Cited by 468Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesAttention Deficit Hyperactivity Disorder

The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.

Neurobehavioral mechanisms of impulsivity: Fronto-striatal systems and functional neurochemistry

Dalley, Jeffrey W., Mar, Adam C., Economidou, Daina, Robbins, Trevor W.·2008·Pharmacology Biochemistry and Behavior

DOI 10.1016/j.pbb.2007.12.021

Open this paper in CoChat — free account

Abstract

Impulsive acts and decisions are a part of everyday normal behavior. However, in its pathological forms, impulsivity can be a debilitating disorder often associated with a number of neuropsychiatric disorders, including attention-deficit hyperactivity disorder (ADHD). This article reviews recent progress in our understanding of the neurobiology of impulsivity using examples from recent investigations in experimental animals. Evidence is reviewed from several well-established paradigms with putative utility in assessing distinct forms of impulsive behavior in rodents, including the 5-choice serial reaction time (5CSRT) task and the delay discounting paradigm. We discuss, in particular, recent psychopharmacological and in-vivo neurochemical data in task-performing rats showing functional heterogeneity of the forebrain dopamine (DA), noradrenaline (NA), serotonin (5-HT) and acetylcholine (ACh) systems and identify how these systems normally function to facilitate flexible goal-directed behavior in situations that tax basic attentional functions and inhibitory response control mechanisms. We also discuss future research needs in terms of understanding the functional diversity of different sub-regions of prefrontal cortex (PFC) and how these systems normally interact with the striatum and main nuclei of origin of DA and NA neurons. Finally, we argue in line with others that animal paradigms are unlikely to model all aspects of complex psychiatric conditions such as ADHD but components of such syndromes may be amenable to investigation using sophisticated animal models based on highly-defined psychiatric endophenotypes.

Integrity signals

Registry

Crossref · 10.1016/j.pbb.2007.12.021

Cites

123 of 123 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615
Anterior Cingulate Conflict Monitoring and Adjustments in Control
Kerns, J. G., Cohen, J. D., MacDonald, A. W., Cho, R. Y., Stenger, V. A., & Carter, C. S. (2004) · Science · doi:10.1126/science.1089910 · Cited by 2,891
Specious reward: A behavioral theory of impulsiveness and impulse control.
Ainslie, G. (1975) · Psychological Bulletin · doi:10.1037/h0076860 · Cited by 2,708
Common regions of the human frontal lobe recruited by diverse cognitive demands
Duncan, J., & Owen, A. M. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01633-7 · Cited by 2,498
Varieties of impulsivity
Evenden, J. L. (1999) · Psychopharmacology · doi:10.1007/pl00005481 · Cited by 2,044
Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli
Jentsch, J. D., & Taylor, J. R. (1999) · Psychopharmacology · doi:10.1007/pl00005483 · Cited by 1,545
CENTRAL CHOLINERGIC SYSTEMS AND COGNITION
Everitt, B. J., & Robbins, T. W. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.649 · Cited by 1,348
Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates
Dalley, J. W., Cardinal, R. N., & Robbins, T. W. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.09.006 · Cited by 1,329
Self-citation
The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry
Robbins, T. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1154-7 · Cited by 1,282
Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
Dalley, J. W., Fryer, T. D., Brichard, L., Robinson, E. S. J., Theobald, D. E. H., Lääne, K., Peña, Y., Murphy, E. R., Shah, Y., Probst, K., et al. (2007) · Science · doi:10.1126/science.1137073 · Cited by 1,188

