The effectiveness of patient activation intervention on type 2 diabetes mellitus glycemic control and self-management behaviors: A systematic review of RCTs
Abstract
Background Type 2 diabetes mellitus T2DM is a major health challenge and associated with several complications and mortality. Self-management behaviors SMBs such as healthy diet, physical activity, blood glucose self-monitoring, foot care and medication adherence are critical part of diabetic care. Empowered or activated patients, are more likely to practice better SMBs. However, the effectiveness of patient activation intervention on T2DM glycemic control and SMBs is not totally well understood.Aim To assess the effectiveness of patient activation intervention on T2DM glycemic control and SMBs.Method A systematic search was undertaken through five databases to find relevant studies published between 2004 and 2018. We included randomized controlled trials with sample size ≥120 and follow up period of ≥12 months and assess the effectiveness of patient activation intervention on T2DM glycemic control and SMBs.Results 10 RCTs were identified for analysis. The total sample size is 3728 and the combined mean age is 57.3 years. The combined mean BMI is 31.2kg/m 2 (obese). Seven intervention demonstrated a significant reduction in HbA1c, ranged from 0.36 to 0.80%. All interventions presented an improvement in at least one self-management behavior.Discussion and conclusion Patient activation intervention showed a significant positive effect on T2DM glycemic control and SMBs, particularly physical activity, healthy diet, foot care and blood glucose self-monitoring. The effectiveness on SMBs was seen across different intervention strategies, modes of delivery, length of intervention, and number of providers. Better effectiveness on HbA1c was associated with poorly controlled participants, culturally tailored-intervention, and in-person sessions intervention combined with telephone calls follow up.
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The development in technologies and infrastructures provides solid ground for digital health advancement, including penetration of cell phones and the internet.
“The development in technologies and infrastructures provide solid ground for digital health advancement, including penetration of cell phones and the internet.”
From Digital health interventions for non-communicable disease management in primary health care in low-and middle-income countries (2023) · cites this paper as [24]
Digital health designs that were integrated into existing healthcare model was a facilitator for successful uptake, and unintegrated digital health interventions that impose additional workload for primary healthcare providers is a barrier.
“Digital health designs that were integrated into existing healthcare model was a facilitator for successful uptake, and unintegrated digital health interventions that impose additional workload for primary healthcare providers is a barrier.”
From Digital health interventions for non-communicable disease management in primary health care in low-and middle-income countries (2023) · cites this paper as [24]
Motivational interviewing, patient activation, goal setting and action planning, problem-solving, tracking or self-monitoring health behaviors, and facilitating opportunities for social support are behavioral strategies with empirical support.
“Behavioral strategies with empirical support include motivational interviewing (303-305), patient activation (306), goal setting and action planning (305,307-309), problem-solving (308,310), tracking or self-monitoring health behaviors with or without feedback from a health care professional (305,307-309), and facilitating opportunities for social support (305,308,309).”
From 5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes:<i>Standards of Care in Diabetes—2023</i> (2023) · cites this paper as [306]
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Hosseinzadeh, H., Ratan, Z. A., Shnaigat, M., Edwards, J. F., Verma, I., Niknami, M., & Dadich, A. (2022) · Health Promotion Journal of Australia · doi:10.1002/hpja.631 · Cited by 12 · see citing works
Self-citationSheehan, J. L., Greene-Higgs, L., Resnicow, K., Patel, M. R., Barnes, E. L., Waljee, A. K., Higgins, P., & Cohen‐Mekelburg, S. (2024) · Digestive Diseases and Sciences · doi:10.1007/s10620-024-08712-2 · Cited by 12 · see citing works
“Higher levels of patient activation have been associated with improved outcomes for patients with chronic conditions and have been the target for self-management intervention for other chronic disease models, such as heart failure and diabetes [4, 5].”
Abbott, L. S., Slate, E. H., Graven, L. J., Lemacks, J. L., & Grant, J. S. (2021) · Nursing Reports · doi:10.3390/nursrep11020024 · Cited by 12 · see citing works
“A systematic review of randomized controlled trials showed that improved HbA1C levels were associated with culturally relevant and face-to-face interventions [48].”
