The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach
Open accessAbstract
Lamina II contains a large number of interneurons involved in modulation and transmission of somatosensory (including nociceptive) information. However, its neuronal circuitry is poorly understood due to the difficulty of identifying functional populations of interneurons. This information is important for understanding nociceptive processing and for identifying changes that underlie chronic pain. In this study, we compared morphology, neurotransmitter content, electrophysiological and pharmacological properties for 61 lamina II neurons recorded in slices from adult rat spinal cord. Morphology was related to transmitter content, since islet cells were GABAergic, while radial and most vertical cells were glutamatergic. However, there was considerable diversity among the remaining cells, some of which could not be classified morphologically. Transmitter phenotype was related to firing pattern, since most (18/22) excitatory cells, but few (2/23) inhibitory cells had delayed, gap or reluctant patterns, which are associated with A-type potassium (I(A)) currents. Somatostatin was identified in axons of 14/24 excitatory neurons. These had variable morphology, but most of those tested showed delayed-firing. Excitatory interneurons are therefore likely to contribute to pain states associated with synaptic plasticity involving I(A) currents. Although noradrenaline and serotonin evoked outward currents in both inhibitory and excitatory cells, somatostatin produced these currents only in inhibitory neurons, suggesting that its pro-nociceptive effects are mediated by disinhibition. Our results demonstrate that certain distinctive populations of inhibitory and excitatory interneuron can be recognised in lamina II. Combining this approach with identification of other neurochemical markers should allow further clarification of neuronal circuitry in the superficial dorsal horn.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Melzack, R., & Wall, P. D. (1965) · Science · doi:10.1126/science.150.3699.971 · Cited by 11,090
Melzack, R., & Wall, P. D. (1996) · Pain Forum · doi:10.1016/s1082-3174(96)80062-6 · Cited by 2,784
The cytoarchitectonic organization of the spinal cord in the cat
Rexed, B. (1952) · Journal of Comparative Neurology · doi:10.1002/cne.900960303 · Cited by 1,632
Sensory Mechanisms of the Spinal Cord
Willis, W. D., & Coggeshall, R. E. (1978) · Springer eBooks · doi:10.1007/978-1-4757-1688-7 · Cited by 1,456
Wall and Melzack's Textbook of Pain
McMahon, S. B., & Koltzenburg, M. (2005) · Cited by 1,014
Light, A. R., & Perl, E. R. (1979) · Journal of Comparative Neurology · doi:10.1002/cne.901860203 · Cited by 799
Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity
Ji, R.-R., Baba, H., Brenner, G. J., & Woolf, C. J. (1999) · Nature Neuroscience · doi:10.1038/16040 · Cited by 783
Central Projections of Identified, Unmyelinated (C) Afferent Fibers Innervating Mammalian Skin
Sugiura, Y., Lee, C. L., & Perl, E. R. (1986) · Science · doi:10.1126/science.3764416 · Cited by 669
Chaudhry, F. A., Reimer, R. J., Bellocchio, E. E., Danbolt, N. C., Osen, K. K., Edwards, R. H., & Storm-Mathisen, J. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09733.1998 · Cited by 634
Todd, A. J., & Sullivan, A. C. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.902960312 · Cited by 500
Self-citation
Cited by
Neuronal circuitry for pain processing in the dorsal horn
Todd, A. J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2947 · Cited by 1,475
Self-citationIdentification of Spinal Circuits Transmitting and Gating Mechanical Pain
Duan, B., Cheng, L., Bourane, S., Britz, O., Padilla, C., Garcia-Campmany, L., Krashes, M., Knowlton, W., Velasquez, T., Ren, X., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.003 · Cited by 582
The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn
Abraira, V. E., Kuehn, E. D., Chirila, A. M., Springel, M. W., Toliver, A. A., Zimmerman, A. L., Orefice, L. L., Boyle, K. A., Bai, L., Song, B. J., et al. (2017) · Cell · doi:10.1016/j.cell.2016.12.010 · Cited by 409
“Current injections into randomly chosen neurons revealed neuronal types exhibiting diverse firing patterns, including single spiking, initial bursting, phasic, delayed, gap, regular spiking, and tonic firing patterns (Figures 1H and 1I), some of which had been observed previously in the rodent superficial dorsal horn…”
Self-citationSomatostatin-expressing neurons in cortical networks
Urban-Ciecko, J., & Barth, A. L. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.53 · Cited by 374
Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord
Kardon, A. P., Polgár, E., Hachisuka, J., Snyder, L. M., Cameron, D., Savage, S., Cai, X., Karnup, S., Fan, C. R., Hemenway, G. M., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.046 · Cited by 369
Self-citation
Metadata
- Authors
- Yasaka, T., Tiong, S. Y. X., Hughes, D. I., Riddell, J. S., & Todd, A. J.
- Venue
- Pain
- Published
- 2010-11
- Volume
- 151
- Issue
- 2
- Pages
- 475-488
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2061340270
- Cited by
- 313
- References
- 65
- FWCI
- 10.84
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach. https://app.cochat.ai/papers/10.1016/j.pain.2010.08.008
- The paper
- Yasaka, T., Tiong, S. Y. X., Hughes, D. I., Riddell, J. S., & Todd, A. J. (2010). Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach. Pain. https://doi.org/10.1016/j.pain.2010.08.008
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
