gallai, V. (2001) · Neurology · doi:10.1212/wnl.57.1.132 · Cited by 126 · see citing works
Common patterns of plasticity contributing to nociceptive sensitization in mammals and Aplysia
Woolf, C. J., & Walters, E. T. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90024-o · Cited by 123 · see citing works
Chadwick, A. L., Sieberg, C. B., Clauw, D. J., Hassett, A. L., Moser, S. E., & Brummett, C. M. (2016) · Journal of Pain · doi:10.1016/j.jpain.2016.09.003 · Cited by 123 · see citing works
Shih, P.-C., Yang, Y., & Wang, R.-Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078163 · Cited by 119 · see citing works
Daley, A., Grimmett, C., Roberts, L., Wilson, S., Fatek, M., Roalfe, A., & Singh, S. (2008) · International Journal of Sports Medicine · doi:10.1055/s-2008-1038600 · Cited by 118 · see citing works
Interactions of mast cells with the nervous system ?Recent advances
Johnson, D. K., & Krenger, W. (1992) · Neurochemical Research · doi:10.1007/bf00993271 · Cited by 116 · see citing works
Kim, Y., Son, J. Y., Kim, T. H., Paik, S. K., Dai, Y., Noguchi, K., Ahn, D. K., & Bae, Y. C. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22238 · Cited by 115 · see citing works
Sweetser, S. R., Camilleri, M., Nord, S. L., Burton, D. D., Castenada, L., Croop, R. S., Tong, G., Dockens, R. C., & Zinsmeister, A. R. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00011.2009 · Cited by 114 · see citing works
Lai, H. H., Jemielita, T., Sutcliffe, S., Bradley, C. S., Naliboff, B., Williams, D. A., Gereau, R. W., Kreder, K., Clemens, J. Q., Rodriguez, L. V., et al. (2017) · Journal of Urology · doi:10.1016/j.juro.2017.03.132 · Cited by 113 · see citing works
What does the evidence show? Efficacy of behavioural treatments for recurrent headaches in adults
Andrasik, F. J. (2007) · Neurological Sciences · doi:10.1007/s10072-007-0754-8 · Cited by 110 · see citing works
Wick, E. C., Hoge, S. G., Grahn, S. W., Kim, E. J., Divino, L., Grady, E. F., Bunnett, N. W., & Kirkwood, K. S. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00154.2005 · Cited by 110 · see citing works
Shpaner, M., Kelly, C. A. M., Lieberman, G., Perelman, H., Davis, M., Keefe, F. J., & Naylor, M. R. (2014) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.07.008 · Cited by 108 · see citing works
Increased plasma histamine levels in migraine patients
Heatley, R. V., Denburg, J. A., BAYER, N., & Bienenstock, J. (1982) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1982.tb01633.x · Cited by 103 · see citing works
Long-term exercise is needed to enhance synaptic plasticity in the hippocampus
Patten, A. R., Sickmann, H., Hryciw, B. N., Kucharsky, T., Parton, R., Kernick, A., & Christie, B. R. (2013) · Learning & Memory · doi:10.1101/lm.030635.113 · Cited by 101 · see citing works
Physical exercise and depression
Rot, M. A. H., Collins, K. A., & Fitterling, H. (2009) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20094 · Cited by 99 · see citing works
Fibromyalgia - New Concepts of Pathogenesis and Treatment
Lucas, H., Brauch, C. M., Settas, L., & Theoharides, T. C. (2006) · International Journal of Immunopathology and Pharmacology · doi:10.1177/205873920601900102 · Cited by 98 · see citing works
Hubbard, C. S., Labus, J. S., Bueller, J. A., Stains, J., Suyenobu, B. Y., Dukes, G. E., Kelleher, D. L., Tillisch, K., Naliboff, B. D., & Mayer, E. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1860-11.2011 · Cited by 98 · see citing works
Pathophysiologic mechanisms of fibromyalgia and its related disorders.
