Cited by 238Hypothalamic control of reproductive hormonesNeuropeptides and Animal PhysiologyReproductive Biology and Fertility

The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.

Menopause and the human hypothalamus: Evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback

Open access

Rance, Naomi E.·2009·Peptides

DOI 10.1016/j.peptides.2008.05.016PMC PMC2632595

Open this paper in CoChat — free account

Abstract

Menopause is characterized by depletion of ovarian follicles, a reduction of ovarian hormones to castrate levels and elevated levels of serum gonadotropins. Rather than degenerating, the reproductive neuroendocrine axis in postmenopausal women is intact and responds robustly to the removal of ovarian hormones. Studies in both human and non-human primates provide evidence that the gonadotropin hypersecretion in postmenopausal women is secondary to increased gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus. In addition, menopause is accompanied by hypertrophy of neurons in the infundibular (arcuate) nucleus expressing KiSS-1, neurokinin B (NKB), substance P, dynorphin and estrogen receptor alpha (ERalpha) mRNA. Ovariectomy in experimental animals induces nearly identical findings, providing evidence that these changes are a compensatory response to ovarian failure. The anatomical site of the hypertrophied neurons, as well as the extensive data implicating kisspeptin, NKB and dynorphin in the regulation of GnRH secretion, provide compelling evidence that these neurons are part of the neural network responsible for the increased levels of serum gonadotropins in postmenopausal women. We propose that neurons expressing KiSS-1, NKB, substance P, dynorphin and ERalpha mRNA in the infundibular nucleus play an important role in sex-steroid feedback on gonadotropin secretion in the human.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.peptides.2008.05.016

