The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
Menopause and the human hypothalamus: Evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback
Open accessAbstract
Menopause is characterized by depletion of ovarian follicles, a reduction of ovarian hormones to castrate levels and elevated levels of serum gonadotropins. Rather than degenerating, the reproductive neuroendocrine axis in postmenopausal women is intact and responds robustly to the removal of ovarian hormones. Studies in both human and non-human primates provide evidence that the gonadotropin hypersecretion in postmenopausal women is secondary to increased gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus. In addition, menopause is accompanied by hypertrophy of neurons in the infundibular (arcuate) nucleus expressing KiSS-1, neurokinin B (NKB), substance P, dynorphin and estrogen receptor alpha (ERalpha) mRNA. Ovariectomy in experimental animals induces nearly identical findings, providing evidence that these changes are a compensatory response to ovarian failure. The anatomical site of the hypertrophied neurons, as well as the extensive data implicating kisspeptin, NKB and dynorphin in the regulation of GnRH secretion, provide compelling evidence that these neurons are part of the neural network responsible for the increased levels of serum gonadotropins in postmenopausal women. We propose that neurons expressing KiSS-1, NKB, substance P, dynorphin and ERalpha mRNA in the infundibular nucleus play an important role in sex-steroid feedback on gonadotropin secretion in the human.
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“given the co-expression of NKB with kisspeptin in neurons in the arcuate nucleus of the hypothalamus.64”
From The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism (2009) · cites this paper as [64]
In the citing paper
“While the underlying mechanism has not been established, it probably involves the regulation of GnRH secretion, perhaps via interactions with the kisspeptin 1–KiSS-1 receptor system given the co-expression of NKB with kisspeptin in neurons in the arcuate nucleus of the hypothalamus.64”
From The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism (2009) · cites this paper as [64]
In the citing paper
“Therefore, the rise in serum LH in postmenopausal women is likely mediated by increased GnRH secretion from the hypothalamus (Rance, 2009).”
From Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes (2013) · cites this paper as Rance, 2009
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Cites
The GPR54 Gene as a Regulator of Puberty
Seminara, S. B., Messager, S., Chatzidaki, E. E., Thresher, R. R., Acierno, J. S., Shagoury, J. K., Bo-Abbas, Y., Kuohung, W., Schwinof, K. M., Hendrick, A. G., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035322 · Cited by 2,557
Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
de Roux, N., Genin, E., Carel, J.-C., Matsuda, F., Chaussain, J.-L., & Milgrom, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834399100 · Cited by 2,431 · cited 4×
“While it is well recognized that GnRH neurons are influenced by multiple converging inputs, studies of GPR54 mutations in humans [16,93] and transgenic mice emphasize the essential nature of this circuitry in the regulation of reproduction.”
BackgroundInfluentialAccelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause
Faddy, M. J., Gosden, R. G., Gougeon, A., Richardson, S. J., & Nelson, J. F. (1992) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137570 · Cited by 1,361
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Regulation of Kiss1 gene expression in the brain of the female mouse
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Research works printed but not linked: 4
- Escobar, 2004, Neuropeptide Y gene expression is increased in the infundibular nucleus of postmenopausal women, J Clin Endocrinol Metab, 89, 2338, 10.1210/jc.2003-031899 · DOI
- Krajewski, 2005, Arcuate neurokinin B neurons project to the median eminence as well as multiple hypothalamic sites: an anterograde tract-tracing study using biotinylated dextran amine, Soc Neurosci Abstr
- McManus, 2005, A neurokinin-B agonist stimulates LH secretion in follicular, but not luteal, phase ewes, Soc Neurosci Abstr
- Rometo, 2007, Changes in morphology and gene expression of dynorphin neurons in the infundibular nucleus of postmenopausal women, Soc Neurosci Abstr
Cited by
Sorted by citations
Dynamics of gonadotropin-releasing hormone release during a pulse.
Moenter, S. M., Brand, R. M., MIDGLEY, A. R., & Karsch, F. J. (1992) · Endocrinology · doi:10.1210/endo.130.1.1727719 · Cited by 1,257
Topaloglu, A. K., Reimann, F., Guclu, M., Yalin, A. S., Kotan, L. D., Porter, K. M., Serin, A., Mungan, N. O., Cook, J. R., Ozbek, M. N., et al. (2009) · Nature Genetics · doi:10.1038/ng.306 · Cited by 961
Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms
Pinilla, L., Aguilar, E., Diéguez, C., Millar, R. P., & Tena‐Sempere, M. (2012) · Physiological Reviews · doi:10.1152/physrev.00037.2010 · Cited by 843
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Wakabayashi, Y., Nakada, T., Murata, K., Ohkura, S., Mogi, K., Navarro, V. M., Clifton, D. K., Mori, Y., Tsukamura, H., Maeda, K.-I., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5848-09.2010 · Cited by 597
“These anatomical observations suggest that kisspeptin/NKB/Dyn neurons in the ARC comprise an oscillatory feedback loop interconnected through collaterals that synchronize their activity, as previously proposed (Burke et al., 2006; Foradori et al., 2006; Rance, 2009; Navarro et al., 2009).”
Background
Metadata
- Authors
- Rance, N. E.
- Affiliations
- University of Arizona (US)
- Corresponding author
- Rance, Naomi E.
- ORCID
- Rance, Naomi E.
- Venue
- Peptides
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 30
- Issue
- 1
- Pages
- 111-122
- ISSN
- 0196-9781 (ISSN-L)
- PMC
- PMC2632595
- OpenAlex
- W2092614270
- Cited by
- 237
- References
- 114
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 15 · 2023: 4 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 10 · 2018: 12 · 2017: 12 · 2016: 12 · 2015: 17 · 2014: 18 · 2013: 21 · 2012: 18
- FWCI
- 22.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Peptides (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG09214, R56AG009214, R01AG009214)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- menopause, hypothalamus, kisspeptin, neurokinin B, estrogen negative feedback, gonadotropin secretion, gonadotropin-releasing hormone, arcuate nucleus, ovariectomy, estrogen receptor alpha, dynorphin, substance P, postmenopausal women, ovarian failure
- MeSH terms
- Aging, Animals, Dynorphins, Estrogens, Female, Humans, Hypothalamus, Menopause, Middle Aged, Neurons, Neurosecretory Systems, Ovary, Substance P, Neurokinin B, Feedback, Physiological, Tumor Suppressor Proteins, Rats, Kisspeptins
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