Bradley, L. A. (2008) · PubMed · Cited by 96 · see citing works
Regulatory Mechanisms Underlying Corticotropin-Releasing Factor Gene Expression in the Hypothalam
Kageyama, K., & Suda, T. (2009) · Endocrine Journal · doi:10.1507/endocrj.k09e-075 · Cited by 95 · see citing works
Anderson, R. U., Orenberg, E. K., Chan, C. A., Morey, A., & Flores, V. L. (2008) · The Journal of Urology · doi:10.1016/j.juro.2007.10.084 · Cited by 92 · see citing works
Santiago, M. D. S., Carvalho, D. D. S., Gabbai, A. A., Pinto, M. M. P., Moutran, A. R. C., & Villa, T. R. (2014) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20140148 · Cited by 91 · see citing works
The Role of Eosinophils and Mast Cells in Intestinal Functional Disease
Walker, M. M., Warwick, A., Ung, C. Y., & Talley, N. J. (2011) · Current Gastroenterology Reports · doi:10.1007/s11894-011-0197-5 · Cited by 90 · see citing works
Haviland, M. G., Morton, K. R., Oda, K., & Fraser, G. E. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.08.017 · Cited by 87 · see citing works
Exercise Strengthens Central Nervous System Modulation of Pain in Fibromyalgia
Ellingson, L. D., Stegner, A. J., Schwabacher, I. J., Koltyn, K. F., & Cook, D. B. (2016) · Brain Sciences · doi:10.3390/brainsci6010008 · Cited by 86 · see citing works
TRPA1 mediates bladder hyperalgesia in a mouse model of cystitis
DeBerry, J. J., Schwartz, E. S., & Davis, B. M. (2014) · Pain · doi:10.1016/j.pain.2014.03.023 · Cited by 85 · see citing works
Moore, J. A., & Kennedy, S. (2000) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1053/beog.1999.0082 · Cited by 84 · see citing works
Role of Mast Cells in Male Chronic Pelvic Pain
Done, J. D., Rudick, C. N., Quick, M. L., Schaeffer, A. J., & Thumbikat, P. (2012) · The Journal of Urology · doi:10.1016/j.juro.2011.11.116 · Cited by 84 · see citing works
Mast cells: an expanding pathophysiological role from allergy to other disorders
Anand, P., Singh, B., Jaggi, A. S., & Singh, N. (2012) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-012-0757-8 · Cited by 83 · see citing works
Kutch, J. J., Yani, M. S., Asavasopon, S., Kirages, D. J., Rana, M., Cosand, L., Labus, J. S., Kilpatrick, L. A., Ashe-McNalley, C., Farmer, M. A., et al. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.05.013 · Cited by 81 · see citing works
Pan, X., Gonzalez, J. A., Chang, S., Chacko, S., Wein, A. J., & Malykhina, A. P. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.05.012 · Cited by 79 · see citing works
Cheng, S.-J., Chen, C.-C., Yang, H.-W., Chang, Y.-T., Bai, S., Chen, C.-C., Yen, C., & Min, M.-Y. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5564-10.2011 · Cited by 79 · see citing works
Differences in Primary Compared With Secondary Vestibulodynia by Immunohistochemistry
Leclair, C. M., Goetsch, M. F., Korcheva, V., Anderson, R. E., Peters, D., & Morgan, T. K. (2011) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31821c33dc · Cited by 77 · see citing works
Translating nociceptor sensitivity: the role of axonal protein synthesis in nociceptor physiology
Price, T. J., & Géranton, S. M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06786.x · Cited by 76 · see citing works
Myers, B., & Meerveld, B. G. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00353.2011 · Cited by 76 · see citing works
Meissner, K., Schweizer-Arau, A., Limmer, A., Preibisch, C., Popovici, R. M., Lange, I., de Oriol, B., & Beissner, F. (2016) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000001691 · Cited by 76 · see citing works
Riva, R., Mork, P. J., Westgaard, R. H., & Lundberg, U. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.06.014 · Cited by 75 · see citing works
Hu, J. C., Link, C. L., McNaughton-Collins, M., Barry, M. J., & McKinlay, J. B. (2007) · Journal of General Internal Medicine · doi:10.1007/s11606-007-0341-y · Cited by 75 · see citing works
Buckley, M. M., O’Halloran, K. D., Rae, M. G., Dinan, T. G., & O’Malley, D. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.279968 · Cited by 74 · see citing works
Corcoran, A. T., Yoshimura, N., Tyagi, V., Jacobs, B. L., Leng, W., & Tyagi, P. (2012) · World Journal of Urology · doi:10.1007/s00345-012-0852-y · Cited by 73 · see citing works
pH ‐Evoked Dural Afferent Signaling Is Mediated by ASIC3 and Is Sensitized by Mast Cell Mediators
