Physiological role of metastin/kisspeptin in regulating gonadotropin-releasing hormone (GnRH) secretion in female rats
Abstract
Various studies have attempted to unravel the physiological role of metastin/kisspeptin in the control of gonadotropin-releasing hormone (GnRH) release. A number of evidences suggested that the population of metastin/kisspeptin neurons in the anteroventral periventricular nucleus (AVPV) is involved in generating a GnRH surge to induce ovulation in rodents, and thus the target of estrogen positive feedback. Females have an obvious metastin/kisspeptin neuronal population in the AVPV, but males have only a few cell bodies in the nucleus, suggesting that the absence of the surge-generating mechanism or positive feedback action in males is due to the limited AVPV metastin/kisspeptin neuronal population. On the other hand, the arcuate nucleus (ARC) metastin/kisspeptin neuronal population is considered to be involved in the regulation of tonic GnRH release. The ARC metastin/kisspeptin neurons show no sex difference in their expression, which is suppressed by gonadal steroids in both sexes. Thus, the ARC population of metastin/kisspeptin neurons is a target of estrogen negative feedback action on tonic GnRH release. The lactating rat model provided further evidence indicating that ARC metastin/kisspeptin neurons are involved in GnRH pulse generation, because pulsatile release of luteinizing hormone (LH) is profoundly suppressed by suckling stimulus and the LH pulse suppression is well associated with the suppression of ARC metastin/kisspeptin and KiSS-1 gene expression in lactating rats.
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Substantial evidence indicates that KNDy neurons are part of the circuitry mediating estrogen negative feedback on pulsatile LH secretion, via modulation of the activity of GnRH neurons.
“KNDy neurons are part of the circuitry mediating estrogen negative feedback on pulsatile LH secretion, via modulation of the activity of GnRH neurons (Lehman et al., 2010; Mittelman-Smith et al., 2012b; Ohkura et al., 2009; Popa et al., 2008; Rance, 2009; Rance et al., 2010)] (Fig. 5).”
From Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes (2013) · cites this paper as Ohkura et al., 2009
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- Authors
- Ohkura, S., Uenoyama, Y., Yamada, S., Homma, T., Takase, K., Inoue, N., Maeda, K.-I., & Tsukamura, H.
- Affiliations
- Nagoya University (JP)
- Corresponding author
- Tsukamura, Hiroko
- Venue
- Peptides
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 30
- Issue
- 1
- Pages
- 49-56
- ISSN
- 0196-9781 (ISSN-L)
- OpenAlex
- W1998983965
- Cited by
- 80
- References
- 59
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 3 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 8 · 2015: 2 · 2014: 5 · 2013: 13 · 2012: 7
- FWCI
- 8.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Peptides (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- KISS1, gonadotropin-releasing hormone, GnRH secretion, anteroventral periventricular nucleus, arcuate nucleus, estrogen positive feedback, estrogen negative feedback, GnRH surge, ovulation, lactation, luteinizing hormone pulsatility, suckling stimulus, sex steroids, sex differences
- MeSH terms
- Receptors, Kisspeptin-1, Animals, Arcuate Nucleus of Hypothalamus, Estrogens, Female, Lactation, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Male, Neurons, Proteins, Feedback, Physiological, Estrous Cycle, Receptors, G-Protein-Coupled, Rats, Kisspeptins
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