The role of gut hormone peptide YY in energy and glucose homeostasis: Twelve years on
Open accessAbstract
Although the role of peptide YY (PYY) as a regulator of energy homeostasis was first highlighted only in 2002, our understanding of the physiological role of PYY has since rapidly advanced. In recent years, insights from mechanistic studies in patients undergoing bariatric surgery, from pancreatic islet research, from functional neuroimaging studies, and from exercise research have greatly added to the field, and these areas provide the focus of discussion for this narrative review. We critically discuss recent findings relating to the role of PYY in mediating the beneficial effects of bariatric surgery, the role of PYY in glucose homeostasis, the role of hepatoportal PYY in mediating its central physiological effects, the specific modulation of brain regions by PYY, and the exercise-induced PYY response.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Total PYY includes both PYY 1-36 and PYY 3-36, which have divergent actions on appetite.
“total PYY which includes both PYY 1-36 and PYY 3-36 , reported by Manning and Batterham (2014) to have divergent actions on appetite.”
From Influence of water-based exercise on energy intake, appetite, and appetite-related hormones in adults: A systematic review and meta-analysis (2023) · cites this paper as Manning and Batterham (2014)
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Gut hormone PYY3-36 physiologically inhibits food intake
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351 · see citing works
Self-citationKRINGELBACH, M. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.03.006 · Cited by 1,977 · see citing works
Sjöström, L. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12012 · Cited by 1,835 · see citing works
Metabolic/Bariatric Surgery Worldwide 2011
Buchwald, H., & Oien, D. M. (2013) · Obesity Surgery · doi:10.1007/s11695-012-0864-0 · Cited by 1,698 · see citing works
Inhibition of Food Intake in Obese Subjects by Peptide YY <sub>3–36</sub>
Batterham, R. L., Cohen, M. A., Ellis, S. M., Le Roux, C. W., Withers, D. J., Frost, G. S., Ghatei, M. A., & Bloom, S. R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030204 · Cited by 1,604 · see citing works
Self-citationLong-term persistence of hormonal adaptations to weight loss
Sumithran, P., Prendergast, L. A., Delbridge, E., Purcell, K., Shulkes, A., Kriketos, A., & Proietto, J. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1105816 · Cited by 1,449 · see citing works
Roux, C. W. L., Aylwin, S. J. B., Batterham, R. L., Borg, C. M., Coyle, F., Prasad, V., Shurey, S., Ghatei, M. A., Patel, A. G., & Bloom, S. R. (2006) · Annals of Surgery · doi:10.1097/01.sla.0000183349.16877.84 · Cited by 985 · see citing works
Self-citationEllingsgaard, H., Hauselmann, I., Schuler, B., Habib, A. M., Baggio, L. L., Meier, D. T., Eppler, E., Bouzakri, K., Wueest, S., Muller, Y. D., et al. (2011) · Nature Medicine · doi:10.1038/nm.2513 · Cited by 922 · see citing works
Kringelbach, M. L. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.10.1064 · Cited by 824 · see citing works
Karamanakos, S. N., Vagenas, K., Kalfarentzos, F. E., & Alexandrides, T. K. (2008) · Annals of Surgery · doi:10.1097/sla.0b013e318156f012 · Cited by 814 · see citing works
Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass
le Roux, C. W., Welbourn, R., Werling, M., Osborne, A., Kokkinos, A., Laurenius, A., Lönroth, H., Fändriks, L., Ghatei, M. A., Bloom, S. R., et al. (2007) · Annals of Surgery · doi:10.1097/sla.0b013e3180caa3e3 · Cited by 741 · see citing works
Mechanick, J. I., Youdim, A., Jones, D. B., Garvey, W. T., Hurley, D. L., McMahon, M. M., Heinberg, L. J., Kushner, R. F., Adams, T. D., Shikora, S. A., et al. (2013) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2012.12.010 · Cited by 701 · see citing works
Ghrelin Modulates Brain Activity in Areas that Control Appetitive Behavior
Malik, S., McGlone, F., Bedrossian, D., & Dagher, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.03.007 · Cited by 677 · see citing works
Incretin-based therapies for type 2 diabetes mellitus
Lovshin, J. A., & Drucker, D. J. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.48 · Cited by 645 · see citing works
Critical role for peptide YY in protein-mediated satiation and body-weight regulation
Batterham, R. L., Heffron, H., Kapoor, S., Chivers, J. E., Chandarana, K., Herzog, H., le Roux, C. W., Thomas, E. L., Bell, J. D., & Withers, D. J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.08.001 · Cited by 623 · see citing works
Self-citationTatemoto, K. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.8.2514 · Cited by 615 · see citing works
The role of gut hormones in glucose homeostasis
Drucker, D. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30076 · Cited by 611 · see citing works
The Hormonal Control of Food Intake
Coll, A. P., Farooqi, I. S., & O’Rahilly, S. (2007) · Cell · doi:10.1016/j.cell.2007.04.001 · Cited by 605 · see citing works
Attenuated Peptide YY Release in Obese Subjects Is Associated with Reduced Satiety
le Roux, C. W., Batterham, R. L., Aylwin, S. J. B., Patterson, M., Borg, C.-M., Wynne, K., Kent, A. S. H., Vincent, R. P., Gardiner, J., Ghatei, M. A., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0972 · Cited by 549 · see citing works
Self-citationPeterli, R., Steinert, R. E., Wölnerhanssen, B. K., Peters, T. T. A., Christoffel-Courtin, C., Gass, M., Kern, B. E., von Fluee, M., & Beglinger, C. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0622-3 · Cited by 529 · see citing works
Wu, T., Gao, X., Chen, M., & Van Dam, R. M. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2008.00547.x · Cited by 515 · see citing works
Metabolic and hedonic drives in the neural control of appetite: who is the boss?
Berthoud, H. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.09.004 · Cited by 501 · see citing works
PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans
Batterham, R. L., Ffytche, D. H., Rosenthal, J., Zelaya, F. O., Barker, G. J., Withers, D. J., & Williams, S. (2007) · Nature · doi:10.1038/nature06212 · Cited by 474 · see citing works
Self-citationKorner, J., Bessler, M., Cirilo, L. J., Conwell, I. M., Daud, A., Restuccia, N. L., & Wardlaw, S. L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1076 · Cited by 417 · see citing works
Sleeve Gastrectomy — A Restrictive Procedure?
