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Multiple instance learning: A survey of problem characteristics and applications
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“With over 30 billion sequences in total, this represents one of the largest multiple instance learning experiments ever conducted (Carbonneau et al., 2018).”
From Hopfield Networks is All You Need (2020) · cites this paper as Carbonneau et al., 2018
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ImageNet Large Scale Visual Recognition Challenge
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SMOTE synthetic minority over-sampling technique
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“There are external methods like SMOTE [193] and RUSBoost [194] that necessitate accurate labels to perform over or under sampling.”
MethodGreedy function approximation: A gradient boosting machine
Friedman, J. H. (2001) · The Annals of Statistics · doi:10.1214/aos/1013203451 · Cited by 30,731 · cited 1×
“The method is essentially the same as gradient boosting [143] except that the loss function is based on bag classification error.”
MethodThe pascal visual object classes (VOC) challenge
Everingham, M., Van Gool, L., Williams, C. K. I., Winn, J., & Zisserman, A. (2010) · International Journal of Computer Vision · doi:10.1007/s11263-009-0275-4 · Cited by 19,599
The WEKA data mining software: an update
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Representation Learning: A Review and New Perspectives
Bengio, Y., Courville, A., & Vincent, P. (2013) · IEEE Transactions on Pattern Analysis and Machine Intelligence · doi:10.1109/tpami.2013.50 · Cited by 13,001 · cited 1×
“Recently, methods for representation learning [160] have gained in popularity because they usually yield a high level of accuracy.”
MethodStatistical Comparisons of Classifiers over Multiple Data Sets
Demšar, J. (2006) · doi:10.5555/1248547.1248548 · Cited by 12,051
Cross validatory choice and assessment of statistical predictions
Stone, M. (1974) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1974.tb00994.x · Cited by 10,881 · cited 1×
“The experiments were conducted using a nested cross-fold validation protocol [149].”
MethodBeyond Bags of Features: Spatial Pyramid Matching for Recognizing Natural Scene Categories
Lazebnik, S., Schmid, C., & Ponce, J. (2006) · 2006 IEEE Computer Society Conference on Computer Vision and Pattern Recognition - Volume 2 (CVPR'06) · doi:10.1109/cvpr.2006.68 · Cited by 7,916 · cited 1×
“In BoW models for computer vision, this can be achieved by dividing the images [102, 103] or videos [80] into different spatial and/or temporal zones.”
The Earth Mover's Distance as a Metric for Image Retrieval
Rubner, Y., Tomasi, C., & Guibas, L. (2000) · International Journal of Computer Vision · doi:10.1023/a:1026543900054 · Cited by 5,547
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Cited by
Sorted by citations
Attention-based Deep Multiple Instance LearningPreprint
Ilse, M., Tomczak, J. M., & Welling, M. (2018) · arXiv (Cornell University) · doi:10.48550/arxiv.1802.04712 · Cited by 1,428
Li, B., Li, Y., & Eliceiri, K. W. (2021) · 2021 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR) · doi:10.1109/cvpr46437.2021.01409 · Cited by 957
“We refer the readers to [4] for a survey.”
BackgroundArtificial intelligence for multimodal data integration in oncology
Lipkova, J., Chen, R. J., Chen, B., Lu, M. Y., Barbieri, M., Shao, D., Vaidya, A. J., Chen, C., Zhuang, L., Williamson, D. F. K., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.09.012 · Cited by 777
Zhong, J.-X., Li, N., Kong, W., Liu, S., Li, T. H., & Li, G. (2019) · IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings - IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings · doi:10.1109/cvpr.2019.00133 · Cited by 626
“…that the label Y = 0 is noiseless, since it means all snippets v i in the video V are normal: However, Y = 1 is noisy because in this case the video V is partially made up of anomalous clips: This is referred to as one-sided label noise [7, 9, 55], for the noise only appears along with Y = 1 .”
