Cited by 173RNA Research and SplicingRNA regulation and diseaseRNA and protein synthesis mechanisms

The DOI matches its Crossref record; 221 of the 224 references it cites were found in a registry or an index.

Modulation of mRNA stability as a novel therapeutic approach

Eberhardt, Wolfgang, Doller, Anke, Akool, El-Sayed, Pfeilschifter, Josef·2007·Pharmacology & Therapeutics

DOI 10.1016/j.pharmthera.2007.01.002

Open this paper in CoChat — free account

Abstract

During the last decade evidence has accumulated that modulation of mRNA stability plays a central role in cellular homeostasis, including cell differentiation, proliferation and adaptation to external stimuli. The functional relevance of posttranscriptional gene regulation is highlighted by many pathologies, wherein occurrence tightly correlates with a dysregulation in mRNA stability, including chronic inflammation, cardiovascular diseases and cancer. Most commonly, the cis-regulatory elements of mRNA decay are represented by the adenylate- and uridylate (AU)-rich elements (ARE) which are specifically bound by trans-acting RNA binding proteins, which finally determine whether mRNA decay is delayed or facilitated. Regulation of mRNA decay by RNA stabilizing and RNA destabilizing factors is furthermore controlled by different intrinsic and environmental stimuli. The modulation of mRNA binding proteins, therefore, illuminates a promising approach for the pharmacotherapy of those key pathologies mentioned above and characterized by a posttranscriptional dysregulation. Most promisingly, intracellular trafficking of many of the mRNA stability regulating factors is, in turn, regulated by some major signaling pathways, including the mitogen-activated protein kinase (MAPK) cascade, the AMP-activated kinase (AMPK) and the protein kinase (PK) C (PKC) family. In this review, we present timely examples of genes regulated by mRNA stability with a special focus on signaling pathways involved in the ARE-dependent mRNA decay. A better understanding of these processes may form the basis for the development of novel therapeutics to treat major human diseases.

Integrity signals

Registry

Crossref · 10.1016/j.pharmthera.2007.01.002

Cites

221 of 221 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Glucose Deprivation Increases mRNA Stability of Vascular Endothelial Growth Factor through Activation of AMP-activated Protein Kinase in DU145 Prostate Carcinoma
Yun, H., Lee, M., Kim, S. S., & Ha, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412994200 · Cited by 147
Retracted
A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
Shaw, G. D., & Kamen, R. (1986) · Cell · doi:10.1016/0092-8674(86)90341-7 · Cited by 3,946
Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor
Kelly, K., Cochran, B., Stiles, C. D., & Leder, P. (1983) · Cell · doi:10.1016/0092-8674(83)90092-2 · Cited by 2,227
AU-rich elements: characterization and importance in mRNA degradation
Chen, C.-Y. A., & Shyu, A.-B. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89102-1 · Cited by 1,948
Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.
Caput, D., Beutler, B., Hartog, K., Thayer, R. M., Brown-Shimer, S. L., & Cerami, A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.6.1670 · Cited by 1,504
Messenger-RNA-binding proteins and the messages they carry
Dreyfuss, G., Kim, V. N., & Kataoka, N. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm760 · Cited by 1,457
THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?
Hardie, D. G., Carling, D., & Carlson, M. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.821 · Cited by 1,440
mRNA stability in mammalian cells
Ross, J. (1995) · Microbiological Reviews · doi:10.1128/mr.59.3.423-450.1995 · Cited by 1,411
Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements
Kontoyiannis, D. L., Pasparakis, M., Pizarro, T. T., Cominelli, F., & Kollias, G. A. (1999) · Immunity · doi:10.1016/s1074-7613(00)80038-2 · Cited by 1,329
Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia
Levy, A. P., Levy, N. S., Wegner, S. A., & Goldberg, M. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13333 · Cited by 1,073