Cites

116 of 116 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The GPR54 Gene as a Regulator of Puberty
Seminara, S. B., Messager, S., Chatzidaki, E. E., Thresher, R. R., Acierno, J. S., Shagoury, J. K., Bo-Abbas, Y., Kuohung, W., Schwinof, K. M., Hendrick, A. G., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035322 · Cited by 2,557
Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
de Roux, N., Genin, E., Carel, J.-C., Matsuda, F., Chaussain, J.-L., & Milgrom, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834399100 · Cited by 2,431 · cited 4×
“While it is well recognized that GnRH neurons are influenced by multiple converging inputs, studies of GPR54 mutations in humans [16,93] and transgenic mice emphasize the essential nature of this circuitry in the regulation of reproduction.”
BackgroundInfluential
Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause
Faddy, M. J., Gosden, R. G., Gougeon, A., Richardson, S. J., & Nelson, J. F. (1992) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137570 · Cited by 1,361
The Neuroendocrine Control of the Menstrual Cycle
Knobil, E. (1980) · Elsevier eBooks · doi:10.1016/b978-0-12-571136-4.50008-5 · Cited by 1,285
Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54
Messager, S., Chatzidaki, E. E., Ma, D., Hendrick, A. G., Zahn, D., Dixon, J., Thresher, R. R., Malinge, I., Lomet, D., Carlton, M. B. L., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409330102 · Cited by 1,242
Regulation of Kiss1 gene expression in the brain of the female mouse
Smith, J. T., Cunningham, M. J., Rissman, E. F., Clifton, D. K., & Steiner, R. A. (2005) · Endocrinology · doi:10.1210/en.2005-0488 · Cited by 1,102
Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty
Han, S.-K., Gottsch, M. L., Lee, K. J., Popa, S. M., Smith, J. T., Jakawich, S. K., Clifton, D. K., Steiner, R. A., & Herbison, A. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3328-05.2005 · Cited by 1,036
The Endocrinology of Aging
Lamberts, S. W. J., van den Beld, A. W., & van der Lely, A.-J. (1997) · Science · doi:10.1126/science.278.5337.419 · Cited by 980
Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat
Irwig, M. S., Fraley, G. S., Smith, J. T., Acohido, B. V., Popa, S. M., Cunningham, M. J., Gottsch, M. L., Clifton, D. K., & Steiner, R. A. (2004) · Neuroendocrinology · doi:10.1159/000083140 · Cited by 930
Postnatal Development of Kisspeptin Neurons in Mouse Hypothalamus; Sexual Dimorphism and Projections to Gonadotropin-Releasing Hormone Neurons
Clarkson, J., & Herbison, A. E. (2006) · Endocrinology · doi:10.1210/en.2006-0787 · Cited by 875
Executive summary: stages of reproductive aging workshop (STRAW)
Soules, M. R., Sherman, S., Parrott, E. C., Rebar, R. W., Santoro, N. F., Utian, W. H., & Woods, N. F. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02909-0 · Cited by 767
Follicular Depletion During the Menopausal Transition: Evidence for Accelerated Loss and Ultimate Exhaustion*
Richardson, S. J., Senikas, V., & Nelson, J. F. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-6-1231 · Cited by 714
Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B
Goodman, R. L., Lehman, M. N., Smith, J. T., Coolen, L. M., de Oliveira, C. V. R., Jafarzadehshirazi, M. R., Pereira, A., Iqbal, J., Caraty, A., Ciofi, P., et al. (2007) · Endocrinology · doi:10.1210/en.2007-0961 · Cited by 692
Hormonal characteristics of the human menstrual cycle throughout reproductive life.
Sherman, B. M., & Korenman, S. G. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107979 · Cited by 587
A GPR54 -Activating Mutation in a Patient with Central Precocious Puberty
Teles, M. G., Bianco, S. D. C., Brito, V. N., Trarbach, E. B., Kuohung, W., Xu, S., Seminara, S. B., Mendonca, B. B., Kaiser, U. B., & Latronico, A. C. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa073443 · Cited by 572
A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause
Hansen, K. R., Knowlton, N. S., Thyer, A., Charleston, J. S., Soules, M. R., & Klein, N. A. (2008) · Human Reproduction · doi:10.1093/humrep/dem408 · Cited by 564
QUANTITATIVE MORPHOLOGICAL INVESTIGATIONS OF THE FOLLICULAR SYSTEM IN WOMEN
Block, E. (2008) · Acta Anatomica · doi:10.1159/000140595 · Cited by 518
Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha
Franceschini, I., Lomet, D., Cateau, M., Delsol, G., Tillet, Y., & Caraty, A. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.03.039 · Cited by 509
Involvement of central metastin in the regulation of preovulatory luteinizing hormone surge and estrous cyclicity in female rats
Kinoshita, M., Tsukamura, H., Adachi, S., Matsui, H., Uenoyama, Y., Iwata, K., Yamada, S., Inoue, K., Ohtaki, T., Matsumoto, H., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0195 · Cited by 507
