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Omega-3 polyunsaturated fatty acids as a treatment strategy for nonalcoholic fatty liver disease
Open accessAbstract
Obese and type 2 diabetic (T2DM) patients have a high prevalence of nonalcoholic fatty liver disease (NAFLD). NAFLD is a continuum of chronic liver diseases ranging from benign hepatosteatosis to nonalcoholic steatohepatitis (NASH), cirrhosis and primary hepatocellular cancer (HCC). Because of its strong association with the obesity epidemic, NAFLD is rapidly becoming a major public health concern worldwide. Surprisingly, there are no FDA approved NAFLD therapies; and current therapies focus on the co-morbidities associated with NAFLD, namely, obesity, hyperglycemia, dyslipidemia, and hypertension. The goal of this review is to provide background on the disease process, discuss human studies and preclinical models that have examined treatment options. We also provide an in-depth rationale for the use of dietary ω3 polyunsaturated fatty acid (ω3 PUFA) supplements as a treatment option for NAFLD. This focus is based on recent studies indicating that NASH patients and preclinical mouse models of NASH have low levels of hepatic C 20-22 ω3 PUFA. This decline in hepatic PUFA may account for the major phenotypic features associated with NASH, including steatosis, inflammation and fibrosis. Finally, our discussion will address the strengths and limitations of ω3 PUFA supplements use in NAFLD therapy.
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“Omega-3 polyunsaturated fatty acids (PUFAs) are compelling candidates for MASLD treatment due to their targeted mechanisms, including promoting fatty acid oxidation through Peroxisome Proliferator–Activated Receptor Alpha (PPARα) activation and inhibiting lipogenesis by suppressing Sterol Regulatory Element–Binding Protein 1c (SREBP-1c).9,10”
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Cites
Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
Kleiner, D. E., Brunt, E. M., Van Natta, M., Behling, C., Contos, M. J., Cummings, O. W., Ferrell, L. D., Liu, Y., Torbenson, M. S., Unalp‐Arida, A., et al. (2005) · Hepatology · doi:10.1002/hep.20701 · Cited by 10,791
The metabolic syndrome—a new worldwide definition
Alberti, K. G. M., Zimmet, P., & Shaw, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67402-8 · Cited by 9,352
Chalasani, N., Younossi, Z., Lavine, J. E., Charlton, M., Cusi, K., Rinella, M., Harrison, S. A., Brunt, E. M., & Sanyal, A. J. (2018) · Hepatology · doi:10.1002/hep.29367 · Cited by 7,239
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638
Nonalcoholic Fatty Liver Disease
Angulo, P. (2002) · New England Journal of Medicine · doi:10.1056/nejmra011775 · Cited by 5,228
The importance of the ratio of omega-6/omega-3 essential fatty acids
Simopoulos, A. P. (2002) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(02)00253-6 · Cited by 4,286
Steatohepatitis: A tale of two “hits”?
Day, C. P., & James, O. F. W. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70599-2 · Cited by 4,285
Forner, A., Llovet, J. M., & Bruix, J. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61347-0 · Cited by 4,083
Chalasani, N., Younossi, Z. M., Lavine, J. E., Diehl, A. M., Brunt, E. M., Cusi, K. J., Charlton, M., & Sanyal, A. J. (2012) · Hepatology · doi:10.1002/hep.25762 · Cited by 3,859
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
Funk, C. D. (2001) · Science · doi:10.1126/science.294.5548.1871 · Cited by 3,817
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,720
Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity
Browning, J. D., Szczepaniak, L. S., Dobbins, R., Nuremberg, P., Horton, J. D., Cohen, J. C., Grundy, S. M., & Hobbs, H. H. (2004) · Hepatology · doi:10.1002/hep.20466 · Cited by 3,664
Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D., & Parks, E. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23621 · Cited by 3,604
Body Fatness and Cancer — Viewpoint of the IARC Working Group
Lauby-Secretan, B., Scoccianti, C., Loomis, D., Grosse, Y., Bianchini, F., & Straif, K. (2016) · New England Journal of Medicine · doi:10.1056/nejmsr1606602 · Cited by 3,596
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
Romeo, S., Kozlitina, J., Xing, C., Pertsemlidis, A., Cox, D., Pennacchio, L. A., Boerwinkle, E., Cohen, J. C., & Hobbs, H. H. (2008) · Nature Genetics · doi:10.1038/ng.257 · Cited by 3,416
Massagué, J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3434 · Cited by 3,239
Vernon, G. C., Baranova, A. V., & Younossi, Z. M. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04724.x · Cited by 3,116
Angulo, P., Kleiner, D. E., Dam-Larsen, S., Adams, L. A., Bjornsson, E. S., Charatcharoenwitthaya, P., Mills, P. R., Keach, J. C., Lafferty, H. D., Stahler, A., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.043 · Cited by 2,987
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932
Ludwig, J., Viggiano, T. R., McGill, D. B., & Ott, B. J. (1980) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(24)00530-5 · Cited by 2,903
The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study
Adams, L. A., Lymp, J. F., St. Sauver, J., Sanderson, S. O., Lindor, K. D., Feldstein, A., & Angulo, P. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.04.014 · Cited by 2,890
Mechanisms of Hepatic Fibrogenesis
Friedman, S. L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.003 · Cited by 2,687