Melissas, J., Koukouraki, S., Askoxylakis, J., Stathaki, M., Daskalakis, M., Perisinakis, K., & Karkavitsas, N. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9006-5 · Cited by 402 · see citing works
Morínigo, R., Moizé, V., Musri, M., Lacy, A. M., Navarro, S., Marín, J. L., Delgado, S., Casamitjana, R., & Vidal, J. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0904 · Cited by 397 · see citing works
Habib, A. M., Richards, P., Cairns, L. S., Rogers, G. J., Bannon, C. A. M., Parker, H. E., Morley, T. C. E., Yeo, G. S. H., Reimann, F. M., & Gribble, F. M. (2012) · Endocrinology · doi:10.1210/en.2011-2170 · Cited by 386 · see citing works
CD26: A Multifunctional Integral Membrane and Secreted Protein of Activated Lymphocytes
Gorrell, M. D., Gysbers, V., & McCaughan, G. W. (2001) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2001.00984.x · Cited by 363 · see citing works
Grandt, D., Schimiczek, M., Beglinger, C., Layer, P., Goebell, H., Eysselein, V. E., & Reeve, J. R. (1994) · Regulatory Peptides · doi:10.1016/0167-0115(94)90204-6 · Cited by 363 · see citing works
Effects of exercise on gut peptides, energy intake and appetite
Martins, C., Morgan, L., Bloom, S. R., & Robertson, M. D. (2007) · Journal of Endocrinology · doi:10.1677/joe-06-0030 · Cited by 356 · see citing works
Silva, A. D., Salem, V., Long, C. J., Makwana, A., Newbould, R. D., Rabiner, E. A., Ghatei, M. A., Bloom, S. R., Matthews, P. M., Beaver, J. D., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.09.010 · Cited by 351 · see citing works
Proteolytic processing of neuropeptide Y and peptide YY by dipeptidyl peptidase IV
Mentlein, R., Dahms, P., Grandt, D., & Krüger, R. (1993) · Regulatory Peptides · doi:10.1016/0167-0115(93)90435-b · Cited by 349 · see citing works
Jacobsen, S. H., Olesen, S. C., Dirksen, C., Jørgensen, N. B., Bojsen-Møller, K. N., Kielgast, U., Worm, D., Almdal, T., Naver, L. S., Hvolris, L. E., et al. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0621-4 · Cited by 342 · see citing works
Korner, J., Inabnet, W., Febres, G., Conwell, I. M., McMahon, D. J., Salas, R., Taveras, C., Schrope, B., & Bessler, M. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.79 · Cited by 338 · see citing works
Egerod, K. L., Engelstoft, M. S., Grunddal, K. V., Nøhr, M. K., Secher, A., Sakata, I., Pedersen, J., Windeløv, J. A., Füchtbauer, E., Olsen, J., et al. (2012) · Endocrinology · doi:10.1210/en.2012-1595 · Cited by 328 · see citing works
King, N. A., Burley, V. J., & Blundell, J. E. (1994) · PubMed · Cited by 327 · see citing works
Broom, D. R., Batterham, R. L., King, J. A., & Stensel, D. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90706.2008 · Cited by 325 · see citing works
Self-citationBorg, C.-M., le Roux, C. W., Ghatei, M. A., Bloom, S. R., Patel, A. G., & Aylwin, S. J. B. (2006) · British journal of surgery · doi:10.1002/bjs.5227 · Cited by 318 · see citing works
Speakman, J. R., Levitsky, D. A., Allison, D. B., Bray, M. S., de Castro, J. M., Clegg, D. J., Clapham, J. C., Dulloo, A. G., Gruer, L. D., Haw, S. J., et al. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.008698 · Cited by 316 · see citing works
Physiology: Does gut hormone PYY3–36 decrease food intake in rodents?
Tschöp, M., Castañeda, T. R., Joost, H., Thöne-Reineke, C., Ortmann, S., Klaus, S., Hagan, M. M., Chandler, P. C., Oswald, K., Benoit, S. C., et al. (2004) · Nature · doi:10.1038/nature02665 · Cited by 311 · see citing works
Strader, A. D., Vahl, T. P., Jandacek, R. J., Woods, S. C., D’Alessio, D. A., & Seeley, R. J. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00153.2004 · Cited by 290 · see citing works
All Bariatric Surgeries Are Not Created Equal: Insights from Mechanistic Comparisons
Stefater, M. A., Wilson, H., Chambers, A. P., Sandoval, D. A., & Seeley, R. J. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1044 · Cited by 281 · see citing works
Sleeve Gastrectomy—A “Food Limiting” Operation
Melissas, J., Daskalakis, M., Koukouraki, S., Askoxylakis, I., Metaxari, M., Dimitriadis, E., Stathaki, M., & Papadakis, J. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9634-4 · Cited by 280 · see citing works
Sloth, B., Holst, J. J., Flint, A., Gregersen, N. T., & Astrup, A. V. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00450.2006 · Cited by 243 · see citing works
Differential Effects of Gastric Bypass and Banding on Circulating Gut Hormone and Leptin Levels
Korner, J., Inabnet, W., Conwell, I. M., Taveras, C., Daud, A., Olivero‐Rivera, L., Restuccia, N. L., & Bessler, M. (2006) · Obesity · doi:10.1038/oby.2006.179 · Cited by 240 · see citing works
The Effects of Exercise-Induced Weight Loss on Appetite-Related Peptides and Motivation to Eat
Martins, C., Kulseng, B., King, N. A., Holst, J. J., & Blundell, J. E. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2082 · Cited by 236 · see citing works
G-Protein-Coupled Receptors in Intestinal Chemosensation
Reimann, F. M., Tolhurst, G., & Gribble, F. M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.019 · Cited by 235 · see citing works
Effects of PYY[3–36] in rodent models of diabetes and obesity
Pittner, R. A., Moore, C. X., Bhavsar, S., Gedulin, B. R., Smith, P. A., Jodka, C. M., Parkes, D. G., Paterniti, J. R., Srivastava, V. P., & Young, A. A. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802696 · Cited by 217 · see citing works
Incretin and islet hormonal responses to fat and protein ingestion in healthy men
Carr, R. D., Larsen, M. O., Winzell, M. S., Jelic, K., Lindgren, O., Deacon, C. F., & Åhrén, B. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90233.2008 · Cited by 202 · see citing works
The regulation of food intake by the gut-brain axis: implications for obesity
Hussain, S., & Bloom, S. R. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.93 · Cited by 195 · see citing works
Characterization of Blood-Brain Barrier Permeability to PYY3-36 in the Mouse
Nonaka, N., Shioda, S., Niehoff, M. L., & Banks, W. A. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.051821 · Cited by 194 · see citing works
Ueda, S.-Y., Yoshikawa, T., Katsura, Y., Usui, T., Nakao, H., & Fujimoto, S. (2009) · Journal of Endocrinology · doi:10.1677/joe-08-0500 · Cited by 192 · see citing works
Gastrointestinal hormones and gastric emptying 20 years after jejunoileal bypass for massive obesity
Näslund, E. B., Grybäck, P., Hellström, P. M., Jacobsson, H., Holst, J. J., Theodorsson, E., & Bäckman, L. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800418 · Cited by 190 · see citing works
Upchurch, B. H., Aponte, G. W., & Leiter, A. B. (1994) · Development · doi:10.1242/dev.120.2.245 · Cited by 190 · see citing works
Gibbons, C., Caudwell, P., Finlayson, G., Webb, D., Hellström, P. M., Näslund, E. B., & Blundell, J. E. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3835 · Cited by 186 · see citing works
Peptide YY ablation in mice leads to the development of hyperinsulinaemia and obesity
Boey, D., Lin, S., Karl, T., Baldock, P., Lee, N., Enriquez, R., Couzens, M., Slack, K., Dallmann, R., Sainsbury, A., et al. (2006) · Diabetologia · doi:10.1007/s00125-006-0237-0 · Cited by 186 · see citing works
Habib, A. M., Richards, P., Rogers, G. J., Reimann, F. M., & Gribble, F. M. (2013) · Diabetologia · doi:10.1007/s00125-013-2887-z · Cited by 184 · see citing works