Surgical Disconnection of the Medial Basal Hypothalamus and Pituitary Function in the Rhesus Monkey. I. Gonadotropin Secretion1,2
Krey, L. C., Butler, W. R., & Knobil, E. (1975) · Endocrinology · doi:10.1210/endo-96-5-1073 · Cited by 473
Estrogen, Menopause, and the Aging Brain: How Basic Neuroscience Can Inform Hormone Therapy in Women
Morrison, J. H., Brinton, R. D., Schmidt, P. J., & Gore, A. C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3369-06.2006 · Cited by 406
KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season
Smith, J. T., Clay, C. M., Caraty, A., & Clarke, I. J. (2007) · Endocrinology · doi:10.1210/en.2006-1435 · Cited by 404
Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys
Rometo, A. M., Krajewski, S. J., Lou Voytko, M., & Rance, N. E. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0553 · Cited by 396
Control of the rhesus monkey menstrual cycle: permissive role of hypothalamic gonadotropin-releasing hormone
Knobil, E., Plant, T. M., Wildt, L., Belchetz, P. E., & Marshall, G. (1980) · Science · doi:10.1126/science.6766566 · Cited by 390
Minireview: Kisspeptin Neurons as Central Processors in the Regulation of Gonadotropin-Releasing Hormone Secretion
Lemko, H. M. D., Clifton, D. K., & Steiner, R. A. (2005) · Endocrinology · doi:10.1210/en.2005-1282 · Cited by 379
Perimenopause: The Complex Endocrinology of the Menopausal Transition
Prior, J. C. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.4.0341 · Cited by 374
Decreased inhibin B secretion is associated with the monotropic FSH rise in older, ovulatory women: a study of serum and follicular fluid levels of dimeric inhibin A and B in spontaneous menstrual cycles
Klein, N. A., Illingworth, P. J., Groome, N. P., McNeilly, A. S., Battaglia, D. E., & Soules, M. R. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.7.8675606 · Cited by 372
New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function
Roa, J., Aguilar, E., Diéguez, C., Pinilla, L., & Tena‐Sempere, M. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.07.002 · Cited by 350
Female Reproductive Aging Is Marked by Decreased Secretion of Dimeric Inhibin1
Welt, C. K., McNicholl, D. J., Taylor, A. E., & Hall, J. E. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.1.5381 · Cited by 333
Characterization of the Hypothalamic-Pituitary-Gonadal Axis in Estrogen Receptor (ER) Null Mice Reveals Hypergonadism and Endocrine Sex Reversal in Females Lacking ERα But Not ERβ
Couse, J. F., Yates, M. M., Walker, V. R., & Korach, K. S. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0398 · Cited by 314
Reproductive aging: accelerated ovarian follicular development associated with a monotropic follicle-stimulating hormone rise in normal older women
Klein, N. A., Battaglia, D. E., Fujimoto, V. Y., Davis, G. S., Bremner, W. J., & Soules, M. R. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.3.8772573 · Cited by 296
Kisspeptin-54 Stimulates Gonadotropin Release Most Potently during the Preovulatory Phase of the Menstrual Cycle in Women
Dhillo, W. S., Chaudhri, O. B., Thompson, E. L., Murphy, K. G., Patterson, M., Ramachandran, R., Nijher, G. M. K., Amber, V., Kokkinos, A. D., Donaldson, M., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1116 · Cited by 296
Coexpression of dynorphin and neurokinin B immunoreactivity in the rat hypothalamus: morphologic evidence of interrelated function within the arcuate nucleus
Burke, M. C., Letts, P. A., Krajewski, S. J., & Rance, N. E. (2006) · Journal of Comparative Neurology · doi:10.1002/cne.21086 · Cited by 280
Self-citation
Hormonal profiles after the menopause.
Chakravarti, S., Collins, W. P., Forecast, J. D., Newton, R., Oram, D. H., & Studd, J. W. W. (1976) · BMJ · doi:10.1136/bmj.2.6039.784 · Cited by 273
Expression of inhibin/activin subunits and follistatin messenger ribonucleic acids and proteins in ovarian follicles and the corpus luteum during the human menstrual cycle
Roberts, V. J. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.77.5.1402 · Cited by 270
Aromatase Inhibition in the Human Male Reveals a Hypothalamic Site of Estrogen Feedback
Hayes, F. J., Seminara, S. B., DeCruz, S., Boepple, P. A., & Crowley, W. F. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6795 · Cited by 268
Hypertrophy and Increased Gene Expression of Neurons Containing Neurokinin-B and Substance-P Messenger Ribonucleic Acids in the Hypothalami of Postmenopausal Women*
Rance, N. E., & Young, W. S. (1991) · Endocrinology · doi:10.1210/endo-128-5-2239 · Cited by 266
Self-citation
Central Electrophysiologic Correlates of Pulsatile Luteinizing Hormone Secretion in the Rhesus Monkey