BackgroundZeidalkilani, J., Milhem, Y. A., Shorafa, R. N., Taha, S., Koni, A. A., Al‐Jabi, S. W., & Zyoud, S. H. (2024) · BMC Nephrology · doi:10.1186/s12882-024-03674-z · Cited by 11 · see citing works
“High activation in patients with DM was found to be associated with fewer admissions, better glycemic control, blood glucose monitoring, physical exercise, improved nutritional habits, and adherence to recommended eye examinations and foot care [17–19].”
BackgroundAgeru, T. A., Le, C. N., Wattanapisit, A., Woticha, E. W., Truong, N. T., Stanikzai, M. H., Abiso, T. L., & Suwanbamrung, C. (2024) · PLoS ONE · doi:10.1371/journal.pone.0305860 · Cited by 11 · see citing works
Caro, J., Villa‐Estrada, F., Gómez‐González, A. J., Lupiáñez‐Pérez, I., Herrera, J. C. M., Kaknani‐Uttumchandani, S., García‐Mayor, S., & Morales‐Asencio, J. M. (2020) · Journal of Advanced Nursing · doi:10.1111/jan.14580 · Cited by 11 · see citing works
Fuentes, S., Hrzic, R., Haneef, R., Kab, S., Cosson, E., & Fosse‐Edorh, S. (2023) · Diabetes Epidemiology and Management · doi:10.1016/j.deman.2023.100137 · Cited by 10 · see citing works
Research status and hotspots of patient engagement: A bibliometric analysis
Man, C., Liu, T., Yan, S., Xie, Q., & Liu, H. (2024) · Patient Education and Counseling · doi:10.1016/j.pec.2024.108306 · Cited by 10 · see citing works
de Frel, D. L., Schroijen, M. A., Aardoom, J. J., van Gils, W., Huisman, S. D., Janssen, V. R., Versluis, A., Kleinsmann, M. S., Atsma, D. E., & Pijl, H. (2023) · JMIR Human Factors · doi:10.2196/45055 · Cited by 8 · see citing works
“Yet, another systematic review reported that encouraging patients to play an active role in self-management, so-called patient activation or empowerment, can also improve glucose regulation [13].”
BackgroundCai, J., Xu, H., Jiang, S., Sung, J., Sawhney, R., Broadley, S., & Sun, J. (2023) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2023.110727 · Cited by 8 · see citing works
Zhang, C., Wu, Z., Lopez, E. R., Magboo, R. G., & Hou, K. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1167721 · Cited by 8 · see citing works
“Biological and psychosocial factors are constantly interconnected and influenced by each other, so it is not enough to control the metabolism of diabetes in diabetes treatment only by drugs, etc., (Almutairi et al., 2020; Que et al., 2021;Wu et al., 2023).”
BackgroundHohberg, V., Kreppke, J.-N., Kohl, J., Seelig, E., Zahner, L., Streckmann, F., Gerber, M., König, D., & Faude, O. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-057948 · Cited by 8 · see citing works
Bendixen, B. E., Wilhelmsen‐Langeland, A., Lomborg, K. E., Måkestad, E., Iversen, M. M., Søfteland, E. W., & Haugstvedt, A. (2025) · The Science of Diabetes Self-Management and Care · doi:10.1177/26350106251326517 · Cited by 8 · see citing works
Tang, T. S., Sidhu, R., Halani, K., Elliott, T., Sohal, P., & Garg, A. (2022) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2021.11.003 · Cited by 7 · see citing works
Patient Activation During the First 6 Months After the Start of Stroke Rehabilitation
van Meijeren-Pont, W., Tamminga, S. J., Fiocco, M. F., Avila, A. G., Volker, G., Janssen, S. M. J., Vlieland, T. P. M. V., & Oosterveer, D. M. (2022) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2022.02.017 · Cited by 7 · see citing works
Strandberg, R. B., Nilsen, R. M., Pouwer, F., Igland, J., Forster, R. B., Jenum, A. K., Buhl, E. S., & Iversen, M. M. (2022) · Patient Education and Counseling · doi:10.1016/j.pec.2022.107577 · Cited by 7 · see citing works
Chu, N. Y., Watson, K. E., Hamarneh, Y. N. A., Yushko, L., Tsuyuki, R. T., & Smyth, P. S. (2023) · BMC Neurology · doi:10.1186/s12883-023-03090-0 · Cited by 7 · see citing works
Obesity and Patient Activation: Confidence, Communication, and Information Seeking Behavior
Chang, J. E., Lindenfeld, Z., & Chang, V. W. (2022) · Journal of Primary Care & Community Health · doi:10.1177/21501319221129731 · Cited by 7 · see citing works
Velasco, E. R., Pedersen, H. S., & Skinner, T. C. (2022) · JMIR Formative Research · doi:10.2196/40058 · Cited by 7 · see citing works
“However, we now know that these NCDs can be prevented, or substantially delayed, by changes in lifestyle (eg, factors such as diet, physical activity, stress, and sleep), as shown in numerous trials [2-4].”