Regulation and Function of NF-κB Transcription Factors in the Immune System
Vallabhapurapu, S., & Karin, M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132641 · Cited by 2,635
Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
Tilg, H., & Moschen, A. R. (2010) · Hepatology · doi:10.1002/hep.24001 · Cited by 2,548
Vilar-Gomez, E., Martinez-Perez, Y., Calzadilla-Bertot, L., Torres-Gonzalez, A., Gra-Oramas, B., Gonzalez-Fabian, L., Friedman, S. L., Diago, M., & Romero-Gomez, M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.005 · Cited by 2,492
Nonalcoholic Fatty Liver Disease: From Steatosis to Cirrhosis
Farrell, G. C., & Larter, C. Z. (2006) · Hepatology · doi:10.1002/hep.20973 · Cited by 2,428
Origins and evolution of the Western diet: health implications for the 21st century1,2
Cordain, L., Eaton, S. B., Sebastian, A., Mann, N., Lindeberg, S., Watkins, B. A., O’Keefe, J. H., & Brand-Miller, J. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn.81.2.341 · Cited by 2,397
Long-term follow-up of patients with NAFLD and elevated liver enzymes
Ekstedt, M., Franzén, L. E., Mathiesen, U. L., Thorelius, L., Holmqvist, M., Bodemar, G., & Kechagias, S. (2006) · Hepatology · doi:10.1002/hep.21327 · Cited by 2,302
Nonalcoholic Steatohepatitis: Summary of An Aasld Single Topic Conference
Neuschwander‐Tetri, B. A., & Caldwell, S. H. (2003) · Hepatology · doi:10.1053/jhep.2003.50193 · Cited by 2,166
Human Fatty Liver Disease: Old Questions and New Insights
Cohen, J. C., Horton, J. D., & Hobbs, H. H. (2011) · Science · doi:10.1126/science.1204265 · Cited by 2,089
Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.013 · Cited by 1,990
Dulai, P. S., Singh, S., Patel, J., Soni, M., Prokop, L. J., Younossi, Z., Sebastiani, G., Ekstedt, M., Hagstrom, H., Nasr, P., et al. (2017) · Hepatology · doi:10.1002/hep.29085 · Cited by 1,965
Chalasani, N., Younossi, Z. M., Lavine, J. E., Diehl, A. M., Brunt, E. M., Cusi, K. J., Charlton, M., & Sanyal, A. J. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.04.001 · Cited by 1,805
Loomba, R. S., & Sanyal, A. J. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.171 · Cited by 1,732
Marine omega-3 fatty acids and inflammatory processes: effects, mechanisms and clinical relevance
Calder, P. C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.010 · Cited by 1,717
Targeting the TGFβ signalling pathway in disease
Akhurst, R. J., & Hata, A. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3810 · Cited by 1,466
A lipidomic analysis of nonalcoholic fatty liver disease
Puri, P., Baillie, R. A., Wiest, M. M., Mirshahi, F., Choudhury, J., Cheung, O., Sargeant, C., Contos, M. J., & Sanyal, A. J. (2007) · Hepatology · doi:10.1002/hep.21763 · Cited by 1,338
Hayashi, H., Abdollah, S., Qiu, Y., Cai, J., Xu, Y., Grinnell, B. W., Richardson, M. A., Topper, J. N., Gimbrone, M. A., Wrana, J. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80303-7 · Cited by 1,322
Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
Xu, H. E., Lambert, M. H., Montana, V. G., Parks, D. J., Blanchard, S. G., Brown, P. J., Sternbach, D. D., Lehmann, J. M., Wisely, G. B., Willson, T. M., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80467-0 · Cited by 1,169
Neuschwander‐Tetri, B. A. (2010) · Hepatology · doi:10.1002/hep.23719 · Cited by 1,077
Lambert, J. E., Ramos–Roman, M. A., Browning, J. D., & Parks, E. J. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.11.049 · Cited by 1,069
Gao, H., Yang, Z. H., Zhang, S., Cao, S., Shen, S.-Q., Pang, Z., & Jiang, X. (2014) · Scientific Reports · doi:10.1038/srep05138 · Cited by 1,062
ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism.Preprint
Kim, J. B., & Spiegelman, B. M. (1996) · Genes & Development · doi:10.1101/gad.10.9.1096 · Cited by 1,026
Epidemiology of Non-Alcoholic Fatty Liver Disease
Bellentani, S., Scaglioni, F., Marino, M., & Bedogni, G. (2010) · Digestive Diseases · doi:10.1159/000282080 · Cited by 1,026
Brasaemle, D. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700014-jlr200 · Cited by 997
Yokoyama, C., Wang, X., Briggs, M. R., Admon, A., Wu, J., Hua, X., Goldstein, J. L., & Brown, M. S. (1993) · Cell · doi:10.1016/s0092-8674(05)80095-9 · Cited by 979
Metabolism of highly unsaturated n-3 and n-6 fatty acids
Sprecher, H. W. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00077-9 · Cited by 894
Non‐alcoholic fatty liver disease
Angulo, P., & Lindor, K. D. (2002) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.17.s1.10.x · Cited by 838
Erridge, C., Attina, T., Spickett, C. M., & Webb, D. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1286 · Cited by 776
The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome
Lim, J. S., Mietus-Snyder, M., Valente, A., Schwarz, J.-M., & Lustig, R. H. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.41 · Cited by 771
Decreased Survival of Subjects With Elevated Liver Function Tests During A 28-Year Follow-Up
Söderberg, C., Stal, P. I., Askling, J., Glaumann, H., Lindberg, G., Marmur, J., & Hultcrantz, R. W. (2009) · Hepatology · doi:10.1002/hep.23314 · Cited by 755
Li, S., Brown, M. S., & Goldstein, J. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914798107 · Cited by 733 · cited 12×
“Like SREBP1c, the CHREBP/MLX heterodimer binds promoters of Acc1, Fasn, Scd1, L-pyruvate kinase (L-PK) leading to the increased gene transcription and increased flow of glucose-derived metabolites into SFA and MUFA synthesis (Jump et al., 2013).”
BackgroundInfluentialLipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores
Lass, A., Zimmermann, R., Oberer, M., & Zechner, R. (2010) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.10.004 · Cited by 677
Min, H., Kapoor, A., Fuchs, M. A., Mirshahi, F., Zhou, H., Maher, J. W., Kellum, J. M., Warnick, R., Contos, M. J., & Sanyal, A. J. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.004 · Cited by 668
Musso, G., Cassader, M., Rosina, F., & Gambino, R. (2012) · Diabetologia · doi:10.1007/s00125-011-2446-4 · Cited by 661
The Biochemistry of n-3 Polyunsaturated Fatty Acids
Jump, D. Β. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r100062200 · Cited by 654
Self-citationEvolving therapies for liver fibrosis
Schuppan, D., & Kim, Y. O. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66028 · Cited by 610
Chalasani, N., Younossi, Z. M., Lavine, J. E., Diehl, A. M., Brunt, E. M., Cusi, K. J., Charlton, M., & Sanyal, A. J. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.128 · Cited by 594
Thornalley, P. J. (1996) · General Pharmacology: The Vascular System · doi:10.1016/0306-3623(95)02054-3 · Cited by 591
The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease
McCullough, A. J. (2004) · Clinics in Liver Disease · doi:10.1016/j.cld.2004.04.004 · Cited by 580
Omega-3 supplementation and non-alcoholic fatty liver disease: A systematic review and meta-analysis
Parker, H. M., Johnson, N. A., Burdon, C. A., Cohn, J. S., O’Connor, H. T., & George, J. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.08.018 · Cited by 569
A Meta-Analysis of Randomized Trials for the Treatment of Nonalcoholic Fatty Liver Disease
Musso, G., Gambino, R., Cassader, M., & Pagano, G. (2010) · Hepatology · doi:10.1002/hep.23623 · Cited by 569
Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
Takahashi, Y. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i19.2300 · Cited by 554
Hua, X., Yokoyama, C., Wu, J., Briggs, M. R., Brown, M. S., Goldstein, J. L., & Wang, X. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11603 · Cited by 544
Hepatocellular carcinoma epidemiology
Bosetti, C., Turati, F., & Vecchia, C. L. (2014) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2014.08.007 · Cited by 543
Uyeda, K., & Repa, J. J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.06.008 · Cited by 538
A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer
Asgharpour, A., Cazanave, S. C., Pacana, T., Seneshaw, M., Vincent, R., Banini, B. A., Kumar, D. P., Daita, K., Min, H.-K., Mirshahi, F., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.05.005 · Cited by 538
World Gastroenterology Organisation Global Guidelines
LaBrecque, D. R., Abbas, Z., Anania, F. A., Ferenci, P., Khan, A. G., Goh, K., Hamid, S. S., Va, I., Lizarzábal, M., Peñaranda, M. M., et al. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000116 · Cited by 524
The Etiology of Hepatocellular Carcinoma and Consequences for Treatment
Sanyal, A. J., Yoon, S. K., & Lencioni, R. (2010) · The Oncologist · doi:10.1634/theoncologist.2010-s4-14 · Cited by 517
Serhan, C. N., Dalli, J., Colas, R. A., Winkler, J. W., & Chiang, N. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.006 · Cited by 492
Wouters, K., van Gorp, P. J., Bieghs, V., Gijbels, M. J., Duimel, H., Lütjohann, D., Kerksiek, A., van Kruchten, R., Maeda, N., Staels, B., et al. (2008) · Hepatology · doi:10.1002/hep.22363 · Cited by 482
Thiazolidinediones and Advanced Liver Fibrosis in Nonalcoholic Steatohepatitis: A Meta-analysis
Musso, G., Cassader, M., Paschetta, E., & Gambino, R. (2017) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.9607 · Cited by 449
Innate immunity in diabetes and diabetic nephropathy
Wada, J., & Makino, H. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.175 · Cited by 441
Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal
Alkhouri, N., Dixon, L. J., & Feldstein, A. E. (2009) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.09.32 · Cited by 413
Capanni, M., Calella, F., Biagini, M. R., Genise, S., Raimondi, L., Bedogni, G., Svegliati‐Baroni, G., Sofi, F., Milani, S., Abbate, R., et al. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02885.x · Cited by 412
Elevated endotoxin levels in non-alcoholic fatty liver disease
Harte, A. L., da Silva, N. F., Creely, S. J., McGee, K. C., Billyard, T., Elabd, E. M. Y., Tripathi, G., Ashour, E., Abdalla, M. S., Sharada, H. M., et al. (2010) · Journal of Inflammation · doi:10.1186/1476-9255-7-15 · Cited by 406
ChREBP•Mlx Is the Principal Mediator of Glucose-induced Gene Expression in the Liver
Ma, L., Robinson, L. N., & Towle, H. C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601576200 · Cited by 387
Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis
Smagris, E., BasuRay, S., Li, J., Huang, Y., Lai, K. V., Gromada, J., Cohen, J. C., & Hobbs, H. H. (2015) · Hepatology · doi:10.1002/hep.27242 · Cited by 379