BackgroundFederated learning for medical image analysis: A survey
Guan, H., Yap, P.-T., Bozoki, A., & Liu, M. (2024) · Pattern Recognition · doi:10.1016/j.patcog.2024.110424 · Cited by 518
Transformers in medical image analysis
He, K., Chen, G., Li, Z., Rekik, I., Yin, Z., Wen, J., Gao, Y., Wang, Q., Zhang, J., & Shen, D. G. (2022) · Intelligent Medicine · doi:10.1016/j.imed.2022.07.002 · Cited by 604
Federated Learning and Differential Privacy for Medical Image Analysis
Adnan, M., Kalra, S., Cresswell, J. C., Taylor, G. W., & Tizhoosh, H. (2021) · doi:10.21203/rs.3.rs-1005694/v1 · Cited by 464
Vanguri, R. S., Luo, J., Aukerman, A. T., Egger, J. V., Fong, C. J., Horvat, N., Pagano, A., Araujo-Filho, J. D. A. B., Geneslaw, L., Rizvi, H., et al. (2022) · Nature Cancer · doi:10.1038/s43018-022-00416-8 · Cited by 395
Multiple instance learning for histopathological breast cancer image classification
Sudharshan, P. J., Petitjean, C., Spanhol, F., Oliveira, L. E., Heutte, L., & Honeine, P. (2019) · Expert Systems with Applications · doi:10.1016/j.eswa.2018.09.049 · Cited by 369
Accurate Screening of COVID-19 Using Attention-Based Deep 3D Multiple Instance Learning
Han, Z., Wei, B., Hong, Y., Li, T., Cong, J., Zhu, X. L., Wei, H., & Zhang, W. (2020) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2020.2996256 · Cited by 328
“are beneficial for MIL classifier [23].”
A Review on Machine Learning Styles in Computer Vision—Techniques and Future Directions
Mahadevkar, S. V., Khemani, B., Patil, S., Kotecha, K. V., Vora, D. R., Abraham, A., & Gabralla, L. A. (2022) · IEEE Access · doi:10.1109/access.2022.3209825 · Cited by 304
“In training bags, image segmentation and feature extraction are performed, based on the size of dictionary bag features computed and finally applied, a classifier; the model predicts the result [30].”
MethodHopfield Networks is All You Need
Ramsauer, H., Schäfl, B., Lehner, J., Seidl, P., Widrich, M., Adler, T., Gruber, L., Holzleitner, M., Pavlović, M., Sandve, G. K., et al. (2020) · arXiv · doi:10.48550/arxiv.2008.02217 · Cited by 236
“With over 30 billion sequences in total, this represents one of the largest multiple instance learning experiments ever conducted [15] (for details see [70], appendix, Section A2).”
BackgroundPooling in convolutional neural networks for medical image analysis: a survey and an empirical study
Nirthika, R., Manivannan, S., Ramanan, A., & Wang, R. (2022) · Neural Computing and Applications · doi:10.1007/s00521-022-06953-8 · Cited by 249
“…are differential approximation of max pooling, they are widely explored in (non-CNN based) Multiple Instance Learning approaches in computer vision [8] and medical image analysis [76, 135] (Table 2), in addition to CNN-based image classification [28, 42, 124, 144] and segmentation [90, 129].”
MethodWeakly supervised machine learning
Ren, Z., Wang, S., & Zhang, Y. (2023) · CAAI Transactions on Intelligence Technology · doi:10.1049/cit2.12216 · Cited by 182
Deep Learning in Breast Cancer Imaging: A Decade of Progress and Future Directions
Luo, L., Wang, X., Lin, Y., Ma, X., Tan, A., Chan, R., Vardhanabhuti, V., Chu, C. W., Cheng, K.-T. T., & Chen, H. (2024) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2024.3357877 · Cited by 192
“In breast cancer imaging, the most used weakly-supervised learning methods are class activation map (CAM) [61] and multiple instancelearning(MIL)[62].”
Towards Safe Weakly Supervised Learning
Li, Y.-F., Guo, L.-Z., & Zhou, Z.-H. (2019) · IEEE Transactions on Pattern Analysis and Machine Intelligence · doi:10.1109/tpami.2019.2922396 · Cited by 165
“There aremanystudies [4], [5], [6], [7], [8],”
BackgroundMethodInfluentialAutomatic diagnosis for thyroid nodules in ultrasound images by deep neural networks
Wang, L., Zhang, L., Zhu, M., Qi, X., & Zhang, Y. (2020) · Medical Image Analysis · doi:10.1016/j.media.2020.101665 · Cited by 151
Gadermayr, M., & Tschuchnig, M. (2024) · Computerized Medical Imaging and Graphics · doi:10.1016/j.compmedimag.2024.102337 · Cited by 177
Weakly-Supervised Action Localization with Expectation-Maximization Multi-Instance Learning
Luo, Z., Guillory, D., Shi, B., Ke, W., Wan, F., Darrell, T., & Xu, H. (2020) · Lecture notes in computer science · doi:10.1007/978-3-030-58526-6_43 · Cited by 140
Song, G., Song, K., & Yan, Y. (2020) · Optics and Lasers in Engineering · doi:10.1016/j.optlaseng.2019.106000 · Cited by 140
Histopathology images predict multi-omics aberrations and prognoses in colorectal cancer patients
Tsai, P.-C., Lee, T.-H., Kuo, K.-C., Su, F.-Y., Lee, T.-L. M., Marostica, E., Ugai, T., Zhao, M., Lau, M. C., Väyrynen, J. P., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37179-4 · Cited by 136
“Moreover, MOMA revealed the previously unknown correlation between histopathology image patterns and the expression levels of BECN1 (Supplemental Figure 2A), with the results validated in the NHS-HPFS dataset (Supplemental Figure 2B and Supplemental Table 1).”