BackgroundJiang, N., Feng, L., Song, N., Ye, Y., Wei, B., Tian, T., Chen, N., Li, Y., & Jiang, X. (2025) · Geriatric Nursing · doi:10.1016/j.gerinurse.2025.02.013 · Cited by 8 · see citing works
Thinakaran, K., Ahern, A. L., Beckett, R. S., Shaida, S. F., Wills, H. M., Richards, R., Birch, J. M., Griffin, S. J., & Mueller, J. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-095456 · Cited by 6 · see citing works
“HbA 1c was the most frequently measured clinical outcome, while physical activity and smoking were the most reported SMBs. Outcomes like LDL, body weight and alcohol consumption were infrequently reported.”
InfluentialInterpersonal (mis)perceptions and (mis)predictions in patient–clinician interactions
Valentine, K. D., & Scherer, L. D. (2021) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2021.07.021 · Cited by 6 · see citing works
Bhukya, N. K. N., Prabhath, S., Devi, E. S., Maiya, A. G., Seetharam, P., Hebbar, S., Karkada, G., Shetty, S., & Karanth, S. (2025) · BMC Health Services Research · doi:10.1186/s12913-025-13244-0 · Cited by 6 · see citing works
“A key component of IPCEP is patient activation interventions, which, as shown in randomized controlled trials, lead to marked improvements in glycemic control and self-management behaviors (SMBs) such as physical activity, healthy eating, foot care, and blood glucose monitoring [104].”
Parsons, S. N., Luzio, S. D., Dowrick, S. C., Dunseath, G. J., Cheung, W., Gibbs, S. L., Owens, D. R., & Stephens, J. W. (2025) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2025.103283 · Cited by 5 · see citing works
Liang, W., Chow, K. M., Ni, X., Tola, Y. O., & Lo, S. H. S. (2025) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2025.105200 · Cited by 6 · see citing works
Pankratz, V. S., Choi, E. E., Qeadan, F., GHAHATE, D. M., Bobelu, J., Nelson, R. G., Faber, T., & Shah, V. O. (2020) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2020.107753 · Cited by 5 · see citing works
“glycemic control measured by reduction of HbA1c level (25).”
BackgroundThe experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM)
Stedman, M., Rea, R. D., Duff, C. J., Livingston, M. A., McLoughlin, K., Wong, L., Brown, S., Grady, K., Gadsby, R., Gibson, M., et al. (2021) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.302 · Cited by 5 · see citing works
Zhang, N., Qu, X., & Kang, L. (2025) · Frontiers in Clinical Diabetes and Healthcare · doi:10.3389/fcdhc.2025.1606330 · Cited by 4 · see citing works
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Type 2 Diabetes Mellitus in Saudi Arabia
Tanveer, M. S., Tanveer, M. S., & Javed, M. (2021) · Journal of Diabetology · doi:10.4103/jod.jod_92_20 · Cited by 4 · see citing works
Mueller, J., Ahern, A. L., Sharp, S. J., Richards, R., Birch, J. M., Davies, A., & Griffin, S. J. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-056293 · Cited by 5 · see citing works
Bendixen, B. E., Wilhelmsen‐Langeland, A., Lomborg, K. E., Måkestad, E., Skogheim, T. L., Schønberg, A., Iversen, M. M., Kvale, G., Søfteland, E. W., & Haugstvedt, A. (2025) · The Science of Diabetes Self-Management and Care · doi:10.1177/26350106241304422 · Cited by 4 · see citing works
“9-13 A systematic review and meta-analysis has shown that group-based self-management education for individuals with T2DM is more effective than standardized care for improvements of lifestyle, psychosocial outcomes, and clinical outcomes.”
