Cited by 124Regulation of Appetite and ObesityNeuropeptides and Animal PhysiologyBariatric Surgery and Outcomes

The role of gut hormone peptide YY in energy and glucose homeostasis: Twelve years on

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Manning, Sean, Batterham, Rachel L.·2014·Annual Review of Physiology

Abstract

Although the role of peptide YY (PYY) as a regulator of energy homeostasis was first highlighted only in 2002, our understanding of the physiological role of PYY has since rapidly advanced. In recent years, insights from mechanistic studies in patients undergoing bariatric surgery, from pancreatic islet research, from functional neuroimaging studies, and from exercise research have greatly added to the field, and these areas provide the focus of discussion for this narrative review. We critically discuss recent findings relating to the role of PYY in mediating the beneficial effects of bariatric surgery, the role of PYY in glucose homeostasis, the role of hepatoportal PYY in mediating its central physiological effects, the specific modulation of brain regions by PYY, and the exercise-induced PYY response.

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Authors
Manning, S., & Batterham, R. L.
Affiliations
University College Hospital (GB)
Venue
Annual Review of Physiology
Published
2014-02-10
Volume
76
Issue
1
Pages
585-608
ISSN
  • 0066-4278 (ISSN-L)
  • 1545-1585
OpenAlex
W2169329075
Cited by
124
References
150
Citations by year
2026: 4 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 11 · 2021: 12 · 2020: 6 · 2019: 16 · 2018: 14 · 2017: 12 · 2016: 11 · 2015: 11 · 2014: 4 · 2012: 1
FWCI
1.04
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Keywords
peptide YY, energy homeostasis, glucose homeostasis, bariatric surgery, pancreatic islets, central nervous system, brain regions, physical activity, gastrointestinal hormones
MeSH terms
Adult, Animals, Energy Metabolism, Female, Glucose, Homeostasis, Humans, Male, Obesity, Weight Loss, Exercise, Peptide YY, Bariatric Surgery

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