The DOI matches its Crossref record; 236 of the 236 references it cites were found in a registry or an index.
Notch inhibitors for cancer treatment
Open accessAbstract
Notch signaling is an evolutionarily conserved cell signaling pathway involved in cell fate during development, stem cell renewal and differentiation in postnatal tissues. Roles for Notch in carcinogenesis, in the biology of cancer stem cells and tumor angiogenesis have been reported. These features identify Notch as a potential therapeutic target in oncology. Based on the molecular structure of Notch receptor, Notch ligands and Notch activators, a set of Notch pathway inhibitors have been developed. Most of these inhibitors had shown anti-tumor effects in preclinical studies. At the same time, the combinatorial effect of these inhibitors with current chemotherapeutical drugs still under study in different clinical trials. In this review, we describe the basics of Notch signaling and the role of Notch in normal and cancer stem cells as a logic way to develop different Notch inhibitors and their current stage of progress for cancer patient’s treatment.
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2 retracted
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RetractedThe Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
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Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
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Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
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Yang, L., Shi, P., Zhao, G., Xu, J., Peng, W., Zhang, J., Zhang, G., Wang, X., Dong, Z., Chen, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0110-5 · Cited by 1,906
Pancancer survival analysis of cancer hallmark genes
Nagy, Á., Munkácsy, G., & Győrffy, B. (2021) · Scientific Reports · doi:10.1038/s41598-021-84787-5 · Cited by 1,381
Saunders, L. R., Bankovich, A. J., Anderson, W. C., Aujay, M. A., Bheddah, S., Black, K., Desai, R., Escarpe, P. A., Hampl, J., Laysang, A., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac9459 · Cited by 600
Chen, X., Tang, J., Shuai, W., Meng, J., Feng, J., & Han, Z. (2020) · Inflammation Research · doi:10.1007/s00011-020-01378-2 · Cited by 423
Hepatocellular carcinoma: signaling pathways and therapeutic advances
Zheng, J., Wang, S., Xia, L., Sun, Z., Chan, K. M., Bernards, R., Qin, W., Chen, J., Xia, Q., & Jin, H. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02075-w · Cited by 341
Metadata
- Authors
- Espinoza, I., & Miele, L.
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 139
- Issue
- 2
- Pages
- 95-110
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W1970820847
- Cited by
- 273
- References
- 236
- FWCI
- 12.37
- Type
- journal article
- Language
- en
- Open access
- green
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