Najafpour, Z., Zeidi, I. M., & Kalhor, R. (2021) · Clinical Diabetology · doi:10.5603/dk.a2021.0040 · Cited by 4 · see citing works
“Diabetes is a chronic and metabolic disease characterized by elevated blood glucose levels and is recognized as a major public health challenge [2, 3].”
BackgroundIntervención educativa de autocuidado en la prevención del pie diabético
Mesa, M. P. Q., Padilla, J. D. V., & Ortiz, E. J. R. (2022) · Avances en Enfermería · doi:10.15446/av.enferm.v40n2.101311 · Cited by 4 · see citing works
Applying the Patient Empowerment, Engagement, and Activation Survey to Improve Patient Outcomes
Stichler, J. F., & Pelletier, L. R. (2023) · JONA The Journal of Nursing Administration · doi:10.1097/nna.0000000000001364 · Cited by 4 · see citing works
Lee, K. S., Kim, H. Y., & Jin, H. Y. (2021) · Journal of Clinical Nursing · doi:10.1111/jocn.15985 · Cited by 4 · see citing works
Outreach Method Predicts Patient Re-engagement in Diabetes Care During Sustained Care Disruption
Cromwell, G. E., Hudson, M., Simonson, D. C., & McDonnell, M. E. (2021) · Endocrine Practice · doi:10.1016/j.eprac.2021.09.003 · Cited by 5 · see citing works
Nair, D., & Cavanaugh, K. L. (2021) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.05050421 · Cited by 4 · see citing works
Bennett‐Brown, M., Gesselman, A. N., & Miller, W. R. (2022) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2022.108957 · Cited by 3 · see citing works
Guo, N., Li, N., Zhao, Y., Sun, H., & Liu, K. (2022) · Journal of Healthcare Engineering · doi:10.1155/2022/1120242 · Cited by 3 · see citing works
Xu, L., & Chen, Y. (2022) · Minerva Medica · doi:10.23736/s0026-4806.22.08338-0 · Cited by 3 · see citing works
Vilafranca-Cartagena, M., Bonet, A., Colillas-Malet, E., Puiggrós-Binefa, A., & Tort‐Nasarre, G. (2024) · Healthcare · doi:10.3390/healthcare12141373 · Cited by 3 · see citing works
“Telephone follow-up and the individualization of programs can increase the effectiveness of interventions, even if they are group-based [39].”
BackgroundLiang, W., Chow, K. M., Ni, X., Tola, Y. O., & Lo, S. H. S. (2024) · Primary care diabetes · doi:10.1016/j.pcd.2024.09.010 · Cited by 3 · see citing works
Larson, M. (2024) · American Journal of Lifestyle Medicine · doi:10.1177/15598276241303728 · Cited by 2 · see citing works
Xie, M., Chen, S., & He, Q. (2024) · Medicine · doi:10.1097/md.0000000000040286 · Cited by 2 · see citing works
“[10,11] Effective management and treatment of this condition is essential to reduce its burden on the public health system.”
BackgroundMartínez, W., Hackstadt, A. J., Hickson, G. B., Rosenbloom, S. T., & Elasy, T. A. (2021) · JMIR Research Protocols · doi:10.2196/25955 · Cited by 2 · see citing works
“Patient activation (ie, knowledge, skills, and confidence in managing one’s own health) is vital to achieving optimal diabetes self-management and is associated with lower health care costs [3-5].”
BackgroundAl‐Gamal, E., Alnaser, Z., Mohammed, I., Kaliyaperumal, L., Qudah, A. A., Hyarat, S. Y., Alawas, H., Alrashed, J., Alhamad, A., & Long, T. (2024) · The Open Nursing Journal · doi:10.2174/0118744346309631240517111532 · Cited by 2 · see citing works
Self-Management Perceptions and Death Concerns of Patients with Diabetes Mellitus
Keskin, A. Y., Tuna, H. İ., & Günhan, E. (2024) · Genel Tıp Dergisi · doi:10.54005/geneltip.1287564 · Cited by 1 · see citing works
Udby, D. L., Smith, D. K., Cushman, N. A., Vue, M., Reyes‐Gastelum, D., Klapperich, A., Ohman, T., Hromika, A. J., & Mackler, E. R. (2025) · JACCP JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY · doi:10.1002/jac5.2075 · Cited by 1 · see citing works
“24,25 It is difficult to ascertain from this study if increased confidence was related to the technology (CGM), the pharmacist, or the number of visits for those within the program.”
