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Cited by 311Curcumin's Biomedical ApplicationsCholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatments

The DOI matches its Crossref record; 59 of the 60 references it cites were found in a registry or an index.

Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer’s disease

Ahmed, Touqeer, Gilani, Anwarul-Hassan·2009·Pharmacology Biochemistry and Behavior
DOI 10.1016/j.pbb.2008.09.010
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Abstract

Curcuminoids (a mixture of curcumin, bisdemethoxycurcumin and demethoxycurcumin) share vital pharmacological properties possessed by turmeric, a well known curry spice, considered useful in Alzheimer's disease (AD). The aim of this study was to evaluate if curcuminoids possess acetylcholinesterase (AChE) inhibitory and memory enhancing activities. The in-vitro and ex-vivo models of AChE inhibitory activity were used along with Morris water maze test to study the effect on memory in rats. Curcuminoids inhibited AChE in the in-vitro assay with IC(50) value of 19.67, bisdemethoxycurcumin 16.84, demethoxycurcumin 33.14 and curcumin 67.69 microM. In the ex-vivo AChE assay, curcuminoids and its individual components except curcumin showed dose-dependent (3-10 mg/kg) inhibition in frontal cortex and hippocampus. When studied for their effect on memory at a fixed dose (10 mg/kg), all compounds showed significant (p<0.001) and comparable effect in scopolamine-induced amnesia. These data indicate that curcuminoids and all individual components except curcumin possess pronounced AChE inhibitory activity. Curcumin was relatively weak in the in-vitro assay and without effect in the ex-vivo AChE model, while equally effective in memory enhancing effect, suggestive of additional mechanism(s) involved. Thus curcuminoids mixture might possess better therapeutic profile than curcumin for its medicinal use in AD.

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Metadata

Authors
Ahmed, T., & Gilani, A.-H.
Affiliations
Aga Khan University (PK)
Corresponding author
Gilani, Anwarul-Hassan
ORCID
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
2009-02
Volume
91
Issue
4
Pages
554-559
ISSN
0091-3057 (ISSN-L)
DOI
10.1016/j.pbb.2008.09.010
OpenAlex
W2010499668
Cited by
301
References
60
Citations by year
2026: 6 · 2025: 13 · 2024: 16 · 2023: 17 · 2022: 17 · 2021: 18 · 2020: 28 · 2019: 28 · 2018: 14 · 2017: 21 · 2016: 19 · 2015: 14 · 2014: 20 · 2013: 22 · 2012: 19
FWCI
4.74
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • eCommons - AKU (Aga Khan University) (submittedVersion)
Funders
  • National Council for Higher Education
  • Yükseköğretim Kurulu
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords
curcuminoids, curcumin, bisdemethoxycurcumin, demethoxycurcumin, acetylcholinesterase inhibition, scopolamine-induced amnesia, memory enhancement, Alzheimer's disease, turmeric, hippocampus, frontal cortex
MeSH terms
Acetylcholinesterase, Alzheimer Disease, Amnesia, Animals, Cholinesterase Inhibitors, Curcumin, Dose-Response Relationship, Drug, Hippocampus, Male, Phytotherapy, Memory, Parasympatholytics, Scopolamine, Rats, Sprague-Dawley, Prefrontal Cortex, Maze Learning, Curcuma, Rats

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