Li, J., Li, W., Sisk, A. E. J., Ye, H., Wallace, W. D., Speier, W. F., & Arnold, C. W. (2021) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2021.104253 · Cited by 125
Modern Hopfield Networks and Attention for Immune Repertoire ClassificationPreprint
Widrich, M., Schäfl, B., Pavlović, M., Ramsauer, H., Gruber, L., Holzleitner, M., Brandstetter, J., Sandve, G. K., Greiff, V., Hochreiter, S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.12.038158 · Cited by 111
“However, in MIL problems considered by machine learning methods up to now, the number of instances per bag is in the range of hundreds or few thousands (Carbonneau et al., 2018; Lee et al., 2019) (see also Tab.”
Jiang, P., Li, X., Shen, H., Chen, Y., Wang, L., Chen, H., Feng, J., & Liu, J. (2023) · Artificial Intelligence Review · doi:10.1007/s10462-023-10588-z · Cited by 120
Ostmeyer, J., Christley, S., Toby, I. T., & Cowell, L. G. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2292 · Cited by 98
“Mapping pertinent receptors in a repertoire to a single phenotype label can formally be described as MIL, which treats problems as bags of instances where the bags are labeled but the instances are not (24).”
BackgroundRepresentation Learning of Histopathology Images using Graph Neural Networks
Adnan, M., Kalra, S., & Tizhoosh, H. R. (2020) · 2020 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW) · doi:10.1109/cvprw50498.2020.00502 · Cited by 109
“[3].”
Multi-Instance Pose Networks: Rethinking Top-Down Pose Estimation
Khirodkar, R., Chari, V., Agrawal, A., & Tyagi, A. (2021) · IEEE/CVF International Conference on Computer Vision (ICCV) · doi:10.1109/iccv48922.2021.00311 · Cited by 100
“Our multi-instance pose network is fully supervised and not related to multiple instance learning [4, 46], which is a form of weakly-supervised learning paradigm where training instances are arranged in sets.”
BackgroundDeep Learning-Based Action Detection in Untrimmed Videos: A Survey
Vahdani, E., & Tian, Y. (2022) · IEEE Transactions on Pattern Analysis and Machine Intelligence · doi:10.1109/tpami.2022.3193611 · Cited by 100
“are arranged in sets, called bags, and a label is provided for the entire bag [67].”
BackgroundDeep computational pathology in breast cancer
Duggento, A., Conti, A., Mauriello, A., Guerrisi, M., & Toschi, N. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.08.006 · Cited by 93
“The authors employed (for the first time in computational pathology) a learning method termed Multiple Instance Learning (MIL) (see [117] for a review).”
MethodArtificial intelligence applications in prostate cancer
Baydoun, A., Jia, A. Y., Zaorsky, N. G., Kashani, R., Rao, S. K., Shoag, J. E., Vince, R., Bittencourt, L. K., Zuhour, R. J., Price, A., et al. (2023) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-023-00684-0 · Cited by 87
Wang, J., Ji, J., Zhang, M., Lin, J., Zhang, G., Gong, W., Cen, L., Lu, Y., Huang, X., Huang, D., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.8758 · Cited by 87
Weakly Supervised Object Detection in Artworks
Gonthier, N., Gousseau, Y., Ladjal, S., & Bonfait, O. (2019) · Lecture notes in computer science · doi:10.1007/978-3-030-11012-3_53 · Cited by 83
MINI-Net: Multiple Instance Ranking Network for Video Highlight Detection
Hong, F.-T., Huang, X., Li, W., & Zheng, W. (2020) · Lecture notes in computer science · doi:10.1007/978-3-030-58601-0_21 · Cited by 79
Exploring Multiple Instance Learning (MIL): A brief survey
Waqas, M., Ahmed, S. U., Tahir, M. A., Wu, J., & Qureshi, R. (2024) · Expert Systems with Applications · doi:10.1016/j.eswa.2024.123893 · Cited by 89
Papadopoulos, A., Kyritsis, K., Klingelhoefer, L., Bostanjopoulou, S., Chaudhuri, K. R., & Delopoulos, A. (2020) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2019.2961748 · Cited by 79
“Multiple-Instance Learning [15] is a supervised learning scenario, where multiple instances or data points are grouped together to form sets, commonly referred to in MIL terminology as bags [16].”
