Opposing viscerovisceral effects of surgically induced endometriosis and a control abdominal surgery on the rat bladder
Open accessAbstract
Objective To determine, in rats, how surgically induced endometriosis and a control surgery (partial hysterectomy; sutures in abdomen) affects micturition thresholds and bladder vascular permeability. Design Two animal studies, each performed in three groups of urethane-anesthetized rats in proestrus. Setting Academic facility. Animal(s) Seventy-three female, regularly cycling Sprague-Dawley rats studied in proestrus. Intervention(s) Surgical induction of endometriosis (ENDO), surgical control (shamENDO), intact control (NoSURG), and bladder inflammation via intravesicular turpentine in all three groups. Main outcome measure(s) [1] Micturition thresholds (MTs; volume voiding thresholds), as measured by repetitive transurethral cystometry before and after bladder inflammation and [2] bladder inflammation, as assessed by extravasation of Evans Blue dye. Result(s) In the uninflamed bladder, MTs were significantly lower and dye extravasation significantly higher in ENDO rats than in shamENDO and NoSURG rats. Bladder inflammation increased dye extravasation in all groups and reduced MTs in the NoSURG and ENDO rats, but not in the shamENDO rats. Conclusion(s) Endometriosis reduces MTs and produces signs of inflammation in the healthy bladder. Surprisingly, the control surgical procedure (partial hysterectomy; sutures on mesenteric blood vessels) protects bladder reflexes from the influence of bladder inflammation, a condition that is named silent bladder inflammation. Such cross-system inducing and masking effects have important clinical relevance.
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The presence of other pain syndromes such as painful bladder or irritable bowel syndrome in women with endometriosis-associated pain suggests that mechanisms of cross-talk between viscera contribute to pain, as they do in the rat model.
“Finding other pain syndromes such as painful bladder or irritable bowel syndrome in women with endometriosis-associated pain suggests that mechanisms underlying cross-talk between viscera contribute to pain, as they do in the rat model”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Morrison et al., 2006
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Cites
The Physiology of Reproduction
Legendre, M., & Jalabert, B. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-109-2-176_1 · Cited by 7,879 · see citing works
Giudice, L. C., & Kao, L. C. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17403-5 · Cited by 3,166 · see citing works
Strategies and Methods for Research on Sex Differences in Brain and Behavior
Becker, J. B., Arnold, A. P., Berkley, K. J., Blaustein, J. D., Eckel, L. A., Hampson, E., Herman, J. P., Marts, S. A., Sadée, W., Steiner, M. S., et al. (2004) · Endocrinology · doi:10.1210/en.2004-1142 · Cited by 799 · see citing works
Self-citationLoewy, A. D., & Burton, H. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901810211 · Cited by 718 · see citing works
The cholinergic anti-inflammatory pathway
Pavlov, V. A., & Tracey, K. J. (2005) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2005.03.015 · Cited by 622 · see citing works
Sinaii, N. (2002) · Human Reproduction · doi:10.1093/humrep/17.10.2715 · Cited by 620 · see citing works
Studies on the surgical induction of endometriosis in the rat.
Vernon, M. W., & Wilson, E. A. (1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48988-0 · Cited by 482 · see citing works
Berkley, K. J., Rapkin, A. J., & Papka, R. E. (2005) · Science · doi:10.1126/science.1111445 · Cited by 455 · see citing works
Self-citationSaria, A., & Lundberg, J. M. (1983) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(83)90050-x · Cited by 429 · see citing works
Interstitial cystitis: Unexplained associations with other chronic disease and pain syndromes
Alagiri, M., Chottiner, S., Ratner, V., Slade, D., & Hanno, P. M. (1997) · Urology · doi:10.1016/s0090-4295(99)80332-x · Cited by 397 · see citing works
Urinary Tract Infection in Women
Sheffield, J. S., & Cunningham, F. G. (2005) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000185257.52328.a2 · Cited by 307 · see citing works
Pezzone, M. A., Liang, R., & Fraser, M. O. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.03.008 · Cited by 292 · see citing works
Neuroendocrine Control of the Ovarian Cycle of the Rat
Freeman, M. R. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50048-8 · Cited by 285 · see citing works
Diffuse Noxious Inhibitory Controls (DNIC) in Animals and in Man
Bars, D. L., Villanueva, L., Bouhassira, D., & Wilier, J. C. (1991) · Acupuncture in Medicine · doi:10.1136/aim.9.2.47 · Cited by 261 · see citing works
Innervation of ectopic endometrium in a rat model of endometriosis
Berkley, K. J., Dmitrieva, N., Curtis, K. S., & Papka, R. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403663101 · Cited by 227 · see citing works
Self-citationSato, A., Sato, Y., Suzuki, A., et al. (1993) · Neuroscience Research · doi:10.1016/0168-0102(93)90105-y · Cited by 206 · see citing works
ANATOMY AND PHYSIOLOGY OF THE LOWER URINARY TRACT
de Groat, W. C. (1993) · Urologic Clinics of North America · doi:10.1016/s0094-0143(21)00501-2 · Cited by 199 · see citing works
Diffuse noxious inhibitory controls (DNIC) in animals and in man.