Yan, J., Wei, X., Bischoff, C. M., Edelmayer, R. M., & Dussor, G. O. (2013) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12152 · Cited by 73 · see citing works
Myers, B., & Meerveld, B. G. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00298.2009 · Cited by 70 · see citing works
Stress in the Adult Rat Exacerbates Muscle Pain Induced by Early-Life Stress
Álvarez, P., Green, P. G., & Levine, J. D. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.04.006 · Cited by 69 · see citing works
Kutch, J. J., Labus, J. S., Harris, R. E., Martucci, K. T., Farmer, M. A., Fenske, S. J., Fling, C., Ichesco, E., Peltier, S., Petre, B., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000000886 · Cited by 68 · see citing works
Kojima, R., Nozawa, K., Doihara, H., Keto, Y., Kaku, H., Yokoyama, T., & Itou, H. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.11.020 · Cited by 67 · see citing works
Self-mutilation after dorsal rhizotomy in rats: Effects of prior pain and pattern of root lesions
Dennis, S. G., & Melzack, R. (1979) · Experimental Neurology · doi:10.1016/0014-4886(79)90108-0 · Cited by 66 · see citing works
Pierce, A. N., Silvestro, E. R. D., Eller, O. C., Wang, R., Ryals, J. M., & Christianson, J. A. (2016) · Brain Research · doi:10.1016/j.brainres.2016.02.039 · Cited by 66 · see citing works
Self-citationWieseler, J. L., Ellis, A., Sprunger, D. B., Brown, K., McFadden, A., Mahoney, J. H., Rezvani, N., Maier, S. F., & Watkins, L. R. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.10.006 · Cited by 65 · see citing works
Burgos-Vega, C., Ahn, D. D.-U., Bischoff, C. M., Wang, W., Horne, D., Wang, L., Gavva, N. R., & Dussor, G. O. (2015) · Cephalalgia · doi:10.1177/0333102415584313 · Cited by 65 · see citing works
Further Validation of a Model of Fibromyalgia Syndrome in the Rat
Green, P. G., Álvarez, P., Gear, R. W., Mendoza, D., & Levine, J. D. (2011) · Journal of Pain · doi:10.1016/j.jpain.2011.01.006 · Cited by 63 · see citing works
Mease, P. J., Clauw, D. J., Arnold, L. M., Goldenberg, D. L., Witter, J. P., Williams, D. A., Simon, L. S., STRAND, C. V., Bramson, C., Martin, S. A., et al. (2005) · PubMed · Cited by 63 · see citing works
Physical Activity and Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Zhang, R., Chomistek, A. K., Dimitrakoff, J. D., Giovannucci, E. L., Willett, W. C., ROSNER, B. A., & Wu, K. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000472 · Cited by 62 · see citing works
Prusator, D. K., & Meerveld, B. G. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12472 · Cited by 62 · see citing works
From Mechanism to Cure: Renewing the Goal to Eliminate the Disease of Pain
Price, T. J., & Gold, M. S. (2017) · Pain Medicine · doi:10.1093/pm/pnx108 · Cited by 60 · see citing works
Chronic stress in women with localised provoked vulvodynia
Ehrström, S., Kornfeld, D., Rylander, E., & Bohm‐Starke, N. (2009) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.1080/01674820802604359 · Cited by 58 · see citing works
The effects of swimming in mice on pain perception and sleeping time in response to hypnotic drugs
Willow, M., CARMODY, J. J., & Carroll, P. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90296-9 · Cited by 58 · see citing works
Hill, L., Droste, S., Nutt, D., Linthorst, A., & Reul, J. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108096983 · Cited by 57 · see citing works
Johnson, A. C., Tran, L., & Meerveld, B. G. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.16 · Cited by 56 · see citing works
Pierce, A. N., Ryals, J. M., Wang, R., & Christianson, J. A. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.022 · Cited by 56 · see citing works
Self-citationAnderson, R. U., Orenberg, E. K., Morey, A., Chavez, N., & Chan, C. A. (2009) · The Journal of Urology · doi:10.1016/j.juro.2009.07.042 · Cited by 55 · see citing works
Pothoulakis, C., Castagliuolo, I., & Leeman, S. E. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09602.x · Cited by 55 · see citing works
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The anatomy of pain and suffering in the brain and its clinical implications
Ridder, D. D., Adhia, D. B., & Vanneste, S. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.08.013 · Cited by 276 · see citing works