The development of a CBT-informed approach to supporting type 2 diabetes self-management
Visagie, E., Deacon, E., & Kok, R. (2025) · Frontiers in Clinical Diabetes and Healthcare · doi:10.3389/fcdhc.2025.1421678 · Cited by 1 · see citing works
Health Literacy and Cognitive Disorders in Diabetic Patients
Florek-Łuszczki, M., Lutomski, P., Strzelecka, A., Łuszczki, J. J., & Dziemidok, P. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14092972 · Cited by 1 · see citing works
Patient Activation Impacts Exercise in Older Adults With Kidney Disease
Mirpuri, K. K., Roach, C., Woodall, E. M., Prigmore, H. L., Greevy, R. A., Wilkinson, T. J., Lightfoot, C. J., Bonnet, K. R., Cukor, D., Taylor, W. D., et al. (2025) · Kidney International Reports · doi:10.1016/j.ekir.2025.07.017 · Cited by 1 · see citing works
“28,29 The few studies of patient activation kidney disease populations exclude older adults but demonstrate associations between patient activation and health literacy, 30 diabetes self-care, 31 decisional conflict, 32 quality of life, 33 and more recently, health care utilization.”
Wang, Q., Shi, X., Zhang, M., Chen, Y., Wang, L., Fan, R., & Lin, Y. (2025) · Geriatric Nursing · doi:10.1016/j.gerinurse.2025.103540 · Cited by 1 · see citing works
Singleton, G., Halcomb, E., Bonney, A. D., & Hosseinzadeh, H. (2025) · JMIR Research Protocols · doi:10.2196/83105 · Cited by 1 · see citing works
“Despite its potential, the role of activation in the primary prevention of chronic conditions remains underexplored [21,22,25,29].”
Self-citationSims, T. J., Kapoor, R., Chinthammit, C., & Spaepen, E. (2025) · Diabetic Medicine · doi:10.1111/dme.70190 · Cited by 1 · see citing works
Alosta, M. R., Atiyeh, H., Hani, S. B., Hamdan‐Mansour, A. M., Al‐yyan, A. A., Afaneh, T., Sarhan, R., Al‐Momani, M., & Othman, E. H. (2026) · Research in Nursing & Health · doi:10.1002/nur.70080 · Cited by 1 · see citing works
Haeruddin, H., Amiruddin, R., Yusuf, S., Naiem, M. F., Sidin, A. I., Wahiduddin, W., Wahyu, A., Kada, M. K. R., Ma'ge, A., & Harbaeni, H. (2026) · F1000Research · doi:10.12688/f1000research.177355.2 · Cited by 1 · see citing works
- Authors
- Almutairi, N., Hosseinzadeh, H., & Gopaldasani, V.
- Affiliations
- University of Wollongong (AU)
- Corresponding author
- Hosseinzadeh, Hassan
- Venue
- Primary Care Diabetes
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 14
- Issue
- 1
- Pages
- 12-20
- ISSN
- 1751-9918 (ISSN-L)
- OpenAlex
- W2974640377
- Cited by
- 144
- References
- 50
- Citations by year
- 2026: 17 · 2025: 22 · 2024: 23 · 2023: 28 · 2022: 23 · 2021: 20 · 2020: 10 · 2019: 1
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Primary care diabetes (publishedVersion)
- PubMed (publishedVersion)
- Research Online (University of Wollongong) (submittedVersion)
- Funders
- ministry of health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- patient activation, type 2 diabetes, glycemic control, HbA1c, self-management behavior, physical activity, healthy eating, foot care, self-monitoring of blood glucose, medication adherence, culturally tailored interventions, telephone follow-up
- MeSH terms
- Healthy Lifestyle, Diet, Healthy, Glycemic Control, Blood Glucose, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Health Knowledge, Attitudes, Practice, Male, Middle Aged, Patient Education as Topic, Patient Participation, Self Care, Biomarkers, Exercise, Randomized Controlled Trials as Topic, Treatment Outcome, Risk Reduction Behavior, Medication Adherence
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