Nanoparticle-based hyperthermia, a local treatment modulating the tumor extracellular matrix
Open accessAbstract
The structural complexity and physical properties of the tumor microenvironment negatively affect the penetration and efficiency of conventional anticancer drugs. While previously underestimated, the tumor microenvironment now becomes a potential target for cancer treatment. This microenvironment can be modulated either systemically by pharmacological means, or locally, through physical effects mediated by certain nanoparticles. Some of them, such as magnetic, plasmonic or carbon-based nanoparticles, can generate heat on demand in a spatially and temporally controlled manner. In addition, the nanoparticles can be either activated by light or magnetic stimuli. The impact of the resulting local heating can be observed on the ultrastructural level, as it strongly affects the organization of collagen fibers, and on the macroscopic level, since the thermal damages alter the mechanical properties of the tumor. Nanoparticle-based hyperthermia thus improves the effect of conventional anticancer drugs, as it allows their better penetration through the altered extracellular matrix. Here we suggest the use of nanoparticle-generated hyperthermia, obtained after magnetic or light activation, as an adjuvant treatment to prime the tumor microenvironment and improve the efficacy of chemotherapy.
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Elevated IFP diminishes convective transport, reduces vascular perfusion, and severely impairs drug accumulation in the tumor core.
“This elevated IFP diminishes convective transport, reduces vascular perfusion, and severely impairs drug accumulation in the tumor core [88,89].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [89]
Increased ECM stiffness and compactness restrict intercellular space, further compromising the efficacy of therapeutic delivery.
“Additionally, increased ECM stiffness and compactness restrict intercellular space, further compromising the efficacy of therapeutic delivery [89,90].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [89]
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- Authors
- Kolosnjaj-Tabi, J., Marangon, I., Nicolas-Boluda, A., Silva, A. K. A., & Gazeau, F.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Gazeau, Florence
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 126
- Pages
- 123-137
- ISSN
- 1043-6618 (ISSN-L)
- OpenAlex
- W2735559316
- Cited by
- 86
- References
- 73
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 14 · 2023: 11 · 2022: 11 · 2021: 9 · 2020: 15 · 2019: 12 · 2018: 1 · 2017: 1
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- Locations
- Pharmacological Research (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- European Union’s Horizon 2020 research and innovation program
- Institute thematique multi-organismes (ITMO) Cancer and the doctoral school Frontières du Vivant (FdV) - Programme Bettencourt
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- tumor extracellular matrix, tumor microenvironment, magnetic nanoparticles, plasmonic nanoparticles, carbon nanoparticles, collagen fiber organization, tumor mechanical properties, drug penetration, adjuvant chemotherapy, photothermal excitation, magnetic activation, cancer thermotherapy
- MeSH terms
- Animals, Antineoplastic Agents, Extracellular Matrix, Fever, Humans, Neoplasms, Nanoparticles, Tumor Microenvironment
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