Flagged first, then by citations

Show all 121 references

Sorted by citations

Items 201–300 of 468

Mirtazapine-associated movement disorders: A literature review
Rissardo, J. P., & Caprara, A. L. F. (2020) · Tzu Chi Medical Journal · doi:10.4103/tcmj.tcmj_13_20 · Cited by 34
A neurochemical yin and yang: does serotonin activate and norepinephrine deactivate the prefrontal cortex?
Fitzgerald, P. J. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1856-1 · Cited by 36
Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Javelle, F., Lampit, A., Bloch, W., Häussermann, P., Johnson, S. L., & Zimmer, P. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz039 · Cited by 35
What Can Neuroscience Bring to Education?
Ferrari, M. (2011) · Educational Philosophy and Theory · doi:10.1111/j.1469-5812.2010.00704.x · Cited by 33
Nucleus accumbens and delay discounting in rats: evidence from a new quantitative protocol for analysing inter-temporal choice
Valencia-Torres, L., Olarte‐Sánchez, C. M., Araújo, S. D. C., Body, S., Bradshaw, C. M., & Szabadi, E. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2459-1 · Cited by 32
COMT and ANKK1 Genetics Interact With Depression to Influence Behavior Following Severe TBI
Myrga, J. M., Juengst, S. B., Failla, M. D., Conley, Y. P., Arenth, P. M., Grace, A. A., & Wagner, A. K. (2016) · Neurorehabilitation and neural repair · doi:10.1177/1545968316648409 · Cited by 33
Functional coding variation in the presynaptic dopamine transporter associated with neuropsychiatric disorders drives enhanced motivation and context-dependent impulsivity in mice
Davis, G. L., Stewart, A., Stanwood, G. D., Gowrishankar, R., Hahn, M. K., & Blakely, R. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.09.043 · Cited by 31
Alterations of cerebral perfusion and functional brain connectivity in medication‐naïve male adults with attention‐deficit/hyperactivity disorder
Tan, Y., Liu, L., Wang, Y., Li, H., Pan, M., Zhao, M., Huang, F., Wang, Y., Yong He, A., Liao, X., et al. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13185 · Cited by 32
Endocannabinoid CB1 receptor activation upon global ischemia adversely impact recovery of reward and stress signaling molecules, neuronal survival and behavioral impulsivity
Dunbar, M., de la Tremblaye, P. B., Azogu, I., & Plamondon, H. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.10.010 · Cited by 32
Profound Changes in Dopaminergic Neurotransmission in the Prefrontal Cortex in Response to Flattening of the Diurnal Glucocorticoid Rhythm: Implications for Bipolar Disorder
Minton, G. O., Young, A. H., McQuade, R., Fairchild, G. F., Ingram, C. D., & Gartside, S. E. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.53 · Cited by 32
Dopamine D2/3 receptor availability and human cognitive impulsivity: a high-resolution positron emission tomography imaging study with [11C]raclopride
Kim, J., Son, Y., Kim, H.-K., Lee, S., Kim, Y.-B., & Cho, Z. (2013) · Acta Neuropsychiatrica · doi:10.1017/neu.2013.29 · Cited by 32
Organization of Prefrontal-Striatal Connections
Groenewegen, H. J., & Uylings, H. B. M. (2010) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-374767-9.00020-2 · Cited by 31
Impulsivity, risk‐taking, and distractibility in rats exhibiting robust conditioned orienting behaviors
Olshavsky, M. E., Shumake, J., Rosenthal, A. A., Kaddour‐Djebbar, A., Gonzalez-Lima, F., Setlow, B., & Lee, H. J. (2014) · Journal of the Experimental Analysis of Behavior · doi:10.1002/jeab.104 · Cited by 30
Impaired Energy Metabolism and Disturbed Dopamine and Glutamate Signalling in the Striatum and Prefrontal Cortex of the Spontaneously Hypertensive Rat Model of Attention-Deficit Hyperactivity Disorder
Dimatelis, J. J., Hsieh, J. H., Sterley, T.-L., Marais, L., Womersley, J. S., Vlok, M., & Russell, V. A. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0491-z · Cited by 29
Sex differences in myelin-associated protein levels within and density of projections between the orbital frontal cortex and dorsal striatum of adult rats: Implications for inhibitory control
Bayless, D. W., & Daniel, J. M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.029 · Cited by 30
Serotonergic neuromodulation of synaptic plasticity
Higa, G. S. V., Viana, F. J. C., Francis-Oliveira, J., Cruvinel, E., Franchin, T. S., Marcourakis, T., Ulrich, H., & De Pasquale, R. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110036 · Cited by 29