Bars, D. L., Villanueva, L., Bouhassira, D., & Jc, W. (1992) · PubMed · Cited by 196 · see citing works
Berkley, K. J., Robbins, A., & Sato, Y. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.69.2.533 · Cited by 163 · see citing works
Self-citationNeuronal responses to stimulation of the cervix, uterus, colon, and skin in the rat spinal cord
Berkley, K. J., Hubscher, C. H., & Wall, P. D. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.69.2.545 · Cited by 140 · see citing works
Self-citationAre there separate central nervous system pathways for touch and pain?
Berkley, K. J., & Hubscher, C. H. (1995) · Nature Medicine · doi:10.1038/nm0895-766 · Cited by 119 · see citing works
Self-citationGiamberardino, M. A., Berkley, K. J., Affaitati, G., Lerza, R., Centurione, L., Lapenna, D., & Vecchiet, L. (2002) · Pain · doi:10.1016/s0304-3959(01)00405-5 · Cited by 114 · see citing works
Self-citationGastric inflammation triggers hypersensitivity to acid in awake rats
Lamb, K. R., Kang, Y., Gebhart, G. F., & Bielefeldt, K. (2003) · Gastroenterology · doi:10.1016/j.gastro.2003.07.010 · Cited by 114 · see citing works
Neuhuber, W., Sandoz, P. A., & Fryscak, T. (1986) · Anatomy and Embryology · doi:10.1007/bf00318344 · Cited by 109 · see citing works
Experimental colitis in mice and sensitization of converging visceral and somatic afferent pathways
Lamb, K. R., Zhong, F., Gebhart, G. F., & Bielefeldt, K. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00353.2005 · Cited by 107 · see citing works
Berkley, K. J. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.013 · Cited by 106 · see citing works
Self-citationEstrous changes in vaginal nociception in a rat model of endometriosis
Cason, A. M., Samuelsen, C. L., & Berkley, K. J. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(03)00121-1 · Cited by 94 · see citing works
Self-citationVagal afferents from the uterus and cervix provide direct connections to the brainstem
Collins, J., Lin, C.-Y., Berthoud, H., & Papka, R. E. (1999) · Cell and Tissue Research · doi:10.1007/s004410051211 · Cited by 93 · see citing works
Berkley, K. J., Guilbaud, G., Benoist, J. M., et al. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.69.2.557 · Cited by 91 · see citing works
Self-citation(2005) · PubMed Central · Cited by 91 · see citing works
Using Rats as a Research Model for the Study of Endometriosis
Sharpe-Timms, K. L. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02792.x · Cited by 90 · see citing works
Giamberardino, M. A., Laurentis, S. D., Affaitati, G., Lerza, R., Lapenna, D., & Vecchiet, L. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01753-0 · Cited by 81 · see citing works
Stanford, E. J., Koziol, J. A., & Feng, A. C. (2005) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2004.12.016 · Cited by 76 · see citing works
Integration of viscerosomatic sensory input at the spinal level
Foreman, R. D. (2000) · Progress in brain research · doi:10.1016/s0079-6123(08)62140-8 · Cited by 69 · see citing works
Contrasting Effects of WIN 55212–2 on Motility of the Rat Bladder and Uterus
Dmitrieva, N., & Berkley, K. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07147.2002 · Cited by 65 · see citing works
Self-citationInhibition of a somatic nociceptive reflex by gastric distention in humans
Bouhassira, D., Chollet, R., Coffin, B., Lémann, M., Bars, D. L., Willer, J. C., & Jian, R. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90222-4 · Cited by 61 · see citing works
The heterotopic effects of visceral pain: Behavioural and electrophysiological approaches in the rat
Calvino, B., Villanueva, L., & Bars, D. L. (1984) · Pain · doi:10.1016/0304-3959(84)90015-0 · Cited by 61 · see citing works
Qin, C., & Foreman, R. D. (2004) · Neuroreport · doi:10.1097/00001756-200403010-00017 · Cited by 59 · see citing works
The prevalence of silent kidney stones--an ultrasonographic screening study.