Abbott, C. R., Small, C. J., Kennedy, A. R., Neary, N. M., Sajedi, A., Ghatei, M. A., & Bloom, S. R. (2005) · Brain Research · doi:10.1016/j.brainres.2005.02.065 · Cited by 184 · see citing works
Dirksen, C., Damgaard, M., Bojsen‐Møller, K. N., Jørgensen, N. B., Kielgast, U., Jacobsen, S. H., Naver, L. S., Worm, D., Holst, J. J., Madsbad, S., et al. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12087 · Cited by 184 · see citing works
Plamboeck, A., Veedfald, S., Deacon, C. F., Hartmann, B., Wettergren, A., Svendsen, L. B., Meisner, S., Hovendal, C. P., Vilsbøll, T., Knop, F. K., et al. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00035.2013 · Cited by 183 · see citing works
Ramón, J. M., Salvans, S., Crous, X., Puig, S., Goday, A., Benaiges, D., Trillo, L., Pera, M., & Grande, L. (2012) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-012-1855-0 · Cited by 181 · see citing works
Perry, J. L., Joseph, J. E., Jiang, Y., Zimmerman, R. S., Kelly, T. H., Darna, M., Huettl, P., Dwoskin, L. P., & Bardo, M. T. (2011) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.09.001 · Cited by 180 · see citing works
Ueda, S.-Y., Yoshikawa, T., Katsura, Y., Usui, T., & Fujimoto, S. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0190 · Cited by 178 · see citing works
Changes in Eating Behaviour and Meal Pattern Following Roux-En-Y Gastric Bypass
Laurenius, A., Larsson, I., Bueter, M., Melanson, K. J., Bosaeus, I., Forslund, H. B., Lönroth, H., Fändriks, L., & Olbers, T. (2012) · International Journal of Obesity · doi:10.1038/ijo.2011.217 · Cited by 174 · see citing works
Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety
Belza, A., Ritz, C., Sørensen, M. Q., Holst, J. J., Rehfeld, J. F., & Astrup, A. V. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.047563 · Cited by 171 · see citing works
Exercise, Appetite and Appetite-Regulating Hormones: Implications for Food Intake and Weight Control
Stensel, D. (2010) · Annals of Nutrition and Metabolism · doi:10.1159/000322702 · Cited by 171 · see citing works
Deighton, K., Barry, R., Connon, C. E., & Stensel, D. J. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2535-1 · Cited by 165 · see citing works
King, J. A., Wasse, L. K., Ewens, J., Crystallis, K., Emmanuel, J. J., Batterham, R. L., & Stensel, D. J. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2735 · Cited by 159 · see citing works
Self-citationCarr, R. D., Larsen, M. O., Jelic, K., Lindgren, O., Vikman, J., Holst, J. J., Deacon, C. F., & Åhrén, B. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2054 · Cited by 154 · see citing works
Basso, N., Capoccia, D., Rizzello, M., Abbatini, F., Mariani, P., Maglio, C., Coccia, F., Borgonuovo, G., Luca, M. L. D., Asprino, R., et al. (2011) · Surgical Endoscopy · doi:10.1007/s00464-011-1755-5 · Cited by 148 · see citing works
Diet and Gastrointestinal Bypass–Induced Weight Loss
Chandarana, K., Gelegen, Ç., Karra, E., Choudhury, A. I., Drew, M. E., Fauveau, V., Viollet, B., Andréelli, F., Withers, D. J., & Batterham, R. L. (2011) · Diabetes · doi:10.2337/db10-0566 · Cited by 148 · see citing works
Self-citationMumphrey, M. B., Patterson, L. M., Zheng, H., & Berthoud, H. (2012) · Neurogastroenterology & Motility · doi:10.1111/nmo.12034 · Cited by 147 · see citing works
Long-Term Persistence of Hormonal Adaptations to Weight Loss
Sumithran, P., Prendergast, L. A., Delbridge, E., Purcell, K., Shulkes, A., Kriketos, A. D., & Proietto, J. (2012) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0b013e318247c6f7 · Cited by 134 · see citing works
Effect of Macronutrient Composition on Postprandial Peptide YY Levels
Essah, P. A., Levy, J. R., Sistrun, S. N., Kelly, S. M., & Nestler, J. E. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2273 · Cited by 133 · see citing works
PYY3–36 Reinforces Insulin Action on Glucose Disposal in Mice Fed a High-Fat Diet
van den Hoek, A. M., Heijboer, A. C., Corssmit, E. P. M., Voshol, P. J., Romijn, J. A., Havekes, L. M., & Pijl, H. (2004) · Diabetes · doi:10.2337/diabetes.53.8.1949 · Cited by 122 · see citing works
Long‐term Exercise Training in Overweight Adolescents Improves Plasma Peptide YY and Resistin
Jones, T. E., Basilio, J. L., Brophy, P. M., McCammon, M. R., & Hickner, R. C. (2009) · Obesity · doi:10.1038/oby.2009.11 · Cited by 121 · see citing works
Peptide YY Is Secreted after Oral Glucose Administration in a Gender-Specific Manner
Kim, B.-J., Carlson, O. D., Jang, H.-J., Elahi, D., Berry, C., & Egan, J. M. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0409 · Cited by 118 · see citing works
Peptide YY Levels Are Elevated After Gastric Bypass Surgery
Chan, J. L., Mun, E. C., Stoyneva, V., Mantzoros, C. S., & Goldfine, A. B. (2006) · Obesity · doi:10.1038/oby.2006.25 · Cited by 113 · see citing works
Guelfi, K. J., Donges, C. E., & Duffield, R. (2012) · Metabolism · doi:10.1016/j.metabol.2012.08.002 · Cited by 112 · see citing works
Pilichiewicz, A. N., Little, T. J., Brennan, I. M., Meyer, J. H., Wishart, J. M., Otto, B., Horowitz, M., & Feinle‐Bisset, C. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00606.2005 · Cited by 108 · see citing works
Effect of Weight Loss by Diet or Gastric Bypass Surgery on Peptide YY3–36 Levels
Oliván, B., Teixeira, J. A., Bose, M., Bawa, B., Chang, T. C., Summe, H., Lee, H., & Laferrère, B. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e3181a6cdb0 · Cited by 104 · see citing works
Goumain, M., Voisin, T., Lorinet, A.-M., & Laburthe, M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8647 · Cited by 104 · see citing works
Sloth, B., Davidsen, L., Holst, J. J., Flint, A., & Astrup, A. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00153.2007 · Cited by 104 · see citing works
Bose, M., Machineni, S., Oliván, B., Teixeira, J., McGinty, J. J., Bawa, B., Koshy, N., Colarusso, A., & Laferrère, B. (2010) · Obesity · doi:10.1038/oby.2009.473 · Cited by 101 · see citing works
Scott, W. R., & Batterham, R. L. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00038.2011 · Cited by 99 · see citing works
Self-citationInfluence of Running and Walking on Hormonal Regulators of Appetite in Women
Larson‐Meyer, D. E., Palm, S. M., Bansal, A., Austin, K. J., Hart, A. M., & Alexander, B. M. (2012) · Journal of Obesity · doi:10.1155/2012/730409 · Cited by 96 · see citing works
Mechanisms underlying the rapid degradation and elimination of the incretin hormones GLP-1 and GIP
Mentlein, R. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2009.03.005 · Cited by 94 · see citing works
Valderas, J. P., Verónica Irribarra, P., Boza, C., de la Cruz, R., Yéssica Liberona, Z., Acosta, A. M., Yolito, M., & Alberto Maiz, G. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0983 · Cited by 92 · see citing works
The gut endocrine system as a coordinator of postprandial nutrient homoeostasis
Gribble, F. M. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000705 · Cited by 90 · see citing works
Chandarana, K., Drew, M. E., Emmanuel, J. J., Karra, E., Gelegen, Ç., Chan, P., Cron, N., & Batterham, R. L. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.047 · Cited by 89 · see citing works
Self-citationDiabetes remission after bariatric surgery: is it just the incretins?
