Cited by 288Pain Mechanisms and TreatmentsCannabis and Cannabinoid ResearchIon Channels and Receptors

The DOI matches its Crossref record; 67 of the 70 references it cites were found in a registry or an index.

The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPARγ receptors and neurotrophic factors

Costa, Barbara, Comelli, Francesca, Bettoni, Isabella, Colleoni, Mariapia, Giagnoni, Gabriella·2008·Pain

DOI 10.1016/j.pain.2008.06.003

Open this paper in CoChat — free account

Abstract

Palmitoylethanolamide (PEA) is an endogenous lipid that is thought to be involved in endogenous protective mechanisms activated as a result of stimulation of inflammatory response. In spite of the well demonstrated anti-inflammatory properties of PEA, its involvement in controlling pain pathways still remains poorly characterized. On this basis, we tested the efficacy of PEA in vivo against a peculiar persistent pain, such as neuropathic one. PEA was administered i.p. to mice with chronic constriction injury of sciatic nerve (CCI) once a day for one week starting the day after the lesion. This therapeutic regimen evoked a relief of both thermal hyperalgesia and mechanical allodynia in neuropathic mice. Various selective receptor antagonists were used in order to clarify the relative contribution of cannabinoid, vanilloid and peroxisome proliferator-activated receptor to PEA-induced effects. The results indicated that CB(1), PPARgamma and TRPV1 receptors mediated the antinociception induced by PEA, suggesting that the most likely mechanism might be the so-called "entourage effect" due to the PEA-induced inhibition of the enzyme catalyzing the endocannabinoid anandamide (AEA) degradation that leads to an enhancement of its tissue levels thus increasing its analgesic action. In addition, the hypothesis that PEA might act through the modulation of local mast cells degranulation is sustained by our findings showing that PEA significantly reduced the production of many mediators such as TNFalpha and neurotrophic factors, like NGF. The findings presented here, in addition to prove the beneficial effects of PEA in chronic pain, identify new potential targets for analgesic medicine.

Integrity signals

Registry

Crossref · 10.1016/j.pain.2008.06.003

Cites

67 of 67 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Ethical guidelines for investigations of experimental pain in conscious animals.
Zimmermann, M. (1983) · Pain · doi:10.1016/0304-3959(83)90201-4 · Cited by 7,762
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H.-H., Sørgård, M., Di Marzo, V., Julius, D., & Högestätt, E. D. (1999) · Nature · doi:10.1038/22761 · Cited by 2,142
Control of pain initiation by endogenous cannabinoids
Calignano, A., Rana, G. L., Giuffrida, A., & Piomelli, D. (1998) · Nature · doi:10.1038/28393 · Cited by 1,069
NEUROTROPHINS: Mediators and Modulators of Pain
Pezet, S., & McMahon, S. B. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112929 · Cited by 890
Molecular Characterization of a Phospholipase D Generating Anandamide and Its Congeners
Okamoto, Y., Morishita, J., Tsuboi, K., Tonai, T., & Ueda, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306642200 · Cited by 800
Immune and inflammatory mechanisms in neuropathic pain
Moalem‐Taylor, G., & Tracey, D. J. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.11.004 · Cited by 781
An anorexic lipid mediator regulated by feeding
de Fonseca, F. R., Navarro, M. A., de Heras, R. G., Escuredo, L., Nava, F. A., Fu, J., Murillo‐Rodríguez, E., Giuffrida, A., LoVerme, J., Gaetani, S., et al. (2001) · Nature · doi:10.1038/35102582 · Cited by 695
Nerve growth factor: from neurotrophin to neurokine
Levi‐Montalcini, R., Skaper, S. D., Toso, R. D., Petrelli, L., & Leon, A. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10058-8 · Cited by 686

Flagged first, then by citations

Show all 70 references

3 of the 70 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Jack, 1996, Aliamides: a new approach to the treatment of inflammation., Drug News Perspectives, 9, 93