Wilson, R. C., Kesner, J. S., Kaufman, J., Uemura, T., Akema, T., & Knobil, E. (2008) · Neuroendocrinology · doi:10.1159/000123988 · Cited by 264
Female Reproductive Aging Is Marked by Decreased Secretion of Dimeric Inhibin
Welt, C. K. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.1.105 · Cited by 253
Evidence That Dynorphin Plays a Major Role in Mediating Progesterone Negative Feedback on Gonadotropin-Releasing Hormone Neurons in Sheep
Goodman, R. L., Coolen, L. M., Anderson, G. M., Hardy, S. L., Valent, M., Connors, J. M., Fitzgerald, M. E., & Lehman, M. N. (2004) · Endocrinology · doi:10.1210/en.2003-1305 · Cited by 251
The Role of Kisspeptins and GPR54 in the Neuroendocrine Regulation of Reproduction
Popa, S. M., Clifton, D. K., & Steiner, R. A. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100540 · Cited by 249
The Role of Kisspeptin–GPR54 Signaling in the Tonic Regulation and Surge Release of Gonadotropin-Releasing Hormone/Luteinizing Hormone
Lemko, H. M. D., Gottsch, M. L., Zeng, H., Gragerov, A., Bergmann, J. E., Vassilatis, D. K., Clifton, D. K., & Steiner, R. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2748-07.2007 · Cited by 224
Morphologic evidence that neurokinin B modulates gonadotropin‐releasing hormone secretion via neurokinin 3 receptors in the rat median eminence
Krajewski, S. J., Anderson, M. J., Iles‐Shih, L., Chen, K. J., Urbanski, H. F., & Rance, N. E. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20626 · Cited by 197
Self-citation
Menopause and Hypothalamic-Pituitary Sensitivity to Estrogen
Weiss, G. (2004) · JAMA · doi:10.1001/jama.292.24.2991 · Cited by 193
Endocrine Features of Menstrual Cycles in Middle and Late Reproductive Age and the Menopausal Transition Classified According to the Staging of Reproductive Aging Workshop (STRAW) Staging System
Hale, G. E., Zhao, X., Hughes, C. L., Burger, H., Robertson, D. M., & Fraser, I. S. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0066 · Cited by 191
Hypothalamic Expression of KiSS-1 System and Gonadotropin-Releasing Effects of Kisspeptin in Different Reproductive States of the Female Rat
Roa, J., Vigo, E., Castellano, J. M., Navarro, V. M., Fernández-Fernández, R., Casanueva, F. F., Diéguez, C., Aguilar, E., Pinilla, L., & Tena‐Sempere, M. (2006) · Endocrinology · doi:10.1210/en.2005-1463 · Cited by 181
Concentration of Unconjugated Estrone and Estradiol in Peripheral Plasma in Nonpregnant Women Throughout the Menstrual Cycle, Castrate and Postmenopausal Women and in Men1
Baird, D. T., & Guevara, A. P. (1969) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-29-2-149 · Cited by 176
Menopause Transition: Annual Changes in Serum Hormonal Patterns over the Menstrual Cycle in Women during a Nine-Year Period Prior to Menopause
Landgren, B.-M., Collins, A., Csemiczky, G., Burger, H., Baksheev, L., & Robertson, D. M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030824 · Cited by 171
Central injection of senktide, an NK3 receptor agonist, or neuropeptide Y inhibits LH secretion and induces different patterns of Fos expression in the rat hypothalamus
Sandoval‐Guzmán, T., & Rance, N. E. (2004) · Brain Research · doi:10.1016/j.brainres.2004.08.026 · Cited by 168
Self-citation
Costorage and coexistence of neuropeptides in the mammalian CNS
Merighi, A. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00031-4 · Cited by 160
Mechanisms underlying episodic gonadotropin-releasing hormone secretion
Moenter, S. M., DeFazio, R. A., Pitts, G. R., & Nunemaker, C. S. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/s0091-3022(03)00013-x · Cited by 155
Estrogen Receptors: Structure, Mechanisms and Function
Hewitt, S. C., & Korach, K. S. (2002) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/a:1020068224909 · Cited by 153
Progestogen-induced luteinizing and follicle-stimulating hormone surge in postmenopausal women: a simulated ovulatory peak.
Odell, W. D., & Swerdloff, R. S. (1968) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.61.2.529 · Cited by 152
Nonhuman Primate Models of Menopause Workshop1
Bellino, F. L., & Wise, P. M. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.102.005215 · Cited by 151
Colocalization of Progesterone Receptors in Parvicellular Dynorphin Neurons of the Ovine Preoptic Area and Hypothalamus
Foradori, C. D., Coolen, L. M., Fitzgerald, M. E., Skinner, D. C., Goodman, R. L., & Lehman, M. N. (2002) · Endocrinology · doi:10.1210/en.2002-220586 · Cited by 149
Postmenopausal hypertrophy of neurons expressing the estrogen receptor gene in the human hypothalamus
RANCE, N. E., McMULLEN, N. T., SMIALEK, J. E., PRICE, D. L., & YOUNG, W. S. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-1-79 · Cited by 148
