Influence of endometriosis on visceromotor and cardiovascular responses induced by vaginal distention in the rat.
Open accessAbstract
This study examined pseudoaffective responses elicited by vaginal distention in urethane-anesthetized rats, and tested hypotheses that responses would be increased by endometriosis (ENDO) and vary with the estrous cycle. Three groups were studied: ENDO, shamENDO, and Naive. ENDO was induced by autotransplanting small pieces of uterine horn (or, for shamENDO, fat) on mesenteric arteries. Ten weeks later, rats in proestrus or metestrus were anesthetized with urethane. Distendable latex balloons were inserted into the vaginal canal. While an increasing series of vaginal distentions was delivered, changes in electromyographic activity of the external oblique musculature (visceromotor response, VMR) and mean arterial pressure (pressor) responses were simultaneously measured. Vaginal distention produced VMR and pressor responses in all groups. These responses were significantly greater in ENDO than in the other groups, and greater in proestrus than metestrus. Although the overall amount of cystic tissue was greater in proestrous than metestrous rats, there was no correlation between these amounts and VMR or pressor responses. Acute spinalization (T8-T9) and bilateral pelvic, but not hypogastric, neurectomy attenuated both VMR and pressor responses, supporting the hypothesis that vaginal nociception involves suprathoracic spinal processing of information conveyed by the pelvic nerve. These effects on VMR and pressor responses to vaginal distention parallel behavioral escape responses to the same stimuli reported previously. The findings encourage continued use of VMR and pressor responses for further investigation of mechanisms underlying pain associated with ENDO and its potential treatment.
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The amount of cystic growth does not correlate with hyperalgesic severity in ENDO rats.
“the amount of cystic growth does not correlate with hyperalgesic severity [8], [9].”
From Sprouted Innervation into Uterine Transplants Contributes to the Development of Hyperalgesia in a Rat Model of Endometriosis (2012) · cites this paper as [8]
The ENDO model's surgical control (shamENDO) develops neither cysts nor pain symptoms.
“The ENDO model’s surgical control (shamENDO) develops neither cysts nor pain symptoms [10,38].”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [38]
A rat model of surgically-induced endometriosis (ENDO) develops pain symptoms similar to those of women, including vaginal hyperalgesia and vaginally-referred abdominal muscle hyperalgesia.
“A rat model of surgically-induced endometriosis (ENDO), in which ectopic uterine cysts form in the abdomen [51], develops pain symptoms similar to those of women, including vaginal hyperalgesia (10) and vaginally-referred abdominal muscle hyperalgesia [38].”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [38]
All assessments were done >6 wks after surgery, when ENDO-induced hyperalgesia is fully-developed and stable.
“All assessments were done > 6 wks after the surgery; i.e., when ENDO-induced hyperalgesia is fully-developed and stable [10,45,38].”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [38]
Studies were done when the rat was in proestrus, the estrous stage when hyperalgesia in the ENDO model is most severe.
“Studies were done when the rat was in proestrus, the estrous stage when hyperalgesia in the ENDO model is most severe [10,45,38].”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [38]
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- Authors
- Nagabukuro, H., & Berkley, K. J.
- Affiliations
- Florida State University (US)
- Venue
- Pain
- Published
- 2007-11
- Volume
- 132
- Issue
- Supplement 1
- Pages
- S96-S103
- ISSN
- 0304-3959 (ISSN-L)
- PMC
- PMC2323582
- OpenAlex
- W2144984385
- Cited by
- 47
- References
- 31
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 5 · 2019: 2 · 2017: 4 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R21DK063937)
- National Institute of Neurological Disorders and Stroke (R01-NS-11892, R01NS011892)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Keywords
- endometriosis, vaginal distention, visceromotor response, cardiovascular response, pressor response, estrous cycle, pelvic nerve, spinal nociceptive processing, neurectomy, visceral pain
- MeSH terms
- Abdominal Muscles, Afferent Pathways, Animals, Blood Pressure, Cardiovascular Physiological Phenomena, Disease Models, Animal, Endometriosis, Female, Hypogastric Plexus, Nociceptors, Pain Measurement, Physical Stimulation, Pressure, Reflex, Abdominal, Vagina, Rats, Sprague-Dawley, Pelvic Pain, Autonomic Pathways, Visceral Afferents, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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