Cited by 679Hypothalamic control of reproductive hormonesGenetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesSexual Differentiation and Disorders

The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system

Funes, Sandrine, Hedrick, Joseph A, Vassileva, Galya, Markowitz, Lisa, Abbondanzo, Susan, Golovko, Andrei, Yang, Shijun, Monsma, Frederick J +1 more·2003·Biochemical and Biophysical Research Communications

Abstract

GPR54 is a G-protein-coupled receptor that displays a high percentage of identity in the transmembrane domains with the galanin receptors. The ligand for GPR54 has been identified as a peptide derived from the KiSS-1 gene. KiSS-1 has been shown to have anti-metastatic effects, suggesting that KiSS-1 or its receptor represents a potential therapeutic target. To further our understanding of the physiological function of this receptor, we have generated a mutant mouse line with a targeted disruption of the GPR54 receptor (GPR54 -/-). The analysis of the GPR54 mutant mice revealed developmental abnormalities of both male and female genitalia and histopathological changes in tissues which normally contain sexually dimorphic features. These data suggest a role for GPR54/KiSS-1 in normal sexual development, and indicate that study of the GPR54 mutant mice may provide valuable insights into human reproductive syndromes.

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Crossref · 10.1016/j.bbrc.2003.11.066

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  • Kiss1r−/− mice have underdeveloped gonads, low gonadotropins and steroid hormone levels, and incomplete gametogenesis.

    “Kiss1r−/− mice have underdeveloped gonads, low gonadotropins and steroid hormone levels, and incomplete gametogenesis.”

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Authors
Funes, S., Hedrick, J. A., Vassileva, G., Markowitz, L., Abbondanzo, S., Golovko, A., Yang, S., Monsma, F. J., & Gustafson, E. L.
Corresponding author
Gustafson, Eric L
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2003-12
Volume
312
Issue
4
Pages
1357-1363
ISSN
0006-291X (ISSN-L)
OpenAlex
W1964782601
Cited by
675
References
26
Citations by year
2026: 4 · 2025: 9 · 2024: 22 · 2023: 15 · 2022: 17 · 2021: 25 · 2020: 29 · 2019: 35 · 2018: 28 · 2017: 26 · 2016: 37 · 2015: 40 · 2014: 38 · 2013: 38 · 2012: 51
FWCI
20.89
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemical and Biophysical Research Communications (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
GPR54, KISS1, galanin receptors, G protein-coupled receptors, reproductive system development, sexual differentiation, genitalia development, mouse mutants, sexual dimorphism
MeSH terms
Receptors, Kisspeptin-1, Animals, Female, Genitalia, Hypogonadism, Male, Mutation, Organ Specificity, Phenotype, Proteins, Reproduction, Sexual Maturation, Tissue Distribution, Receptors, Neuropeptide, Mice, Knockout, Receptors, G-Protein-Coupled, Mice, Kisspeptins

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