Glycyrrhizic acid (GA), a triterpenoid saponin glycoside alleviates ultraviolet-B irradiation-induced photoaging in human dermal fibroblasts
Abstract
Glycyrrhizic acid (GA), a triterpenoid saponin glycoside from the roots and rhizomes of licorice is used in traditional and modern medicine for the treatment of numerous medical conditions including skin diseases and beauty care product. In the present study, we investigated the effect of GA against ultraviolet B (UVB) irradiation-induced photoaging in human dermal fibroblasts (HDFs) and its possible mechanism of action. HDFs were subjected to photoaging by sub-toxic dose of UVB (10 mj/cm(2)) irradiation. Cell viability, matrix metalloproteinase 1 (MMP1), pro-collagen 1, cellular and nuclear morphology, cell cycle, intracellular reactive oxygen species (ROS), caspase 3 and hyaluronidase inhibition assays were performed. Western blotting was used to evaluate the expression of NF-kappa B (NF-κB) and cytochrome-C proteins. GA treatment significantly inhibited photoaging. It achieved this by reducing ROS, NF-κB, cytochrome c, caspase 3 levels and inhibiting hyaluronidase enzyme. The main mechanism seems to be, most likely by blocking MMP1 activation by modulating NF-κB signaling. These findings may be useful for development of natural and safe photoprotective agents against UVB irradiation.
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Glycyrrhizinic acid blocks MMP1 activation by modulating NF-kB signaling.
“The principal mechanism appeared to be connected with the block of MMP1 activation by modulating NF-kB signaling [65].”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [65]
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Crosstalk of reactive oxygen species and NF-κB signaling
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Mechanisms of photoaging and chronological skin aging
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Plant extracts and natural compounds used against UVB-induced photoaging
Cavinato, M., Waltenberger, B., Baraldo, G., Grade, C. V. C., Stuppner, H., & Jansen-Dürr, P. (2017) · Biogerontology · doi:10.1007/s10522-017-9715-7 · Cited by 218 · see citing works
Cerulli, A., Masullo, M., Montoro, P., & Piacente, S. (2022) · Cosmetics · doi:10.3390/cosmetics9010007 · Cited by 83 · see citing works
- Authors
- Afnan, Q., Adil, M. D., Nissar-Ul, A., Rafiq, A. R., Amir, H. F., Kaiser, P., Gupta, V. K., Vishwakarma, R., & Tasduq, S. A.
- Affiliations
- Indian Institute of Integrative Medicine (IN)
- Corresponding author
- Tasduq, Sheikh Abdullah
- ORCID
- Vishwakarma, Ram
- Venue
- Phytomedicine
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 19
- Issue
- 7
- Pages
- 658-664
- ISSN
- 0944-7113 (ISSN-L)
- OpenAlex
- W2017380658
- Cited by
- 60
- References
- 3
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 7 · 2021: 4 · 2020: 9 · 2019: 8 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 3
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytomedicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- glycyrrhizin, licorice, UVB irradiation, photoaging, human dermal fibroblasts, reactive oxygen species, NF-κB signaling, MMP-1, hyaluronidase inhibition, caspase-3, cytochrome c, photoprotective agents, collagen
- MeSH terms
- Fibroblasts, Glycyrrhiza, Humans, Hyaluronoglucosaminidase, Plant Extracts, Skin, Ultraviolet Rays, Signal Transduction, Skin Aging, NF-kappa B, Reactive Oxygen Species, Plant Roots, Glycyrrhizic Acid, Rhizome, Cytochromes c, Caspase 3, Matrix Metalloproteinase Inhibitors
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