Sorted by citations

Items 101–200 of 288

Palmitoylethanolamide Reverses Paclitaxel-Induced Allodynia in Mice
Donvito, G., Wilkerson, J. L., Damaj, M. I., & Lichtman, A. H. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.236182 · Cited by 50
Synthesis and biological evaluation of new potential inhibitors of N-acylethanolamine hydrolyzing acid amidase
Saturnino, C., Petrosino, S., Ligresti, A., Palladino, C., Martino, G., Bisogno, T., & Marzo, V. D. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.11.134 · Cited by 49
Biosynthesis and Fate of Endocannabinoids
Cascio, M. G., & Marini, P. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-20825-1_2 · Cited by 53
Micronized Palmitoylethanolamide Reduces the Symptoms of Neuropathic Pain in Diabetic Patients
Schifilliti, C., Cucinotta, L., Fedele, V., Ingegnosi, C., Luca, S., & Leotta, C. (2014) · Pain Research and Treatment · doi:10.1155/2014/849623 · Cited by 48
Genetic contributions to the etiology of anorexia nervosa: new perspectives in molecular diagnosis and treatment
Paolacci, S., Kiani, A. K., Manara, E., Beccari, T., Ceccarini, M. R., Stuppia, L., Chiurazzi, P., Dalla Ragione, L., & Bertelli, M. (2020) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.1244 · Cited by 47
Palmitoylethanolamide Protects Dentate Gyrus Granule Cells via Peroxisome Proliferator-Activated Receptor-Alpha
Koch, M., Kreutz, S., Böttger, C., Benz, A., Maronde, E., Ghadban, C., Korf, H., & Dehghani, F. (2010) · Neurotoxicity Research · doi:10.1007/s12640-010-9166-2 · Cited by 46
Cannabinoids: Potential Role in Inflammatory and Neoplastic Skin Diseases
Milando, R., & Friedman, A. (2018) · American Journal of Clinical Dermatology · doi:10.1007/s40257-018-0410-5 · Cited by 50
Skin Matters: A Review of Topical Treatments for Chronic Pain. Part Two: Treatments and Applications
Peppin, J. F., Albrecht, P. J., Argoff, C. E., Gustorff, B., Pappagallo, M., Rice, F. L., & Wallace, M. S. (2015) · Pain and Therapy · doi:10.1007/s40122-015-0032-z · Cited by 46
Peroxisome proliferator-activated receptor agonists modulate neuropathic pain: a link to chemokines?
Freitag, C. M., & Miller, R. J. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00238 · Cited by 46
Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6, and TNF-α in a mouse model of neuropathic pain
Gopalsamy, B., Farouk, A. A. O., Mohamad, T. A. S. T., Sulaiman, M. R., & Perimal, E. K. (2017) · Journal of Pain Research · doi:10.2147/jpr.s143024 · Cited by 45
Functional and biochemical interaction between PPARα receptors and TRPV1 channels: Potential role in PPARα agonists-mediated analgesia
Ambrosino, P., Soldovieri, M. V., Maria, M. D., Russo, C., & Taglialatela, M. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.06.015 · Cited by 44
Topical Application of Adelmidrol + Trans-Traumatic Acid Enhances Skin Wound Healing in a Streptozotocin-Induced Diabetic Mouse Model
Siracusa, R., Impellizzeri, D., Cordaro, M., Gugliandolo, E., Peritore, A. F., Paola, R. D., & Cuzzocrea, S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00871 · Cited by 43
Endocannabinoid signaling and its regulation by nutrients
Bisogno, T., & Maccarrone, M. (2014) · BioFactors · doi:10.1002/biof.1167 · Cited by 42
An Analysis of Endocannabinoid Concentrations and Mood Following Singing and Exercise in Healthy Volunteers
Stone, N. L., Millar, S., Herrod, P., Barrett, D. A., Ortori, C. A., Mellon, V. A., & O’Sullivan, S. E. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00269 · Cited by 46
Cannabidivarin for HIV‐Associated Neuropathic Pain: A Randomized, Blinded, Controlled Clinical Trial
Eibach, L., Scheffel, S., Cardebring, M., Lettau, M., Celik, M. Ö., Morguet, A. J., Roehle, R., & Stein, C. (2020) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.2016 · Cited by 44
Targeting the endocannabinoid system for the treatment of abdominal pain in irritable bowel syndrome
Brierley, S. M., Meerveld, B. G., Sarnelli, G., Sharkey, K. A., Storr, M., & Tack, J. F. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00682-y · Cited by 41
Diacerein is a potent and selective inhibitor of palmitoylethanolamide inactivation with analgesic activity in a rat model of acute inflammatory pain
Petrosino, S., Ahmad, A., Marcolongo, G., Esposito, E., Allarà, M., Verde, R., Cuzzocrea, S., & Marzo, V. D. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.10.008 · Cited by 41
Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats
Rea, K., Olango, W. M., Harhen, B., Kerr, D. M., Galligan, R., Fitzgerald, S. T., Moore, M., Roche, M., & Finn, D. P. (2012) · Pain · doi:10.1016/j.pain.2012.12.021 · Cited by 41
Inhibition of the Soluble Epoxide Hydrolase as an Analgesic Strategy: A Review of Preclinical Evidence
Wang, Y., Wagner, K. M., Morisseau, C. H. P., & Hammock, B. D. (2021) · Journal of Pain Research · doi:10.2147/jpr.s241893 · Cited by 43
Chapter 13 PPAR and Pain
Maeda, T., & Kishioka, S. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)85013-7 · Cited by 42
Antiepileptogenic Effect of Subchronic Palmitoylethanolamide Treatment in a Mouse Model of Acute Epilepsy
Post, J. M., Loch, S., Lerner, R., Remmers, F., Lomazzo, E., Lutz, B., & Bîndilă, L. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00067 · Cited by 41
Bioactive lipids ALIAmides differentially modulate inflammatory responses of distinct subsets of primary human T lymphocytes
Chiurchiù, V., Leuti, A., Smoum, R., Mechoulam, R., & Maccarrone, M. (2018) · The FASEB Journal · doi:10.1096/fj.201800107r · Cited by 39
Misdiagnosed Chronic Pelvic Pain: Pudendal Neuralgia Responding to a Novel Use of Palmitoylethanolamide: Table 1
Calabrò, R. S., Gervasi, G., Marino, S., Mondo, P. N., & Bramanti, P. (2010) · Pain Medicine · doi:10.1111/j.1526-4637.2010.00823.x · Cited by 39
Transdermal application of diacerin loaded-terpene enriched invasomes: an approach to augment anti-edema and nociception inhibition activity
Ahmed, S., Farag, M. M., Sadek, M. A., & Aziz, D. E. (2024) · Journal of Liposome Research · doi:10.1080/08982104.2024.2382974 · Cited by 37
Non-psychotropic analgesic drugs from the endocannabinoid system: “Magic bullet” or “multiple-target” strategies?
Starowicz, K., & Marzo, V. D. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.01.075 · Cited by 39
High Levels of N-Palmitoylethanolamide and N-Stearoylethanolamide in Microdialysate Samples from Myalgic Trapezius Muscle in Women
Ghafouri, N., Ghafouri, B., Larsson, B. K., Turkina, M. V., Karlsson, L., Fowler, C. J., & Gerdle, B. U. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027257 · Cited by 37
An Introduction to Pain Pathways and Pain “Targets”
Das, V. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.01.003 · Cited by 44
Adelmidrol, a palmitoylethanolamide analogue, as a new pharmacological treatment for the management of acute and chronic inflammation
Impellizzeri, D., Paola, R. D., Cordaro, M., Gugliandolo, E., Casili, G., Morittu, V. M., Britti, D., Esposito, E., & Cuzzocrea, S. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.09.001 · Cited by 36
The Role of Metabolism in Migraine Pathophysiology and Susceptibility
Grech, O., Mollan, S. P., Wakerley, B. R., Fulton, D. J., Lavery, G. G., & Sinclair, A. J. (2021) · Life · doi:10.3390/life11050415 · Cited by 36
Mediterranean Diet and Neurodegenerative Diseases: The Neglected Role of Nutrition in the Modulation of the Endocannabinoid System
Armeli, F., Bonucci, A., Maggi, E., Pinto, A., & Businaro, R. (2021) · Biomolecules · doi:10.3390/biom11060790 · Cited by 40
N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism
Okine, B. N., Madasu, M. K., McGowan, F., Prendergast, C., Gaspar, J. C., Harhen, B., Roche, M., & Finn, D. P. (2016) · Pain · doi:10.1097/j.pain.0000000000000687 · Cited by 33
Food-Derived Natural Compounds for Pain Relief in Neuropathic Pain
Lim, E. Y., & Kim, Y. T. (2016) · BioMed Research International · doi:10.1155/2016/7917528 · Cited by 33
Effects of Add-On Ultramicronized N-Palmitol Ethanol Amide in Patients Suffering of Migraine With Aura: A Pilot Study
Chirchiglia, D., Cione, E., Caroleo, M. C., Wang, M., Mizio, G. D., Faedda, N., Giacolini, T., Siviglia, S., Guidetti, V., & Gallelli, L. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00674 · Cited by 33
The Cannabidiol Analog PECS-101 Prevents Chemotherapy-Induced Neuropathic Pain via PPARγ Receptors
da Silva, N. R., Gomes, F. I. F., Lopes, A. H., Cortez, I. L., dos Santos, J. C., Silva, C. E. A., Mechoulam, R., Gomes, F. V., Cunha, T. M., & Guimarães, F. S. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01164-w · Cited by 34
Protective Effect of Palmitoylethanolamide in a Rat Model of Cystitis