Reframing chronic pain as a disease, not a symptom: rationale and implications for pain management
Clauw, D. J., Essex, M. N., Pitman, V. W., & Jones, K. D. (2019) · Postgraduate Medicine · doi:10.1080/00325481.2019.1574403 · Cited by 262 · see citing works
Altered microbiome composition in individuals with fibromyalgia
Minerbi, A., Gonzalez, E., Brereton, N. J. B., Anjarkouchian, A., Dewar, K., Fitzcharles, M.-A., Chevalier, S., & Shir, Y. (2019) · Pain · doi:10.1097/j.pain.0000000000001640 · Cited by 220 · see citing works
Myofascial trigger points in migraine and tension-type headache
Do, T. P., Heldarskard, G. F., Kolding, L. T., Hvedstrup, J., & Schytz, H. (2018) · The Journal of Headache and Pain · doi:10.1186/s10194-018-0913-8 · Cited by 188 · see citing works
Central sensitization, chronic pain, and other symptoms: Better understanding, better management
Volcheck, M. M., Graham, S. M., Fleming, K. C., Mohabbat, A. B., & Luedtke, C. A. (2023) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.90a.22019 · Cited by 186 · see citing works
Goadsby, P. J., & Holland, P. R. (2019) · Neurologic Clinics · doi:10.1016/j.ncl.2019.07.008 · Cited by 170 · see citing works
Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network
Clemens, J. Q., Mullins, C. E., Ackerman, A. L., Bavendam, T. G., van Bokhoven, A., Ellingson, B. M., Harte, S. E., Kutch, J. J., Lai, H. H., Martucci, K. T., et al. (2018) · Nature Reviews Urology · doi:10.1038/s41585-018-0135-5 · Cited by 166 · see citing works
From transformation to chronification of migraine: pathophysiological and clinical aspects
Torres‐Ferrús, M., Ursitti, F., Alpuente, A., Brunello, F., Chiappino, D., de Vries, T., Marco, S. D., Ferlisi, S., Guerritore, L., González-García, N., et al. (2020) · The Journal of Headache and Pain · doi:10.1186/s10194-020-01111-8 · Cited by 152 · see citing works
Jurado-Priego, L. N., Cueto‐Ureña, C., Ramı́rez-Expósito, M. J., & Martı́nez-Martos, J. M. (2024) · Biomedicines · doi:10.3390/biomedicines12071543 · Cited by 126 · see citing works
Kundakci, B., Kaur, J., Goh, S. L., Hall, M. C., Doherty, M., Zhang, W., & Abhishek, A. (2021) · Pain · doi:10.1097/j.pain.0000000000002500 · Cited by 113 · see citing works
Borisovskaya, A., Chmelik, E., & Karnik, A. (2020) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-15-1792-1_16 · Cited by 102 · see citing works
Park, H. C., Kim, H.-S., & Lee, Y. (2020) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13879 · Cited by 98 · see citing works
Neurotransmitter and neuropeptide regulation of mast cell function: a systematic review
Xu, H., Shi, X., Li, X., Zou, J.-X., Zhou, C., Liu, W., Shao, H., Chen, H., & Shi, L. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02029-3 · Cited by 87 · see citing works
Mauch, J. T., Kao, D. S., Friedly, J. L., & Liu, Y. K. (2023) · PM&R · doi:10.1002/pmrj.12972 · Cited by 86 · see citing works
Shared Fate of Meningeal Mast Cells and Sensory Neurons in Migraine
Irmak, D. K., Kılınç, E., & Töre, F. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00136 · Cited by 79 · see citing works
Chronic Stress and Headaches: The Role of the HPA Axis and Autonomic Nervous System
Sič, A., Bogicevic, M., Brezić, N., Nemr, C., & Knežević, N. N. (2025) · Biomedicines · doi:10.3390/biomedicines13020463 · Cited by 89 · see citing works
Chen, J., Wang, X., & Xu, Z. (2023) · Journal of Pain Research · doi:10.2147/jpr.s416253 · Cited by 81 · see citing works
Mease, P. J., McLean, R. R., Dube, B., Liu, M., Rebello, S., Glynn, M., Yi, E., Park, Y., & Ogdie, A. (2021) · The Journal of Rheumatology · doi:10.3899/jrheum.201549 · Cited by 70 · see citing works
Traina, G. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00345 · Cited by 69 · see citing works
Phan, V. T., Stratton, P., Tandon, H. K., Sinaii, N., Aredo, J. V., Karp, B. I., Merideth, M. A., & Shah, J. P. (2020) · European Journal of Pain · doi:10.1002/ejp.1713 · Cited by 64 · see citing works
Chandan, J. S., Keerthy, D., Zemedikun, D. T., Okoth, K., Gokhale, K. M., Raza, K., Bandyopadhyay, S., Taylor, J. S., & Nirantharakumar, K. (2020) · EClinicalMedicine · doi:10.1016/j.eclinm.2020.100392 · Cited by 64 · see citing works
Gabapentinoid Benefit and Risk Stratification: Mechanisms Over Myth
