Cited by 65TGF-β signaling in diseasesMechanisms of cancer metastasisCancer Cells and Metastasis

TGFβ and cancer metastasis: an inflammation link

Open access
Yang, Li·2010·Cancer and Metastasis Reviews

Abstract

Dysregulated transforming growth factor beta (TGFbeta) signaling is observed in a variety of human cancers. TGFbeta is produced in large quantities by many tumor types and is known to be pro-oncogenic. Therapeutic strategies directed against TGFbeta signaling using neutralizing antibodies and small molecular inhibitors have been developed. However, TGFbeta is also found to function as a tumor suppressor. This switch from a tumor suppressor in premalignant stages of tumorigenesis to a tumor promoter in later stages of the disease poses great challenges in TGFbeta-targeted cancer therapy. It remains unclear what mechanisms underlie the dual role of TGFbeta and what factors mediate the switch. In the past, most work on dissecting underlying mechanisms was focused on differential regulation of signaling pathways by tumor cell autonomous TGFbeta signaling. Recent progress in elucidating TGFbeta effects on host immune/inflammatory reactions in the tumor microenvironment and distant organs brings exciting new perspectives to the field.

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  • Cancer tissue is riddled with immune cells which support tumor growth, while inflammation is also evident at the whole-body level.

    “Cancer tissue is riddled with immune cells which support tumor growth, while inflammation is also evident at the whole‐body level.33, 34”

    From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [33]

    The “Tumor microenvironment” section describes tumors as filled with inflammatory and immune cells and explains how some of these cells promote tumor progression. It also says other immune cells inhibit tumor development. The paper discusses immune and inflammatory responses in distant organs and systemic immune suppression, but does not establish the claim that inflammation is evident at the whole-body level. (LLM, conf=0.86)

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Authors
Yang, L.
Venue
Cancer and Metastasis Reviews
Published
2010-05-02
Volume
29
Issue
2
Pages
263-271
ISSN
  • 0167-7659 (ISSN-L)
  • 1573-7233
OpenAlex
W2049952383
Cited by
65
References
87
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 7 · 2020: 3 · 2019: 1 · 2018: 6 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 6 · 2012: 3
FWCI
0.53
Type
journal article
Language
en
Open access
Locations
  • Cancer and Metastasis Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (Z99 CA999999)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
TGF-beta signaling, metastasis, inflammation, tumor microenvironment, tumor suppressor, tumor promoters, host immune response
MeSH terms
Humans, Inflammation, Neoplasm Metastasis, Neoplasms, Signal Transduction, Genes, Tumor Suppressor, Transforming Growth Factor beta

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