Laferrère, B. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.143 · Cited by 88 · see citing works
Morı́nigo, R., Vidal, J., Lacy, A. M., Delgado, S., Casamitjana, R., & Gomis, R. (2008) · Annals of Surgery · doi:10.1097/sla.0b013e31815f6e77 · Cited by 85 · see citing works
Walther, C., Mörl, K., & Beck‐Sickinger, A. G. (2011) · Journal of Peptide Science · doi:10.1002/psc.1357 · Cited by 85 · see citing works
Peptide YY Regulates Bone Remodeling in Mice: A Link between Gut and Skeletal Biology
Wong, I. P. L., Drießler, F., Khor, E. C., Shi, Y., Hörmer, B. A., Nguyen, A., Enriquez, R. F., Eisman, J. A., Sainsbury, A., Herzog, H., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040038 · Cited by 84 · see citing works
Effects of acute exercise on appetite hormones and ad libitum energy intake in men and women
Hagobian, T. A., Yamashiro, M., Hinkel-Lipsker, J., Streder, K., Evero, N., & Hackney, T. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0104 · Cited by 83 · see citing works
The Gut Hormone Response Following Roux-en-Y Gastric Bypass: Cross-sectional and Prospective Study
Pournaras, D. J., Osborne, A., Hawkins, S. C., Mahon, D., Ghatei, M. A., Bloom, S. R., Welbourn, R., & le Roux, C. W. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9989-1 · Cited by 82 · see citing works
Deighton, K., Karra, E., Batterham, R. L., & Stensel, D. J. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0484 · Cited by 81 · see citing works
Self-citationWerling, M., Olbers, T., Fändriks, L., Bueter, M., Lönroth, H., Stenlöf, K., & le Roux, C. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060280 · Cited by 81 · see citing works
Effects of dipeptidyl peptidase IV on the satiety actions of peptide YY
Unniappan, S., McIntosh, C. H. S., Demuth, H. U., Heiser, U. F., Wolf, R., & Kieffer, T. J. (2006) · Diabetologia · doi:10.1007/s00125-006-0310-8 · Cited by 80 · see citing works
The role of peptide YY in regulating glucose homeostasis
Boey, D., Sainsbury, A., & Herzog, H. (2007) · Peptides · doi:10.1016/j.peptides.2006.07.031 · Cited by 77 · see citing works
Selective Ablation of Peptide YY Cells in Adult Mice Reveals Their Role in Beta Cell Survival
Sam, A. H., Gunner, D. J., King, A., Persaud, S. J., Brooks, L. J., Hostomska, K., Ford, H. E., Liu, B., Ghatei, M. A., Bloom, S. R., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.04.047 · Cited by 76 · see citing works
Effects of different modes of exercise on appetite and appetite-regulating hormones
Kawano, H., Mineta, M., Asaka, M., Miyashita, M., Numao, S., Gando, Y., Ando, T., Sakamoto, S., & Higuchi, M. (2013) · Appetite · doi:10.1016/j.appet.2013.01.017 · Cited by 75 · see citing works
Peptide YY: intrapancreatic localization and effects on insulin and glucagon secretion in the mouse.
Böttcher, G., Åhrén, B., Lundquist, I., & Sundler, F. (1989) · PubMed · Cited by 70 · see citing works
Ortiz, A. A., Milardo, L. F., DeCarr, L. B., Buckholz, T. M., Mays, M. R., Claus, T. H., Livingston, J. N., Mahle, C. D., & Lumb, K. J. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.125211 · Cited by 69 · see citing works
Kirino, Y., Sei, M., Kawazoe, K., Minakuchi, K., & Sato, Y. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej12-0158 · Cited by 68 · see citing works
Appetite regulation via exercise prior or subsequent to high-fat meal consumption
Cheng, M. H.-Y., Bushnell, D., Cannon, D. T., & Kern, M. (2009) · Appetite · doi:10.1016/j.appet.2008.09.015 · Cited by 68 · see citing works
Boey, D., Heilbronn, L. K., Sainsbury, A., Laybutt, D. R., Kriketos, A. D., Herzog, H., & Campbell, L. V. (2006) · Neuropeptides · doi:10.1016/j.npep.2006.08.002 · Cited by 67 · see citing works
Peripheral activation of the Y2-receptor promotes secretion of GLP-1 and improves glucose tolerance
Chandarana, K., Gelegen, Ç., Irvine, E. E., Choudhury, A. I., Amouyal, C., Andréelli, F., Withers, D. J., & Batterham, R. L. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.03.001 · Cited by 64 · see citing works
Self-citationBöttcher, G., Åhrén, B., Lundquist, I., & Sundler, F. (1989) · Pancreas · doi:10.1097/00006676-198906000-00002 · Cited by 64 · see citing works
Kelly, K. R., Brooks, L. M., Solomon, T. P. J., Kashyap, S., O’Leary, V. B., & Kirwan, J. P. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00112.2009 · Cited by 60 · see citing works
Gueugnon, C., Mougin, F., Nguyen, N. U., Bouhaddi, M., Nicolet-Guénat, M., & Dumoulin, G. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2154-2 · Cited by 59 · see citing works
Wang, L.-X., Gourcerol, G., Yuan, P.-Q., Wu, S., Million, M., Larauche, M., & Taché, Y. (2010) · American Journal of Physiology - Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00349.2009 · Cited by 59 · see citing works
Increased insulin concentrations and glucose storage in neuropeptide Y Y1 receptor-deficient mice
Burcelin, R., Brunner, H. R., Seydoux, J., Thorensa, B., & Pedrazzini, T. (2001) · Peptides · doi:10.1016/s0196-9781(01)00357-6 · Cited by 59 · see citing works
Exercise and ghrelin. A narrative overview of research
King, J. A., Wasse, L. K., Stensel, D. J., & Nimmo, M. A. (2013) · Appetite · doi:10.1016/j.appet.2013.04.018 · Cited by 58 · see citing works
Ghrelin and PYY in the regulation of energy balance and metabolism: lessons from mouse mutants
Kirchner, H., Tong, J., Tschöp, M. H., & Pfluger, P. T. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00191.2009 · Cited by 57 · see citing works
Characterization of brainstem peptide YY (PYY) neurons
Glavas, M. M., Grayson, B. E., Allen, S. E., Copp, D. R., Smith, M. S., Cowley, M. A., & Grove, K. L. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21543 · Cited by 57 · see citing works
Effect of bypassing the proximal gut on gut hormones involved with glycemic control and weight loss
Pournaras, D. J., Aasheim, E. T., Bueter, M., Ahmed, A. R., Welbourn, R., Olbers, T., & le Roux, C. W. (2012) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2012.01.021 · Cited by 54 · see citing works