Self-citation
Critical Role for Estrogen Receptor alpha in Negative Feedback Regulation of Gonadotropin-Releasing Hormone mRNA Expression in the Female Mouse
Dorling, A. A., Todman, M. G., Korach, K. S., & Herbison, A. E. (2003) · Neuroendocrinology · doi:10.1159/000073703 · Cited by 141
Sexual dimorphism in the organization of the rat hypothalamic infundibular area
Ciofi, P., Leroy, D., & Tramu, G. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.05.041 · Cited by 140
Identification of Neurokinin B-Expressing Neurons as an Highly Estrogen-Receptive, Sexually Dimorphic Cell Group in the Ovine Arcuate Nucleus**This work was supported by the United Kingdom Biotechnology and Biological Sciences Research Council (to J.E.R. and A.E.H.) and a European Community Marie Curie Research Training Grant (to M.L.G.).
Goubillon, M.-L., Forsdike, R. A., Robinson, J. E., Ciofi, P., Caraty, A., & Herbison, A. E. (2000) · Endocrinology · doi:10.1210/endo.141.11.7743 · Cited by 137
Molecular Endocrinology and Physiology of the Aging Central Nervous System
Smith, R. G., Betancourt, L., & Sun, Y. (2005) · Endocrine Reviews · doi:10.1210/er.2002-0017 · Cited by 129
Colocalisation of Dynorphin A and Neurokinin B Immunoreactivity in the Arcuate Nucleus and Median Eminence of the Sheep
Foradori, C. D., Amstalden, M., Goodman, R. L., & Lehman, M. N. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01445.x · Cited by 126
Neurokinin B Gene Expression Is Increased in the Arcuate Nucleus of Ovariectomized Rats
Rance, N. E., & Bruce, T. R. (2008) · Neuroendocrinology · doi:10.1159/000126768 · Cited by 123
Self-citation
Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axis
Gottsch, M. L., Clifton, D. K., & Steiner, R. A. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.04.030 · Cited by 123
Progesterone increases dynorphin A concentrations in cerebrospinal fluid and preprodynorphin messenger ribonucleic acid levels in a subset of dynorphin neurons in the sheep
Foradori, C. D., Goodman, R. L., Adams, V. L., Valent, M., & Lehman, M. N. (2005) · Endocrinology · doi:10.1210/en.2004-1326 · Cited by 123
Hypophysiotropic Signal Frequency and the Functioning of the Pituitary-Ovarian System in the Rhesus Monkey*
Pohl, C. R., Richardson, D. W., HUTCHISON, J. S., Germak, J. A., & Knobil, E. (1983) · Endocrinology · doi:10.1210/endo-112-6-2076 · Cited by 111
Neuroendocrine Modulation and Repercussions of Female Reproductive Aging
Wise, P. M. (2002) · Recent Progress in Hormone Research · doi:10.1210/rp.57.1.235 · Cited by 109
Evidence That GnRH Decreases with Gonadal Steroid Feedback but Increases with Age in Postmenopausal Women
Gill, S., Sharpless, J. L., Rado, K. B., & Hall, J. E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8508 · Cited by 101
Decrease in Gonadotropin-Releasing Hormone (GnRH) Pulse Frequency with Aging in Postmenopausal Women1
Hall, J. E., Lavoie, H. B., Marsh, E. E., & Martin, K. A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.5.6612 · Cited by 101
More basic forms of both human follicle-stimulating hormone and luteinizing hormone in serum at midcycle compared with the follicular or luteal phase.
WIDE, L. E., & Bakos, O. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.4.8473400 · Cited by 101
Age-Related Analysis of Inhibin A, Inhibin B, and Activin A Relative to the Intercycle Monotropic Follicle-Stimulating Hormone Rise in Normal Ovulatory Women
Klein, N. A., Houmard, B. S., Hansen, K. R., Woodruff, T. K., Sluss, P. M., Bremner, W. J., & Soules, M. R. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031515 · Cited by 101
Negative feedback effects of estrogen on luteinizing hormone-releasing hormone release occur in pubertal, but not prepubertal, ovariectomized female rhesus monkeys
Chongthammakun, S., & Terasawa, E. (1993) · Endocrinology · doi:10.1210/endo.132.2.8425492 · Cited by 100
The role of KiSS-1 in the regulation of puberty in higher primates
Plant, T. M. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02232 · Cited by 97
The Effects of Hormone Replacement Therapy on Hypothalamic Neuropeptide Gene Expression in a Primate Model of Menopause1
Abel, T. W., Voytko, M. L., & Rance, N. E. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.6.5689 · Cited by 97
Self-citation
Metastin and its G protein-coupled receptor, GPR54: Critical pathway modulating GnRH secretion
Seminara, S. B. (2005) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2005.10.001 · Cited by 91
Neuroendocrine Changes with Reproductive Aging in Women
Hall, J. E. (2007) · Seminars in Reproductive Medicine · doi:10.1055/s-2007-984740 · Cited by 91
Neuroendocrine physiology of the early and late menopause