McAnally, H. B., Bonnet, U., & Kaye, A. D. (2020) · Pain and Therapy · doi:10.1007/s40122-020-00189-x · Cited by 63 · see citing works
Pain Biomarkers in Fibromyalgia Syndrome: Current Understanding and Future Directions
Favretti, M., Iannuccelli, C., & Franco, M. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310443 · Cited by 68 · see citing works
Kieskamp, S. C., Paap, D., Carbo, M., Wink, F. R., Bos, R., Bootsma, H., Arends, S., & Spoorenberg, A. J. P. L. (2021) · Rheumatology · doi:10.1093/rheumatology/keab019 · Cited by 60 · see citing works
Pinto, A. M., Luís, M., Geenen, R., Palavra, F., Lumley, M. A., Ablin, J. N., Amris, K., Branco, J., Buskila, D., Castelhano, J., et al. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105235 · Cited by 68 · see citing works
Tetrahydrocannabinol and cannabidiol medicines for chronic pain and mental health conditions
Henson, J. D., Vitetta, L., & Hall, S. (2022) · Inflammopharmacology · doi:10.1007/s10787-022-01020-z · Cited by 61 · see citing works
Health-related quality of life in osteoarthritis patients: a systematic review and meta-analysis
Yan, H., Guo, J., Zhou, W., Dong, C., & Liu, J. L. (2021) · Psychology Health & Medicine · doi:10.1080/13548506.2021.1971725 · Cited by 53 · see citing works
Impact of water therapy on pain management in patients with fibromyalgia: current perspectives
Zamunér, A. R., Andrade, C. P., Arca, E. A., & Ávila, M. A. (2019) · Journal of Pain Research · doi:10.2147/jpr.s161494 · Cited by 65 · see citing works
Lai, J., Harrison, R. A., Plecash, A. R., & Field, T. S. (2018) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13382 · Cited by 49 · see citing works
Manuel, J., Rudolph, L., Beißner, F., Neubert, T.-A., Dusch, M., & Karst, M. (2023) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001181 · Cited by 47 · see citing works
Neuromodulation for Pelvic and Urogenital Pain
Roy, H., Offiah, I., & Dua, A. (2018) · Brain Sciences · doi:10.3390/brainsci8100180 · Cited by 47 · see citing works
Lowering barometric pressure induces neuronal activation in the superior vestibular nucleus in mice
Sato, J., Inagaki, H., Kusui, M., Yokosuka, M., & Ushida, T. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211297 · Cited by 47 · see citing works
Central sensitization has major impact on quality of life in patients with axial spondyloarthritis
Kieskamp, S. C., Paap, D., Carbo, M., Wink, F. R., Bos, R., Bootsma, H., Arends, S., & Spoorenberg, A. J. P. L. (2021) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2021.11.006 · Cited by 46 · see citing works
T Cell Subpopulations in the Physiopathology of Fibromyalgia: Evidence and Perspectives
Banfi, G., Diani, M., Pigatto, P. D., & Reali, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041186 · Cited by 46 · see citing works
Villafañe, J. H., Pedersini, P., Bertozzi, L., Drago, L., Fernández‐Carnero, J., Bishop, M. D., & Berjano, P. L. (2020) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2020.02.836 · Cited by 43 · see citing works
Cognitive behavioral therapy for the treatment of chronic pelvic pain
Urits, I., Callan, J., Moore, W., Fuller, M. C., Renschler, J. S., Fisher, P., Jung, J. W., Hasoon, J. J., Eskander, J. P., Kaye, A. D., et al. (2020) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2020.08.001 · Cited by 41 · see citing works
The role of mast cells in the gut and brain
Traina, G. (2021) · Journal of Integrative Neuroscience · doi:10.31083/j.jin.2021.01.313 · Cited by 42 · see citing works
Sex differences in the transition to chronic pain
Smith, A. F., Plumb, A. N., Berardi, G., & Sluka, K. A. (2025) · Journal of Clinical Investigation · doi:10.1172/jci191931 · Cited by 40 · see citing works
The Landscape of Chronic Pain: Broader Perspectives
Johnson, M. I. (2019) · Medicina · doi:10.3390/medicina55050182 · Cited by 38 · see citing works
Bilika, P., Nijs, J., Fandridis, E. M., Dimitriadis, Z., Στριμπάκος, Ν., & Kapreli, E. (2022) · Healthcare · doi:10.3390/healthcare10091658 · Cited by 37 · see citing works
Ueda, H. (2019) · Pain Management · doi:10.2217/pmt-2019-0036 · Cited by 34 · see citing works
Adamian, L., Urits, I., Orhurhu, V., Hoyt, D. J., Driessen, R., Freeman, J. A., Kaye, A. D., Kaye, R. J., Garcia, A. J., Cornett, E. M., et al. (2020) · Current Pain and Headache Reports · doi:10.1007/s11916-020-00857-9 · Cited by 34 · see citing works