Bays, H. E., Ballantyne, C. M., Kastelein, J. J., Isaacsohn, J. L., Braeckman, R. A., & Soni, P. N. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.04.015 · Cited by 358
Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease
Miura, K. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i23.7381 · Cited by 355
Mediterranean diet and nonalcoholic fatty liver disease
Anania, C., Perla, F. M., Olivero, F., Pacifico, L., & Chiesa, C. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i19.2083 · Cited by 353
Isoprostane Generation and Function
Milne, G. L., Yin, H., Hardy, K. D., Davies, S. S., & Roberts, L. J. (2011) · Chemical Reviews · doi:10.1021/cr200160h · Cited by 349
Sunny, N. E., Bril, F., & Cusi, K. J. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.11.006 · Cited by 327
Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity
Wang, Y., Botolin, D., Xu, J., Christian, B., Mitchell, E., Bolleddula, J., Nair, M. G., Peters, J. M., Busik, J. V., Olson, L. K., et al. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600177-jlr200 · Cited by 326
Self-citationScorletti, E., Bhatia, L. S., McCormick, K. G., Clough, G. F., Nash, K. L., Hodson, L., Moyses, H. E., Calder, P. C., Byrne, C. D., Sheron, N., et al. (2014) · Hepatology · doi:10.1002/hep.27289 · Cited by 320
Pathophysiology of nonalcoholic steatohepatitis.
McCullough, A. J. (2006) · PubMed · doi:10.1097/01.mcg.0000168645.86658.22 · Cited by 319
Arendt, B. M., Comelli, E. M., Ma, D. W. L., Lou, W., Teterina, A., Kim, T., Fung, S. K., Wong, D. K. H., McGilvray, I., Fischer, S. E., et al. (2015) · Hepatology · doi:10.1002/hep.27695 · Cited by 313
Sanyal, A. J., Abdelmalek, M. F., Suzuki, A., Cummings, O. W., & Chojkier, M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.04.046 · Cited by 309
Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids.
Jump, D. Β., Clarke, S. D., Thelen, A. P., & Liimatta, M. B. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40103-8 · Cited by 305
Self-citationInsulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase
Owen, J. L., Zhang, Y., Bae, S., Farooqi, M. S., Liang, G., Hammer, R. E., Goldstein, J. L., & Brown, M. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213343109 · Cited by 305
Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation
Laugerette, F., Vors, C., Géloën, A., Chauvin, M., Soulage, C. O., Lambert-Porcheron, S., Peretti, N., Alligier, M., Burcelin, R., Laville, M., et al. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.11.011 · Cited by 304
Effects of n-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease
Spadaro, L., Magliocco, O., Spampinato, D., Piro, S., Oliveri, C. E., Alagona, C., Papa, G. F. S., Rabuazzo, A. M., & Purrello, F. (2007) · Digestive and Liver Disease · doi:10.1016/j.dld.2007.10.003 · Cited by 296
Pathophysiology of Nonalcoholic Steatohepatitis
Başaranoğlu, M. (2009) · Cited by 293
Toll-like Receptor Status in Obesity and Metabolic Syndrome: A Translational Perspective
Jialal, I., Kaur, H., & Devaraj, S. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3092 · Cited by 290
Wei, M. Y., & Jacobson, T. A. (2011) · Current Atherosclerosis Reports · doi:10.1007/s11883-011-0210-3 · Cited by 284
Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases
Wang, Y., Botolin, D., Christian, B., Busik, J. V., Xu, J., & Jump, D. Β. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400335-jlr200 · Cited by 265
Self-citationRen, B., Thelen, A. P., Peters, J. M., Gonzalez, F. J., & Jump, D. Β. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.43.26827 · Cited by 264
Self-citationChung, M., Ma, J., Patel, K., Berger, S. E., Lau, J. S. M., & Lichtenstein, A. H. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.086314 · Cited by 263
Nobili, V., Bedogni, G., Alisi, A., Pietrobattista, A., Risé, P., Galli, C., & Agostoni, C. V. (2011) · Archives of Disease in Childhood · doi:10.1136/adc.2010.192401 · Cited by 258
Pathophysiology of Nonalcoholic Steatohepatitis
Watanabe, S. (2017) · Juntendō Igaku/Juntendo igaku · doi:10.14789/jmj.63.230 · Cited by 257
Allaire, J., Couture, P., Leclerc, M., Charest, A., Marin, J., Lépine, M.-C., Talbot, D., Tchernof, A., & Lamarche, B. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.131896 · Cited by 252
The differential effects of EPA and DHA on cardiovascular risk factors
Cottin, S. C., Sanders, T. A., & Hall, W. L. (2011) · Proceedings of the Nutrition Society · doi:10.1017/s0029665111000061 · Cited by 247
Allard, J. P., Aghdassi, E., Mohammed, S., Raman, M., Avand, G., Arendt, B. M., Jalali, P., Kandasamy, T., Prayitno, N., Sherman, M., et al. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2007.09.009 · Cited by 247
Stanhope, K. L., & Havel, P. J. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.25825d · Cited by 238
Fatty Acid–Regulated Transcription Factors in the Liver
Jump, D. Β., Tripathy, S., & Depner, C. M. (2013) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161139 · Cited by 238