Ghitza, U. E., Nair, S. G., Golden, S. A., Gray, S. M., Uejima, J. L., Bossert, J. M., & Shaham, Y. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5405-06.2007 · Cited by 52 · see citing works
Fenske, W. K., Bueter, M., Miras, A. D., Ghatei, M. A., Bloom, S. R., & le Roux, C. W. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.126 · Cited by 51 · see citing works
Cooper, J. A., Watras, A. C., Paton, C. M., Wegner, F. H., Adams, A., & Schoeller, D. A. (2010) · Appetite · doi:10.1016/j.appet.2010.10.009 · Cited by 51 · see citing works
Effects of surgical manipulation of the intestine on peptide YY and its physiology
Imamura, M. (2002) · Peptides · doi:10.1016/s0196-9781(01)00618-0 · Cited by 50 · see citing works
Tam, C. S., Berthoud, H., Bueter, M., Chakravarthy, M. V., Geliebter, A., Hajnal, A. S., Holst, J. J., Kaplan, L. M., Pories, W. J., Raybould, H. E., et al. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00902.x · Cited by 48 · see citing works
Central and peripheral regulation of gastric acid secretion by peptide YY
Yang, H. (2002) · Peptides · doi:10.1016/s0196-9781(01)00611-8 · Cited by 48 · see citing works
Patel, R. T., Shukla, A. P., Ahn, S. M., Moreira, M., & Rubino, F. (2013) · Obesity · doi:10.1002/oby.20441 · Cited by 46 · see citing works
Possible Mechanisms of Circulating PYY-Induced Satiation in Male Rats
Weber‐Stadlbauer, U., Arnold, M., Weber, E., & Langhans, W. (2012) · Endocrinology · doi:10.1210/en.2012-1956 · Cited by 44 · see citing works
Dumont, Y., Moyse, E., Fournier, A., & Quirion, R. (2007) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-9007-9 · Cited by 42 · see citing works
Shedding pounds after going under the knife: Metabolic insights from cutting the gut
Chandarana, K., & Batterham, R. L. (2012) · Nature Medicine · doi:10.1038/nm.2748 · Cited by 41 · see citing works
Self-citationLessons Learned from Gastric Bypass Operations in Rats
Seyfried, F., le Roux, C. W., & Bueter, M. (2011) · Obesity Facts · doi:10.1159/000327301 · Cited by 40 · see citing works
Mechanisms underlying the insulinostatic effect of peptide YY in mouse pancreatic islets
Nieuwenhuizen, A. G., Karlsson, S., Fridolf, T., & Ahr�n, B. (1994) · Diabetologia · doi:10.1007/bf00400941 · Cited by 39 · see citing works
Gaining New Insights into Food Reward with Functional Neuroimaging
Neary, M. T., & Batterham, R. L. (2009) · Forum of nutrition/Bibliotheca Nutritio et dieta · doi:10.1159/000264403 · Cited by 38 · see citing works
Self-citationSatiety, but not total PYY, Is increased with continuous and intermittent exercise
Holmstrup, M. E., Fairchild, T. J., Keslacy, S., Weinstock, R. S., & Kanaley, J. A. (2013) · Obesity · doi:10.1002/oby.20335 · Cited by 38 · see citing works
Chelikani, P. K., Shah, I. H., Taqi, E., Sigalet, D. L., & Koopmans, H. H. (2010) · Obesity Surgery · doi:10.1007/s11695-010-0139-6 · Cited by 37 · see citing works
Alam, M. L., der Schueren, B. V., Åhrén, B., Wang, G. C., Swerdlow, N. J., Arias, S., Bose, M., Gorroochurn, P., Teixeira, J. A., McGinty, J., et al. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01358.x · Cited by 35 · see citing works
Tsilchorozidou, T., Batterham, R. L., & Conway, G. S. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03285.x · Cited by 33 · see citing works
Self-citationPeptide YY does not inhibit glucose-stimulated insulin secretion in humans
Åhrén, B., & Larsson, H. (1996) · European Journal of Endocrinology · doi:10.1530/eje.0.1340362 · Cited by 30 · see citing works
Fernández‐García, J. C., Murri, M., Coín‐Aragüez, L., Alcaide, J., Bekay, R. E., & Tinahones, F. J. (2013) · Clinical Endocrinology · doi:10.1111/cen.12221 · Cited by 30 · see citing works
Chandarana, K., & Batterham, R. L. (2008) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282f3f4b1 · Cited by 28 · see citing works
Self-citationFeedback regulation of pancreatic secretion by peptide YY
Naruse, S., Kitagawa, M., Ishiguro, H., & Hayakawa, T. (2002) · Peptides · doi:10.1016/s0196-9781(01)00612-x · Cited by 28 · see citing works
Effects of endurance running and dietary fat on circulating ghrelin and peptide YY.
Russel, R. R., Willis, K. S., Ravussin, É., & Larson‐Meyer, E. (2009) · Europe PMC (PubMed Central) · Cited by 26 · see citing works
Ukkola, O. H., Puurunen, V.-P., Piira, O.-P., Niva, J., Lepojärvi, E. S., Tulppo, M. P., & Huikuri, H. V. (2011) · Regulatory Peptides · doi:10.1016/j.regpep.2011.05.006 · Cited by 26 · see citing works
Incretin-based Therapies for Type 2 Diabetes
McIntosh, C. H. S. (2008) · Canadian Journal of Diabetes · doi:10.1016/s1499-2671(08)22010-1 · Cited by 24 · see citing works
Heden, T. D., Liu, Y., Sims, L. J., Kearney, M. L., Whaley‐Connell, A. T., Chockalingam, A., Dellsperger, K. C., Fairchild, T. J., & Kanaley, J. A. (2013) · European Journal of Endocrinology · doi:10.1530/eje-12-0884 · Cited by 20 · see citing works
Shedding pounds after going under the knife: Guts over glory—why diets fail
Larder, R., & O’Rahilly, S. (2012) · Nature Medicine · doi:10.1038/nm.2747 · Cited by 19 · see citing works
Weise, C. M., Thiyyagura, P., Reiman, E. M., Chen, K., & Krakoff, J. A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.12.023 · Cited by 16 · see citing works
Gelegen, Ç., Chandarana, K., Choudhury, A. I., Al‐Qassab, H., Evans, I. M., Irvine, E. E., Hyde, C., Claret, M., Andréelli, F., Sloan, S. E., et al. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00033.2012 · Cited by 16 · see citing works
Self-citationBuchan, A. M. J., Pederson, R. A., Koop, I., Gourlay, R. H., & Cleator, I. G. M. (1993) · PubMed · Cited by 15 · see citing works
Hill, B. R., Souza, M. J. D., Wagstaff, D. A., Sato, R., & Williams, N. I. (2012) · Peptides · doi:10.1016/j.peptides.2012.08.017 · Cited by 12 · see citing works
Neuroimaging the interaction of mind and metabolism in humans
D’Agostino, A. E., & Small, D. M. (2012) · Molecular Metabolism · doi:10.1016/j.molmet.2012.06.002 · Cited by 11 · see citing works
The Dynamic Incretin Adaptation and Type 2 Diabetes
Åhrén, B. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0299 · Cited by 6 · see citing works
Feedback regulation of pancreatic secretion.