“I Don’t Know Why I’ve Got this Pain!” Allostasis as a Possible Explanatory Model
Rabey, M. I., & Moloney, N. A. (2022) · Physical Therapy · doi:10.1093/ptj/pzac017 · Cited by 32 · see citing works
Greenspan, J. D., Slade, G. D., Rathnayaka, N. S., Fillingim, R. B., Ohrbach, R. K., & Maixner, W. D. (2020) · Journal of Oral & Facial Pain and Headache · doi:10.11607/ofph.2583 · Cited by 32 · see citing works
Women’s Lived Experiences of Chronic Pain: Faces of Gendered Suffering
Arman, M., Gebhardt, A., Nordberg, J. H., & Andermo, S. (2019) · Qualitative Health Research · doi:10.1177/1049732319888478 · Cited by 31 · see citing works
Ioachim, G., Warren, H. J. M., Powers, J. M., Staud, R. M., Pukall, C. F., & Stroman, P. W. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.862976 · Cited by 32 · see citing works
Artacho‐Cordón, F., Salinas-Asensio, M. D. M., Galiano‐Castillo, N., Hernández, O. O., Peinado, F. M., Mundo-López, A., Lozano‐Lozano, M., Álvarez-Salvago, F., Arroyo‐Morales, M., Fernández‐Lao, C., et al. (2023) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2023.06.020 · Cited by 29 · see citing works
Neuroimaging Studies of Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Zhao, Y., Lin, J., Dong, Y., Tian, Z., Ye, Y., Ma, Z., Xia, S., Huang, X., Chen, D., & Zhang, P. (2022) · Pain Research and Management · doi:10.1155/2022/9448620 · Cited by 28 · see citing works
Salaffi, F., Farah, S., Bianchi, B., & Carlo, M. D. (2023) · The Journal of Rheumatology · doi:10.3899/jrheum.2023-0177 · Cited by 26 · see citing works
Pain at the Slaughterhouse in Ruminants with a Focus on the Neurobiology of Sensitisation
Mota‐Rojas, D., Napolitano, F., Strappini, A., Orihuela, A., Ghezzi, M. D., Hernández-Ávalos, I., Mora‐Medina, P., & Whittaker, A. L. (2021) · Animals · doi:10.3390/ani11041085 · Cited by 26 · see citing works
Argus, M., & Pääsuke, M. (2021) · International Journal of Occupational Safety and Ergonomics · doi:10.1080/10803548.2021.1999616 · Cited by 26 · see citing works
Are menstrual symptoms associated with central sensitization inventory? A cross‐sectional study
de Arruda, G. T., Driusso, P., Rodrigues, J. C., de Godoy, A. G., Degani, A. M., Danna‐dos‐Santos, A., & Ávila, M. A. (2022) · European Journal of Pain · doi:10.1002/ejp.1999 · Cited by 26 · see citing works
Leite, P. M. S., Mendonça, A. R. C., Maciel, L. Y. D. S., Neto, M. L. P., de Araújo, C. C. A., Góis, H. C. J., Souza, J. H. S., & DeSantana, J. M. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/8586746 · Cited by 27 · see citing works
van Aken, M., Oosterman, J., van Rijn, T., Woudsma, K., Ferdek, M., Ruigt, G., Kozicz, T., Braat, D., Peeters, A., & Nap, A. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.06.040 · Cited by 26 · see citing works
Eller, O. C., Willits, A., Young, E. E., & Baumbauer, K. M. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.991736 · Cited by 28 · see citing works
Chronic pain after hand-assisted laparoscopic donor nephrectomy
Zorgdrager, M., van Londen, M., Westenberg, L. B., Nieuwenhuijs‐Moeke, G. J., Lange, J. F. M., de Borst, M. H., Bakker, S. J. L., Leuvenink, H. G. D., & Pol, R. A. (2019) · British journal of surgery · doi:10.1002/bjs.11127 · Cited by 24 · see citing works
Nociplastic Pain in Endometriosis: A Scoping Review
Gentles, A., Goodwin, E., Bedaiwy, Y., Marshall, N., & Yong, P. J. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13247521 · Cited by 26 · see citing works
Psychological Resilience and Stress Coping Styles in Migraine Patients
Gürsoy, B. K., & Toksoy, C. K. (2023) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s398838 · Cited by 26 · see citing works
Elkholy, N. S., Shafaa, M. W., & Mohammed, H. S. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166150 · Cited by 22 · see citing works
Increased migraine-free intervals with multifocal repetitive transcranial magnetic stimulation
Leahu, P., Bange, M., Ciolac, D., Scheiter, S., Matei, A., González‐Escamilla, G., Chirumamilla, V. C., Groppa, S. A., Muthuraman, M., & Groppa, S. (2021) · Brain stimulation · doi:10.1016/j.brs.2021.10.383 · Cited by 22 · see citing works
Is painful temporomandibular disorder a real headache for many patients?