Impairment of Oligodendroglia Maturation Leads to Aberrantly Increased Cortical Glutamate and Anxiety-Like Behaviors in Juvenile Mice
Chen, X., Zhang, W., Li, T., Guo, Y., Tian, Y., Wang, F., Liu, S., Shen, H., Feng, Y., & Xiao, L. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00467 · Cited by 30
Dopamine Modulation of Intertemporal Decision-making: Evidence from Parkinson Disease
Foerde, K., Figner, B., Doll, B. B., Woyke, I. C., Braun, E. K., Weber, E. U., & Daphna Shohamy, A. (2016) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00929 · Cited by 29
General Habit Propensity Relates to the Sensation Seeking Subdomain of Impulsivity But Not Obesity
Dietrich, A., de Wit, S., & Horstmann, A. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00213 · Cited by 31
Altered experiential, but not hypothetical, delay discounting in schizophrenia.
Horan, W. P., Johnson, M. W., & Green, M. F. (2017) · Journal of Abnormal Psychology · doi:10.1037/abn0000249 · Cited by 31
Amygdala reactivity and ventromedial prefrontal cortex coupling in the processing of emotional face stimuli in attention-deficit/hyperactivity disorder
Viering, T., Naaijen, J., van Rooij, D., Thiel, C. M., Philipsen, A., Dietrich, A., Franke, B., Buitelaar, J. K., & Hoekstra, P. J. (2021) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-021-01809-3 · Cited by 32
Frontostriatal systems comprising connections between ventral medial prefrontal cortex and nucleus accumbens subregions differentially regulate motor impulse control in rats
Feja, M., & Koch, M. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3763-3 · Cited by 28
Mouse Models of Huntington’s Disease
Brooks, S. P., & Dunnett, S. B. (2013) · Current topics in behavioral neurosciences · doi:10.1007/7854_2013_256 · Cited by 28
Circuits Regulating Pleasure and Happiness in Bipolar Disorder
LOONEN, A. J. M. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00035 · Cited by 30
Dopamine effects on stress-induced working memory deficits
Bahari, Z., Meftahi, G. H., & Meftahi, M. A. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000429 · Cited by 29
Analyses of microstructural variation in the human striatum using non-negative matrix factorization
Robert, C. M., Patel, R., Blostein, N., Steele, C. C., & Chakravarty, M. M. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118744 · Cited by 23
Muscarinic mechanisms in psychotic disorders.
McKinzie, D., & Bymaster, F. (2012) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-25758-2_9 · Cited by 22
Infection of male rats withToxoplasma gondiiresults in enhanced delay aversion and neural changes in the nucleus accumbens core
Tan, D., Soh, L. J. T., Lim, L. W., Daniel, T. C. W., Zhang, X., & Vyas, A. (2015) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2015.0042 · Cited by 27
Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability
Miller, M. L., Ren, Y., Szutorisz, H., Warren, N. A., Tessereau, C., Egervári, G., Mlodnicka, A., Kapoor, M., Chaarani, B., Morris, C. V., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.80 · Cited by 26
A spatial discounting test to assess impulsivity in dogs
Brady, K., Hewison, L., Wright, H., Zulch, H. E., Cracknell, N. R., & Mills, D. S. (2018) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2018.01.003 · Cited by 26
Post-weaning social isolation in male mice leads to abnormal aggression and disrupted network organization in the prefrontal cortex: Contribution of parvalbumin interneurons with or without perineuronal nets
Bíró, L., Miskolczi, C., Szebik, H., Bruzsik, B., Varga, Z. K., Szente, L., Tóth, M., Halász, J., & Mikics, É. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100546 · Cited by 28
Serotonergic modulation of response inhibition and re‐engagement? Results of a study in healthy human volunteers
Drueke, B., Boecker, M., Schlaegel, S. M. A., Moeller, O., Hiemke, C., Gründer, G., & Gauggel, S. (2010) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1141 · Cited by 28
Pregabalin‐ and topiramate‐mediated regulation of cognitive and motor impulsivity in DBA/2 mice
Navarrete, F., Pérez-Ortiz, J., & Manzanares, J. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01981.x · Cited by 26
Fetal alcohol-induced hyperactivity is reversed by treatment with the PPARα agonist fenofibrate in a rat model
Marche, K., Danel, T., & Bordet, R. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1960-2 · Cited by 25
Response requirement and increases in accuracy produced by stimulant drugs in a 5-choice serial reaction-time task in rats
