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Cited by 342

The DOI matches its Crossref record; 314 of the 314 references it cites were found in a registry or an index.

Oxidative stress in Alzheimer's disease

Open access
Chauhan, Ved, Chauhan, Abha·2006·Pathophysiology

Abstract

Oxidative damage is a major feature in the pathophysiology of Alzheimer's disease (AD). In this review, we discuss free radical-mediated damage to the biochemical components involved in the pathology and clinical symptoms of AD. We explain how amyloid beta-protein (Abeta), microtubule-associated protein tau, presenilins, apolipoprotein E, mitochondria and proteases play a role in increasing oxidative stress in AD. Abeta not only can induce oxidative stress, but its generation is also increased as a result of oxidative stress. Finally, a hypothetical model linking oxidative stress with beta-amyloid and neurofibrillary tangle pathology in AD is proposed.

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Crossref · 10.1016/j.pathophys.2006.05.004

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Metadata

Authors
Chauhan, V., & Chauhan, A.
Venue
Pathophysiology
Publisher
Elsevier BV
Published
2006-08
Volume
13
Issue
3
Pages
195-208
ISSN
0928-4680 (ISSN-L)
OpenAlex
W2091711919
Cited by
342
References
314
FWCI
8.04
Type
journal article
Language
en
Open access
gold

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.