Yakkaphan, P., Elias, L.-A., Ravindranath, P. T., & Renton, T. F. (2024) · BDJ · doi:10.1038/s41415-024-7178-1 · Cited by 22 · see citing works
Kapfhammer, H. (2018) · Psychiatria Danubina · doi:10.24869/psyd.2018.254 · Cited by 22 · see citing works
Cross-lagged longitudinal analysis of pain intensity and sleep disturbance
Amtmann, D., Bamer, A. M., Askew, R. L., & Jensen, M. P. (2020) · Disability and health journal · doi:10.1016/j.dhjo.2020.100908 · Cited by 22 · see citing works
Verdi, M., Candido, D., Madan, J. C., Bernstein, J. A., Bukstein, D. A., Anagnostou, A., Greenhawt, M., Mustafa, S. S., Wang, J., Nowak-Wegrzyn, A. H., et al. (2025) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2025.05.020 · Cited by 21 · see citing works
Ma, J., Zhang, T., Li, X., Chen, X., & Zhao, Q. (2022) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2022.2119906 · Cited by 21 · see citing works
Wu, P. Y., Yang, X., Wright, D. E., & Christianson, J. A. (2019) · Pain · doi:10.1097/j.pain.0000000000001703 · Cited by 20 · see citing works
Self-citationWillaert, W., Leysen, L., Lenoir, D., Meeus, M., Cagnie, B. J., Nijs, J., Sterling, M. M., & Coppieters, I. (2021) · Physical Therapy · doi:10.1093/ptj/pzab105 · Cited by 20 · see citing works
Gerra, M. C., Carnevali, D., Ossola, P., González-Villar, A. J., Pedersen, I. S., Triñanes, Y., Donnini, C., Manfredini, M., Arendt‐Nielsen, L., & Carrillo‐de‐la‐Peña, M. T. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10214992 · Cited by 21 · see citing works
Chandan, J. S., Keerthy, D., Gokhale, K. M., Bradbury‐Jones, C., Raza, K., Bandyopadhyay, S., Taylor, J. S., & Nirantharakumar, K. (2021) · European Journal of Pain · doi:10.1002/ejp.1750 · Cited by 25 · see citing works
Garattini, E. G., Santos, B. M., Ferrari, D. P., Capel, C. P., Francescato, H. D. C., Coimbra, T. M., Leite‐Panissi, C. R. A., Branco, L. G. S., & Nascimento, G. C. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.10.001 · Cited by 19 · see citing works
Exercise Reduces Pain and Deleterious Histological Effects in Fibromyalgia-like Model
Ferrarini, E. G., Gonçalves, E. C. D., Menegasso, J. F., Rabelo, B. D., Felipetti, F. A., & Dutra, R. C. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.04.017 · Cited by 18 · see citing works
Deodato, M., Granato, A., Ceschin, M., Galmonte, A., & Manganotti, P. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.770397 · Cited by 18 · see citing works
Frick, J. M., Eller, O. C., Foright, R. M., Levasseur, B. M., Yang, X., Wang, R., Winter, M. K., O’Neil, M. F., Morris, E. M., Thyfault, J. P., et al. (2023) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00216.2022 · Cited by 18 · see citing works
Self-citationSadighparvar, S., Al‐Hamed, F. S., Sharif‐Naeini, R., & Meloto, C. B. (2023) · Frontiers in Pain Research · doi:10.3389/fpain.2023.1150749 · Cited by 16 · see citing works
Exaptation and Evolutionary Adaptation in Nociceptor Mechanisms Driving Persistent Pain
Walters, E. T. (2023) · Brain Behavior and Evolution · doi:10.1159/000535552 · Cited by 16 · see citing works
Yoon, A. P., Wang, C., Speth, K. A., Wang, L., Chung, K. C., & for The WRIST Group (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.28929 · Cited by 16 · see citing works
Central Nervous System Changes in Pelvic Inflammation/Pain Patients
Asiri, M. D., Banjar, R., Al-Qahtani, W., Goodarzynejad, H., & HASSOUNA, M. M. (2019) · Current Bladder Dysfunction Reports · doi:10.1007/s11884-019-00530-x · Cited by 16 · see citing works
Koga, M., Shigetoh, H., Tanaka, Y., & Morioka, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-06453-8 · Cited by 15 · see citing works
Choo, Y. J., Kwak, S. G., & Chang, M. C. (2021) · Pain Medicine · doi:10.1093/pm/pnab354 · Cited by 15 · see citing works
Gong, T., Yu, W., Zhao, P., Wu, Z.-Y., Zhu, Y., Gong, Q., & Zhu, Z. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1641903 · Cited by 14 · see citing works
Sánchez, D. G., Pajares-Hachero, B., Trinidad‐Fernández, M., Escriche-Escuder, A., Campos, M. I., Bermejo-Pérez, M. J., Alba, E., Roldán‐Jiménez, C., & Cuesta‐Vargas, A. (2022) · Pain Management Nursing · doi:10.1016/j.pmn.2022.01.003 · Cited by 15 · see citing works
Zoltick, A. H., Mann, S., & Coetzee, J. F. (2024) · Frontiers in Pain Research · doi:10.3389/fpain.2024.1396992 · Cited by 14 · see citing works
Ren, J., Li, N., Danning, X., Wei, N., Shao, X., Liu, B., Liang, Y., Du, J., Jin, X., Fang, J., et al. (2024) · Acupuncture and Herbal Medicine · doi:10.1097/hm9.0000000000000140 · Cited by 14 · see citing works
Seaton, N., Wileman, V., Norton, C. S., Hudson, J. L., Mondelli, V., & Moss-Morris, R. E. (2025) · BMC Gastroenterology · doi:10.1186/s12876-025-03691-8 · Cited by 14 · see citing works
Fuentes, I. M., Jones, B. M., Brake, A. D., Pierce, A. N., Eller, O. C., Supple, R. M., Wright, D. E., & Christianson, J. A. (2020) · Pain · doi:10.1097/j.pain.0000000000002178 · Cited by 13 · see citing works
Self-citationNon-pharmacological therapies for treating chronic pelvic pain in women: A review
Wang, X., Ding, N., Sun, Y., Chen, Y., Shi, H., Zhu, L., Gao, S., & Liu, Z. (2022) · Medicine · doi:10.1097/md.0000000000031932 · Cited by 13 · see citing works
Wang, X. J., Ebbert, J. O., Loftus, C. G., Rosedahl, J. K., & Philpot, L. M. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14546 · Cited by 13 · see citing works
del Paso, G. A. R., Garcia‐Hernandez, A., Contreras‐Merino, A. M., Galvez-Sánchez, C. M., de la Coba, P., Montoro, C. I., & Davydov, D. M. (2023) · European Journal of Pain · doi:10.1002/ejp.2223 · Cited by 16 · see citing works
Suárez, N. A., Pérez, J. M., Redolar-Ripoll, E., Hogg, B., Gardoki-Souto, I., García-Guerrero, F., Cabrera‐Jaime, S., Bernal, D. S., Amann, B. L., & Moreno‐Alcázar, A. (2020) · Journal of EMDR Practice and Research · doi:10.1891/emdr-d-20-00004 · Cited by 13 · see citing works
Seidman, L. C., Temme, C. R., Zeltzer, L. K., Rapkin, A. J., Naliboff, B. D., & Payne, L. A. (2020) · Journal of Pain Research · doi:10.2147/jpr.s283363 · Cited by 12 · see citing works
A Review on Various Topics on the Thermal Grill Illusion
Shin, D. A., & Chang, M. C. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10163597 · Cited by 12 · see citing works
Cellular and Molecular Roles of Immune Cells in the Gut-Brain Axis in Migraine
Zhou, Y., Pang, M., Ma, Y., Lu, L., Zhang, J., Wang, P., Li, Q., & Yang, F. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03623-1 · Cited by 12 · see citing works
Do patients with low back pain and central sensitization have differences in physical fitness?
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- Authors
- Eller-Smith, O. C., Nicol, A. L., & Christianson, J. A.
- Affiliations
- University of Kansas Medical Center (US)
- Corresponding author
- Christianson, Julie A.
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2018-02-13
- Volume
- 12
- Pages
- 35-35
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC5816755
- OpenAlex
- W2793570991
- Cited by
- 227
- References
- 235
- Citations by year
- 2026: 31 · 2025: 24 · 2024: 20 · 2023: 31 · 2022: 31 · 2021: 31 · 2020: 26 · 2019: 23 · 2018: 10
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (DK099611, DK103872, GM123320, HD057850)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- fibromyalgia, chronic pelvic pain, migraine, temporomandibular disorders, central sensitization, HPA axis dysregulation, mast cells, hyperalgesic priming, wind-up, long-term potentiation, functional connectivity, non-pharmacological treatment, physical activity, cognitive behavioral therapy, comorbidities, quality of life
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