Koffarnus, M. N., & Katz, J. L. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2027-0 · Cited by 26
Effects of acute intra-cerebral administration of the 5-HT2A/C receptor ligands DOI and ketanserin on impulse control in rats
Hadamitzky, M., & Koch, M. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.05.021 · Cited by 24
A modified adjusting delay task to assess impulsive choice between isocaloric reinforcers in non-deprived male rats: effects of 5-HT2A/C and 5-HT1A receptor agonists
Blasio, A., Narayan, A. R., Kaminski, B. J., Steardo, L., Sabino, V., & Cottone, P. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2517-8 · Cited by 25
The differential yet concurrent contributions of motor, cognitive and affective disturbance to freezing of gait in Parkinson's disease
Shine, J. M., Naismith, S. L., & Lewis, S. J. G. (2012) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2012.06.027 · Cited by 25
Investigating the roles of different monoamine transmitters and impulse control using the 5-choice serial reaction time task
Humpston, C. S., Wood, C. M., & Robinson, E. S. J. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112466182 · Cited by 26
Predictive coding in neuropsychiatric disorders: a systematic transdiagnostic review.
Qela, B., Damiani, S., De Santis, S., Groppi, F., Pichiecchio, A., Asteggiano, C., Brondino, N., Monteleone, A. M., Grassi, L., Politi, P., et al. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106020 · Cited by 26
“The deficits activity of the striatum and frontal areas may contribute to impulsivity and inflexibility (Dalley et al., 2008; Sakagami and Pan, 2007; Trempler et al., 2017), while reduced activity in the anterior cingulate cortex, hippocampus, and amygdala support their role in generating…”
Alcohol Use and the Alcohol Use Disorders Over the Life Course: A Cross‐Level Developmental Review
Zucker, R. A., Hicks, B. M., & Heitzeg, M. M. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy318 · Cited by 26
Inhibitory Control and Drug Abuse Prevention
Bardo, M. T., Fishbein, D. H., & Milich, R. S. (2011) · Springer eBooks · doi:10.1007/978-1-4419-1268-8 · Cited by 66
Behavioral, pharmacological and neuroanatomical analysis of serotonin 2C receptor agonism on maternal behavior in rats
Wu, R., Gao, J., Chou, S., Davis, C., & Li, M. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.08.017 · Cited by 24
Top-down control of the medial orbitofrontal cortex to nucleus accumbens core pathway in decisional impulsivity
Wang, Z., Yue, L., Cui, C., Liu, S., Wang, X., Li, Y., & Ma, L. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01913-w · Cited by 23
Buspirone-associated Movement Disorder: A Literature Review
Rissardo, J. P., & Caprara, A. L. F. (2020) · Prague Medical Report · doi:10.14712/23362936.2020.1 · Cited by 23
Shared and unique brain network features predict cognition, personality and mental health in childhoodPreprint
Chen, J.-Z., Tam, A., Kebets, V., Orban, C., Ooi, L. Q. R., Marek, S. A., Dosenbach, N. U. F., Eickhoff, S., Bzdok, D., Holmes, A., et al. (2020) · bioRxiv · doi:10.1101/2020.06.24.168724 · Cited by 24
Sign tracking predicts suboptimal behavior in a rodent gambling task
Swintosky, M., Brennan, J. T., Koziel, C., Paulus, J. P., & Morrison, S. E. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05887-8 · Cited by 22
Dopa therapy and action impulsivity: subthreshold error activation and suppression in Parkinson’s disease
Fluchère, F., Deveaux, M., Burle, B., Vidal, F., van den Wildenberg, W. P. M., Witjas, T., Eusébio, A., Azulay, J., & Hasbroucq, T. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3805-x · Cited by 21
Antagonizing 5-HT2A receptors with M100907 and stimulating 5-HT2C receptors with Ro60-0175 blocks cocaine-induced locomotion and zif268 mRNA expression in Sprague-Dawley rats
Burton, C. L., Rizos, Z., Diwan, M., Nóbrega, J. N., & Fletcher, P. J. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.11.030 · Cited by 22
Decreased serotonin levels associated with behavioral disinhibition in tissue plasminogen activator deficient (tPA−/−) mice
Pothakos, K., Robinson, J. K., Gravanis, I., Marsteller, D. A., Dewey, S. L., & Tsirka, S. E. (2010) · Brain Research · doi:10.1016/j.brainres.2009.12.095 · Cited by 23
Equivalence of mother and father ratings of ADHD in children
Mayfield, A., Parke, E. M., Barchard, K. A., Zenisek, R., Thaler, N. S., Etcoff, L. M., & Allen, D. N. (2016) · Child Neuropsychology · doi:10.1080/09297049.2016.1236186 · Cited by 29