Fushiki, T., Tsuzuki, S., Pierzynowski, S. G., & Zabielski, R. (1999) · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Toward a Wiring Diagram Understanding of Appetite Control
Andermann, M. L., & Lowell, B. B. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.014 · Cited by 606 · see citing works
Steinert, R. E., Feinle-Bisset, C., Asarian, L., Horowitz, M., Beglinger, C., & Geary, N. (2017) · Physiological Reviews · doi:10.1152/physrev.00031.2014 · Cited by 578 · see citing works
Health Benefits of Resistant Starch: A Review of the Literature
Bojarczuk, A., Skąpska, S., Mousavi Khaneghah, A., & Marszałek, K. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105094 · Cited by 372 · see citing works
Cardi, V., Leppänen, J., & Treasure, J. L. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.011 · Cited by 351 · see citing works
Dorling, J. L., Broom, D. R., Burns, S. F., Clayton, D. J., Deighton, K., James, L. J., King, J. A., Miyashita, M., Thackray, A. E., Batterham, R. L., et al. (2018) · Nutrients · doi:10.3390/nu10091140 · Cited by 235 · see citing works
Self-citationBahne, E., Sun, E. W. L., Young, R. L., Hansen, M., Sonne, D. P., Hansen, J. S., Rohde, U., Liou, A. P., Jackson, M. L., de Fontgalland, D., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.93936 · Cited by 173 · see citing works
Hypertension Related to Obesity: Pathogenesis, Characteristics and Factors for Control
Meouchy, P., Wahoud, M., Allam, S., Chedid, R., Karam, W., & Karam, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012305 · Cited by 145 · see citing works
Manning, S., Pucci, A. B. F., Carter, N. C., Elkalaawy, M., Querci, G., Magno, S., Tamberi, A., Finer, N., Fiennes, A., Hashemi, M., et al. (2014) · Surgical Endoscopy · doi:10.1007/s00464-014-3829-7 · Cited by 140 · see citing works
Self-citationBiological Control of Appetite: A Daunting Complexity
MacLean, P. S., Blundell, J. E., Mennella, J. A., & Batterham, R. L. (2017) · Obesity · doi:10.1002/oby.21771 · Cited by 140 · see citing works
Self-citationGenomic dissection of conserved transcriptional regulation in intestinal epithelial cells
Lickwar, C. R., Camp, J. G., Weiser, M., Cocchiaro, J. L., Kingsley, D. M., Furey, T. S., Sheikh, S. Z., & Rawls, J. F. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2002054 · Cited by 118 · see citing works
Intestinal Sensing by Gut Microbiota: Targeting Gut Peptides
Covașă, M., Stephens, R. W., Toderean, R., & Cobuz, C. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00082 · Cited by 114 · see citing works
Monteiro, M. P., & Batterham, R. L. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.01.053 · Cited by 104 · see citing works
Self-citationSchiellerup, S. P., Skov‐Jeppesen, K., Windeløv, J. A., Svane, M. S., Holst, J. J., Hartmann, B., & ROSENKILDE, M. M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00075 · Cited by 109 · see citing works
Prinz, P., & Stengel, A. (2017) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16194 · Cited by 103 · see citing works
Roux-en-Y gastric bypass: effects on feeding behavior and underlying mechanisms
Manning, S., Pucci, A. B. F., & Batterham, R. L. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76305 · Cited by 88 · see citing works
Self-citationMultifactorial Basis and Therapeutic Strategies in Metabolism-Related Diseases
Guerra, J. V. D. S., Dias, M. M. G., Brilhante, A. J. V. C., Terra, M. F., García‐Arévalo, M., & Figueira, A. C. M. (2021) · Nutrients · doi:10.3390/nu13082830 · Cited by 87 · see citing works
Effects of acute exercise on appetite hormones and ad libitum energy intake in men and women
Hagobian, T. A., Yamashiro, M., Hinkel-Lipsker, J., Streder, K., Evero, N., & Hackney, T. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0104 · Cited by 83 · see citing works
Koliaki, C. C., Liatis, S., Dalamaga, Μ., & Kokkinos, A. D. (2020) · Current Obesity Reports · doi:10.1007/s13679-020-00396-9 · Cited by 83 · see citing works
Steensels, S., & Depoortere, I. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021317-121332 · Cited by 79 · see citing works
Obesity, body weight regulation and the brain: insights from fMRI
Makaronidis, J., & Batterham, R. L. (2018) · British Journal of Radiology · doi:10.1259/bjr.20170910 · Cited by 72 · see citing works
Self-citationWong, T. H. T., & Louie, J. C. Y. (2016) · Starch - Stärke · doi:10.1002/star.201600205 · Cited by 66 · see citing works
GLP-1: A Mediator of the Beneficial Metabolic Effects of Bariatric Surgery?
Manning, S., Pucci, A. B. F., & Batterham, R. L. (2015) · Physiology · doi:10.1152/physiol.00027.2014 · Cited by 63 · see citing works
Self-citationFarhadipour, M., & Depoortere, I. (2021) · Nutrients · doi:10.3390/nu13061839 · Cited by 63 · see citing works
Beta-glucans and cancer: The influence of inflammation and gut peptide
Baldassano, S., Accardi, G., & Vasto, S. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.09.013 · Cited by 57 · see citing works
Effects of resistant starch on glycaemic control: a systematic review and meta-analysis
Xiong, K., Wang, J., Kang, T., Xu, F., & Ma, A. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520003700 · Cited by 54 · see citing works
Weber‐Stadlbauer, U., Woods, S. C., Langhans, W., & Meyer, U. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.12.003 · Cited by 53 · see citing works
Douglas, J. A., King, J. A., McFarlane, E., Baker, L. A., Bradley, C., Crouch, N., Hill, D. W., & Stensel, D. J. (2015) · Appetite · doi:10.1016/j.appet.2015.05.006 · Cited by 45 · see citing works
Smitka, K., Procházková, P., Roubalová, R., Dvořák, J., Papežová, H., Hill, M., Pokorny, J., Kittnar, O., Bilej, M., & Tlaskalová‐Hogenová, H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.613983 · Cited by 45 · see citing works
Zhu, X., Gillespie, D. G., & Jackson, E. K. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00070.2015 · Cited by 42 · see citing works
Suzuki, K., Iwasaki, K., Murata, Y., Harada, N., Yamane, S., Hamasaki, A., Shibue, K., Joo, E., Sankoda, A., Fujiwara, Y., et al. (2017) · Journal of Diabetes Investigation · doi:10.1111/jdi.12681 · Cited by 40 · see citing works
Dorling, J. L., Clayton, D. J., Jones, J., Carter, W. G., Thackray, A. E., King, J. A., Pucci, A. B. F., Batterham, R. L., & Stensel, D. J. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz188 · Cited by 39 · see citing works
Self-citationSequence-based prediction of the intrinsic solubility of peptides containing non-natural amino acids
Oeller, M., Kang, R. J. D., Bolt, H. L., dos Santos, A. L. G., Weinmann, A. L., Nikitidis, A., Zlatoidský, P., Su, W., Czechtizky, W., Maria, L. D., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42940-w · Cited by 38 · see citing works
Bardet‐Biedl syndrome: A focus on genetics, mechanisms and metabolic dysfunction
Tomlinson, J. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15480 · Cited by 39 · see citing works
Li, N., Yang, Z.-Y., Li, Q., Yu, Z., Chen, X., Li, J.-C., Li, B., Ning, S., Cui, M., Sun, J.-P., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0741-4 · Cited by 35 · see citing works
Blé‐Castillo, J. L., Juárez‐Rojop, I. E., Tovilla‐Zárate, C. A., García-Vázquez, C., Servin-Cruz, M., Rodríguez-Hernández, A., Araiza-Saldaña, C. I., Nolasco-Coleman, A. M., & Díaz-Zagoya, J. C. (2017) · Nutrients · doi:10.3390/nu9070696 · Cited by 37 · see citing works
