Cited by 107Cardiovascular and exercise physiologyPhysical Activity and HealthObesity, Physical Activity, Diet

The joint association of fitness and fatness on cardiovascular disease mortality: a meta-analysis.

Barry, Vaughn W., Caputo, Jennifer L., Kang, Minsoo·2018·Progress in Cardiovascular Diseases

Abstract

The joint association of cardiorespiratory fitness (CRF) and body mass index (BMI) on cardiovascular disease (CVD) mortality was determined. PubMed and CINAHL were searched following PRISMA guidelines. Included studies were prospective, had objective assessments of maximal CRF and BMI, and compared the joint impact of CRF and BMI on CVD mortality risk to normal weight, fit referents. Pooled hazard ratios and 95% confidence intervals were calculated from eight articles with nine independent groups using a random effects model. Unfit individuals had two to three times the risk of mortality across all levels of BMI. Overweight and obese-fit individuals had 25% and 42% increased mortality risk, respectively, compared to normal weight-fit individuals. However, for the obese-fit group, a one study removed analysis for five studies resulted in non-significant changes in mortality risk. Researchers, clinicians, and public health officials are encouraged to employ CRF interventions to reduce CDV mortality risk.

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Crossref · 10.1016/j.pcad.2018.07.004

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  • Individuals with obesity but without diabetes are at elevated risk of developing diabetes and other cardiometabolic conditions compared with individuals without obesity.

    “This subgroup, while sometimes characterized as metabolically healthy due to the lack of prevalent disease, is at elevated risk of developing diabetes and other cardiometabolic conditions compared with individuals without obesity.4,5,6,7”

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Authors
Barry, V. W., Caputo, J. L., & Kang, M.
Affiliations
  • Middle Tennessee State University (US)
  • University of Mississippi (US)
Corresponding author
Barry, Vaughn W.
Venue
Progress in Cardiovascular Diseases
Publisher
Elsevier BV
Published
2018-07
Volume
61
Issue
2
Pages
136-141
ISSN
0033-0620 (ISSN-L)
OpenAlex
W2834093841
Cited by
107
References
31
Citations by year
2026: 4 · 2025: 16 · 2024: 10 · 2023: 13 · 2022: 12 · 2021: 19 · 2020: 18 · 2019: 14 · 2018: 1
FWCI
3.05
Type
journal article
Language
en
Open access
closed
Locations
  • Progress in Cardiovascular Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
cardiorespiratory fitness, body mass index, cardiovascular mortality, obesity, overweight, mortality risk
MeSH terms
Healthy Lifestyle, Cardiorespiratory Fitness, Cardiovascular Diseases, Health Status, Humans, Obesity, Prognosis, Risk Factors, Exercise, Body Mass Index, Risk Reduction Behavior, Adiposity

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