Buchholz, N. P., Abbas, F., Afzal, M., et al. (2003) · PubMed · Cited by 58 · see citing works
Hormonal manipulation in women with chronic, cyclic irritable bladder symptoms and pelvic pain
Lentz, G. M., Bavendam, T. G., Stenchever, M. A., Miller, J. L., & Smalldridge, J. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.123729 · Cited by 55 · see citing works
Cadden, S. W., & Morrison, J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90714-7 · Cited by 52 · see citing works
Brain stem convergence of pelvic viscerosomatic inputs via spinal and vagal afferents
Hubscher, C. H., Kaddumi, E. G., & Johnson, R. D. (2004) · Neuroreport · doi:10.1097/01.wnr.0000128428.74337.ef · Cited by 43 · see citing works
Estrous influences on micturition thresholds of the female rat before and after bladder inflammation
Johnson, O. L., & Berkley, K. J. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2002.282.1.r289 · Cited by 40 · see citing works
Self-citationThe origin of sensory innervation of the peritoneum in the rat
Tanaka, K., Matsugami, T. R., & Chiba, T. (2002) · Anatomy and Embryology · doi:10.1007/s00429-002-0254-9 · Cited by 35 · see citing works
Bladder inflammation and hypogastric neurectomy influence uterine motility in the rat
Dmitrieva, N., Johnson, O. L., & Berkley, K. J. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02247-9 · Cited by 35 · see citing works
Self-citationBrüggemann, J., Shi, T., & Apkarian, A. V. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01512-6 · Cited by 34 · see citing works
Wall, P. D., Hubscher, C. H., & Berkley, K. J. (1993) · Brain Research · doi:10.1016/0006-8993(93)90803-u · Cited by 29 · see citing works
Self-citationSILENT PYONEPHROSIS AS A CAUSE OF CHRONIC ILL-HEALTH
Kirk, D. (1982) · The Lancet · doi:10.1016/s0140-6736(82)92621-6 · Cited by 9 · see citing works
Silent myocardial ischaemia: clinical relevance and treatment
Kaski, J. C., Cosı́n-Sales, J., & Espliguero, R. A. (2005) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.14.4.423 · Cited by 7 · see citing works
Influence of estradiol on micturition thresholds in the rat: involvement of the hypogastric nerve
Dmitrieva, N., & Berkley, K. J. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00468.2005 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 5
- Dmitrieva N, Berkley KJ. Contrasting effects of WIN 55212-2 on motility of the rat bladder and uterus. J Neurosci 2002;22:7147-53.
- Berkley KJ, Hubscher CH. Are there separate central nervous system pathways for touch and pain? Nat Med 1995;1:766 -73.
- Kaski JC, Cosin Sales J, Arroyo Espliguero R. Silent myocardial ischaemia: clinical relevance and treatment. Expert Opin Investig Drugs 2005;14:423-34.
- Buchholz NP, Abbas F, Afzal M, Khan R, Rizvi I, Talati J. The prevalence of silent kidney stones-an ultrasonographic screening study. JPMA J Pak Med Assoc 2003;53:24 -5.
- Sheffield JS, Cunningham FG. Urinary tract infection in women. Obstet Gynecol 2005;106:1085-92.
Cited by
Sorted by citations
Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications
Stratton, P., & Berkley, K. J. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmq050 · Cited by 442 · see citing works
Self-citationPeripheral changes in endometriosis-associated pain
Morotti, M., Vincent, K., Brawn, J., Zondervan, K. T., & Becker, C. M. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu021 · Cited by 198 · see citing works
McAllister, S. L., McGinty, K. A., Resuehr, D., & Berkley, K. J. (2009) · Pain · doi:10.1016/j.pain.2009.09.022 · Cited by 59 · see citing works
Self-citationNagabukuro, H., & Berkley, K. J. (2007) · Pain · doi:10.1016/j.pain.2007.04.039 · Cited by 47 · see citing works
Self-citation
- Authors
- Morrison, T. C., Dmitrieva, N., Winnard, K. P., & Berkley, K. J.
- Affiliations
- Florida State University (US)
- Corresponding author
- Berkley, Karen J.
- ORCID
- Dmitrieva, Natalia
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2006-10
- Volume
- 86
- Issue
- 4
- Pages
- 1067-1073
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2055999473
- Cited by
- 35
- References
- 50
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 2
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R21DK063937)
- National Institute of Neurological Disorders and Stroke (R01NS011892)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
- Keywords
- surgically induced endometriosis, urinary bladder, cystitis, cystometry, Evans blue extravasation, subtotal hysterectomy, turpentine
- MeSH terms
- Abdomen, Animals, Urinary Bladder, Cystitis, Differential Threshold, Disease Models, Animal, Coloring Agents, Endometriosis, Evans Blue, Female, Urination, Rats, Sprague-Dawley, Rats
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