Hou, W., Yu, L., Lin, C., Huang, H., Yu, R., Qin, J., & Wang, L. (2022) · Proceedings of the AAAI Conference on Artificial Intelligence · doi:10.1609/aaai.v36i1.19976 · Cited by 78
“Readers can refer Carbonneau et al. (2018) for a comprehensive survey.”
BackgroundLabel-efficient learning in agriculture: A comprehensive review
Li, J., Chen, D., Qi, X., Li, Z., Huang, Y., Morris, D., & Tan, X. (2023) · Computers and Electronics in Agriculture · doi:10.1016/j.compag.2023.108412 · Cited by 90
A Comprehensive Survey of Machine Learning Methods for Surveillance Videos Anomaly Detection
Choudhry, N., Abawajy, J., Huda, S., & Rao, I. (2023) · IEEE Access · doi:10.1109/access.2023.3321800 · Cited by 83
Cheplygina, V., de Bruijne, M., & Pluim, J. P. W. (2019) · Medical Image Analysis · doi:10.1016/j.media.2019.03.009 · Cited by 93
Self-citationDas, K., Conjeti, S., Chatterjee, J., & Sheet, D. (2020) · IEEE Access · doi:10.1109/access.2020.3040106 · Cited by 80
“The conventional MIL implementations were used from [49].”
MethodMelanoma Detection by Means of Multiple Instance Learning
Astorino, A., Fuduli, A., Veltri, P., & Vocaturo, E. (2019) · Interdisciplinary Sciences Computational Life Sciences · doi:10.1007/s12539-019-00341-y · Cited by 70
Appropriateness of performance indices for imbalanced data classification: An analysis
Mullick, S. S., Datta, S., Dhekane, S. G., & Das, S. (2020) · Pattern Recognition · doi:10.1016/j.patcog.2020.107197 · Cited by 76
“A natural future extension of this work would be to investigate the behavior of indices which are used in imbalanced multi-label [41] and multi-instance [42] classification problems.”
BackgroundYu, J.-G., Wu, Z., Ming, Y., Deng, S., Li, Y., Ou, C., He, C., Wang, B., Zhang, P., & Wang, Y. (2023) · Medical Image Analysis · doi:10.1016/j.media.2023.102748 · Cited by 70
Robust support vector machine with generalized quantile loss for classification and regression
Yang, L., & Dong, H. (2019) · Applied Soft Computing · doi:10.1016/j.asoc.2019.105483 · Cited by 67
Marini, N., Marchesin, S., Otálora, S., Wodziński, M., Caputo, A., van Rijthoven, M., Aswolinskiy, W., Bokhorst, J., Podareanu, D., Petters, E., et al. (2022) · npj Digital Medicine · doi:10.1038/s41746-022-00635-4 · Cited by 71
Deep Learning in Diverse Intelligent Sensor Based Systems
Zhu, Y., Wang, M., Yin, X., Zhang, J., Meijering, E. H. W., & Hu, J. (2022) · Sensors · doi:10.3390/s23010062 · Cited by 73
Weakly supervised histopathology image segmentation with self-attention
Li, K., Qian, Z., Han, Y., Chang, E., Wei, B., Lai, M., Liao, J., Fan, Y., & Xu, Y. L. (2023) · Medical Image Analysis · doi:10.1016/j.media.2023.102791 · Cited by 73
Inductive Relation Prediction by BERT
Zha, H., Chen, Z., & Yan, X. (2022) · Proceedings of the AAAI Conference on Artificial Intelligence · doi:10.1609/aaai.v36i5.20537 · Cited by 67
Multiple instance-based video anomaly detection using deep temporal encoding–decoding
Kamoona, A. M., Gostar, A. K., Bab‐Hadiashar, A., & Hoseinnezhad, R. (2022) · Expert Systems with Applications · doi:10.1016/j.eswa.2022.119079 · Cited by 61
Weakly Supervised Action Selection Learning in Video
Ma, J., Gorti, S. K., Volkovs, M., & Yu, G. (2021) · IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings - IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings · doi:10.1109/cvpr46437.2021.00750 · Cited by 63
“Multiple instance learning [5] is commonly used to train the classifier, where top-k pooling is applied over CAS for each class to aggregate the highest”
Deep learning in histopathology: A review
Banerji, S., & Mitra, S. (2021) · Wiley Interdisciplinary Reviews Data Mining and Knowledge Discovery · doi:10.1002/widm.1439 · Cited by 69
“A good survey on the state-of-the-art MIL algorithms, their characteristics and challenges, along with several applications, is provided in Carbonneau et al. (2018).”
