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Decoding the rosetta stone of mitonuclear communication
Open accessAbstract
Cellular homeostasis in eukaryotic cells requires synchronized coordination of multiple organelles. A key role in this stage is played by mitochondria, which have recently emerged as highly interconnected and multifunctional hubs that process and coordinate diverse cellular functions. Beyond producing ATP, mitochondria generate key metabolites and are central to apoptotic and metabolic signaling pathways. Because most mitochondrial proteins are encoded in the nuclear genome, the biogenesis of new mitochondria and the maintenance of mitochondrial functions and flexibility critically depend upon effective mitonuclear communication. This review addresses the complex network of signaling molecules and pathways allowing mitochondria-nuclear communication and coordinated regulation of their independent but interconnected genomes, and discusses the extent to which dynamic communication between the two organelles has evolved for mutual benefit and for the overall maintenance of cellular and organismal fitness.
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“The human homolog of Rtg3p is the microphthalmia-associated transcription factor (MITF) (Goding and Arnheiter 2019), which is not involved in mitonuclear signaling that in Metazoa evolved independently and uses different mechanisms (Butow and Avadhani 2004; Jazwinski 2014; English et al. 2020).”
From Mitochondrial retrograde control of transcription evolves with respiratory stress, metabolic adaptation, and virulence in budding yeasts (2026) · cites this paper as English et al. 2020
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“The human homolog of Rtg3p is the microphthalmia-associated transcription factor (MITF) (Goding and Arnheiter 2019), which is not involved in mitonuclear signaling that in Metazoa evolved independently and uses different mechanisms (Butow and Avadhani 2004; Jazwinski 2014; English et al. 2020).”
From Mitochondrial retrograde control of transcription evolves with respiratory stress, metabolic adaptation, and virulence in budding yeasts (2026) · cites this paper as English et al. 2020
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Metadata
- Authors
- English, J., Son, J. M., Cardamone, M. D., Lee, C., & Perissi, V.
- Affiliations
- Boston University (US)
- University of Southern California (US)
- Corresponding author
- Perissi, Valentina
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 161
- Pages
- 105161
- ISSN
- 1043-6618 (ISSN-L)
- PMC
- PMC7755734
- OpenAlex
- W3081296598
- Cited by
- 55
- References
- 359
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 17 · 2023: 8 · 2022: 4 · 2021: 8 · 2020: 1
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Pharmacological Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R01GM127625, 5T32GM008541)
- VP, NIH (R01AG052258)
- AFAR fellowship
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- mitochondria, nuclear genome, mitochondrial biogenesis, cellular homeostasis, mitochondrial pathway, mitochondrial metabolism, apoptosis, organelle evolution
- MeSH terms
- Animals, Cell Communication, Cell Nucleus, Gene Expression Regulation, Humans, Mitochondria, Nuclear Proteins, Signal Transduction, Mitochondrial Proteins
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