FFA2 and FFA3 in Metabolic Regulation
Tang, C., & Offermanns, S. (2016) · Handbook of experimental pharmacology · doi:10.1007/164_2016_50 · Cited by 36 · see citing works
Gastrointestinal hormones and their role in obesity
Choudhury, S., Tan, T., & Bloom, S. R. (2015) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000216 · Cited by 35 · see citing works
Atanes, P., Ruz‐Maldonado, I., Hawkes, R. G., Liu, B., Zhao, M., Huang, G. C., Al-Amily, I. M., Salehi, A. A., Amisten, S., & Persaud, S. J. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2778-z · Cited by 33 · see citing works
The role of polydextrose in body weight control and glucose regulation
Canfora, E. E., & Blaak, E. E. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000184 · Cited by 32 · see citing works
Castagneto‐Gissey, L., Mariolo, J. R. C., & Mingrone, G. (2018) · Peptides · doi:10.1016/j.peptides.2017.12.010 · Cited by 31 · see citing works
Distribution and Stimulus Secretion Coupling of Enteroendocrine Cells along the Intestinal Tract
Adriaenssens, A. E., Reimann, F. M., & Gribble, F. M. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170047 · Cited by 35 · see citing works
Liu, P. Y., Lawrence-Sidebottom, D., Piotrowska, K., Zhang, W., Iranmanesh, A., Auchus, R. J., Veldhuis, J. D., & Van Dongen, H. P. A. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab375 · Cited by 28 · see citing works
Kullman, E. L., Kelly, K. R., Haus, J. M., Fealy, C. E., Scelsi, A. R., Pagadala, M. R., Flask, C. A., McCullough, A. J., & Kirwan, J. P. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00693.2015 · Cited by 29 · see citing works
Alhadeff, A. L., Golub, D., Hayes, M. R., & Grill, H. J. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00346.2015 · Cited by 25 · see citing works
Hughes, R., Horn, W. F., Wen, A., RUST, B. M., Woodhouse, L. R., Newman, J. W. I., & Keim, N. L. (2021) · Appetite · doi:10.1016/j.appet.2021.105802 · Cited by 26 · see citing works
Ly, H. G., Dupont, P. J., Laere, K. V., Depoortere, I., Tack, J. F., & Oudenhove, L. V. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.09.032 · Cited by 25 · see citing works
Physical Exercise and Appetite Regulation: New Insights
Caruso, L., Zauli, E., & Vaccarezza, M. (2023) · Biomolecules · doi:10.3390/biom13081170 · Cited by 24 · see citing works
Half-Life Extending Modifications of Peptide YY3–36 Direct Receptor-Mediated Internalization
Bech, E. M., Kaiser, A., Bellmann‐Sickert, K., Bohr, S. S.-R., Sørensen, K. K., Elster, L., Hatzakis, N. S., Pedersen, S. L., Beck‐Sickinger, A. G., & Jensen, K. J. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00554 · Cited by 23 · see citing works
Kim, T. Y., Shoback, D., Black, D. M., Rogers, S. J., Stewart, L., Carter, J. T., Posselt, A. M., King, N. J., & Schafer, A. L. (2019) · Bone · doi:10.1016/j.bone.2019.115115 · Cited by 22 · see citing works
Peptide YY3–36 concentration in acute- and long-term recovered anorexia nervosa
Tam, F. I., Seidel, M., Boehm, I., Ritschel, F., Bahnsen, K., Biemann, R., Weidner, K., Roessner, V., & Ehrlich, S. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02210-7 · Cited by 20 · see citing works
Glucagon and other proglucagon-derived peptides in the pathogenesis of obesity
Holst, J. J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.964406 · Cited by 20 · see citing works
Netto, B. D. M., Earthman, C. P., Bettini, S. C., Clemente, A. P. G., Masquio, D. C. L., Farias, G., Boritza, K. C., da Silva, L. G., von der Heyde, M. E., & Dâmaso, A. R. (2016) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000665 · Cited by 20 · see citing works
β Cell GHS-R Regulates Insulin Secretion and Sensitivity
Pradhan, G., Wu, C., Villarreal, D., Lee, J. H., Han, H. W., Gaharwar, A. K., Tian, Y., Fu, W., Guo, S., Smith, R. G., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083950 · Cited by 19 · see citing works
Mukorako, P., Lemoine, N., Biertho, L. D., Lebel, S., Roy, M.-C., Plamondon, J., Tchernof, A., Varin, T. V., Anhê, F. F., St-Pierre, D. H., et al. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00973-5 · Cited by 18 · see citing works
The role of gut hormones in obesity
Mok, J., Makaronidis, J., & Batterham, R. L. (2018) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2018.09.005 · Cited by 18 · see citing works
Self-citationCould the Gut Microbiota Serve as a Therapeutic Target in Ischemic Stroke?
Zhang, J., Tang, Q., & Zhu, L. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/1391384 · Cited by 17 · see citing works
Sheng, K., Zhang, H., Yue, J., Gu, W., Gu, C., Zhang, H., & Wu, W. (2018) · Toxicology · doi:10.1016/j.tox.2018.04.007 · Cited by 17 · see citing works
Rational Development of Stable PYY3–36 Peptide Y2 Receptor Agonists
Poulsen, C., Pedersen, M. Ø., Wahlund, P., Sjölander, A., Thomsen, J. K., Conde‐Frieboes, K. W., Paulsson, J. F., Wulff, B. S., & Østergaard, S. (2021) · Pharmaceutical Research · doi:10.1007/s11095-021-03077-x · Cited by 17 · see citing works
Erina, Y., Yasoshima, Y., & Shimura, T. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.12.034 · Cited by 15 · see citing works
Cao, W., Fang, L., Li, R. W., Chin, Y., Wang, Y., Xue, C., & Tang, Q. (2021) · Food Science and Human Wellness · doi:10.1016/j.fshw.2021.07.018 · Cited by 15 · see citing works
Potential Therapeutic Targeting Neurotransmitter Receptors in Diabetes
Pan, X., Tao, S., & Tong, N. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.884549 · Cited by 14 · see citing works
Holst, J. J., Madsbad, S., Bojsen-Møller, K. N., Dirksen, C., & Svane, M. S. (2024) · Peptides · doi:10.1016/j.peptides.2024.171199 · Cited by 14 · see citing works
Zhang, J., Jia, H., Wang, Q., Zhang, Y., Wu, W., & Zhang, H. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx128 · Cited by 14 · see citing works
Camacho-Ramírez, A., Oliveira, J. A. P., Ribelles-García, A., Gomar, D. A., & Pérez-Arana, G.-M. (2019) · Obesity Surgery · doi:10.1007/s11695-019-04239-y · Cited by 14 · see citing works
Eickhoff, H., Rodrigues, T., Neves, I. J., Marques, D., Ribeiro, D. C., Costa, S., Seiça, R. M. F., & Matafome, P. N. (2019) · Obesity Surgery · doi:10.1007/s11695-019-03935-z · Cited by 13 · see citing works
McMillan, C. J., Zapata, R. C., Chelikani, P. K., Snead, E. C. R., & Cosford, K. (2015) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2015.10.001 · Cited by 13 · see citing works
Rahmatallah, Y., Khaidakov, M., Lai, K., Goyne, H. E., Lamps, L. W., Hagedorn, C. H., & Glazko, G. V. (2017) · BMC Medical Genomics · doi:10.1186/s12920-017-0317-7 · Cited by 13 · see citing works
Plasma proteomic signature of frailty in 50,506 adults
Jia, X., Gao, W., Hagelin, H., Zhao, Y., Zhang, J., Cao, X., Zhang, L., Wu, Y., Ma, L., Chen, L., et al. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.02.013 · Cited by 13 · see citing works
Xu, Y., Song, J., Ren, Y., Barnhart, W. R., Dixit, U., Ji, F., Chen, C., & He, J. (2024) · Eating Behaviors · doi:10.1016/j.eatbeh.2024.101899 · Cited by 12 · see citing works
Bigford, G. E., Szeto, A., Darr, A. J., Illiano, P., Zambrano, R., Mendez, A. J., & Nash, M. S. (2022) · Journal of Neurotrauma · doi:10.1089/neu.2021.0490 · Cited by 11 · see citing works