Hall, J. E. (2004) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2004.08.002 · Cited by 89
Unexpected responses of the hypothalamic gonadotropin-releasing hormone "pulse generator" to physiological estradiol inputs in the absence of the ovary.
Kesner, J. S., Wilson, R. C., Kaufman, J., Hotchkiss, J., Chen, Y., Yamamoto, H., Pardo, R. R., & Knobil, E. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8745 · Cited by 88
Gonadotropin-releasing hormone gene expression is increased in the medial basal hypothalamus of postmenopausal women
Rance, N. E., & Uswandi, S. V. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.10.8855798 · Cited by 86
Self-citation
Perimenopause: The Complex Endocrinology of the Menopausal Transition
Prior, J. C. (1998) · Endocrine Reviews · doi:10.1210/er.19.4.397 · Cited by 84
The Effects of Hormone Replacement Therapy on Hypothalamic Neuropeptide Gene Expression in a Primate Model of Menopause
Abel, T. W. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.6.2111 · Cited by 80
Menopausal Increases in Pulsatile Gonadotropin-Releasing Hormone Release in a Nonhuman Primate (Macaca mulatta)
Gore, A. C., Windsor-Engnell, B. M., & Terasawa, E. (2004) · Endocrinology · doi:10.1210/en.2004-0379 · Cited by 78
Negative Feedback Effects of Gonadal Steroids Are Preserved with Aging in Postmenopausal Women
Gill, S., Lavoie, H. B., Bo-Abbas, Y. Y., & Hall, J. E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8510 · Cited by 78
Regulation of Human Gonadotropins
Jaffe, R. B., MIDGLEY, A. R., Goebelsmann, U., & Snyder, D. L. (2010) · Gynecologic Investigation · doi:10.1159/000301943 · Cited by 75
Decrease in Gonadotropin-Releasing Hormone (GnRH) Pulse Frequency with Aging in Postmenopausal Women
Hall, J. E. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.5.1794 · Cited by 73
Estrogen regulation of neurokinin B gene expression in the mouse arcuate nucleus is mediated by estrogen receptor alpha.
Dellovade, T., & Merchenthaler, I. (2004) · Endocrinology · doi:10.1210/en.2003-0894 · Cited by 72
Effects of aging and gonadal failure on the hypothalamic-pituitary axis in women
Santoro, N. F., Banwell, T., Tortoriello, D. V., Lieman, H., Adel, T., & Skurnick, J. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70483-1 · Cited by 70
Short‐Term Effect of Oestradiol on Neurokinin B mRNA Expression in the Infundibular Nucleus of Ewes
Pillon, D., Caraty, A., Fabre‐Nys, C., & Bruneau, G. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01054.x · Cited by 66
Ovariectomy Increases in vivo Luteinizing Hormone‐Releasing Hormone Release in Pubertal, but not Prepubertal, Female Rhesus Monkeys
Chongthammakun, S., Claypool, L. E., & Terasawa, E. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00362.x · Cited by 66
Widespread expression of rat collapsin response-mediated protein 4 in the telencephalon and other areas of the adult rat central nervous system
Nácher, J., Rosell, D. R., & McEwen, B. S. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20000904)424:4 · Cited by 65
Self-citation
Changes in Radioimmunoassayable Luteinizing Hormone-Releasing Hormone in Discrete Brain Areas of the Rat at Various Times on Proestrus, Diestrous Day 1, and after Phenobarbital Administration*
Wise, P. M., Rance, N. E., SELMANOFF, M. K., & Barraclough, C. A. (1981) · Endocrinology · doi:10.1210/endo-108-6-2179 · Cited by 63
Self-citation
Effects of ovariectomy on the neuroendocrine axes regulating reproduction and energy balance in young cynomolgus macaques
Sandoval‐Guzmán, T., Stalcup, S. T., Krajewski, S. J., Voytko, M. L., & Rance, N. E. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.0953-8194.2004.01143.x · Cited by 60
Self-citation
Serum Gonadotropin Responses to Estrogen and Progestogen in Recently Castrated Human Females
Wallach, E. E., Root, A. W., & García, C.-R. (1970) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-31-4-376 · Cited by 56
Is follicular atresia biphasic?
Leidy, L. E., Godfrey, L. R., & Sutherland, M. R. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00316-1 · Cited by 56
Gonadotropin Secretion during Aging in Postmenopausal Women
Rossmanith, W. G., Scherbaum, W. A., & Lauritzen, C. (2008) · Neuroendocrinology · doi:10.1159/000125878 · Cited by 56
Aging-Related Changes in Release of Growth Hormone and Luteinizing Hormone in Female Rhesus Monkeys
Woller, M. J., Everson-Binotto, G., Nichols, E., Acheson, A., Keen, K. L., Bowers, C. Y., & Terasawa, E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020659 · Cited by 54
Regulation of Human Gonadotropins. XIII. Changes in Serum Gonadotropins in Menstruating Women in Response to Oophorectomy