Pessina, F., Capasso, R., Borrelli, F., Aveta, T., Buono, L., Valacchi, G., Fiorenzani, P., Marzo, V. D., Orlando, P., & Izzo, A. A. (2014) · The Journal of Urology · doi:10.1016/j.juro.2014.11.083 · Cited by 32
Zerumbone Modulates α2A-Adrenergic, TRPV1, and NMDA NR2B Receptors Plasticity in CCI-Induced Neuropathic Pain In Vivo and LPS-Induced SH-SY5Y Neuroblastoma In Vitro Models
Chia, J. S. M., Izham, N. A. M., Farouk, A. A. O., Sulaiman, M. R., Mustafa, S., Hutchinson, M. R., & Perimal, E. K. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00092 · Cited by 32
Role of palmitoylethanolamide (PEA) in depression: Translational evidence
Gregorio, D. D., Manchia, M., Carpiniello, B., Valtorta, F., Nobile, M., Gobbi, G., & Comai, S. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.10.117 · Cited by 34
N-of-1 Randomized Trials of Ultra-Micronized Palmitoylethanolamide in Older Patients with Chronic Pain
Germini, F., Coerezza, A., Andreinetti, L., Nobili, A., Rossi, P. D., Mari, D., Guyatt, G. H., & Marcucci, M. (2017) · Drugs & Aging · doi:10.1007/s40266-017-0506-2 · Cited by 30
N-Palmitoyl-ethanolamine (PEA) Induces Peripheral Antinociceptive Effect by ATP-Sensitive K+-Channel Activation
Romero, T. R. L., & Duarte, I. D. G. (2012) · Journal of Pharmacological Sciences · doi:10.1254/jphs.11150fp · Cited by 31
Impact of Inflammation on the Blood–Neural Barrier and Blood–Nerve Interface: From Review to Therapeutic Preview
Skaper, S. D. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.08.004 · Cited by 31
Food for Special Medical Purposes and Nutraceuticals for Pain: A Narrative Review
Casale, R., Symeonidou, Z., Ferfeli, S., Micheli, F., Scarsella, P., & Paladini, A. (2021) · Pain and Therapy · doi:10.1007/s40122-021-00239-y · Cited by 31
MiR-155 modulates the progression of neuropathic pain through targeting SGK3.
Liu, S., Zhu, B., Sun, Y., & Xie, X. (2015) · PubMed Central · Cited by 29
Chronic Pain in Dogs and Cats: Is There Place for Dietary Intervention with Micro-Palmitoylethanolamide?
Rocca, G. D., & Gamba, D. (2021) · Animals · doi:10.3390/ani11040952 · Cited by 33
The Effect of Palmitoylethanolamide on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers—A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial
Lang-Illievich, K., Klivinyi, C., Rumpold‐Seitlinger, G., Dorn, C., & Bornemann‐Cimenti, H. (2022) · Nutrients · doi:10.3390/nu14194084 · Cited by 29
Pain and beyond: fatty acid amides and fatty acid amide hydrolase inhibitors in cardiovascular and metabolic diseases
Pillarisetti, S., Alexander, C. W., & Khanna, I. (2009) · Drug Discovery Today · doi:10.1016/j.drudis.2009.08.002 · Cited by 29
Randomized Split-Mouth Study on Postoperative Effects of Palmitoylethanolamide for Impacted Lower Third Molar Surgery
Bacci, C., Cassetta, G., Emanuele, B., & Berengo, M. (2011) · ISRN Surgery · doi:10.5402/2011/917350 · Cited by 29
Efficacy of ultramicronized palmitoylethanolamide in burning mouth syndrome-affected patients: a preliminary randomized double-blind controlled trial
Ottaviani, G., Rupel, K., Gobbo, M., Poropat, A., Zoi, V., Faraon, M., Lenarda, R. D., & Biasotto, M. (2018) · Clinical Oral Investigations · doi:10.1007/s00784-018-2720-7 · Cited by 29
Recent advances in the discovery and evaluation of fatty acid amide hydrolase inhibitors
Deng, H. (2010) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2010.513378 · Cited by 28
The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain
Małek, N., Kostrzewa, M., Makuch, W., Pajak, A., Kucharczyk, M. W., Piscitelli, F., Przewłocka, B., Marzo, V. D., & Starowicz, K. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.06.012 · Cited by 28
Effect of Ultra-Micronized-Palmitoylethanolamide and Acetyl-l-Carnitine on Experimental Model of Inflammatory Pain
Ardizzone, A., Fusco, R., Casili, G., Lanza, M., Impellizzeri, D., Esposito, E., & Cuzzocrea, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041967 · Cited by 27
Non‐drug pain relievers active on non‐opioid pain mechanisms
Marchesi, N., Govoni, S. M., & Allegri, M. (2021) · Pain Practice · doi:10.1111/papr.13073 · Cited by 27
The Beneficial Effects of Ultramicronized Palmitoylethanolamide in the Management of Neuropathic Pain and Associated Mood Disorders Induced by Paclitaxel in Mice
Cristiano, C., Avagliano, C., Cuozzo, M., Liguori, F. M., Calignano, A., & Russo, R. (2022) · Biomolecules · doi:10.3390/biom12081155 · Cited by 28
HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of enteric glia
Sarnelli, G., Seguella, L., Pesce, M., Lu, J., Gigli, S., Bruzzese, E., Lattanzi, R., D’Alessandro, A., Cuomo, R., Steardo, L., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1126-4 · Cited by 27
Combination of Rehabilitative Therapy with Ultramicronized Palmitoylethanolamide for Chronic Low Back Pain: An Observational Study
Scaturro, D., Asaro, C., Lauricella, L., Tomasello, S., Varrassi, G., & Mauro, G. L. (2019) · Pain and Therapy · doi:10.1007/s40122-019-00140-9 · Cited by 26
Short-Term Efficacy of Ultramicronized Palmitoylethanolamide in Peripheral Neuropathic Pain
Cocito, D., Peci, E., Ciaramitaro, P., Merola, A., & Lopiano, L. (2014) · Pain Research and Treatment · doi:10.1155/2014/854560 · Cited by 26
The Endocannabinoid System: An Osteopathic Perspective
McPartland, J. M. (2008) · Journal of Osteopathic Medicine · doi:10.7556/jaoa.2008.108.10.586 · Cited by 26
Treatment of chronic regional pain syndrome type 1 with palmitoylethanolamide and topical ketamine cream: modulation of nonneuronal cells
Kopsky, D. J., & Hesselink, J. M. K. (2013) · Journal of Pain Research · doi:10.2147/jpr.s42417 · Cited by 25
Peroxisome Proliferator-Activated Receptor-α Inhibition Protects Against Doxorubicin-Induced Cardiotoxicity in Mice
Rahmatollahi, M., Baram, S. M., Rahimian, R., Saravi, S. S. S., & Dehpour, A. R. (2015) · Cardiovascular Toxicology · doi:10.1007/s12012-015-9332-0 · Cited by 25
Inhibitory effect of topical Adelmidrol on antigen-induced skin wheal and mast cell behavior in a canine model of allergic dermatitis
Cerrato, S., Brazís, P., della Valle, M. F., Miolo, A., & Puigdemont, A. (2012) · BMC Veterinary Research · doi:10.1186/1746-6148-8-230 · Cited by 25
Pharmacokinetic-pharmacodynamic influence of N-palmitoylethanolamine, arachidonyl-2′-chloroethylamide and WIN 55,212-2 on the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice
Citraro, R., Russo, E., Leo, A., Russo, R., Avagliano, C., Navarra, M., Calignano, A., & Sarro, G. D. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.09.029 · Cited by 25
Palmitoylethanolamide Regulates Development of Intestinal Radiation Injury in a Mast Cell-Dependent Manner
Wang, J., Zheng, J., Kulkarni, A., Wang, W., Garg, S., Prather, P. L., & Hauer‐Jensen, M. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3212-5 · Cited by 24
Zerumbone Ameliorates Neuropathic Pain Symptoms via Cannabinoid and PPAR Receptors Using In Vivo and In Silico Models
Chia, J. S. M., Farouk, A. A. O., Mohamad, T. A. S. T., Sulaiman, M. R., Zakaria, H., Hassan, N. I., & Perimal, E. K. (2021) · Molecules · doi:10.3390/molecules26133849 · Cited by 23
Analgesic Action of Catechin on Chronic Constriction Injury–Induced Neuropathic Pain in Sprague–Dawley Rats
Foudah, A. I., Alqarni, M. H., Devi, S., Singh, A., Alam, A., Alam, P., & Singh, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.895079 · Cited by 23
Palmitoylethanolamide in the Treatment of Failed Back Surgery Syndrome
Paladini, A., Varrassi, G., Bentivegna, G., Carletti, S., Piroli, A., & Coaccioli, S. (2017) · Pain Research and Treatment · doi:10.1155/2017/1486010 · Cited by 23
Adelmidrol + sodium hyaluronate in IC/BPS or conditions associated to chronic urothelial inflammation. A translational study
Ostardo, E., Impellizzeri, D., Cervigni, M., Porru, D., Sommariva, M., Cordaro, M., Siracusa, R., Fusco, R., Gugliandolo, E., Crupi, R., et al. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.05.013 · Cited by 22
The Protective Effects of Pre- and Post-Administration of Micronized Palmitoylethanolamide Formulation on Postoperative Pain in Rats
Siracusa, R., Fusco, R., Cordaro, M., Peritore, A. F., D’Amico, R., Gugliandolo, E., Crupi, R., Genovese, T., Evangelista, M., Paola, R. D., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207700 · Cited by 21
Chronic idiopathic axonal neuropathy and pain, treated with the endogenous lipid mediator palmitoylethanolamide: a case collection
Hesselink, J. M. K. (2013) · International Medical Case Reports Journal · doi:10.2147/imcrj.s51572 · Cited by 21
Ultramicronized N-palmitoylethanolamine associated with analgesics: Effects against persistent pain
Nobili, S., Micheli, L., Lucarini, E., Toti, A., Ghelardini, C., & Mannelli, L. D. C. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108649 · Cited by 22