Self-citationStoeckman, A. K., Ma, L., & Towle, H. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311301200 · Cited by 237
Non-alcoholic fatty liver disease and risk of cardiovascular disease
Lonardo, A., Sookoian, S. C., Pirola, C. J., & Targher, G. (2015) · Metabolism · doi:10.1016/j.metabol.2015.09.017 · Cited by 236
Smagris, E., Gilyard, S., BasuRay, S., Cohen, J. C., & Hobbs, H. H. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.719955 · Cited by 226
Gugliucci, A. (2017) · Advances in Nutrition · doi:10.3945/an.116.013912 · Cited by 225
Argo, C. K., Patrie, J. T., Lackner, C., Henry, T. D., de Lange, E. E., Weltman, A. L., Shah, N. L., Al-Osaimi, A. M., Pramoonjago, P., Jayakumar, S., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2014.08.036 · Cited by 224
Relationships between plasma fatty acid composition and coronary artery disease.
Itakura, H., Yokoyama, M., Matsuzaki, M., Saito, Y., Origasa, H., Ishikawa, Y., Oikawa, S., Sasaki, J., Hishida, H., Kita, T., et al. (2011) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.5876 · Cited by 218
Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame
Ibrahim, S. H., Hirsova, P., Malhi, H., & Gores, G. J. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3977-1 · Cited by 218
Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus.
Prashanth, M., Ganesh, H. K., Vima, M. V., John, M., Bandgar, T., Joshi, S., Shah, S., Rathi, P. M., Joshi, A. S., Thakkar, H. U., et al. (2009) · PubMed · Cited by 217
Uyeda, K., Yamashita, H., & Kawaguchi, T. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01012-2 · Cited by 216
Burgess, E., Hassmén, P., Welvaert, M., & Pumpa, K. L. (2017) · Clinical Obesity · doi:10.1111/cob.12180 · Cited by 214
Novel insights into ChREBP regulation and function
Filhoulaud, G., Guilmeau, S., Dentin, R., Girard, J. R., & Postic, C. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.01.003 · Cited by 211
Human Biochemistry of the Isoprostane Pathway
Milne, G. L., Yin, H., & Morrow, J. D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r700047200 · Cited by 209
Sato, K., Gosho, M., Yamamoto, T., Kobayashi, Y., Ishii, N., Ohashi, T., Nakade, Y., Ito, K., Fukuzawa, Y., & Yoneda, M. (2014) · Nutrition · doi:10.1016/j.nut.2014.11.018 · Cited by 207
Pawar, A., & Jump, D. Β. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306238200 · Cited by 197
Self-citationMater, M. K., Thelen, A. P., Pan, D. A., & Jump, D. Β. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.32725 · Cited by 194
Self-citationZhu, F., Liu, S., Chen, X.-M., Huang, Z., & Zhang, D. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.6395 · Cited by 189
Fatty acid synthesis during early linoleic acid deficiency in the mouse
Allmann, D. W., & Gibson, D. M. (1965) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39639-5 · Cited by 187
Changes in insulin action, triglycerides, and lipid composition during sucrose feeding in rats
Pagliassotti, M. J., Prach, P. A., Koppenhafer, T. A., & Pan, D. A. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.271.5.r1319 · Cited by 186
Cussons, A. J., Watts, G. F., Mori, T. A., & Stuckey, B. G. A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0870 · Cited by 183
Glass, L. M., Dickson, R. C., Anderson, J. C., Suriawinata, A. A., Putra, J., Berk, B. S., & Toor, A. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3380-3 · Cited by 179
Omega-3 fatty acids for the treatment of non-alcoholic fatty liver disease
Minno, M. N. D. D. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i41.5839 · Cited by 175
Zhang, J., Zhao, Y. Y., Xu, C., Hong, Y., Lu, H., Wu, J., & Chen, Y. (2014) · Scientific Reports · doi:10.1038/srep05832 · Cited by 175
Bieghs, V., van Gorp, P. J., Wouters, K., Hendrikx, T., Gijbels, M. J., van Bilsen, M., Bakker, J. A., Binder, C. J., Lütjohann, D., Staels, B., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030668 · Cited by 175
Strategies for anti-fibrotic therapies
Rosenbloom, J., Mendoza, F. A., & Jiménez, S. A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.12.007 · Cited by 174
Melanocortin 4 Receptor–Deficient Mice as a Novel Mouse Model of Nonalcoholic Steatohepatitis
Itoh, M., Suganami, T., Nakagawa, N., Tanaka, M., Yamamoto, Y., Kamei, Y., Terai, S., Sakaida, I., & Ogawa, Y. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.07.014 · Cited by 170
Singh, S., Khera, R., Allen, A. M., Murad, M. H., & Loomba, R. S. (2015) · Hepatology · doi:10.1002/hep.27999 · Cited by 165
Palmitoleic acid is elevated in fatty liver disease and reflects hepatic lipogenesis
Lee, J. J., Lambert, J. E., Hovhannisyan, Y., Ramos-Román, M. A., Trombold, J. R., Wagner, D. A., & Parks, E. J. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.092262 · Cited by 165
Dasarathy, S., Dasarathy, J., Khiyami, A., Yerian, L. M., Hawkins, C., Sargent, R., & McCullough, A. J. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000099 · Cited by 163
Botolin, D., Wang, Y., Christian, B., & Jump, D. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m500365-jlr200 · Cited by 162
Self-citationVisceral adipose tissue area is an independent risk factor for hepatic steatosis
Park, B. J., Kim, Y. J., Kim, D., Kim, W. K., Jung, Y. J., Yoon, J., Kim, C. Y., Cho, Y. M., Kim, S. H., Lee, K. B., et al. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05212.x · Cited by 154
Epidemiology of the metabolic syndrome in the USA
McCullough, A. J. (2010) · Journal of Digestive Diseases · doi:10.1111/j.1751-2980.2010.00469.x · Cited by 152
Glucose as a regulator of eukaryotic gene transcription
Towle, H. C. (2005) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2005.10.003 · Cited by 152
HEP computing : where are we now? - open questions for the CHEP'91 conference
Thresher, J. J. (1992) · CERN Document Server (European Organization for Nuclear Research) · Cited by 150
Lee, J. Y., Zhao, L., & Hwang, D. H. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00259.x · Cited by 147
Depner, C. M., Philbrick, K. A., & Jump, D. Β. (2013) · Journal of Nutrition · doi:10.3945/jn.112.171322 · Cited by 147
Self-citationDocosahexaenoic acid for the treatment of fatty liver: Randomised controlled trial in children
Nobili, V., Alisi, A., Corte, C. D., Risé, P., Galli, C., Agostoni, C. V., & Bedogni, G. (2012) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.10.010 · Cited by 144
Polyunsaturated fatty acids inhibit S14 gene transcription in rat liver and cultured hepatocytes.
Jump, D. Β., Clarke, S. D., MacDougald, O. A., & Thelen, A. P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8454 · Cited by 141
Self-citationImplication of Gut Microbiota in Nonalcoholic Fatty Liver Disease
Boursier, J., & Diehl, A. M. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004559 · Cited by 140
Yoshida, K., & Matsuzaki, K. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00053 · Cited by 131
Effects of Omega-3 Fatty Acid in Nonalcoholic Fatty Liver Disease: A Meta-Analysis
Lu, W., Li, S., Li, J., Wang, J., Zhang, R., Zhou, Y., Yin, Q., Zheng, Y., Wang, F., Xia, Y., et al. (2016) · Gastroenterology Research and Practice · doi:10.1155/2016/1459790 · Cited by 130
He, X., Wu, X., Chen, R., Chen, C., Liu, X., Wu, B.-J., & Huang, Z. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162368 · Cited by 129
Transcriptional Control of the Stearoyl-CoA Desaturase-1 Gene by Polyunsaturated Fatty Acids1
Landschulz, K., Jump, D. Β., MacDougald, O. A., & Lane, M. D. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1516 · Cited by 128
Self-citationJańczyk, W., Lebensztejn, D. M., Wierzbicka, A., Mazur, A., Neuhoff-Murawska, J., Matusik, P., & Socha, P. (2015) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2015.01.056 · Cited by 126
Nobili, V., Carpino, G., Alisi, A., Vito, R. D., Franchitto, A., Alpini, G. D., Onori, P., & Gaudio, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088005 · Cited by 123
Nonalcoholic fatty liver disease and cardiovascular risk
Misra, V. L., Khashab, M. A., & Chalasani, N. (2009) · Current Gastroenterology Reports · doi:10.1007/s11894-009-0008-4 · Cited by 123
Nogueira, M. A., de Oliveira, C. P. M. S., Alves, V. A. F., Stefano, J. T., Rodrigues, L., Torrinhas, R. S., Cogliati, B., Barbeiro, H. V., Carrilho, F. J., & Waitzberg, D. L. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.05.001 · Cited by 123
Gut microbiota and liver disease
Goel, A., Gupta, M. C., & Aggarwal, R. (2014) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12556 · Cited by 112
Plourde, M., Chouinard‐Watkins, R., Vandal, M., Zhang, Y., Lawrence, P., Brenna, J. T., & Cunnane, S. C. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-5 · Cited by 111
Liimatta, M. B., Towle, H. C., Clarke, S. D., & Jump, D. Β. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.9.7838147 · Cited by 108
Self-citationDavies, M. N., O’Callaghan, B. L., & Towle, H. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801539200 · Cited by 106
Regulation of Nuclear Import/Export of Carbohydrate Response Element-binding Protein (ChREBP)
Sakiyama, H., Wynn, R., Lee, W.-R., Fukasawa, M., Mizuguchi, H., Gardner, K. H., Repa, J. J., & Uyeda, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804308200 · Cited by 106
Qin, Y., Zhou, Y. G., Chen, S., Zhao, X.-L., Ran, L., Zeng, X.-L., Wu, Y., Chen, J., Kang, C., Shu, F., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133496 · Cited by 104
Pacifico, L., Bonci, E., Martino, M. D., Versacci, P., Andreoli, G., Silvestri, L. M., & Chiesa, C. (2015) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.04.003 · Cited by 103
Schuck, R. N., Zha, W., Edin, M. L., Gruzdev, A., Vendrov, K. C., Miller, T. M., Xu, Z., Lih, F. B., DeGraff, L. M., Tomer, K. B., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110162 · Cited by 92
Mediterranean diet and non-alcoholic fatty liver disease: New therapeutic option around the corner?
Sofi, F. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i23.7339 · Cited by 91
Ishii, H., Horie, Y., Ohshima, S., Anezaki, Y., Kinoshita, N., Dohmen, T., Kataoka, E., Sato, W., Goto, T., Sasaki, J., et al. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.10.031 · Cited by 90
Pickens, M., Yan, J. S., Ng, R., Ogata, H., Grenert, J. P., Beysen, C., Turner, S., & Maher, J. J. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m900022-jlr200 · Cited by 90
The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling
Nyati, S., Schinske, K. A., Pitchiaya, S., Chekhovskiy, K., Chator, A., Chaudhry, N., Dosch, J. S., Dort, M. E. V., Varambally, S., Kumar‐Sinha, C., et al. (2015) · Science Signaling · doi:10.1126/scisignal.2005379 · Cited by 90
Wang, X., Li, W., Zhang, Y., Yang, Y., & Qin, G. (2015) · PubMed Central · Cited by 88
Pawar, A., Xu, J., Jerks, E., Mangelsdorf, D. J., & Jump, D. Β. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206170200 · Cited by 80
Self-citationBoyraz, M., Pirgon, Ö., Dündar, B. N., Çekmez, F., & Hatipoğlu, N. (2015) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.1749 · Cited by 80
Efficacy of poly-unsaturated fatty acid therapy on patients with nonalcoholic steatohepatitis
Li, Y.-H., Yang, L., Sha, K., Liu, T., Zhang, L., & Liu, X. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i22.7008 · Cited by 80
Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease
Leung, C., Herath, C. B., Jia, Z., Andrikopoulos, S., Brown, B. E., Davies, M. J., Rivera, L. R., Furness, J. B., Forbes, J. M., & Angus, P. W. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i35.8026 · Cited by 80
Xu, J., Christian, B., & Jump, D. Β. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601277200 · Cited by 76
Self-citationAsztalos, I. B., Gleason, J. A., Sever, S., Gedik, R., Asztalos, B. F., Horvath, K. V., Dansinger, M. L., Lamon‐Fava, S., & Schaefer, E. J. (2016) · Metabolism · doi:10.1016/j.metabol.2016.07.010 · Cited by 76
How should we manage patients with non‐alcoholic fatty liver disease in 2007?
Chan, H. L., de Silva, H. J., Leung, N. W. Y., Lim, S. G., Farrell, G. C., & NAFLD, T. A. W. P. O. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.04977.x · Cited by 74
Effectiveness of Combined Statin Plus Omega-3 Fatty Acid Therapy for Mixed Dyslipidemia
Barter, P. J., & Ginsberg, H. N. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.05.056 · Cited by 73
Tripathy, S., Torres‐Gonzalez, M., & Jump, D. Β. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m006080 · Cited by 70
Self-citationSuzuki‐Kemuriyama, N., Matsuzaka, T., Kuba, M., Ohno, H., Han, S., Takeuchi, Y., Isaka, M., Kobayashi, K., IWASAKI, H. O., Yatoh, S., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157580 · Cited by 69
Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice
Tripathy, S., Lytle, K. A., Stevens, R. D., Bain, J. R., Newgard, C. B., Greenberg, A. S., Huang, L., & Jump, D. Β. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m050062 · Cited by 65
Self-citationFarooqui, A. A. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712798918851 · Cited by 65
Lytle, K. A., Wong, C. P., & Jump, D. Β. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173376 · Cited by 62
Self-citationComparative efficacy of interventions on nonalcoholic fatty liver disease (NAFLD)
Sawangjit, R., Chongmelaxme, B., Phisalprapa, P., Saokaew, S., Thakkinstian, A., Kowdley, K. V., & Chaiyakunapruk, N. (2016) · Medicine · doi:10.1097/md.0000000000004529 · Cited by 61
Depner, C. M., Traber, M. G., Bobe, G., Kensicki, E., Bohren, K. M., Milne, G. L., & Jump, D. Β. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083756 · Cited by 58
Self-citationCholesterol and nonalcoholic fatty liver disease: Renewed focus on an old villain
Kerr, T. A., Davidson, N. O., Groszmann, R. J., Iwakiri, Y., & Taddei, T. H. (2012) · Hepatology · doi:10.1002/hep.26088 · Cited by 55
Integration of ChREBP-Mediated Glucose Sensing into Whole Body Metabolism
Baraille, F., Planchais, J., Dentin, R., Guilmeau, S., & Postic, C. (2015) · Physiology · doi:10.1152/physiol.00016.2015 · Cited by 55
Thiazolidinediones for nonalcoholic steatohepatitis
He, L., Liu, X., Wang, L., & Yang, Z. (2016) · Medicine · doi:10.1097/md.0000000000004947 · Cited by 55
Signorini, C., Felice, C. D., Durand, T., Oger, C., Galano, J., Leoncini, S., Pecorelli, A., Valacchi, G., Ciccoli, L., & Hayek, J. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/343824 · Cited by 54
Isoprostanes and Related Compounds: Update 2006
Milne, G. L., & Morrow, J. D. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1379 · Cited by 51
Current and future pharmacologic treatment of nonalcoholic steatohepatitis
Banini, B. A., & Sanyal, A. J. (2017) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000356 · Cited by 50
HIGGINS, J. A., Jackman, M. R., Brown, I. L., Johnson, G. C., Steig, A. J., Wyatt, H. R., Hill, J. O., & MacLean, P. S. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-49 · Cited by 47
Lytle, K. A., Depner, C. M., Wong, C. P., & Jump, D. B. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m061275 · Cited by 45
Self-citationUpregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice
Vasandani, C., Kafrouni, A. I., Caronna, A., Bashmakov, Y. K., Gotthardt, M., Horton, J. D., & Spady, D. K. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30120-6 · Cited by 44
Ces3/TGH Deficiency Attenuates Steatohepatitis
Lian, J., Wei, E., Groenendyk, J., Das, S. K., Hermansson, M., Li, L., Watts, R., Thiesen, A., Oudit, G. Y., Michalak, M., et al. (2016) · Scientific Reports · doi:10.1038/srep25747 · Cited by 44
Konuma, K., Itoh, M., Suganami, T., Kanai, S., Nakagawa, N., Sakai, T., Kawano, H., Hara, M., Kojima, S., Izumi, Y., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121528 · Cited by 43
Depner, C. M., Torres‐Gonzalez, M., Tripathy, S., Milne, G. L., & Jump, D. Β. (2012) · Journal of Nutrition · doi:10.3945/jn.112.158865 · Cited by 43
Self-citationBotolin, D., & Jump, D. Β. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212846200 · Cited by 42
Self-citationIs Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible?
Lytle, K. A., & Jump, D. Β. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146942 · Cited by 42
Self-citationPark, H. G., Lawrence, P., Engel, M. G., Kothapalli, K. S. D., & Brenna, J. T. (2016) · FEBS Letters · doi:10.1002/1873-3468.12368 · Cited by 42
Role of serum toll‐like receptors 2 and 4 in non‐alcoholic steatohepatitis and liver fibrosis
Cengiz, M., Özeni̇rler, S., & Elbeğ, Ş. (2015) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12924 · Cited by 41
Management of non-alcoholic fatty liver disease in 2015
Malhotra, N. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i30.2962 · Cited by 41
Petit, J. M., Guiu, B., Duvillard, L., Jooste, V., Brindisi, M., Athias, A., Bouillet, B., Habchi, M., Cottet, V., Gambert, P., et al. (2011) · Clinical Nutrition · doi:10.1016/j.clnu.2011.12.007 · Cited by 39
Dietary approach in the treatment of nonalcoholic fatty liver disease
Ferolla, S. M. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i24.2522 · Cited by 38
New therapies for hepatic fibrosis
Koyama, Y., & Brenner, D. A. (2015) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2015.06.011 · Cited by 38
Impact of dietary fat on the development of non-alcoholic fatty liver disease in Ldlr−/− mice
Jump, D. Β., Depner, C. M., Tripathy, S., & Lytle, K. A. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s002966511500244x · Cited by 36
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n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review
Wang, M., Ma, L., Yang, Y., Xiao, Z., & Wan, J. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1544542 · Cited by 163
Santos, H. O., Price, J. C., & Bueno, A. A. (2020) · Nutrients · doi:10.3390/nu12103159 · Cited by 157
Metadata
- Authors
- Jump, D. B., Lytle, K. A., Depner, C. M., & Tripathy, S.
- Affiliations
- Oregon State University (US)
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 181
- Pages
- 108-125
- ISSN
- 0163-7258 (ISSN-L)
- PMC
- PMC5743581
- OpenAlex
- W2735867008
- Cited by
- 142
- References
- 218
- Citations by year
- 2026: 13 · 2025: 8 · 2024: 20 · 2023: 21 · 2022: 14 · 2021: 18 · 2020: 23 · 2019: 12 · 2018: 11
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 355 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Pharmacology & Therapeutics (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Food and Agriculture (2009-65200-05846)
- National Institutes of Health (DK 094600)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- omega-3 polyunsaturated fatty acids, non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, dietary supplementation, hepatic steatosis, liver fibrosis, liver inflammation, obesity, type 2 diabetes
- MeSH terms
- Animals, Disease Models, Animal, Humans, Fatty Acids, Omega-3, Disease Progression, Non-alcoholic Fatty Liver Disease
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