Monroe, S. E., Jaffe, R. B., & MIDGLEY, A. R. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-34-2-420 · Cited by 49
Proopiomelanocortin gene expression is decreased in the infundibular nucleus of postmenopausal women.
Abel, T. W., & Rance, N. (1999) · Brain Research. Molecular Brain Research · doi:10.1016/s0169-328x(99)00111-4 · Cited by 48
Self-citation
THE SUBVENTRICULAR NUCLEUS OF THE HUMAN HYPOTHALAMUS
Sheehan, H. L., & Kovács, K. (1966) · Brain · doi:10.1093/brain/89.3.589 · Cited by 47
Sex steroid modulation of neurokinin B gene expression in the arcuate nucleus of adult male rats
Danzer, S. C., Price, R. O., McMullen, N. T., & Rance, N. E. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00024-8 · Cited by 43
Self-citation
Correlation between serum inhibin B and other indicators of the ovarian function
Tinkanen, H., Bläuer, M., Laippala, P., Tuohimaa, P., & Kujansuu, E. (2001) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(00)00319-5 · Cited by 41
Luteinizing Hormone-Releasing Hormone and Thyrotropin-Releasing Hormone in the Hypothalamus of Women: Effects of Age and Reproductive Status*
Parker, C. R., & Porter, J. C. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-58-3-488 · Cited by 39
Disappearance of Endogenous Luteinizing Hormone Is Prolonged in Postmenopausal Women1
Sharpless, J. L., Supko, J. G., Martin, K. A., & Hall, J. E. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.2.5433 · Cited by 39
Neuropeptide Y Gene Expression Is Increased in the Hypothalamus of Older Women
Escobar, C. M., Krajewski, S. J., Sandoval‐Guzmán, T., Voytko, M. L., & Rance, N. E. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031899 · Cited by 39
Self-citation
Ovarian Control of Gonadotropin Hormone-Releasing Hormone Pulse Generator Activity in the Rhesus Monkey: Duration of the Associated Hypothalamic Signal
O’Byrne, K. T., Chen, M., Nishihara, M., Williams, C. L., Thalabard, J., Hotchkiss, J., & Knobil, E. (2008) · Neuroendocrinology · doi:10.1159/000126411 · Cited by 36
Effect of Estrogen on Hypothalamic Transforming Growth Factor Alpha and Gonadotropin-Releasing Hormone Gene Expression in the Female Rhesus Monkey
Majdoubi, M. E., Sahu, A., & Plant, T. M. (1998) · Neuroendocrinology · doi:10.1159/000054318 · Cited by 36
Disappearance of Endogenous Luteinizing Hormone Is Prolonged in Postmenopausal Women
Sharpless, J. L. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.2.688 · Cited by 35
Search for Neural Substrates Mediating Inhibitory Effects of Oestrogen on Pulsatile Luteinising Hormone‐Releasing Hormone Release In Vivo in Ovariectomized Female Rhesus Monkeys (Macaca mulatta)
Mizuno, M., & Terasawa, E. (2005) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2005.01295.x · Cited by 33
More basic forms of both human follicle-stimulating hormone and luteinizing hormone in serum at midcycle compared with the follicular or luteal phase
WIDE, L. E. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.76.4.885 · Cited by 28
Ovarian steroids differentially modulate the gene expression of gonadotropin-releasing hormone neuronal subtypes in the ovariectomized cynomolgus monkey.
Krajewski, S. J., Abel, T., Voytko, M., & Rance, N. (2003) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2002-020887 · Cited by 25
Self-citation
Impaired Estrogen-Induced Luteinizing Hormone Release in Young Women with Anovulatory Dysfunctional Uterine Bleeding*
Look, P. F. A. V., Hunter, W. M., Fraser, I. S., & Baird, D. T. (1978) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-46-5-816 · Cited by 22
Variations in the subventricular nucleus
Sheehan, H. L. (1967) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700940222 · Cited by 22
Identification of Neurokinin B-Expressing Neurons as an Highly Estrogen-Receptive, Sexually Dimorphic Cell Group in the Ovine Arcuate Nucleus
Goubillon, M.-L. (2000) · Endocrinology · doi:10.1210/en.141.11.4218 · Cited by 21
In Pubertal Girls, Naloxone Fails to Reverse the Suppression of Luteinizing Hormone Secretion by Estradiol1
Cemeroğlu, A. P., Kletter, G. B., Guo, W.-S., Brown, M. B., Kelch, R. P., Marshall, J. C., Padmanabhan, V., & Foster, C. M. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.10.5207 · Cited by 14
Perimenopausal Reproductive Endocrinology
Hale, G. E., & Burger, H. (2005) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2005.07.013 · Cited by 11
In Pubertal Girls, Naloxone Fails to Reverse the Suppression of Luteinizing Hormone Secretion by Estradiol
Cemeroğlu, A. P. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.10.3501 · Cited by 9
Feedback of Estrogen in Postmenopausal Women
Nishi, T., Yagi, S., & Nakano, R. (1987) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016348709103642 · Cited by 4