Alterations in the Anandamide Metabolism in the Development of Neuropathic Pain
Małek, N., Kucharczyk, M. W., & Starowicz, K. (2014) · BioMed Research International · doi:10.1155/2014/686908 · Cited by 19
Synergistic antinociceptive interaction between palmitoylethanolamide and tramadol in the mouse formalin test
Déciga‐Campos, M., Ramírez-Marín, P. M., & López‐Muñoz, F. J. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.08.025 · Cited by 19
Effects of Dual Peroxisome Proliferator-Activated Receptors α and γ Activation in Two Rat Models of Neuropathic Pain
Alsalem, M., Haddad, M., Aldossary, S. A., Kalbouneh, H., Azab, B., Dweik, A., Imraish, A., & El‐Salem, K. (2019) · PPAR Research · doi:10.1155/2019/2630232 · Cited by 19
A next generation sequencing gene panel for use in the diagnosis of anorexia nervosa
Ceccarini, M. R., Precone, V., Manara, E., Paolacci, S., Maltese, P. E., Benfatti, V., Dhuli, K., Donato, K., Guerri, G., Marceddu, G., et al. (2021) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-021-01331-0 · Cited by 19
Involvement of the L‐arginine/nitric oxide/cyclic guanosine monophosphate pathway in peripheral antinociception induced by N‐palmitoyl‐ethanolamine in rats
Romero, T. R. L., Galdino, G. S., da Silva, G. C., Resende, L. C., Perez, A. C., Côrtes, S. F., & Duarte, I. D. G. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.22797 · Cited by 19
The Interaction Between Intrathecal Administration of Low Doses of Palmitoylethanolamide and AM251 in Formalin-Induced Pain Related Behavior and Spinal Cord IL1-β Expression in Rats
Naderi, N., Majidi, M., Mousavi, Z., Tusi, S. K., Mansouri, Z., & Khodagholi, F. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0672-2 · Cited by 19
A catalyst-free, waste-less ethanol-based solvothermal synthesis of amides
Dalu, F., Scorciapino, M. A., Cara, C., Luridiana, A., Musinu, A., Casu, M., Secci, F., & Cannas, C. (2017) · Green Chemistry · doi:10.1039/c7gc02967e · Cited by 18
Anti-inflammatory activity of palmitoylethanolamide ameliorates osteoarthritis induced by monosodium iodoacetate in Sprague–Dawley rats
Jung, J. I., Lee, H. S., Jeon, Y. E., Kim, S. M., Hong, S. H., Moon, J. M., Lim, C. Y., Kim, Y. H., & Kim, E. J. (2021) · Inflammopharmacology · doi:10.1007/s10787-021-00870-3 · Cited by 19
Therapeutic Potential of Palmitoylethanolamide in Gastrointestinal Disorders
Branković, M., Gmizić, T., Dukić, M., Zdravkovic, M. D., Daskalovic, B., Mrda, D., Nikolić, N., Brajković, M., Gojgić, M., Lalatović, J., et al. (2024) · Antioxidants · doi:10.3390/antiox13050600 · Cited by 19
Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy
Didangelos, T., Karlafti, E., Kotzakioulafi, E., Giannoulaki, P., Kontoninas, Z., Kontana, A., Evripidou, P., Savopoulos, C., Birkenfeld, A. L., & Kantartzis, K. (2024) · Nutrients · doi:10.3390/nu16183045 · Cited by 18
The role of transient receptor potential vanilloid receptor 1 and peroxisome proliferator-activated receptors-α in mediating the antinociceptive effects of palmitoylethanolamine in rats
Aldossary, S. A., Alsalem, M., Kalbouneh, H., Haddad, M., Azab, B., Al-Shboul, O. A., Mustafa, A., Obiedat, S., & El‐Salem, K. (2018) · Neuroreport · doi:10.1097/wnr.0000000000001161 · Cited by 18
The Potential Benefits of Palmitoylethanolamide in Palliation: A Qualitative Systematic Review
Davis, M. P., Behm, B., Mehta, Z. Y., & Fernandez, C. (2019) · American Journal of Hospice and Palliative Medicine® · doi:10.1177/1049909119850807 · Cited by 20
Is there a role for palmitoylethanolamide in the treatment of depression?
Coppola, M., & Mondola, R. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2013.12.016 · Cited by 19
Palmitoylethanolamide (PEA)—‘Promiscuous’ anti-inflammatory and analgesic molecule at the interface between nutrition and pharma
Hesselink, J. M. K., Kopsky, D. J., & Witkamp, R. F. (2013) · PharmaNutrition · doi:10.1016/j.phanu.2013.11.127 · Cited by 18
Efficacy of a Combination of N-Palmitoylethanolamide, Beta-Caryophyllene, Carnosic Acid, and Myrrh Extract on Chronic Neuropathic Pain: A Preclinical Study
Fotio, Y., Alaoui, A. A. E., Borruto, A. M., Acciarini, S., Giordano, A., & Ciccocioppo, R. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00711 · Cited by 18
Activation of Neuronal FLT3 Promotes Exaggerated Sensorial and Emotional Pain-Related Behaviors Facilitating the Transition from Acute to Chronic Pain
Tassou, A., Thouaye, M., Gilabert, D., Jouvenel, A., Leyris, J.-P., Sonrier, C., Diouloufet, L., Méchaly, I., Mallié, S., Bertin, J., et al. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2023.102405 · Cited by 18
Spinal nociceptive sensitization and plasma palmitoylethanolamide levels during experimentally induced migraine attacks
Icco, R. D., Greco, R., Demartini, C., Vergobbi, P., Zanaboni, A., Tumelero, E., Reggiani, A. M., Realini, N., Sances, G., Grillo, V., et al. (2021) · Pain · doi:10.1097/j.pain.0000000000002223 · Cited by 17
Effects of dietary CLA on n-3 HUFA score and N-acylethanolamides biosynthesis in the liver of obese Zucker rats
Piras, A., Carta, G., Murru, E., Lopes, P. A., Martins, S. V., Prates, J. A. M., & Banni, S. (2015) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2015.04.004 · Cited by 17
Palmitoylethanolamide: A Multifunctional Molecule for Neuroprotection, Chronic Pain, and Immune Modulation
Stefano, V. D., Steardo, L., D’Angelo, M., Monaco, F., & Steardo, L. (2025) · Biomedicines · doi:10.3390/biomedicines13061271 · Cited by 20
Ultramicronized N-palmitoylethanolamine Contributes to Morphine Efficacy Against Neuropathic Pain: Implication of Mast Cells and Glia
Micheli, L., Lucarini, E., Nobili, S., Bartolucci, G., Pallecchi, M., Toti, A., Ferrara, V., Ciampi, C., Ghelardini, C., & Mannelli, L. D. C. (2022) · Current Neuropharmacology · doi:10.2174/1570159x21666221128091453 · Cited by 18
Use of palmitoylethanolamide in carpal tunnel syndrome: a prospective randomized study
Faig‐Martí, J., & Martínez‐Catasús, A. (2017) · Journal of Orthopaedics and Traumatology · doi:10.1007/s10195-017-0453-z · Cited by 16
Do cannabinoids have a role in cancer pain management?
Farquhar-Smith, W. P. (2009) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e3283260612 · Cited by 15
Micronized Palmitoylethanolamide: A Post Hoc Analysis of a Controlled Study in Patients with Low Back Pain – Sciatica
Cruccu, G., Stefano, G. D., Marchettini, P., & Truini, A. (2019) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527318666190703110036 · Cited by 15
N‐docosahexaenoyl ethanolamine (synaptamide) has antinociceptive effects in male mice
Paton, K. F., Shirazi, R. S., Vyssotski, M. V., & Kivell, B. M. (2020) · European Journal of Pain · doi:10.1002/ejp.1641 · Cited by 15
Palmitoylethanolamide for sleep disturbance. A double-blind, randomised, placebo-controlled interventional study
Rao, A., Ebelt, P., Mallard, A. R., & Briskey, D. R. (2021) · Sleep Science and Practice · doi:10.1186/s41606-021-00065-3 · Cited by 16
Fatty Acid Amide Hydrolase (FAAH) Inhibitors Exert Pharmacological Effects, but Lack Antinociceptive Efficacy in Rats with Neuropathic Spinal Cord Injury Pain
Hama, A. T., Germano, P., Varghese, M. S., Cravatt, B. F., Milne, G. T., Pearson, J. P., & Sagen, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096396 · Cited by 15
Role of G Protein-coupled Orphan Receptors in Intestinal Inflammation
Wasilewski, A., Storr, M., Zielińska, M., & Fichna, J. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000258 · Cited by 15
Pharmacological Blockade of PPARα Exacerbates Inflammatory Pain-Related Impairment of Spatial Memory in Rats
Gaspar, J. C., Healy, C. R., Ferdousi, M. I., Roche, M., & Finn, D. P. (2021) · Biomedicines · doi:10.3390/biomedicines9060610 · Cited by 14
Transient receptor potential vanilloid (TRPV) channels: Basal properties and physiological potential
Sasase, T., Fatchiyah, F., & Ohta, T. (2022) · General Physiology and Biophysics · doi:10.4149/gpb_2022016 · Cited by 13
The association of adelmidrol with sodium hyaluronate displays beneficial properties against bladder changes following spinal cord injury in mice
Campolo, M., Siracusa, R., Cordaro, M., Filippone, A., Gugliandolo, E., Peritore, A. F., Impellizzeri, D., Crupi, R., Paterniti, I., & Cuzzocrea, S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0208730 · Cited by 13
The Influence of Dietary Supplementations on Neuropathic Pain
D’Egidio, F., Lombardozzi, G., Kacem, H., Mastroiacovo, G., Alfonsetti, M., & Cimini, A. (2022) · Life · doi:10.3390/life12081125 · Cited by 17
Post-COVID-19 Anosmia and Therapies: Stay Tuned for New Drugs to Sniff Out
Riccardi, G., Niccolini, G. F., Bellizzi, M. G., Fiore, M., Minni, A., & Barbato, C. (2023) · Diseases · doi:10.3390/diseases11020079 · Cited by 13