Show all 224 references

Sorted by citations

Regulation of cytoplasmic mRNA decay
Schoenberg, D. R., & Maquat, L. E. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3160 · Cited by 656
Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements
Barrett, L. W., Fletcher, S., & Wilton, S. D. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0990-9 · Cited by 641
Advances in COVID-19 mRNA vaccine development
Fang, E., Liu, X., Li, M., Zhang, Z., Song, L., Zhu, B., Wu, X., Liu, J., Zhao, D., & Li, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00950-y · Cited by 601
Regulation of the expression of inducible nitric oxide synthase
Pautz, A., Art, J., Hahn, S., Nowag, S., Voss, C., & Kleinert, H. (2010) · Nitric Oxide · doi:10.1016/j.niox.2010.04.007 · Cited by 549
Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer
Boutros, T., Chevet, É., & Metrakos, P. P. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.00106 · Cited by 558
RNA modifications: importance in immune cell biology and related diseases
Cui, L., Ma, R., Cai, J., Guo, C., Chen, Z., Yao, L., Wang, Y., Fan, R., Wang, X., & Shi, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01175-9 · Cited by 432
The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes
Lisi, L., Navarra, P., Feinstein, D., & Russo, C. D. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-1 · Cited by 194
Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR
Doller, A., Pfeilschifter, J. M., & Eberhardt, W. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.05.007 · Cited by 218
Self-citation
Posttranslational Modification of the AU-Rich Element Binding Protein HuR by Protein Kinase Cδ Elicits Angiotensin II-Induced Stabilization and Nuclear Export of Cyclooxygenase 2 mRNA
Doller, A., Akool, E., Huwiler, A., Müller, R., Radeke, H. H., Pfeilschifter, J. M., & Eberhardt, W. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01530-07 · Cited by 187
Self-citation
ARED Organism: expansion of ARED reveals AU-rich element cluster variations between human and mouse
Halees, A. S., El-Badrawi, R., & Khabar, K. S. A. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm959 · Cited by 142
Platelet‐derived microparticles promote invasiveness of prostate cancer cells via upregulation of MMP‐2 production
Dashevsky, O., Varon, D., & Brill, A. G. (2008) · International Journal of Cancer · doi:10.1002/ijc.24016 · Cited by 140
Localization of AMP kinase is regulated by stress, cell density, and signaling through the MEK→ERK1/2 pathway
Kodiha, M., Rassi, J. G., Brown, C. M., & Stochaj, U. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00176.2007 · Cited by 138
Glyceraldehyde-3-Phosphate Dehydrogenase Regulates Endothelin-1 Expression by a Novel, Redox-Sensitive Mechanism Involving mRNA Stability
Rodríguez‐Pascual, F., Redondo‐Horcajo, M., Magán-Marchal, N., Lagares, D., Martı́nez-Ruiz, A., Kleinert, H., & Lamas, S. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01145-08 · Cited by 119
Control of cytokine mRNA expression by RNA-binding proteins and microRNAs
Palanisamy, V., Jakymiw, A., Van Tubergen, E. A., D’Silva, N. J., & Kirkwood, K. L. (2012) · Journal of Dental Research · doi:10.1177/0022034512437372 · Cited by 117
The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding
Wang, H., Zeng, F., Liu, Q., Liu, H., Liu, Z., Niu, L., Teng, M., & Li, X. (2013) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444912047828 · Cited by 119
Modified mRNA as an alternative to plasmid DNA (pDNA) for transcript replacement and vaccination therapy
Youn, H., & Chung, J.-K. (2015) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.1057563 · Cited by 114
An overview of rational design of mRNA-based therapeutics and vaccines
To, K. K. W., & Cho, W. C. S. (2021) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2021.1935859 · Cited by 110
Trans‐acting translational regulatory RNA binding proteins
Harvey, R. F., Smith, T. S., Mulroney, T. E., Queiroz, R. M. L., Pizzinga, M., Dezi, V., Villanueva, E., Ramakrishna, M., Lilley, K. S., & Willis, A. E. (2018) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1465 · Cited by 106
The heparanase system and tumor metastasis: is heparanase the seed and soil?
Arvatz, G., Shafat, I., Levy‐Adam, F., Ilan, N., & Vlodavsky, I. (2011) · Cancer and Metastasis Reviews · doi:10.1007/s10555-011-9288-x · Cited by 98
The complex world of post-transcriptional mechanisms: is their deregulation a common link for diseases? Focus on ELAV-like RNA-binding proteins
Pascale, A., & Govoni, S. M. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0810-7 · Cited by 93
Expanding medicinal chemistry space
Barker, A. J., Kettle, J. G., Nowak, T., & Pease, J. E. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.10.008 · Cited by 89
Toll-like receptor 4 signaling pathway can be triggered by grass carp reovirus and Aeromonas hydrophila infection in rare minnow Gobiocypris rarus
Su, J., Yang, C., Xiong, F., Wang, Y., & Zhu, Z. (2009) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2009.02.016 · Cited by 85
Posttranscriptional control and the role of RNA‐binding proteins in gene regulation in trypanosomatid protozoan parasites
Moya, S. M. F., & Estévez, A. M. (2010) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.6 · Cited by 86
Alternative splicing of TIA‐1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance
Zadeh, M. A. H., Amin, E. M., Hoareau‐Aveilla, C., Domingo, E., Symonds, K. E., Ye, X., Heesom, K., Salmon, A. H. J., D'Silva, O., Betteridge, K. B., et al. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.07.017 · Cited by 81
A synonymous polymorphism of the Tristetraprolin (TTP) gene, an AU-rich mRNA-binding protein, affects translation efficiency and response to Herceptin treatment in breast cancer patients
Griseri, P., Bourcier, C., Hiéblot, C., Essafi‐Benkhadir, K., Chamorey, E., Touriol, C., & Pagès, G. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr390 · Cited by 77
Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells.
Ju, W., Keun-young Kim, A., Lindsey, J. D., Angert, M., Patel, A., Scott, R. T., Liu, Q., Crowston, J. G., Ellisman, M. H., Perkins, G. A., et al. (2009) · PubMed Central · Cited by 74
RNA-binding proteins and gene regulation in myogenesis
Apponi, L. H., Corbett, A. H., & Pavlath, G. K. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.06.004 · Cited by 78
Regulation of cyclooxygenase-2 expression by cyclic AMP
Klein, T., Shephard, P., Kleinert, H., & Kömhoff, M. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.09.001 · Cited by 73
MicroRNAs in cancer drug resistance: Basic evidence and clinical applications
Ghasabi, M., Mansoori, B., Mohammadi, A., Duijf, P. H. G., Shomali, N., Shirafkan, N., Mokhtarzadeh, A., & Baradaran, B. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26810 · Cited by 71
GAPDH as a model non-canonical AU-rich RNA binding protein
Garcin, E. D. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.03.013 · Cited by 70
The role of KSRP in mRNA decay and microRNA precursor maturation
Gherzi, R., Chen, C., Trabucchi, M., Ramos, A., & Briata, P. (2010) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.2 · Cited by 67
A Novel High Throughput Biochemical Assay to Evaluate the HuR Protein-RNA Complex Formation
D’Agostino, V., Adami, V., & Provenzani, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072426 · Cited by 66
Glucocorticoid‐induced leucine zipper is downregulated in human alveolar macrophages upon T oll‐like receptor activation
Hoppstädter, J., Diesel, B., Eifler, L. K., Schmid, T., Brüne, B., & Kiemer, A. K. (2012) · European Journal of Immunology · doi:10.1002/eji.201142081 · Cited by 65
Overexpression of the IGF2-mRNA binding protein p62 in transgenic mice induces a steatotic phenotype
Tybl, E., Shi, F.-D., Kessler, S. M., Tierling, S., Walter, J., Bohle, R. M., Wieland, S., Zhang, J., Tan, E. M., & Kiemer, A. K. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2010.08.034 · Cited by 65
High-constitutive HuR phosphorylation at Ser 318 by PKCδ propagates tumor relevant functions in colon carcinoma cells
Doller, A., Winkler, C., Azrilian, I., Schulz, S., Hartmann, S., Pfeilschifter, J. M., & Eberhardt, W. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr024 · Cited by 65
Self-citation
Role of the RNA-binding protein HuR in human renal cell carcinoma
Danilin, S., Sourbier, C., Thomas, L., Lindner, V., Rothhut, S., Dormoy, V., Helwig, J., Didier Jacqmin, D., Lang, H., & Massfelder, T. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq052 · Cited by 64
Tristetraprolin-dependent Post-transcriptional Regulation of Inflammatory Cytokine mRNA Expression by Apolipoprotein A-I
Yin, K., Deng, X., Mo, Z., Zhao, G., Jiang, J., Cui, L.-B., Tan, C.-Z., Wen, G., Fu, Y., & Tang, C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.202275 · Cited by 64
PLAB induction in fenretinide-induced apoptosis of ovarian cancer cells occurs via a ROS-dependent mechanism involving ER stress and JNK activation
Appierto, V., Tiberio, P., Villani, M. G., Cavadini, E., & Formelli, F. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp067 · Cited by 64
Networks controlling mRNA decay in the immune system
Schott, J., & Stoecklin, G. (2010) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.13 · Cited by 64
mRNA stability and cancer: an emerging link?
Benjamin, D., & Moroni, C. (2007) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.7.10.1515 · Cited by 67
hnRNPDL extensively regulates transcription and alternative splicing.
Li, R., Hou, J., Wei, Y., Luo, X.-T., Ye, Y.-L., & Zhang, Y. (2019) · Gene · doi:10.1016/j.gene.2018.11.026 · Cited by 49
Advances and prospects of RNA delivery nanoplatforms for cancer therapy
Attia, M. S., Kijanka, G. S., Nguyen, N., Zhang, J., & An, H. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.09.009 · Cited by 64
Post-transcriptional gene regulation by MAP kinases via AU-rich elements
Clark, A. R. (2009) · Frontiers in bioscience · doi:10.2741/3282 · Cited by 59
Advances of mRNA vaccine in tumor: a maze of opportunities and challenges
Yuan, Y., Gao, F., Chang, Y., Zhao, Q., & He, X. (2023) · Biomarker Research · doi:10.1186/s40364-023-00449-w · Cited by 60
Design, Assembly, Production, and Transfection of Synthetic Modified mRNA
Oh, S., & Kessler, J. A. (2018) · Methods · doi:10.1016/j.ymeth.2017.10.008 · Cited by 58
KSRP, many functions for a single protein
Briata, P. (2010) · Frontiers in bioscience · doi:10.2741/3821 · Cited by 60
The sweet side of RNA regulation: glyceraldehyde‐3‐phosphate dehydrogenase as a noncanonical RNA ‐binding protein
White, M. R., & Garcin, E. D. (2015) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1315 · Cited by 56
Expression of vasopressin receptors in ACTH-independent macronodular bilateral adrenal hyperplasia causing Cushing's syndrome: molecular, immunohistochemical and pharmacological correlates
Louiset, E., Contesse, V., Groussin, L., Cartier, D., Duparc, C., Perraudin, V., Bertherat, J. Y., & Lefèbvre, H. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0413 · Cited by 51
FXR1 Is an IL-19-Responsive RNA-Binding Protein that Destabilizes Pro-inflammatory Transcripts in Vascular Smooth Muscle Cells
Herman, A. B., Vrakas, C. N., Ray, M., Kelemen, S. E., Sweredoski, M. J., Moradian, A., Haines, D. S., & Autieri, M. V. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.002 · Cited by 49
RNA-binding proteins as a point of convergence of the PI3K and p38 MAPK pathways
Venigalla, R. K., & Turner, M. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00398 · Cited by 48
RBP EIF2S2 Promotes Tumorigenesis and Progression by Regulating MYC-Mediated Inhibition via FHIT-Related Enhancers
Zhang, J., Li, S., Zhang, L., Xu, J., Song, M., Shao, T., Huang, Z., & Li, Y. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.02.004 · Cited by 47
Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli
Qiu, L., Lai, W. S., Bradbury, A., Zeldin, D. C., & Blackshear, P. J. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a0214-106r · Cited by 46
Aberrant activation of AMP‐activated protein kinase contributes to the abnormal distribution of HuR in amyotrophic lateral sclerosis
Liu, Y., Lee, L.-M., Lai, H., & Chern, Y. (2015) · FEBS Letters · doi:10.1016/j.febslet.2014.12.029 · Cited by 47
Plasminogen Activator Inhibitor Type 2
Medcalf, R. L. (2011) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-386471-0.00006-7 · Cited by 45
The role of mammalian ribonucleases (RNases) in cancer
Kim, W.-C., & Lee, C. H. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.05.002 · Cited by 44
Activation of p38 signaling increases utrophin A expression in skeletal muscle via the RNA-binding protein KSRP and inhibition of AU-rich element-mediated mRNA decay: implications for novel DMD therapeutics
Amirouche, A., Tadesse, H., Lunde, J. A., Belanger, G., Côté, J., & Jasmin, B. J. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt165 · Cited by 44
A Review of Methods to Monitor the Modulation of mRNA Stability: A Novel Approach to Drug Discovery and Therapeutic Intervention
Cheneval, D., Kastelic, T., Fuerst, P., & Parker, C. N. (2010) · SLAS DISCOVERY · doi:10.1177/1087057110365897 · Cited by 43
Resolution of inflammation in immune and nonimmune cells by interleukin-19
Leigh, T., Scalia, R. G., & Autieri, M. V. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00247.2020 · Cited by 43
Deletion of protein kinase Cδ in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo
Cantley, J., Boslem, E., Laybutt, D. R., Cordery, D. V., Pearson, G. L., Carpenter, L., Leitges, M., & Biden, T. J. (2010) · Diabetologia · doi:10.1007/s00125-010-1962-y · Cited by 38
Regulation of the Expression of Inducible Nitric Oxide Synthase
Kleinert, H., Art, J., & Pautz, A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00007-1 · Cited by 42
Terminal Adenosyl Transferase Activity of Posttranscriptional Regulator HuR Revealed by Confocal On-Bead Screening
Meisner-Kober, N. C., Hintersteiner, M., Seifert, J., Bauer, R., Benoit, R., Widmer, A., Schindler, T., Uhl, V., Lang, M., Gstach, H., et al. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.12.020 · Cited by 38
Recent Advances and Innovations in the Preparation and Purification of In Vitro-Transcribed-mRNA-Based Molecules
Zhang, J., Liu, Y., Li, C., Xiao, Q., Zhang, D., Chen, Y., Rosenecker, J., Ding, X., & Guan, S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15092182 · Cited by 39
The cytoskeletal inhibitors latrunculin A and blebbistatin exert antitumorigenic properties in human hepatocellular carcinoma cells by interfering with intracellular HuR trafficking
Doller, A., Badawi, A., Schmid, T., Brauß, T. F., Pleli, T., zu Heringdorf, D. M., Piiper, A., Pfeilschifter, J. M., & Eberhardt, W. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.09.010 · Cited by 36
Self-citation
Similar Regulation of Human Inducible Nitric-oxide Synthase Expression by Different Isoforms of the RNA-binding Protein AUF1
Pautz, A., Linker, K., Altenhöfer, S., Heil, S., Schmidt, N., Art, J., Knauer, S. K., Stauber, R. H., Sadri, N., Pont, A. R., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m809314200 · Cited by 36
Control of Pro-Angiogenic Cytokine mRNA Half-Life in Cancer: The Role of AU-Rich Elements and Associated Proteins
Griseri, P., & Pagès, G. (2014) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2013.0140 · Cited by 36
Genetic Deletion of IL-19 (Interleukin-19) Exacerbates Atherogenesis in Il19 −/− × Ldlr −/− Double Knockout Mice by Dysregulation of mRNA Stability Protein HuR (Human Antigen R)
Ray, M., Gabunia, K., Vrakas, C. N., Herman, A. B., Kako, F., Kelemen, S. E., Grisanti, L. A., & Autieri, M. V. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.310929 · Cited by 34
Role of RNA-Binding Proteins in MAPK Signal Transduction Pathway
Sugiura, R., Satoh, R., Ishiwata, S., Umeda, N., & Kita, A. (2011) · Journal of Signal Transduction · doi:10.1155/2011/109746 · Cited by 34
Post-transcriptional regulation of heparanase gene expression by a 3′ AU-rich element
Arvatz, G., Barash, U., Nativ, O., Ilan, N., & Vlodavsky, I. (2010) · The FASEB Journal · doi:10.1096/fj.10-156372 · Cited by 33
SMN Transcript Stability: Could Modulation of Messenger RNA Degradation Provide a Novel Therapy for Spinal Muscular Atrophy?
Heier, C. R., Gogliotti, R. G., & DiDonato, C. J. (2007) · Journal of Child Neurology · doi:10.1177/0883073807305669 · Cited by 33
Differential modulation of the cytokine-induced MMP-9/TIMP-1 protease–antiprotease system by the mTOR inhibitor rapamycin
Osman, B., Akool, E., Doller, A., Müller, R., Pfeilschifter, J. M., & Eberhardt, W. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.09.011 · Cited by 32
Self-citation
Regulation of the mRNA half-life in breast cancer
Griseri, P. (2014) · World Journal of Clinical Oncology · doi:10.5306/wjco.v5.i3.323 · Cited by 33
HuR-mediated SCN5A messenger RNA stability reduces arrhythmic risk in heart failure
Zhou, A., Xie, A., Kim, T. Y., Liu, H., Shi, G., Kang, G.-J., Jiang, N., Liu, M., Jeong, E.-M., Choi, B., et al. (2018) · Heart Rhythm · doi:10.1016/j.hrthm.2018.02.018 · Cited by 31
Post‐transcriptional and post‐translational regulation of PTEN by transforming growth factor‐β1
Yang, Y., Zhou, F., Fang, Z., Wang, L., Li, Z., Sun, L., Wang, C., Yao, W., Cai, X., Jin, J., et al. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22100 · Cited by 30
Aldosterone and vasopressin affect - and -ENaC mRNA translation
Perlewitz, A., Nafz, B., Skalweit, A., Fähling, M., Persson, P. B., & Thiele, B. J. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq267 · Cited by 30
Matrix metalloproteinase 9 expression: new regulatory elements
Surgucheva, I. G., Chidambaram, K., Willoughby, D. A., & Surguchov, A. P. (2010) · Journal of ocular biology, diseases, and informatics · doi:10.1007/s12177-010-9054-2 · Cited by 28
Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5′ cap Analogs: Synthesis and Evaluation as Modulators of Translation
Wojcik, R., Baranowski, M. R., Markiewicz, Ł., Kubacka, D., Bednarczyk, M., Baran, N., Wojtczak, A., Sikorski, P. J., Zuberek, J., Kowalska, J., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111941 · Cited by 26
In the Rat Brain Acetyl-l-carnitine Treatment Modulates the Expression of Genes Involved in Neuronal Ceroid Lipofuscinosis
Traina, G., Bernardi, R., Cataldo, E., Macchi, M., Durante, M., & Brunelli, M. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8038-8 · Cited by 26
HuRdling Senescence: HuR Breaks BRAF-Induced Senescence in Melanocytes and Supports Melanoma Growth
Liebig, J. K., Kuphal, S., & Bosserhoff, A. (2020) · Cancers · doi:10.3390/cancers12051299 · Cited by 26
Tumor-promoting function and prognostic significance of the RNA-binding protein T-cell intracellular antigen-1 in esophageal squamous cell carcinoma
Hamada, J., Shoda, K., Masuda, K., Fujita, Y., Naruto, T., Kohmoto, T., Miyakami, Y., Watanabe, M., Kudo, Y., Fujiwara, H., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7937 · Cited by 25
Transcriptional regulation of the VEGF gene in dependence of individual genomic variations
Metzger, C., Koutsimpelas, D., & Brieger, J. (2015) · Cytokine · doi:10.1016/j.cyto.2015.07.015 · Cited by 25
Advancing Cancer Immunotherapy: The Potential of mRNA Vaccines As a Promising Therapeutic Approach
Goyal, F., Chattopadhyay, A., Navik, U., Jain, A., Reddy, P. H., Bhatti, G. K., & Bhatti, J. S. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300255 · Cited by 25
Dual role of the arginine methyltransferase CARM1 in the regulation of c‐Fos target genes
Fauquier, L., Duboé, C., Joré, C., Trouche, D., & Vandel, L. (2008) · The FASEB Journal · doi:10.1096/fj.07-104604 · Cited by 24
Shotgun proteomic analysis to study the decrease of xenograft tumor growth after rosemary extract treatment
Valdés, A., García‐Cañas, V., Pérez-Sánchez, A., Barrajón‐Catalán, E., Ruiz-Torres, V., Artemenko, K. A., Micol, V., Bergquist, J., & Cifuentes, A. (2017) · Journal of Chromatography A · doi:10.1016/j.chroma.2017.03.072 · Cited by 23
The expression of dual-specificity phosphatase 1 mRNA is downregulated in lesional psoriatic skin
Kjellerup, R. B., Johansen, C., Kragballe, K., & Iversen, L. (2012) · British Journal of Dermatology · doi:10.1111/bjd.12020 · Cited by 23
Regulation of pro- and anti-atherogenic cytokines
Ray, M., & Autieri, M. V. (2017) · Cytokine · doi:10.1016/j.cyto.2017.09.031 · Cited by 24
Inhibition of Caspase-2 Translation by the mRNA Binding Protein HuR: A Novel Path of Therapy Resistance in Colon Carcinoma Cells?
Eberhardt, W., Nasrullah, U., & Haeussler, K. (2019) · Cells · doi:10.3390/cells8080797 · Cited by 23
Self-citation
Mining Functional Elements in Messenger RNAs: Overview, Challenges, and Perspectives
Ahmed, F., Benedito, V. A., & Zhao, P. X. (2011) · Frontiers in Plant Science · doi:10.3389/fpls.2011.00084 · Cited by 22
Sequence variations affecting AU-rich element function and disease
Hitti, E. (2011) · Frontiers in bioscience · doi:10.2741/4023 · Cited by 23
Expression of receptors for luteinizing hormone, gastric-inhibitory polypeptide, and vasopressin in normal adrenal glands and cortisol-secreting adrenocortical tumors in dogs
Galac, S., Kars, V. J., Klarenbeek, S., Teerds, K. J., Mol, J. A., & Kooistra, H. S. (2010) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2010.02.003 · Cited by 22
Heparanase-The Message Comes in Different Flavors
Ilan, N., Bhattacharya, U., Barash, U., Boyango, I., Yanku, Y., Gross-Cohen, M., & Vlodavsky, I. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-34521-1_9 · Cited by 23
PPARγ stabilizes HO-1 mRNA in monocytes/macrophages which affects IFN-β expression
von Knethen, A., Neb, H., Morbitzer, V., Schmidt, M. V., Kühn, A., Kuchler, L., & Brüne, B. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.033 · Cited by 22
“In vitro” studies on galectin-3 in human natural killer cells
Brittoli, A., Fallarini, S., Zhang, H., Pieters, R. J., & Lombardi, G. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.12.004 · Cited by 21
ADP-Ribosylation Post-Translational Modification: An Overview with a Focus on RNA Biology and New Pharmacological Perspectives
Manco, G., Lacerra, G., Porzio, E., & Catara, G. (2022) · Biomolecules · doi:10.3390/biom12030443 · Cited by 23
RNA nanomedicine in liver diseases
Bakrania, A. K., Mo, Y., Zheng, G., & Bhat, M. (2023) · Hepatology · doi:10.1097/hep.0000000000000606 · Cited by 21
Inflammation-regulated mRNA stability and the progression of vascular inflammatory diseases
Herman, A. B., & Autieri, M. V. (2017) · Clinical Science · doi:10.1042/cs20171373 · Cited by 17
A potential proliferative gene, NUDT6, is down-regulated by green tea catechins at the posttranscriptional level
Sukhthankar, M., Choi, C. K., English, A. E., Kim, J.-S., & Baek, S. J. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.11.002 · Cited by 18
RNA modifications in aging-associated cardiovascular diseases
Yang, X., Gokulnath, P., Lehmann, H. I., Hou, Z., Yang, S., You, L., Zhang, G., Xing, Y., Lei, J., Li, G., et al. (2022) · Aging · doi:10.18632/aging.204311 · Cited by 17
2,3,7,8-Tetrachlorodibenzo-para-dioxin increases aromatase (CYP19) mRNA stability in MCF-7 cells
Chan, M. Y., Huang, H., & Leung, L. K. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.11.012 · Cited by 17
Tristetraprolin regulation of interleukin-22 production
Härdle, L., Bachmann, M., Bollmann, F., Pautz, A., Schmid, T., Eberhardt, W., Kleinert, H., Pfeilschifter, J. M., & Mühl, H. (2015) · Scientific Reports · doi:10.1038/srep15112 · Cited by 17
Self-citation
Post-transcriptional regulation of the human inducible nitric oxide synthase (iNOS) expression by the cytosolic poly(A)-binding protein (PABP)
Casper, I., Nowag, S., Koch, K., Hubrich, T., Bollmann, F., Henke, J., Schmitz, K., Kleinert, H., & Pautz, A. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.05.002 · Cited by 18

Authors: Eberhardt, W., Doller, A., Akool, E.-S., & Pfeilschifter, J.
Affiliations: Goethe University Frankfurt (DE)
Corresponding author: Eberhardt, Wolfgang
ORCID: Eberhardt, Wolfgang
Pfeilschifter, Josef
Venue: Pharmacology & Therapeutics
Publisher: Elsevier BV
Published: 2007-04
Volume: 114
Issue: 1
Pages: 56-73
ISSN: 0163-7258 (ISSN-L)
DOI: 10.1016/j.pharmthera.2007.01.002
OpenAlex: W2073507583
Cited by: 173
References: 224
Citations by year: 2026: 2 · 2025: 4 · 2024: 8 · 2023: 8 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 2 · 2018: 8 · 2017: 7 · 2016: 2 · 2015: 9 · 2014: 10 · 2013: 10 · 2012: 12
FWCI: 1.54
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: mRNA stability, post-transcriptional regulation, AU-rich elements, mRNA degradation, RNA-binding proteins, MAPK signaling, AMPK, protein kinase C, chronic inflammation, cardiovascular disease, cancer, therapeutic target
MeSH terms: Animals, Humans, RNA, Messenger, Signal Transduction, RNA Stability, Regulatory Elements, Transcriptional

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Modulation of mRNA stability as a novel therapeutic approach

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks