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Cited by 79Treatment of Major DepressionMicroRNA in disease regulationCancer-related molecular mechanisms research

Non-coding RNAs in depression: Promising diagnostic and therapeutic biomarkers

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Shi, Yachen, Wang, Qingyun, Song, Ruize, Kong, Yan, Zhang, Zhijun·2021·eBioMedicine
DOI 10.1016/j.ebiom.2021.103569PMC PMC8441067
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Abstract

Non-coding RNAs (ncRNAs), including microRNAs, circular RNAs, and long non-coding RNAs, are important regulators of normal biological processes and their abnormal expression may be involved in the pathogenesis of human diseases including depression. Multiple studies have demonstrated a significantly increased or reduced ncRNAs expression in depressed patients compared with healthy subjects and that antidepressant therapy can alter the aberrant expression of ncRNAs in depressed patients. Although the existing evidence is important, it is also mixed and a comprehensive review to guide an effective clinical translation is lacking. Focused on human research, this review summarizes clinical findings of ncRNAs in depression, including those in brain tissues and peripheral samples. We outlined the characteristics and functions of ncRNAs and highlighted their performance in the diagnosis and treatment of depression. Although their precise roles in depression remain uncertain, ncRNAs have shown potential value as biomarkers for diagnosis and therapy in depressed patients.

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Cited by

Sorted by citations

Authors
Shi, Y., Wang, Q., Song, R., Kong, Y., & Zhang, Z.
Affiliations
  • Zhongda Hospital Southeast University (CN)
  • University of California, Davis (US)
  • Southeast University (CN)
  • Chinese Academy of Sciences (CN)
Corresponding author
  • Kong, Yan
  • Zhang, Zhijun
ORCID
Venue
eBioMedicine
Publisher
Elsevier BV
Published
2021-09
Volume
71
Pages
103569
ISSN
2352-3964 (ISSN-L)
DOI
10.1016/j.ebiom.2021.103569
PMC
PMC8441067
OpenAlex
W3201505584
Cited by
79
References
20
Citations by year
2026: 6 · 2025: 23 · 2024: 22 · 2023: 10 · 2022: 18
FWCI
1.58
Type
journal article
Language
en
Open access
Licence
Locations
  • EBioMedicine (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords
non-coding RNA, depression, microRNA, circular RNA, long non-coding RNA, biomarkers, depression diagnosis, antidepressant treatment, brain tissue, depression pathogenesis
MeSH terms
Cell-Free Nucleic Acids, Drug Development, RNA, Circular, Animals, Depression, Disease Susceptibility, Gene Expression Regulation, Humans, Prognosis, Biomarkers, Molecular Diagnostic Techniques, RNA Interference, MicroRNAs, Gene Regulatory Networks, Molecular Targeted Therapy, RNA, Long Noncoding

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