The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Targeting the TGFβ pathway for cancer therapy
Open accessAbstract
The TGFβ signaling pathway has pleiotropic functions regulating cell growth, differentiation, apoptosis, motility and invasion, extracellular matrix production, angiogenesis, and immune response. TGFβ signaling deregulation is frequent in tumors and has crucial roles in tumor initiation, development and metastasis. TGFβ signaling inhibition is an emerging strategy for cancer therapy. The role of the TGFβ pathway as a tumor-promoter or suppressor at the cancer cell level is still a matter of debate, due to its differential effects at the early and late stages of carcinogenesis. In contrast, at the microenvironment level, the TGFβ pathway contributes to generate a favorable microenvironment for tumor growth and metastasis throughout all the steps of carcinogenesis. Then, targeting the TGFβ pathway in cancer may be considered primarily as a microenvironment-targeted strategy. In this review, we focus on the TGFβ pathway as a target for cancer therapy. In the first part, we provide a comprehensive overview of the roles played by this pathway and its deregulation in cancer, at the cancer cell and microenvironment levels. We go on to describe the preclinical and clinical results of pharmacological strategies to target the TGFβ pathway, with a highlight on the effects on tumor microenvironment. We then explore the perspectives to optimize TGFβ inhibition therapy in different tumor settings.
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EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
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Concepts of extracellular matrix remodelling in tumour progression and metastasis
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The Tumour Microenvironment after Radiotherapy: Mechanisms of Resistance and Recurrence
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Metadata
- Authors
- Neuzillet, C., Tijeras-Raballand, A., Cohen, R., Cros, J., Faivre, S., Raymond, E., & de Gramont, A.
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 147
- Pages
- 22-31
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W2000315116
- Cited by
- 611
- References
- 10
- FWCI
- 12.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Neuzillet, C., Tijeras-Raballand, A., Cohen, R., Cros, J., Faivre, S., Raymond, E., & de Gramont, A. (2015). Targeting the TGFβ pathway for cancer therapy. Pharmacology & Therapeutics. https://doi.org/10.1016/j.pharmthera.2014.11.001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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