Surgical treatment of nonalcoholic fatty liver disease in severely obese patients
Holterman, A. L., Naalt, S. V., & Gurria, J. P. (2014) · Hepatic Medicine Evidence and Research · doi:10.2147/hmer.s64819 · Cited by 10 · see citing works
Gut Molecules in Cardiometabolic Diseases: The Mechanisms behind the Story
Inceu, A.-I., Neag, M. A., Craciun, A. E., & Buzoianu, A. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043385 · Cited by 10 · see citing works
Bile Diversion Improves Metabolic Phenotype Dependent on Farnesoid X Receptor (FXR)
Pierre, J. F., Li, Y., Gomes, C., Rao, P., Chang, E. B., & Yin, D. (2019) · Obesity · doi:10.1002/oby.22440 · Cited by 10 · see citing works
Barkholt, P., Rigbolt, K. T. G., Falkenhahn, M., Hübschle, T., Schwahn, U., Fernandez-Cachon, M. L., Schmidt, T., Theis, S., Hansen, H. H., Hay‐Schmidt, A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-52257-8 · Cited by 10 · see citing works
Distribution and Stimulus Secretion Coupling of Enteroendocrine Cells along the Intestinal Tract
Adriaenssens, A. E., Reimann, F. M., & Gribble, F. M. (2018) · Comprehensive physiology · doi:10.1002/j.2040-4603.2018.tb00048.x · Cited by 9 · see citing works
The Chemical Methods of Disulfide Bond Formation and Their Applications to Drug Conjugates
He, R., Pan, J. H., Mayer, J. P., & Liu, F. (2019) · Current Organic Chemistry · doi:10.2174/1385272823666191202111723 · Cited by 9 · see citing works
Vila, G., Hopfgartner, J., Grimm, G., Baumgartner-Parzer, S. M., Kautzky‐Willer, A., Clodi, M., & Luger, A. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515002536 · Cited by 9 · see citing works
Gut Peptide Agonism in the Treatment of Obesity and Diabetes
Grandl, G., Novikoff, A., DiMarchi, R. D., Tschöp, M. H., & Müller, T. D. (2019) · Comprehensive physiology · doi:10.1002/cphy.c180044 · Cited by 9 · see citing works
Molecular Design of Unimolecular Tetra-Receptor Agonists
Dinsmore, T. C., Cortigiano, J. E., Xiang, S., Spenciner, M. V., Dobbins, A. R., Zhao, R. R., Waldman, B. M., Beinborn, M., & Kumar, K. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c04095 · Cited by 8 · see citing works
Valentí, V., Cienfuegos, J. A., Becerril, S., & Frühbeck, G. (2020) · Revista Española de Enfermedades Digestivas · doi:10.17235/reed.2020.6925/2020 · Cited by 8 · see citing works
Inter-organ regulation by the brain in Drosophila development and physiology
Yoon, S., Shin, M., & Shim, J. (2022) · Journal of Neurogenetics · doi:10.1080/01677063.2022.2137162 · Cited by 7 · see citing works
Zhong, H., Wang, L., Abdullah, Du, J., Feng, F., & Guan, R. (2025) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2025.2511971 · Cited by 7 · see citing works
Amylin receptors as therapeutic targets in obesity: Emerging peptide-based strategies.
Rejili, M., Hussain, M. S., Khan, Y., Haouala, F., Ganesan, S., Sahoo, S., Pal, A., & Arora, V. (2025) · Vascular pharmacology · doi:10.1016/j.vph.2025.107563 · Cited by 7 · see citing works
Muñoz-Mireles, G., Mantzios, M., Schellinger, J. N., Messiah, S. E., & Marroquín, E. (2023) · Mindfulness · doi:10.1007/s12671-023-02236-y · Cited by 8 · see citing works
Brainstem peptides and peptidergic neurons in the regulation of appetite
D’Agostino, G., & Luckman, S. M. (2022) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2022.100339 · Cited by 7 · see citing works
The hunger games of skeletal metabolism
Wee, N. K. Y., & Baldock, P. A. J. (2014) · BoneKEy Reports · doi:10.1038/bonekey.2014.83 · Cited by 7 · see citing works
Gastrointestinal Hormones Controlling Energy Homeostasis and Their Potential Role in Obesity
Andreoli, M. F., Francesco, P. N. D., & Perelló, M. (2018) · Springer eBooks · doi:10.1007/978-3-319-89506-2_7 · Cited by 7 · see citing works
Grigg, M. J., Thake, C. D., Allgrove, J. E., King, J. A., Thackray, A. E., Stensel, D. J., Owen, A., & Broom, D. R. (2023) · Appetite · doi:10.1016/j.appet.2022.106375 · Cited by 6 · see citing works
The Potential Mechanism of Remission in Type 2 Diabetes Mellitus After Vertical Sleeve Gastrectomy
Wang, R., Mijiti, S., Xu, Q., Liu, Y., Deng, C., Huang, J., Yasheng, A., Tian, Y., Cao, Y., & Su, Y. (2024) · Obesity Surgery · doi:10.1007/s11695-024-07378-z · Cited by 6 · see citing works
The influence of emotion on eating behavior
Zhou, A., Xie, P., Zhe, T. I. A. N., & Pan, C. (2021) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2021.02013 · Cited by 6 · see citing works
Latif, M. A., Tunacao, J. M., Fu, Y., Moran, T. H., Yenokyan, G., Fischman, A. M., Cheskin, L. J., Holly, B. P., Hong, K. K., Shin, E. J., et al. (2022) · CardioVascular and Interventional Radiology · doi:10.1007/s00270-022-03280-2 · Cited by 6 · see citing works
Zou, N., Zhou, P., Zhou, Q. W., Ma, J., Feng, S., Rong, P., & Li, S. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.12.003 · Cited by 5 · see citing works
In Vivo Models for Incretin Research: From the Intestine to the Whole Body
Oh, T. J. (2016) · Endocrinology and Metabolism · doi:10.3803/enm.2016.31.1.45 · Cited by 6 · see citing works
Emerging Role of Taste Receptors, Entero-Endocrine Cells in Type 2 Diabetes and Metabolic Disorders
Khin, K. L. S., Youssefi, S., Yang, Q., Page, A. J., Nateri, A. S., Eldeghaidy, S., Young, R. L., & IDRIS, I. R. (2026) · Nutrients · doi:10.3390/nu18050759 · Cited by 4 · see citing works
Yang, Z., Kirschke, C. P., Cai, Y., & Huang, L. (2024) · Genes & Nutrition · doi:10.1186/s12263-024-00759-0 · Cited by 4 · see citing works
Gut-Derived Hormones and Energy Homeostasis
Cheung, W.-H., Pucci, A. B. F., & Batterham, R. L. (2015) · Springer eBooks · doi:10.1007/978-3-319-04343-2_3 · Cited by 3 · see citing works
Self-citationSporadic Pancreatic Cancer: Glucose Homeostasis and Pancreatogenic Type 3 Diabetes
Škrha, J., Fric, P., Bušek, P., Škrha, P., & Šedo, A. (2018) · InTech eBooks · doi:10.5772/intechopen.75740 · Cited by 3 · see citing works
Jampour, L., Hashemi, H., Behrouzian, F., & Jafarirad, S. (2019) · Nutrition & Food Science · doi:10.1108/nfs-04-2019-0128 · Cited by 3 · see citing works
Imperatore, A., Mennitti, C., Fonzo, G. D., Amitrano, R., Gentile, A., Calvanese, M., Iafusco, F., Coppola, S., Digno, M., Borrelli, P., et al. (2025) · Genes · doi:10.3390/genes16111309 · Cited by 4 · see citing works
Zhang, H., Wu, X., & Qiu, S. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1831265 · Cited by 2 · see citing works
- Authors
- Manning, S., & Batterham, R. L.
- Affiliations
- University College Hospital (GB)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2014-02-10
- Volume
- 76
- Issue
- 1
- Pages
- 585-608
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2169329075
- Cited by
- 124
- References
- 150
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 11 · 2021: 12 · 2020: 6 · 2019: 16 · 2018: 14 · 2017: 12 · 2016: 11 · 2015: 11 · 2014: 4 · 2012: 1
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Keywords
- peptide YY, energy homeostasis, glucose homeostasis, bariatric surgery, pancreatic islets, central nervous system, brain regions, physical activity, gastrointestinal hormones
- MeSH terms
- Adult, Animals, Energy Metabolism, Female, Glucose, Homeostasis, Humans, Male, Obesity, Weight Loss, Exercise, Peptide YY, Bariatric Surgery
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review