Asymmetry of tremor intensity and frequency in parkinson's disease and essential tremor
Abstract
We investigated the asymmetry of tremor intensity, frequency and frequency dispersion of Parkinsonian (PT) and essential (ET) tremor using accelerometry. Data of the more and less trembling hands were statistically elaborated. We found that tremor intensity was significantly asymmetric not only in PT but also in ET, while frequency and frequency dispersion were symmetric in ET but asymmetric in PT. We conclude that bilateral assessment of frequency related tremor parameters may be used for differentiation between ET and PT, and provides further details on the central organization of tremor generators.
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Farkas et al. (2006) found a significant difference in bilateral asymmetry of tremor intensity between PD and ET under a writing context.
“Farkas et al. (2006) used a pen-like tube to record a combination of resting and postural tremor under a writing context, and found a significant difference in bilateral asymmetry of tremor intensity between PD and ET (Farkas et al., 2006).”
From A Novel Posture for Better Differentiation Between Parkinson's Tremor and Essential Tremor (2018) · cites this paper as Farkas et al., 2006
Cites
Consensus Statement of the Movement Disorder Society on Tremor
Deuschl, G., Bain, P., & Brin, M. (2008) · Movement Disorders · doi:10.1002/mds.870131303 · Cited by 1,981 · see citing works
Hughes, A. J., Ben-Shlomo, Y., Daniel, S. E., & Lees, A. J. (1992) · Neurology · doi:10.1212/wnl.42.6.1142 · Cited by 1,313 · see citing works
Bain, P. G., Findley, L. J. J., Atchison, P. R., Behari, M., Vidailhet, M., Gresty, M. A., Rothwell, J. C., Thompson, P. D., & MARSDEN, C. D. (1993) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.56.8.868 · Cited by 443 · see citing works
Cohen, O., Pullman, S., Jurewicz, E., Watner, D., & Louis, E. D. (2003) · Archives of Neurology · doi:10.1001/archneur.60.3.405 · Cited by 298 · see citing works
Elble, R. J. (1996) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199603000-00004 · Cited by 269 · see citing works
Physiologic and essential tremor
Elble, R. J. (1986) · Neurology · doi:10.1212/wnl.36.2.225 · Cited by 231 · see citing works
The dynamics of resting and postural tremor in Parkinson's disease
Vaillancourt, D. E., & Newell, K. M. (2000) · Clinical Neurophysiology · doi:10.1016/s1388-2457(00)00467-3 · Cited by 210 · see citing works
(2000) · PubMed · Cited by 193 · see citing works
Diagnostic criteria for essential tremor and differential diagnosis.
Rj, E. (2000) · PubMed · Cited by 179 · see citing works
Essential tremor frequency decreases with time
Elble, R. J. (2000) · Neurology · doi:10.1212/wnl.55.10.1547 · Cited by 166 · see citing works
Overview of Human Tremor Physiology
Hallett, M. (2008) · Movement Disorders · doi:10.1002/mds.870131308 · Cited by 158 · see citing works
Time-frequency analysis of tremors
O'Suilleabhain, P. (1998) · Brain · doi:10.1093/brain/121.11.2127 · Cited by 157 · see citing works
Accelerometry to distinguish psychogenic from essential or parkinsonian tremor
Zeuner, K. E., Shoge, R. O., Goldstein, S. R., Dambrosia, J. M., & Hallett, M. (2003) · Neurology · doi:10.1212/01.wnl.0000076183.34915.cd · Cited by 126 · see citing works
Quantitative analysis of tremor time series.
Timmer, J., Lauk, M., & Deuschl, G. (1996) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0924-980x(96)94658-5 · Cited by 105 · see citing works
Standardization of a neuromotor test battery: the CATSYS system.
DESPRES, C., Lamoureux, D., & Beuter, A. C. (2000) · PubMed · Cited by 104 · see citing works
Findley, L. J. (1996) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199603000-00003 · Cited by 104 · see citing works
Hariz, M. I., Johansson, F., Shamsgovara, P., Johansson, E., Hariz, G., & Fagerlund, M. (2000) · Movement Disorders · doi:10.1002/1531-8257(200001)15:1 · Cited by 102 · see citing works
Factors influencing the amplitude and frequency of essential tremor
Elble, R. J., Higgins, C., Leffler, K., & Hughes, L. F. (1994) · Movement Disorders · doi:10.1002/mds.870090602 · Cited by 99 · see citing works
Is Essential Tremor Symmetric?
Louis, E. D., Wendt, K. J., Pullman, S. L., & Ford, B. (1998) · Archives of Neurology · doi:10.1001/archneur.55.12.1553 · Cited by 95 · see citing works
Anomalies of asymmetry of clinical signs in parkinsonism
Toth, C. C., Rajput, M., & Rajput, A. H. (2003) · Movement Disorders · doi:10.1002/mds.10685 · Cited by 81 · see citing works
Dynamic synchronisation of central oscillators in essential tremor
Hellwig, B., Schelter, B. O., Guschlbauer, B., Timmer, J., & Lücking, C. H. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(03)00116-0 · Cited by 75 · see citing works
Using Time Domain Characteristics to Discriminate Physiologic and Parkinsonian Tremors
Edwards, R., & Beuter, A. C. (2000) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-200001000-00009 · Cited by 74 · see citing works
Calzetti, S., Baratti, M., Gresty, M., & Findley, L. (1987) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.50.5.561 · Cited by 74 · see citing works
Spectral analysis of tremor: understanding the results.
Gresty, M. A., & Buckwell, D. (1990) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.53.11.976 · Cited by 72 · see citing works
Griggs, R. C. (2000) · Neurology · doi:10.1212/wnl.54.1.2 · Cited by 69 · see citing works
Louis, E. D., Ford, B., Pullman, S. L., & Baron, K. (1998) · Archives of Neurology · doi:10.1001/archneur.55.2.222 · Cited by 67 · see citing works
Burne, J. A., Hayes, M. W., Fung, V. S. C., Yiannikas, C., & Boljevac, D. (2002) · Journal of Clinical Neuroscience · doi:10.1054/jocn.2001.1017 · Cited by 51 · see citing works
Using Frequency Domain Characteristics to Discriminate Physiologic and Parkinsonian Tremors
Beuter, A. C., & Edwards, R. (1999) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199909000-00010 · Cited by 50 · see citing works
SIMULTANEOUS ELECTROMYOGRAMS AND ELECTROENCEPHALOGRAMS IN PARALYSIS AGITANS
Schwab, R. S., & COBB, S. S. (1939) · Journal of Neurophysiology · doi:10.1152/jn.1939.2.1.36 · Cited by 47 · see citing works
Voluntarily simulated tremor in normal subjects
Burkhard, P. R., Langston, J. W., & Tetrud, J. W. (2002) · Neurophysiologie Clinique · doi:10.1016/s0987-7053(02)00296-4 · Cited by 47 · see citing works
Carr, J. (2002) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(01)00037-2 · Cited by 39 · see citing works
Indexes for identification of abnormal tremor using computer tremor evaluation systems
Edwards, R., & Beuter, A. (1999) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.771207 · Cited by 38 · see citing works
Sensitivity and specificity of a portable system measuring postural tremor
Edwards, R., & Beuter, A. C. (1997) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(96)00179-1 · Cited by 28 · see citing works
Joint amplitude and frequency analysis of tremor activity.
Foerster, F., & Smeja, M. (1999) · PubMed · Cited by 27 · see citing works
Computerized coordination ability testing
Gyntelberg, F., Flarup, M., Mikkelsen, S. S., PALM, T., Ryom, C., & Suadicani, P. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1990.tb01585.x · Cited by 21 · see citing works
Evaluation of electronic equipment for quantitative registration of tremor
ørsnes, G. B., & Sørensen, P. S. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1998.tb00606.x · Cited by 12 · see citing works
Familial recurrent cranial nerve palsy.
Golnik, K. C., & Miller, N. R. (1992) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.10.976-a · Cited by 6 · see citing works
Flagged first, then by citations
4 of the 41 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Tremor Syndromes: An Updated Review
Lenka, A., & Jankovic, J. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.684835 · Cited by 132 · see citing works
A neurobehavioral study of current and former welders exposed to manganese
Ellingsen, D. G., Константинов, Р. В., Bast‐Pettersen, R., Merkurjeva, L., Chashchin, M. V., Thomassen, Y., & Chashchin, V. (2007) · NeuroToxicology · doi:10.1016/j.neuro.2007.08.014 · Cited by 123 · see citing works
Finger Tapping Clinimetric Score Prediction in Parkinson's Disease Using Low-Cost Accelerometers
Stamatakis, J., Ambroise, J., Crémers, J., Sharei, H., Delvaux, V., Macq, B., & Garraux, G. (2013) · Computational Intelligence and Neuroscience · doi:10.1155/2013/717853 · Cited by 108 · see citing works
A Review on Techniques for Tremor Recording and Quantification
Mansur, P. H. G., Cury, L. K. P., Andrade, A. D. O., Pereira, A. A., Miotto, G., Soares, A. B., & Naves, E. L. M. (2007) · Critical Reviews in Biomedical Engineering · doi:10.1615/critrevbiomedeng.v35.i5.10 · Cited by 100 · see citing works
Lee, H. J., Lee, W. W., Kim, S. K., Park, H.-Y., Jeon, H. S., Kim, H. B., Jeon, B. S., & Park, K. S. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.01.058 · Cited by 76 · see citing works
Tremor: From Pathogenesis to Treatment
Grimaldi, G., & Manto, M. (2008) · Synthesis Lectures on Biomedical Engineering · doi:10.1007/978-3-031-01627-1 · Cited by 28 · see citing works
Pattern Mining of Multichannel sEMG for Tremor Classification
Palmes, P., Ang, W. T., Widjaja, F., Tan, L. C. S., & Au, W. L. (2010) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2010.2076810 · Cited by 43 · see citing works
Papapetropoulos, S., Katzen, H., Scanlon, B. K., Guevara, A., Singer, C., & Levin, B. E. (2010) · Parkinson s Disease · doi:10.4061/2010/760196 · Cited by 40 · see citing works
Costa, J., González, H. A., Valldeoriola, F., Gaig, C., Tolosa, E., & Valls‐Solé, J. (2010) · Movement Disorders · doi:10.1002/mds.23334 · Cited by 33 · see citing works
Herrnstadt, G., McKeown, M. J., & Menon, C. (2019) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-019-0484-1 · Cited by 30 · see citing works
A deep explainable artificial intelligent framework for neurological disorders discrimination
Shahtalebi, S., Atashzar, S. F., Patel, R. V., Jog, M., & Mohammadi, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-88919-9 · Cited by 31 · see citing works
Admittance-Based Voluntary-Driven Motion With Speed-Controlled Tremor Rejection
Herrnstadt, G., & Menon, C. (2016) · IEEE/ASME Transactions on Mechatronics · doi:10.1109/tmech.2016.2555811 · Cited by 28 · see citing works
Hernandez, D. I., Delgado, N., McGurn, M. M., Huey, E. D., Cosentino, S., & Louis, E. D. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.782694 · Cited by 27 · see citing works
A role for accelerometry in the differential diagnosis of tremor syndromes
Bove, F. (2018) · Functional Neurology · doi:10.11138/fneur/2018.33.1.045 · Cited by 27 · see citing works
Bhidayasiri, R., Petchrutchatachart, S., Pongthornseri, R., Anan, C., Dumnin, S., & Thanawattano, C. (2014) · Journal of Parkinson s Disease · doi:10.3233/jpd-130311 · Cited by 26 · see citing works
A Novel Posture for Better Differentiation Between Parkinson's Tremor and Essential Tremor
Zhang, B., Huang, F., Liu, J., & Zhang, D. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00317 · Cited by 24 · see citing works
“Farkas et al. (2006) used a pen-like tube to record a combination of resting and postural tremor under a writing context, and found a significant difference in bilateral asymmetry of tremor intensity between PD and ET (Farkas et al., 2006).”
MethodMeasures of Fine Motor Skills in People with Tremor Disorders: Appraisal and Interpretation
Norman, K. E., & Héroux, M. E. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00050 · Cited by 18 · see citing works
Time measurement characterization of stand-to-sit and sit-to-stand transitions by using a smartphone
Rojas, H. A. G., Chaná‐Cuevas, P., Figueras, E. E. Z., Foix, S. C., & Egea, A. J. S. (2017) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-017-1728-5 · Cited by 16 · see citing works
Neurobehavioral performance of patients diagnosed with manganism and idiopathic Parkinson disease
Ellingsen, D. G., Shvartsman, G. I., Bast‐Pettersen, R., Chashchin, M. V., Thomassen, Y., & Chashchin, V. (2019) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-019-01415-6 · Cited by 15 · see citing works
Machowska-Majchrzak, A., Pierzchała, K., Pietraszek, S., & Łabuz-Roszak, B. (2011) · Neurologia i Neurochirurgia Polska · doi:10.1016/s0028-3843(14)60022-0 · Cited by 13 · see citing works
Quantitative analysis of motor performance in epilepsy patients treated with valproate
Farkas, Z., Gulyás, S., Molnár, R., Szirmai, I. G., & Kamondi, A. (2010) · Seizure · doi:10.1016/j.seizure.2010.01.013 · Cited by 13 · see citing works
Self-citationMansur, P. H. G., Cury, L. K. P., Leite, J. O. B., Pereira, A. A., Penha‐Silva, N., & Andrade, A. D. O. (2010) · BioMedical Engineering OnLine · doi:10.1186/1475-925x-9-29 · Cited by 13 · see citing works
Objective tremor registration during DBS surgery for Essential Tremor
Papapetropoulos, S., Gallo, B. V., Guevara, A., Singer, C., Mitsi, G., Lyssikatos, C., & Jagid, J. R. (2009) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2008.10.017 · Cited by 13 · see citing works
Clinical and kinematic characterization of parkinsonian soft signs in essential tremor
Angelini, L., Paparella, G., Cannavacciuolo, A., Costa, D. D., Birreci, D., Riggi, M. D., Passaretti, M., Colella, D., Guerra, A., Berardelli, A., et al. (2024) · Journal of Neural Transmission · doi:10.1007/s00702-024-02784-0 · Cited by 12 · see citing works
Machowska-Majchrzak, A., Pierzchała, K., Pietraszek, S., Labuz-Roszak, B. M., & Bartman, W. (2012) · Neurologia i Neurochirurgia Polska · doi:10.5114/ninp.2012.28257 · Cited by 12 · see citing works
Characteristics of Tremor Induced by Lesions of the Cerebellum
Kovács, A., Kiss, M., Pinter, N. K., Szirmai, I. G., & Kamondi, A. (2019) · The Cerebellum · doi:10.1007/s12311-019-01027-3 · Cited by 12 · see citing works
Self-citationDelayed beta synchronization after movement of the more affected hand in essential tremor
Tamás, G., Pálvölgyi, L., Takáts, A., Szirmai, I. G., & Kamondi, A. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.07.001 · Cited by 10 · see citing works
Self-citationLamotrigine Induces Tremor among Epilepsy Patients Probably via Cerebellar Pathways
Kovács, A., Farkas, Z., Kelemen, A., Juhos, V., Szűcs, A., & Kamondi, A. (2019) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.248.273 · Cited by 9 · see citing works
Self-citationWastensson, G., Holmberg, B., Johnels, B., & Barregård, L. (2013) · Europe PMC (PubMed Central) · doi:10.7916/d8vm4b0n · Cited by 9 · see citing works
Tremorography in the clinical practice
Govorova, T. G., Popova, T. E., & Tappakhov, A. A. (2020) · Neuromuscular Diseases · doi:10.17650/2222-8721-2019-9-4-61-72 · Cited by 6 · see citing works
Another Case of "Shopping Bag" Tremor: A Difficult to Classify Action Tremor
Robakis, D., & Louis, E. D. (2014) · PubMed Central · doi:10.7916/d84j0csn · Cited by 4 · see citing works
Tremor Measurement System for Neurological Disorders Screening
Chiuchisan, I., Chiuchisan, I., Geman, O., Milici, R.-M., & Milici, D. L. (2017) · Advances in intelligent systems and computing · doi:10.1007/978-3-319-62521-8_28 · Cited by 4 · see citing works
Visualisation of Parkinsonian, essential and physiological tremor planes in 3Dspace
Jombík, P., Spodniak, P., Bahýľ, V., & Necpál, J. (2020) · Physiological Research · doi:10.33549/physiolres.934066 · Cited by 4 · see citing works
Terranova, R., Terravecchia, C., Messina, A., Caruso, D., Donzuso, G., Cicero, C. E., Mostile, G., & Nicoletti, A. S. Q. (2025) · Journal of Neural Transmission · doi:10.1007/s00702-025-02968-2 · Cited by 3 · see citing works
Kwon, K., Ryu, H., Lee, H. M., Kim, M., Shin, H., Park, H. K., You, S., Sung, Y. H., Chung, S. J., & Koh, S. (2018) · Journal of Clinical Neurology · doi:10.3988/jcn.2018.14.3.381 · Cited by 3 · see citing works
Actigraphy: a valuable diagnostic tool or a luxury investigation? (Neuropsychiatric aspects).
Rajna, P., & Szomszéd, A. (2009) · PubMed · Cited by 2 · see citing works
Electrophysiological Investigations in Neurosurgically Treated Movement Disorders
Kovács, N. (2009) · Pesci Egyetemi Archivum (University of Pécs) · Cited by 1 · see citing works
Changes in Bilateral Phase Synchronization in Parkinsonian Tremor Related to Amplitude Difference
Kim, S. K., Jeon, H. S., Kim, H. B., Kim, K. K., Jeon, B. S., & Park, K.-S. (2013) · Biomedical Engineering · doi:10.2316/p.2013.791-159
Visual Information Influences Postural Tremor
Loncharich, M. F. (2011)
Voluntary Driven, Velocity Controlled Tremor Suppression
Herrnstadt, G. (2017) · Summit (Simon Fraser University)
Tremor quantification and parameter extraction
Bejugam, S. K. (2011) · Diva portal (Dalarna University Library)
Grimaldi, G., & Manto, M. U. (2008) · Synthesis lectures on biomedical engineering · doi:10.1007/978-3-031-01627-1_6
León, J. S. T. (2021) · CID - Centro de Investigación y Desarrollo eBooks · doi:10.37811/cl_w800
Swinnen, B., Buijink, A. W. G., Espay, A. J., & de Bie, R. M. A. (2025) · Seminars in Neurology · doi:10.1055/a-2768-3003
- Authors
- Farkas, Z., Csillik, A., Szirmai, I., & Kamondi, A.
- Affiliations
- Semmelweis University (HU)
- Venue
- Parkinsonism & Related Disorders
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 12
- Issue
- 1
- Pages
- 49-55
- ISSN
- 1353-8020 (ISSN-L)
- OpenAlex
- W2080227806
- Cited by
- 44
- References
- 41
- Citations by year
- 2025: 2 · 2024: 1 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 2 · 2014: 2 · 2013: 4 · 2012: 1
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Parkinsonism & Related Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- Parkinson's disease, essential tremor
- MeSH terms
- Aged, Diagnosis, Differential, Electrophysiology, Female, Hand, Humans, Functional Laterality, Male, Middle Aged, Parkinson Disease, Essential Tremor
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