Shift in the Intrinsic Excitability of Medial Prefrontal Cortex Neurons following Training in Impulse Control and Cued-Responding Tasks
Hayton, S. J., Olmstead, M. C., & Dumont, É. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023885 · Cited by 21
Attentional performance, impulsivity, and related neurotransmitter systems in apoE2, apoE3, and apoE4 female transgenic mice
Reverte, I., Peris‐Sampedro, F., Basaure, P., Campa, L., Sunol, C. E., Moreno, M., Domingo, J. L., & Colomina, M. T. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4113-9 · Cited by 23
Network failures: When incentives trigger impulsive responses
Zhukovsky, P., Morein‐Zamir, S., Meng, C., Dalley, J. W., & Ersche, K. D. (2020) · Human Brain Mapping · doi:10.1002/hbm.24941 · Cited by 22
ACC GABA levels are associated with functional activation and connectivity in the fronto-striatal network during interference inhibition in patients with borderline personality disorder
Wang, G.-Y., van Eijk, J., Demirakça, T., Sack, M., Krause-Utz, A., Cackowski, S., Schmahl, C. G., & Ende, G. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.12.013 · Cited by 21
Association of 24 h maternal deprivation with a saline injection in the neonatal period alters adult stress response and brain monoamines in a sex-dependent fashion
Cabbia, R., Consoli, A., & Suchecki, D. (2018) · Stress · doi:10.1080/10253890.2018.1456525 · Cited by 21
Transgenerational transmission of behavioral phenotypes produced by exposure of male mice to saccharin and nicotine
McCarthy, D. M., Lowe, S. E., Morgan, T. J., Cannon, E. N., Biederman, J., Spencer, T. J., & Bhide, P. G. (2020) · Scientific Reports · doi:10.1038/s41598-020-68883-6 · Cited by 22
Dopamine D2/3 Receptor Availabilities and Evoked Dopamine Release in Striatum Differentially Predict Impulsivity and Novelty Preference in Roman High- and Low-Avoidance Rats
Bellés, L., Dimiziani, A., Tsartsalis, S., Millet, P., Herrmann, F. R., & Ginovart, N. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa084 · Cited by 20
Identifying the Basal Ganglia Network Model Markers for Medication-Induced Impulsivity in Parkinson's Disease Patients
Balasubramani, P. P., Chakravarthy, V. S., Ali, M. A., Ravindran, B., & Moustafa, A. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127542 · Cited by 23
Modelling human drug abuse and addiction with dedicated small animal positron emission tomography
Dalley, J. W., Fryer, T. D., Aigbirhio, F. I., Brichard, L., Richards, H. K., Hong, Y. T., Baron, J., Everitt, B. J., & Robbins, T. W. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.05.029 · Cited by 21
Attention-deficit/hyperactivity disorder symptoms and psychological comorbidity in eating disorder patients
Sala, L., Martinotti, G., Carenti, M. L., Romo, L., Oumaya, M., Pham‐Scottez, A., Rouillon, F., Gorwood, P. A. P. M., & Janiri, L. (2017) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-017-0395-8 · Cited by 20
Dissociable roles of dopamine and serotonin transporter function in a rat model of negative urgency
Yates, J. R., Darna, M., Gipson, C. D., Dwoskin, L. P., & Bardo, M. T. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.05.023 · Cited by 20
Conduct disorder
McDonough-Caplan, H. M., & Beauchaine, T. P. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811323-3.00003-1 · Cited by 19
Individual Differences in Impulsivity Predict Anticipatory Eye Movements
Cirilli, L., de Timary, P., Lefèvre, P., & Missal, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026699 · Cited by 21
Prenatal Cocaine Disrupts Serotonin Signaling-Dependent Behaviors:Implications for Sex Differences, Early Stress and Prenatal SSRI Exposure
Williams, S. K., Lauder, J. M., & Johns, J. M. (2011) · Current Neuropharmacology · doi:10.2174/157015911796557957 · Cited by 18
Long term compulsivity on the 5-choice serial reaction time task after acute Chlorpyrifos exposure
de, L. M., Moreno, M., Cardona, D., Campa, L., Sunol, C. E., Galofré, M., Flores, P., & Sánchez-Santed, F. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.11.012 · Cited by 19
Systemic administration of guanfacine improves food-motivated impulsive choice behavior primarily via direct stimulation of postsynaptic α 2A -adrenergic receptors in rats
Nishitomi, K., Yano, K., Kobayashi, M., Jino, K., Kano, T., Horiguchi, N., Shinohara, S., & Hasegawa, M. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.02.022 · Cited by 20