Authors: Costa, B., Comelli, F., Bettoni, I., Colleoni, M., & Giagnoni, G.
Affiliations: University of Milano-Bicocca (IT)
University of Milan (IT)
Corresponding author: Costa, Barbara
ORCID: Costa, Barbara
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2008-10-31
Volume: 139
Issue: 3
Pages: 541-550
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/j.pain.2008.06.003
OpenAlex: W2162105352
Cited by: 286
References: 70
Citations by year: 2026: 5 · 2025: 6 · 2024: 11 · 2023: 11 · 2022: 15 · 2021: 20 · 2020: 17 · 2019: 17 · 2018: 20 · 2017: 18 · 2016: 18 · 2015: 19 · 2014: 22 · 2013: 23 · 2012: 19
FWCI: 10.41
Type: journal article
Language: en
Open access: closed
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
BOA (University of Milano-Bicocca) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: palmitoylethanolamide, neuropathic pain, chronic constriction injury, thermal hyperalgesia, mechanical allodynia, CB1 receptor, TRPV1 receptor, PPARγ, entourage effect, mast cell degranulation, TNF-α, nerve growth factor, neurotrophic factors, analgesic mechanism
MeSH terms: Amides, Animals, Cytoplasmic Granules, Drug Evaluation, Preclinical, Ethanolamines, Hot Temperature, Hyperalgesia, Ligation, Mast Cells, Nerve Growth Factors, Palmitic Acids, Physical Stimulation, Sciatic Nerve, Sciatica, Spinal Cord, Touch, Tumor Necrosis Factor-alpha, NF-kappa B, Analgesics, Non-Narcotic, Receptor, Cannabinoid, CB1, PPAR alpha, PPAR gamma, TRPV Cation Channels, Mice, Endocannabinoids

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPARγ receptors and neurotrophic factors

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks