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Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer’s disease
Abstract
Curcuminoids (a mixture of curcumin, bisdemethoxycurcumin and demethoxycurcumin) share vital pharmacological properties possessed by turmeric, a well known curry spice, considered useful in Alzheimer's disease (AD). The aim of this study was to evaluate if curcuminoids possess acetylcholinesterase (AChE) inhibitory and memory enhancing activities. The in-vitro and ex-vivo models of AChE inhibitory activity were used along with Morris water maze test to study the effect on memory in rats. Curcuminoids inhibited AChE in the in-vitro assay with IC(50) value of 19.67, bisdemethoxycurcumin 16.84, demethoxycurcumin 33.14 and curcumin 67.69 microM. In the ex-vivo AChE assay, curcuminoids and its individual components except curcumin showed dose-dependent (3-10 mg/kg) inhibition in frontal cortex and hippocampus. When studied for their effect on memory at a fixed dose (10 mg/kg), all compounds showed significant (p<0.001) and comparable effect in scopolamine-induced amnesia. These data indicate that curcuminoids and all individual components except curcumin possess pronounced AChE inhibitory activity. Curcumin was relatively weak in the in-vitro assay and without effect in the ex-vivo AChE model, while equally effective in memory enhancing effect, suggestive of additional mechanism(s) involved. Thus curcuminoids mixture might possess better therapeutic profile than curcumin for its medicinal use in AD.
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“The inhibitory effect of curcuminoids on acetylcholinesterase activity in AD has already been established by Ahmed and group [80].”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [80]
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Aqeel, Y., Iqbal, J., Siddiqui, R., Gilani, A. H., & Khan, N. A. (2012) · Experimental Parasitology · doi:10.1016/j.exppara.2012.09.007 · Cited by 42
Self-citationSex Differences in Alzheimer’s Disease: Where Do We Stand?
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Curcuminoids rescue long‐term potentiation impaired by amyloid peptide in rat hippocampal slices
Ahmed, T., Gilani, A. H., Hosseinmardi, N., Semnanian, S., Enam, S. A., & Fathollahi, Y. (2010) · Synapse · doi:10.1002/syn.20876 · Cited by 42
Self-citationJamal, Q. M. S., Khan, M. I., Alharbi, A. H., Ahmad, V., & Yadav, B. S. (2023) · Nutrients · doi:10.3390/nu15071579 · Cited by 42
Metadata
- Authors
- Ahmed, T., & Gilani, A.-H.
- Affiliations
- Aga Khan University (PK)
- Corresponding author
- Gilani, Anwarul-Hassan
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 91
- Issue
- 4
- Pages
- 554-559
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2010499668
- Cited by
- 301
- References
- 60
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 16 · 2023: 17 · 2022: 17 · 2021: 18 · 2020: 28 · 2019: 28 · 2018: 14 · 2017: 21 · 2016: 19 · 2015: 14 · 2014: 20 · 2013: 22 · 2012: 19
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- eCommons - AKU (Aga Khan University) (submittedVersion)
- Funders
- National Council for Higher Education
- Yükseköğretim Kurulu
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- curcuminoids, curcumin, bisdemethoxycurcumin, demethoxycurcumin, acetylcholinesterase inhibition, scopolamine-induced amnesia, memory enhancement, Alzheimer's disease, turmeric, hippocampus, frontal cortex
- MeSH terms
- Acetylcholinesterase, Alzheimer Disease, Amnesia, Animals, Cholinesterase Inhibitors, Curcumin, Dose-Response Relationship, Drug, Hippocampus, Male, Phytotherapy, Memory, Parasympatholytics, Scopolamine, Rats, Sprague-Dawley, Prefrontal Cortex, Maze Learning, Curcuma, Rats
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