Impulsivity in heroin‐dependent individuals: structural and functional abnormalities within frontostriatal circuits
Wang, S., Zhang, M., Liu, S., Xu, Y., Shao, Z., Chen, L., Li, J., Yang, W., Liu, J., & Yuan, K. (2021) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00445-w · Cited by 17
Motivational State and Reward Content Determine Choice Behavior under Risk in Mice
Leblond, M., Fan, D., Brynildsen, J. K., & Yin, H. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025342 · Cited by 17
Our Mythical Hope. The Ancient Myths as Medicine for the Hardships of Life in Children’s and Young Adults’ Culture
Marciniak, K., & Warszawskiego, W. U. (2021) · Wydawnictwa Uniwersytetu Warszawskiego eBooks · doi:10.31338/uw.9788323552888 · Cited by 17
Factor structure of symptom dimensions in attention-deficit/hyperactivity disorder (ADHD).
Parke, E. M., Mayfield, A., Barchard, K. A., Thaler, N. S., Etcoff, L. M., & Allen, D. N. (2015) · Psychological Assessment · doi:10.1037/pas0000121 · Cited by 19
Individual differences in novelty-seeking behavior in spontaneously hypertensive rats: Enhanced sensitivity to the reinforcing effect of methylphenidate in the high novelty-preferring subpopulation
Peña, I. D., Gonzales, E. L., de la Peña, J. B., Kim, B.-N., Han, D. H., Shin, C. Y., & Cheong, J. H. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.08.019 · Cited by 18
Pharmacological insights into impulsive‐compulsive spectrum disorders associated with dopaminergic therapy
Napier, T. C., & Persons, A. L. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14177 · Cited by 19
Impulsive Action and Impulsive Choice Are Differentially Associated With Gene Expression Variations of the GABAA Receptor Alfa 1 Subunit and the CB1 Receptor in the Lateral and Medial Orbitofrontal Cortices
Ucha, M., Roura‐Martínez, D., Contreras, A., Pinto-Rivero, S., Orihuel, J., Ambrosio, E., & Higuera‐Matas, A. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00022 · Cited by 17
Effects of the selective 5-HT7 receptor antagonist SB-269970 on premature responding in the five-choice serial reaction time test in rats
Nikiforuk, A., Hołuj, M., Potasiewicz, A., & Popik, P. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.030 · Cited by 17
Sex differences in impulsivity in adult rats are mediated by organizational actions of neonatal gonadal hormones and not by hormones acting at puberty or in adulthood
Darling, J. S., Bayless, D. W., Dartez, L. R., Taylor, J. J., Mehrotra, A., Smith, W. L., & Daniel, J. M. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112843 · Cited by 16
Involvement of high plasma corticosterone status and activation of brain regional serotonin metabolism in long-term erythrosine-induced rearing motor hyper activity in young adult male rats
Dalal, A., & Poddar, M. K. (2010) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2010.483070 · Cited by 16
Toward a multiscale modeling framework for understanding serotonergic function
Wong‐Lin, K., Wang, D., Moustafa, A. A., Cohen, J. Y., & Nakamura, K. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117699612 · Cited by 16
Long-Term Effects of Chronic Oral Ritalin Administration on Cognitive and Neural Development in Adolescent Wistar Kyoto Rats
Pardey, M. C., Kumar, N. N., Goodchild, A. K., Clemens, K. J., Homewood, J., & Cornish, J. L. (2012) · Brain Sciences · doi:10.3390/brainsci2030375 · Cited by 17
Mifepristone treatment during early adolescence fails to restore maternal deprivation-induced deficits in behavioral inhibition of adult male rats.
Kentrop, J., van der Tas, L., Loi, M., van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., Joëls, M., & van der Veen, R. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00122 · Cited by 16
Impulsivity and home-cage activity are decreased by lentivirus-mediated silencing of serotonin transporter in the rat hippocampus
Zoratto, F., Tringle, A. L., Bellenchi, G. C., Speranza, L., Travaglini, D., di Porzio, U., Perrone‐Capano, C., Laviola, G., Dreyer, J., & Adriani, W. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.05.076 · Cited by 17
Deleting Snord115 genes in mice remodels monoaminergic systems activity in the brain toward cortico-subcortical imbalances
Marty, V., Butler, J. J., Coutens, B., Chargui, O., Chagraoui, A., Guiard, B. P., Deurwaerdère, P. D., & Cavaillé, J. (2022) · Human Molecular Genetics · doi:10.1093/hmg/ddac139 · Cited by 16
Milnacipran enhances the control of impulsive action by activating D1-like receptors in the infralimbic cortex
Tsutsui‐Kimura, I., Ohmura, Y., Izumi, T., Kumamoto, H., Yamaguchi, T., Yoshida, T., & Yoshioka, M. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2835-5 · Cited by 15
Cocaine self-administration in male and female rats perinatally exposed to PCBs: Evaluating drug use in an animal model of environmental contaminant exposure.
Miller, M. M., Meyer, A. E., Sprowles, J. L. N., & Sable, H. J. K. (2017) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000113 · Cited by 15
The Link Between Cannabis Use and Violent Behavior in the Early Phase of Psychosis: The Potential Role of Impulsivity
Moulin, V., Framorando, D., Gasser, J., & Dan‐Glauser, E. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.746287 · Cited by 15
Concurrent measures of impulsive action and choice are partially related and differentially modulated by dopamine D1- and D2-like receptors in a rat model of impulsivity
Bellés, L., Arrondeau, C., Urueña‐Méndez, G., & Ginovart, N. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173508 · Cited by 15
Evaluating the Relationship Between Inattention and Impulsivity-Related Falls in Hospitalized Older Adults
Harrison, B. E., Ferrari, M., Campbell, C., Maddens, M. E., & Whall, A. L. (2009) · Geriatric Nursing · doi:10.1016/j.gerinurse.2009.09.002 · Cited by 15
Barratt Impulsivity in Healthy Adults Is Associated with Higher Gray Matter Concentration in the Parietal Occipital Cortex that Represents Peripheral Visual Field
Ide, J. S., Tung, H. C., Yang, C.-T., Tseng, Y., & Li, C. R. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00222 · Cited by 15
Frontostriatal circuitry as a target for fMRI-based neurofeedback interventions: A systematic review
Orth, L., Meeh, J., Gur, R. C., Neuner, I., & Sarkheil, P. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.933718 · Cited by 14
Milnacipran Remediates Impulsive Deficits in Rats with Lesions of the Ventromedial Prefrontal Cortex
Tsutsui‐Kimura, I., Yoshida, T., Ohmura, Y., Izumi, T., & Yoshioka, M. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu083 · Cited by 15
Complex living conditions impair behavioral inhibition but improve attention in rats.
van der Veen, R., Kentrop, J., van der Tas, L., Loi, M., van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., & Joëls, M. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00357 · Cited by 14
The association between in vivo central noradrenaline transporter availability and trait impulsivity
Hesse, S., Müller, U., Rullmann, M., Luthardt, J., Bresch, A., Becker, G., Zientek, F., Patt, M., Meyer, P., Blüher, M., et al. (2017) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2017.06.013 · Cited by 16
Psychopathic traits are differentially associated with efficiency of neural communication
Tillem, S., van Dongen, J. D. M., Brazil, I. A., & Baskin-sommers, A. R. (2018) · Psychophysiology · doi:10.1111/psyp.13194 · Cited by 14
Noradrenaline reuptake inhibition increases control of impulsive action by activating D1-like receptors in the infralimbic cortex
Sasamori, H., Ohmura, Y., Yoshida, T., & Yoshioka, M. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.11.041 · Cited by 14
Volume of motor area predicts motor impulsivity
Ai, H., Xin, Y., Luo, Y., Gu, R., & Xu, P. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14339 · Cited by 13
The Link Between Amitriptyline and Movement Disorders: Clinical Profile and Outcome
Rissardo, J. P., & Caprara, A. L. F. (2020) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmed.sg.202023 · Cited by 14
Comparisons of impulsivity among patients with different subtypes of epilepsy
Lee, S., Yang, H.-R., Im, K., Choi, E. J., Jeon, J.-Y., Han, S., Kim, H., Lee, G.-H., & Ryu, H. U. (2022) · Epilepsy Research · doi:10.1016/j.eplepsyres.2022.106997 · Cited by 12
Validation of a method to assess ADHD-related impulsivity in animal models
Watterson, E., Mazur, G. J., & Sanabria, F. (2015) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2015.03.020 · Cited by 13
Effect of a human serotonin 5-HT2A receptor gene polymorphism on impulsivity: Dependence on cholesterol levels
Tomson, K., Vaht, M., Laas, K., Veidebaum, T., & Harro, J. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.07.036 · Cited by 13
Dissecting drug effects in preclinical models of impulsive choice: emphasis on glutamatergic compounds
Yates, J. R. (2018) · Psychopharmacology · doi:10.1007/s00213-017-4825-0 · Cited by 13

Authors: Dalley, J. W., Mar, A. C., Economidou, D., & Robbins, T. W.
Affiliations: University of Cambridge (GB)
Corresponding author: Dalley, Jeffrey W.
ORCID: Dalley, Jeffrey W.
Mar, Adam C.
Robbins, Trevor W.
Venue: Pharmacology Biochemistry and Behavior
Publisher: Elsevier BV
Published: 2008-08
Volume: 90
Issue: 2
Pages: 250-260
ISSN: 0091-3057 (ISSN-L)
DOI: 10.1016/j.pbb.2007.12.021
OpenAlex: W2074006378
Cited by: 467
References: 121
Citations by year: 2026: 7 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 15 · 2021: 14 · 2020: 64 · 2019: 16 · 2018: 26 · 2017: 21 · 2016: 33 · 2015: 35 · 2014: 35 · 2013: 41 · 2012: 31
FWCI: 2.03
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology Biochemistry and Behavior (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (076274/Z04/Z)
University of Cambridge
Medical Research Council
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Keywords: impulsivity, dopamine, norepinephrine, serotonin, acetylcholine, prefrontal cortex, striatum, 5-choice serial reaction time task, delay discounting, attention deficit hyperactivity disorder, goal-directed behavior, animal models of psychiatric disorders, endophenotypes
MeSH terms: Acetylcholine, Animals, Attention Deficit Disorder with Hyperactivity, Conditioning, Operant, Corpus Striatum, Dopamine, Humans, Impulsive Behavior, Reaction Time, Serotonin, Prefrontal Cortex

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neurobehavioral mechanisms of impulsivity: Fronto-striatal systems and functional neurochemistry

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks