CSF hypocretin-1 levels are normal in multiple-system atrophy
Abstract
Sleep disturbances occur in 70% of the patients with multiple system atrophy (MSA). Disturbances of the hypothalamic hypocretin neurotransmission have been suggested as a possible cause. Since a systematic study of CSF hypocretin-1 levels in MSA has not yet been performed, we analysed CSF hypocretin-1 concentrations in 6 MSA-P and 6 MSA-C patients and 11 age-matched controls. We did not observe any differences from control values.
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Prior work to measure stress-related biomarkers has utilized high-performance liquid chromatography (HPLC), enzyme-linked immunosorbent assay, radioimmunoassay kit, or a HPLC mass spectrometry (MS) system.
“Prior work to measure stress-related biomarkers has utilized high-performance liquid chromatography (HPLC),99 enzyme-linked immunosorbent assay,100 radioimmunoassay kit,101 or a HPLC mass spectrometry (MS) system.102”
From Wearable sensors for monitoring the physiological and biochemical profile of the athlete (2019) · cites this paper as [101]
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Self-citationCSF hypocretin/orexin levels in narcolepsy and other neurological conditions
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Wearable sensors for monitoring the physiological and biochemical profile of the athlete
Seshadri, D. R., Li, R. T., Voos, J. E., Rowbottom, J. R., Alfes, C. M., Zorman, C. A., & Drummond, C. K. (2019) · npj Digital Medicine · doi:10.1038/s41746-019-0150-9 · Cited by 537 · see citing works
Detection of Orexin A Neuropeptide in Biological Fluids Using a Zinc Oxide Field Effect Transistor
Hagen, J., Lyon, W., Chushak, Y., Tomczak, M., Naik, R., Stone, M., & Kelley-Loughnane, N. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn300159e · Cited by 22 · see citing works
- Authors
- Abdo, W. F., Bloem, B. R., Kremer, H. P. H., Lammers, G. J., Verbeek, M. M., & Overeem, S.
- Affiliations
- Radboud University Medical Center (NL)
- Leiden University Medical Center (NL)
- Corresponding author
- Verbeek, M.M.
- Venue
- Parkinsonism & Related Disorders
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 14
- Issue
- 4
- Pages
- 342-344
- ISSN
- 1353-8020 (ISSN-L)
- OpenAlex
- W2053030724
- Cited by
- 34
- References
- 12
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Parkinsonism & Related Disorders (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Keywords
- multiple system atrophy, orexin-A
- MeSH terms
- Orexins, Aged, Female, Humans, Male, Middle Aged, Neuropeptides, Case-Control Studies, Multiple System Atrophy, Intracellular Signaling Peptides and Proteins
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