Flagged first, then by citations

Research works printed but not linked: 4

Escobar, 2004, Neuropeptide Y gene expression is increased in the infundibular nucleus of postmenopausal women, J Clin Endocrinol Metab, 89, 2338, 10.1210/jc.2003-031899 · DOI
Krajewski, 2005, Arcuate neurokinin B neurons project to the median eminence as well as multiple hypothalamic sites: an anterograde tract-tracing study using biotinylated dextran amine, Soc Neurosci Abstr
McManus, 2005, A neurokinin-B agonist stimulates LH secretion in follicular, but not luteal, phase ewes, Soc Neurosci Abstr
Rometo, 2007, Changes in morphology and gene expression of dynorphin neurons in the infundibular nucleus of postmenopausal women, Soc Neurosci Abstr

Sorted by citations

Dynamics of gonadotropin-releasing hormone release during a pulse.
Moenter, S. M., Brand, R. M., MIDGLEY, A. R., & Karsch, F. J. (1992) · Endocrinology · doi:10.1210/endo.130.1.1727719 · Cited by 1,257
TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for neurokinin B in the central control of reproduction
Topaloglu, A. K., Reimann, F., Guclu, M., Yalin, A. S., Kotan, L. D., Porter, K. M., Serin, A., Mungan, N. O., Cook, J. R., Ozbek, M. N., et al. (2009) · Nature Genetics · doi:10.1038/ng.306 · Cited by 961
Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms
Pinilla, L., Aguilar, E., Diéguez, C., Millar, R. P., & Tena‐Sempere, M. (2012) · Physiological Reviews · doi:10.1152/physrev.00037.2010 · Cited by 843
Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion
Lehman, M. N., Coolen, L. M., & Goodman, R. L. (2010) · Endocrinology · doi:10.1210/en.2010-0022 · Cited by 768
Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat
Wakabayashi, Y., Nakada, T., Murata, K., Ohkura, S., Mogi, K., Navarro, V. M., Clifton, D. K., Mori, Y., Tsukamura, H., Maeda, K.-I., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5848-09.2010 · Cited by 597
“These anatomical observations suggest that kisspeptin/NKB/Dyn neurons in the ARC comprise an oscillatory feedback loop interconnected through collaterals that synchronize their activity, as previously proposed (Burke et al., 2006; Foradori et al., 2006; Rance, 2009; Navarro et al., 2009).”
Background

See all 238

Authors: Rance, N. E.
Affiliations: University of Arizona (US)
Corresponding author: Rance, Naomi E.
ORCID: Rance, Naomi E.
Venue: Peptides
Publisher: Elsevier BV
Published: 2009-01
Volume: 30
Issue: 1
Pages: 111-122
ISSN: 0196-9781 (ISSN-L)
DOI: 10.1016/j.peptides.2008.05.016
PMC: PMC2632595
OpenAlex: W2092614270
Cited by: 237
References: 114
Citations by year: 2026: 4 · 2025: 11 · 2024: 15 · 2023: 4 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 10 · 2018: 12 · 2017: 12 · 2016: 12 · 2015: 17 · 2014: 18 · 2013: 21 · 2012: 18
FWCI: 22.44
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Peptides (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (AG09214, R56AG009214, R01AG009214)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords: menopause, hypothalamus, kisspeptin, neurokinin B, estrogen negative feedback, gonadotropin secretion, gonadotropin-releasing hormone, arcuate nucleus, ovariectomy, estrogen receptor alpha, dynorphin, substance P, postmenopausal women, ovarian failure
MeSH terms: Aging, Animals, Dynorphins, Estrogens, Female, Humans, Hypothalamus, Menopause, Middle Aged, Neurons, Neurosecretory Systems, Ovary, Substance P, Neurokinin B, Feedback, Physiological, Tumor Suppressor Proteins, Rats, Kisspeptins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Menopause and the human hypothalamus: Evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks