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Anticipatory brainstem activity predicts neural processing of pain in humans
Abstract
Previous neuroimaging studies have shown brain activity during not only the application of noxious stimuli, but also prior to stimulation. The functional significance of the anticipatory response, however, has yet to be explored. Two theoretical responses involve either a decrease or an increase in sensitivity of the nociceptive system. In a functional magnetic resonance imaging (fMRI) study, brainstem responses during anticipation and processing of thermal noxious stimuli were investigated. Twelve healthy subjects were warned prior to and then received noxious stimulation to their left hand. Behavioral data showed a positive correlation between the intensity of anticipation and pain. FMRI data revealed brainstem activation in the PAG during the anticipation period. When correlated with individual anticipation ratings, activation during anticipation included significant clusters within the entorhinal cortex and ventral tegmental area (VTA). During receipt, activation within the brainstem included the PAG, VTA, rostral ventromedial medulla (RVM), and the parabrachial nucleus (PB), all elements of descending pain pathways. Using a backward model approach, we explored the functional significance of the anticipatory neural response for subsequent pain processing. Results of this regression analysis revealed that insula activity during receipt was predicted by activity in both the entorhinal cortex and VTA during anticipation. We suggest that activation in both regions before and during pain may underlie anticipation and subsequent pain modulatory responses, possibly involving the appraisal and control of attention necessary for pain modulation. Together, the results suggest a possible role of brainstem areas in anticipatory mechanisms involved in the maintenance of chronic pain.
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“The activity in the PAG and the OFC has also been often related to the processing of anxiety associated with anticipating nociceptive stimuli (Brodersen et al., 2012; Fairhurst et al., 2007).”
From Distinct neural representations of placebo and nocebo effects (2015) · cites this paper as Fairhurst et al., 2007
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Cites
Fast robust automated brain extraction
Smith, S. M. (2002) · Human Brain Mapping · doi:10.1002/hbm.10062 · Cited by 10,496
A global optimisation method for robust affine registration of brain images
Jenkinson, M., & Smith, S. M. (2001) · Medical Image Analysis · doi:10.1016/s1361-8415(01)00036-6 · Cited by 7,018
Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art.
Vlaeyen, J. W. S., & Linton, S. J. (2000) · Pain · doi:10.1016/s0304-3959(99)00242-0 · Cited by 4,931
Human brain mechanisms of pain perception and regulation in health and disease
Apkarian, A. V., Bushnell, M. C., Treede, R., & Zubieta, J. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2004.11.001 · Cited by 3,126
Temporal Autocorrelation in Univariate Linear Modeling of FMRI Data
Woolrich, M. W., Ripley, B. D., Brady, M., & Smith, S. M. (2001) · NeuroImage · doi:10.1006/nimg.2001.0931 · Cited by 2,859
Interoception: the sense of the physiological condition of the body
(Bud) Craig, A. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00090-4 · Cited by 2,556
Bonica, J. J., Melzack, R., & Wall, P. D. (1999) · Cited by 2,537
Theoretical perspectives on the relation between catastrophizing and pain
Sullivan, M. J. L., Thorn, B., Haythornthwaite, J. A., Keefe, F., Martin, M., Bradley, L. A., & Lefebvre, J. C. (2001) · The Clinical Journal of Pain · doi:10.1097/00002508-200103000-00008 · Cited by 2,472
Functional imaging of brain responses to pain. A review and meta-analysis (2000)
Peyron, R., Laurent, B., & García-Larrea, L. (2000) · Neurophysiologie Clinique/Clinical Neurophysiology · doi:10.1016/s0987-7053(00)00227-6 · Cited by 2,171
A three-dimensional statistical analysis for CBF activation studies in human brain
Worsley, K. J., Evans, A. C., Marrett, S., & Neelin, P. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.127 · Cited by 2,036
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Metadata
- Authors
- Fairhurst, M., Wiech, K., Dunckley, P., & Tracey, I.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Tracey, Irene
- Venue
- Pain
- Published
- 2007-03
- Volume
- 128
- Issue
- 1
- Pages
- 101-110
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2044479451
- Cited by
- 231
- References
- 60
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 13 · 2019: 8 · 2018: 14 · 2017: 20 · 2016: 8 · 2015: 12 · 2014: 19 · 2013: 15 · 2012: 11
- FWCI
- 10.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-41622)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- pain anticipation, brainstem, pain processing, periaqueductal gray, ventral tegmental area, entorhinal cortex, rostral ventromedial medulla, parabrachial nucleus, descending pain modulation, insula, chronic pain
- MeSH terms
- Adult, Brain Mapping, Brain Stem, Cognition, Cues, Evoked Potentials, Somatosensory, Female, Humans, Magnetic Resonance Imaging, Male, Models, Neurological, Pain, Pain Threshold
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