The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system
Abstract
GPR54 is a G-protein-coupled receptor that displays a high percentage of identity in the transmembrane domains with the galanin receptors. The ligand for GPR54 has been identified as a peptide derived from the KiSS-1 gene. KiSS-1 has been shown to have anti-metastatic effects, suggesting that KiSS-1 or its receptor represents a potential therapeutic target. To further our understanding of the physiological function of this receptor, we have generated a mutant mouse line with a targeted disruption of the GPR54 receptor (GPR54 -/-). The analysis of the GPR54 mutant mice revealed developmental abnormalities of both male and female genitalia and histopathological changes in tissues which normally contain sexually dimorphic features. These data suggest a role for GPR54/KiSS-1 in normal sexual development, and indicate that study of the GPR54 mutant mice may provide valuable insights into human reproductive syndromes.
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Kiss1r−/− mice have underdeveloped gonads, low gonadotropins and steroid hormone levels, and incomplete gametogenesis.
“Kiss1r−/− mice have underdeveloped gonads, low gonadotropins and steroid hormone levels, and incomplete gametogenesis.”
From The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism (2009) · cites this paper as [47]
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- Authors
- Funes, S., Hedrick, J. A., Vassileva, G., Markowitz, L., Abbondanzo, S., Golovko, A., Yang, S., Monsma, F. J., & Gustafson, E. L.
- Corresponding author
- Gustafson, Eric L
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 312
- Issue
- 4
- Pages
- 1357-1363
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W1964782601
- Cited by
- 675
- References
- 26
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 22 · 2023: 15 · 2022: 17 · 2021: 25 · 2020: 29 · 2019: 35 · 2018: 28 · 2017: 26 · 2016: 37 · 2015: 40 · 2014: 38 · 2013: 38 · 2012: 51
- FWCI
- 20.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- GPR54, KISS1, galanin receptors, G protein-coupled receptors, reproductive system development, sexual differentiation, genitalia development, mouse mutants, sexual dimorphism
- MeSH terms
- Receptors, Kisspeptin-1, Animals, Female, Genitalia, Hypogonadism, Male, Mutation, Organ Specificity, Phenotype, Proteins, Reproduction, Sexual Maturation, Tissue Distribution, Receptors, Neuropeptide, Mice, Knockout, Receptors, G-Protein-Coupled, Mice, Kisspeptins
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