Cited by 142Liver Disease Diagnosis and TreatmentFatty Acid Research and HealthAlcohol Consumption and Health Effects

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Omega-3 polyunsaturated fatty acids as a treatment strategy for nonalcoholic fatty liver disease

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Jump, Donald B., Lytle, Kelli A., Depner, Christopher M., Tripathy, Sasmita·2018·Pharmacology & Therapeutics

DOI 10.1016/j.pharmthera.2017.07.007PMC PMC5743581

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Abstract

Obese and type 2 diabetic (T2DM) patients have a high prevalence of nonalcoholic fatty liver disease (NAFLD). NAFLD is a continuum of chronic liver diseases ranging from benign hepatosteatosis to nonalcoholic steatohepatitis (NASH), cirrhosis and primary hepatocellular cancer (HCC). Because of its strong association with the obesity epidemic, NAFLD is rapidly becoming a major public health concern worldwide. Surprisingly, there are no FDA approved NAFLD therapies; and current therapies focus on the co-morbidities associated with NAFLD, namely, obesity, hyperglycemia, dyslipidemia, and hypertension. The goal of this review is to provide background on the disease process, discuss human studies and preclinical models that have examined treatment options. We also provide an in-depth rationale for the use of dietary ω3 polyunsaturated fatty acid (ω3 PUFA) supplements as a treatment option for NAFLD. This focus is based on recent studies indicating that NASH patients and preclinical mouse models of NASH have low levels of hepatic C 20-22 ω3 PUFA. This decline in hepatic PUFA may account for the major phenotypic features associated with NASH, including steatosis, inflammation and fibrosis. Finally, our discussion will address the strengths and limitations of ω3 PUFA supplements use in NAFLD therapy.

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Authors: Jump, D. B., Lytle, K. A., Depner, C. M., & Tripathy, S.
Affiliations: Oregon State University (US)
ORCID: Lytle, Kelli A.
Depner, Christopher M.
Venue: Pharmacology & Therapeutics
Publisher: Elsevier BV
Published: 2018-01
Volume: 181
Pages: 108-125
ISSN: 0163-7258 (ISSN-L)
DOI: 10.1016/j.pharmthera.2017.07.007
PMC: PMC5743581
OpenAlex: W2735867008
Cited by: 142
References: 218
Citations by year: 2026: 13 · 2025: 8 · 2024: 20 · 2023: 21 · 2022: 14 · 2021: 18 · 2020: 23 · 2019: 12 · 2018: 11
FWCI: 1.74
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 355 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Pharmacology & Therapeutics (acceptedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Food and Agriculture (2009-65200-05846)
National Institutes of Health (DK 094600)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords: omega-3 polyunsaturated fatty acids, non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, dietary supplementation, hepatic steatosis, liver fibrosis, liver inflammation, obesity, type 2 diabetes
MeSH terms: Animals, Disease Models, Animal, Humans, Fatty Acids, Omega-3, Disease Progression, Non-alcoholic Fatty Liver Disease

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Omega-3 polyunsaturated fatty acids as a treatment strategy for nonalcoholic fatty liver disease

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