BackgroundRony, J., Belharbi, S., Dolz, J., Ayed, I. B., McCaffrey, L. M., & Granger, É. (2023) · The Journal of Machine Learning for Biomedical Imaging · doi:10.59275/j.melba.2023-5g54 · Cited by 83
“Under this scenario, powerful techniques for multiple-instance learning (MIL) (Carbonneau et al., 2018; Cheplygina et al., 2019; Wang et al., 2018; Zhou, 2004) are generally considered, where individual instance labels (e.g . image pixels, segments or patches) are not observable or do not belong to…”
MethodTemporal Cue Guided Video Highlight Detection with Low-Rank Audio-Visual Fusion
Ye, Q., Shen, X., Gao, Y., Wang, Z., Bi, Q., Li, P., & Yang, G. (2021) · IEEE/CVF International Conference on Computer Vision (ICCV) · doi:10.1109/iccv48922.2021.00785 · Cited by 60
“Early MIL related works [2, 4] pointed out that simply applying the video label to segment label might be inaccurate since labels in positive video could be noisy.”
BackgroundVisualizing the outcome of dynamic analysis of Android malware with VizMal
Lorenzo, A. D., Martinelli, F., Medvet, E., Mercaldo, F., & Santone, A. (2019) · Journal of Information Security and Applications · doi:10.1016/j.jisa.2019.102423 · Cited by 59
“Another approach which can fit our scenario is the Multiple Instance Learning (MIL) framework [22, 70].”
BackgroundDigital mapping of heavy metals in urban soils: A review and research challenges
Shi, T., Li, H., Wang, R., Li, Z., Hu, Z., & Wu, G. (2023) · CATENA · doi:10.1016/j.catena.2023.107183 · Cited by 58
Artificial intelligence in COPD CT images: identification, staging, and quantitation
Wu, Y., Xia, S., Liang, Z., Chen, R., & Qi, S. (2024) · Respiratory Research · doi:10.1186/s12931-024-02913-z · Cited by 66
“MIL is a weakly supervised learning paradigm where the training data consists of labeled bags, each containing multiple instances [55].”
BackgroundMultiple Instance Learning for Emotion Recognition Using Physiological Signals
Romeo, L., Cavallo, A., Pepa, L., Bianchi‐Berthouze, N., & Pontil, M. (2019) · IEEE Transactions on Affective Computing · doi:10.1109/taffc.2019.2954118 · Cited by 58
“MIL has attracted much attention from the research community, especially in recent years, as the amount of data needed to learn difficult tasks has increased exponentially [26].”
BackgroundLearning to select cuts for efficient mixed-integer programming
Huang, Z., Wang, K., Liu, F., Zhen, H., Zhang, W., Yuan, M., Hao, J., Yu, Y. H., & Wang, Y.-X. (2021) · Pattern Recognition · doi:10.1016/j.patcog.2021.108353 · Cited by 56
Li, X., Guo, R., Lu, J., Chen, T., & Qian, X. (2023) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2023.3236162 · Cited by 56
“The MIL has been widely employed in many computer vision tasks [15], where this framework generally exhibited good feature representation capabilities [12], [16], [17], [18].”
MethodMRI-based Alzheimer’s disease prediction via distilling the knowledge in multi-modal data
Guan, H., Wang, C., & Tao, D. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118586 · Cited by 58
“set contains multiple unlabelled instances [1, 9].”
Myronenko, A., Xu, Z., Yang, D., Roth, H. R., & Xu, D. (2021) · Lecture notes in computer science · doi:10.1007/978-3-030-87237-3_32 · Cited by 55
Multilabel Appliance Classification With Weakly Labeled Data for Non-Intrusive Load Monitoring
Tanoni, G., Principi, E., & Squartini, S. (2022) · IEEE Transactions on Smart Grid · doi:10.1109/tsg.2022.3191908 · Cited by 55
“Learning from bags raises important challenges that are unique to MIL formulation [43].”
BackgroundAdvMIL: Adversarial multiple instance learning for the survival analysis on whole-slide images
Liu, P., Ji, L., Ye, F., & Fu, B. (2023) · Medical Image Analysis · doi:10.1016/j.media.2023.103020 · Cited by 63
Machine learning and related approaches in transcriptomics
Cheng, Y., Xu, S.-M., Santucci, K., Lindner, G., & Janitz, M. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150225 · Cited by 55
Masked Conditional Neural Networks for sound classification
Medhat, F., Chesmore, D., & Robinson, J. (2020) · Applied Soft Computing · doi:10.1016/j.asoc.2020.106073 · Cited by 56
“The evaluation of the MCLNN for sound classification follows the Multiple Instance Learning paradigm [56] used in most of the attempts referenced in the literature, where the original tag of the sound file is used to label each segment in isolation and the final decision for the clip follows a…”
Method(2023) · doi:10.1126/sciadv.abo5128 · Cited by 53
“The repertoire-level analysis task can be formulated as a typical MIL problem ( 55 ), where each repertoire can be regarded as a bag containing receptors that are instances.”
Deep multiple-instance learning for abnormal cell detection in cervical histopathology images
Pal, A., Xue, Z., Desai, K. T., Banjo, A. A. F., Adepiti, C. A., Long, L. R., SCHIFFMAN, M. H., & Antani, S. (2021) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2021.104890 · Cited by 55
Rymarczyk, D., Borowa, A., Tabor, J., & Zieliński, B. (2021) · IEEE Winter Conference on Applications of Computer Vision · doi:10.1109/wacv48630.2021.00176 · Cited by 62
“MIL problems are common in medical image analysis due to the vast resolution of images and the weakly-labeled small datasets [4, 21].”
BackgroundPapadopoulos, A., Iakovakis, D., Klingelhoefer, L., Bostantjopoulou, S., Chaudhuri, К. R., Kyritsis, K., Hadjidimitriou, S., Charisis, V. S., Hadjileontiadis, L. J., & Delopoulos, A. N. (2020) · Scientific Reports · doi:10.1038/s41598-020-78418-8 · Cited by 52
Mann, P., Paes, A., & Matsushima, E. H. (2020) · Proceedings of the International AAAI Conference on Web and Social Media · doi:10.1609/icwsm.v14i1.7313 · Cited by 56
Real-time incident prediction for online service systems
Zhao, N., Chen, J., Wang, Z., Peng, X., Wang, G., Wu, Y., Zhou, F., Feng, Z., Nie, X., Zhang, W., et al. (2020) · ACM Joint European Software Engineering Conference and Symposium on the Foundations of Software Engineering (ESEC/FSE) · doi:10.1145/3368089.3409672 · Cited by 59
“To reduce the influence of noisy alerts, eWarn adopts multi-instance learning (MIL) [11].”
BackgroundMethodInfluentialSilva-Rodríguez, J., Colomer, A., & Naranjo, V. (2021) · Computerized Medical Imaging and Graphics · doi:10.1016/j.compmedimag.2020.101846 · Cited by 52
“A recent extensive review of MIL and its characteristics can be found in [6].”
BackgroundDiscrepant multiple instance learning for weakly supervised object detection
Gao, W., Wan, F., Yue, J., Xu, S., & Ye, Q. (2021) · Pattern Recognition · doi:10.1016/j.patcog.2021.108233 · Cited by 54
A Comprehensive Review on Multiple Instance Learning
Fatima, S., Ali, S., & Kim, H. (2023) · Electronics · doi:10.3390/electronics12204323 · Cited by 51
Chikontwe, P., Luna, M., Kang, M., Hong, K. S., Ahn, J. H., & Park, S. H. (2021) · Medical Image Analysis · doi:10.1016/j.media.2021.102105 · Cited by 54
Liu, T., Zhang, C., Lam, K., & Kong, J. (2022) · IEEE Transactions on Information Forensics and Security · doi:10.1109/tifs.2022.3216479 · Cited by 50
“Wan et al. [23] leverage a center loss to cluster normal instances, which is complementary to the conventional MIL principle for tackling the WS-VAD task.”
BackgroundInfluentialMulti-instance learning of graph neural networks for aqueous p K a prediction
Xiong, J., Li, Z. S., Wang, G., Fu, Z., Zhong, F., Xu, T., Liu, X., Huang, Z., Liu, X., Chen, K., et al. (2021) · Bioinformatics · doi:10.1093/bioinformatics/btab714 · Cited by 52
Golden Standard or Obsolete Method? Review of ECG Applications in Clinical and Experimental Context
Stračina, T., Ronzhina, M., Ředina, R., & Novàkovâ, M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.867033 · Cited by 56
“MIL is a type of supervised learning, which works with labeled bags of data (instead of the labeled instances) (Carbonneau et al., 2018).”
BackgroundDCT-MIL: Deep CNN transferred multiple instance learning for COPD identification using CT images
Xu, C., Qi, S., Feng, J., Xia, S., Kang, Y., Yao, Y., & Qian, W. (2020) · Physics in Medicine and Biology · doi:10.1088/1361-6560/ab857d · Cited by 47
“Second, as one method of MIL, Citation-KNN also has the advantages similar to the image retrieval and ensemble learning (Carbonneau et al 2016).”
BackgroundMethodA survey of class-imbalanced semi-supervised learning
Gui, Q., Hong, Z., Guo, N., & Niu, B. (2023) · Machine Learning · doi:10.1007/s10994-023-06344-7 · Cited by 51
“…incomplete supervision (Chapelle et al., 2006) (e.g., semi-supervised learning), inexact supervision (Dietterich et al., 1997; Foulds & Frank, 2010; Carbonneau et al., 2018) (e.g.,multi-instance learning) and inaccurate supervision (Frénay & Ver-leysen, 2014; Gao et al., 2016) (e.g., label noise…”
Weakly Supervised Learning Guided by Activation Mapping Applied to a Novel Citrus Pest Benchmark
Bollis, E., Pedrini, H., & Avila, S. (2020) · IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW) · doi:10.1109/cvprw50498.2020.00043 · Cited by 44
“The labels are provided only for the bags and the instances inherit from the bags creating a weakly supervised environment [4].”
BackgroundDeveloping image analysis pipelines of whole-slide images: Pre- and post-processing
Smith, B. H., Hermsen, M., Lesser, E. R., Ravichandar, D., & Kremers, W. K. (2020) · Journal of Clinical and Translational Science · doi:10.1017/cts.2020.531 · Cited by 43
“More details of these methods are provided in Carbonneau et al [33].”
BackgroundMethodDual Attention Networks for Few-Shot Fine-Grained Recognition
Xu, S.-L., Zhang, F., Wei, X.-S., & Wang, J. (2022) · Proceedings of the AAAI Conference on Artificial Intelligence · doi:10.1609/aaai.v36i3.20196 · Cited by 42
“In particular, the MIL methods for image recognition (Tang et al. 2018; Carbonneau et al. 2018; Angles et al. 2021) has also achieved some good results.”
MethodVenugopalan, M., & Gupta, D. (2022) · Expert Systems with Applications · doi:10.1016/j.eswa.2022.118228 · Cited by 42
A Transfer Learning-Based Multi-Instance Learning Method With Weak Labels
Xiao, Y., Liang, F., & Liu, B. (2020) · IEEE Transactions on Cybernetics · doi:10.1109/tcyb.2020.2973450 · Cited by 41
Ienco, D., Gbodjo, Y. J. E., Gaetano, R., & Interdonato, R. (2020) · IEEE Access · doi:10.1109/access.2020.3024133 · Cited by 41
“Multiple Instance learning [26] (MIL) is a supervised learning paradigm in which a classification model is learnt to supply prediction for a group of instances.”
BackgroundZhang, W., Yang, C., Cao, Z., Li, Z., Zhuo, L., Tan, Y., He, Y., Yao, L., Zhou, Q. F., Gong, Q., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104541 · Cited by 42
Chaos Based Cryptographic Pseudo-Random Number Generator Template with Dynamic State Change
Datcu, O., Macovei, C., & Hobincu, R. (2020) · Applied Sciences · doi:10.3390/app10020451 · Cited by 40
“A Monte Carlo analysis [28] with initial conditions x0, y0, z0 chosen randomly from an uniform distribution in [−2,2] was performed.”
MethodSuperpixel-based multi-scale multi-instance learning for hyperspectral image classification
Huang, S., Liu, Z., Jin, W., & Mu, Y. (2024) · Pattern Recognition · doi:10.1016/j.patcog.2024.110257 · Cited by 38
Tajeddin, N. Z., Jahanifar, M., Bilal, M., Eastwood, M., & Rajpoot, N. (2024) · Medical Image Analysis · doi:10.1016/j.media.2023.103071 · Cited by 36
Bag-Level Aggregation for Multiple-Instance Active Learning in Instance Classification Problems
Carbonneau, M., Granger, É., & Gagnon, G. (2018) · IEEE Transactions on Neural Networks and Learning Systems · doi:10.1109/tnnls.2018.2869164 · Cited by 38
“Moreover, experiments in [13] and [22] show that single-instance classifiers often perform comparably to MIL methods, especially for instance classification.”
BackgroundMethodInfluentialSelf-citationXu, X., Nemati, E., Vatanparvar, K., Nathan, V., Ahmed, T., Rahman, M. M., McCaffrey, D., Kuang, J., & Gao, J. A. (2021) · Proceedings of the ACM on Interactive, Mobile, Wearable and Ubiquitous Technologies · doi:10.1145/3448124 · Cited by 38
“Labels are only provided for entire sets, and the specific labels of the instances in the bags are not available [16].”
BackgroundRobust bag classification approach for multi-instance learning via subspace fuzzy clustering
Waqas, M., Tahir, M. A., & Khan, S. A. (2022) · Expert Systems with Applications · doi:10.1016/j.eswa.2022.119113 · Cited by 37
Shi, J., Tang, L., Li, Y., Zhang, X., Gao, Z., Zheng, Y., Wang, C., Gong, T., & Li, C. (2023) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2023.3273236 · Cited by 40
“WSI classification tasks [11], [12], [13], [15], [16], [17], [18], [19], [20], [21], there still exist two limitations for directly applying MIL to the challenging pT staging task.”
Automated HER2 Scoring in Breast Cancer Images Using Deep Learning and Pyramid Sampling
Selçuk, Ş. Y., Yang, X., Bai, B., Zhang, Y., Li, Y., Aydın, M., Unal, A. F., Gomatam, A., Guo, Z., Angus, D. M., et al. (2024) · BME Frontiers · doi:10.34133/bmef.0048 · Cited by 37
“MIL is a form of weakly supervised learning where training instances are arranged in sets, called bags, and a label is provided for the entire bag—usually on WSI level— instead of individual instances/image patches [25].”
A Lagrangian Relaxation Approach for Binary Multiple Instance Classification
Astorino, A., Fuduli, A., & Gaudioso, M. (2019) · IEEE Transactions on Neural Networks and Learning Systems · doi:10.1109/tnnls.2018.2885852 · Cited by 36
“Exhaustive surveys on MIL problems are [2] and [9].”
BackgroundA Semiproximal Support Vector Machine Approach for Binary Multiple Instance Learning
Avolio, M., & Fuduli, A. (2020) · IEEE Transactions on Neural Networks and Learning Systems · doi:10.1109/tnnls.2020.3015442 · Cited by 36
QSAR Modeling Based on Conformation Ensembles Using a Multi-Instance Learning Approach
Zankov, D. V., Matveieva, M., Nikonenko, A., Ирекович, Н. Р., Baskin, I. I., Varnek, A. A., Полищук, П. Г., & Madzhidov, T. (2021) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.1c00692 · Cited by 40
Li, N., Zhong, J.-X., Shu, X.-J., & Guo, H. (2022) · Neurocomputing · doi:10.1016/j.neucom.2022.01.026 · Cited by 38
Classification in the multiple instance learning framework via spherical separation
Gaudioso, M., Giallombardo, G., Miglionico, G., & Vocaturo, E. (2019) · Soft Computing · doi:10.1007/s00500-019-04255-1 · Cited by 35
Metadata
- Authors
- Carbonneau, M.-A., Cheplygina, V., Granger, E., & Gagnon, G.
- Affiliations
- École de Technologie Supérieure (CA)
- Erasmus MC (NL)
- Corresponding author
- Carbonneau, Marc-André
- Venue
- Pattern Recognition
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 77
- Pages
- 329-353
- ISSN
- 0031-3203 (ISSN-L)
- OpenAlex
- W2560886373
- Cited by
- 740
- References
- 223
- Citations by year
- 2026: 75 · 2025: 118 · 2024: 91 · 2023: 124 · 2022: 98 · 2021: 92 · 2020: 84 · 2019: 41 · 2018: 14
- FWCI
- 22.10
- Type
- journal article
- Language
- en
- Open access
- green
- arxiv.org
- Locations
- Pattern Recognition (publishedVersion)
- arXiv (Cornell University) (submittedVersion)
- TU/e Research Portal (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Espace ÉTS (ETS) (submittedVersion)
- TU/e Research Portal (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- arXiv (Cornell University)
- Topics
- Physical Sciences › Computer Science › Artificial Intelligence › Machine Learning and Algorithms
- Physical Sciences › Computer Science › Artificial Intelligence › Machine Learning and Data Classification
- Physical Sciences › Computer Science › Artificial Intelligence › Domain Adaptation and Few-Shot Learning
- Keywords
- multiple instance learning, weakly supervised learning, problem characteristics, data distribution, label ambiguity, computer vision, document classification
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